| UniProt ID | COE3_HUMAN | |
|---|---|---|
| UniProt AC | Q9H4W6 | |
| Protein Name | Transcription factor COE3 | |
| Gene Name | EBF3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 596 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Transcriptional activator. [PubMed: 28017373] | |
| Protein Sequence | MFGIQENIPRGGTTMKEEPLGSGMNPVRSWMHTAGVVDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNEKTNNGIHYKLQLLYSNGVRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTAPSYLENATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQIPTLGNNPAHTGMMGVNSFSSQLAVNVSETSQANDQVGYSRNTSSVSPRGYVPSSTPQQSNYNTVSTSMNGYGSGAMASLGVPGSPGFLNGSSANSPYGIVPSSPTMAASSVTLPSNCSSTHGIFSFSPANVISAVKQKSAFAPVVRPQASPPPSCTSANGNGLQAMSGLVVPPM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Methylation | GIQENIPRGGTTMKE CCCCCCCCCCCCCCC | 52.99 | - | |
| 45 | Phosphorylation | DANTAAQSGVGLARA CHHHHHHHCCCHHHH | 30.62 | 24719451 | |
| 56 | Ubiquitination | LARAHFEKQPPSNLR HHHHHHHCCCCCCCC | 68.13 | 32142685 | |
| 65 | Phosphorylation | PPSNLRKSNFFHFVL CCCCCCCCCHHHHHH | 32.22 | - | |
| 111 | Methylation | TNNGIHYKLQLLYSN CCCHHHHHHHHHHHC | 18.65 | - | |
| 331 | Ubiquitination | VEVTLSYKSKQFCKG EEEEEEECCHHHCCC | 48.04 | - | |
| 337 | Phosphorylation | YKSKQFCKGAPGRFV ECCHHHCCCCCCCEE | 60.44 | 24719451 | |
| 346 | Phosphorylation | APGRFVYTALNEPTI CCCCEEEEECCCCCC | 21.26 | 24719451 | |
| 353 | Ubiquitination | TALNEPTIDYGFQRL EECCCCCCCHHHHHH | 5.86 | 32142685 | |
| 355 | Phosphorylation | LNEPTIDYGFQRLQK CCCCCCCHHHHHHHH | 18.91 | 24719451 | |
| 413 | Phosphorylation | ADIAEALYSVPRNHN HHHHHHHHCCCCCCC | 18.05 | 25884760 | |
| 414 | Phosphorylation | DIAEALYSVPRNHNQ HHHHHHHCCCCCCCC | 26.88 | 29978859 | |
| 465 | Phosphorylation | VGYSRNTSSVSPRGY CCCCCCCCCCCCCCC | 32.09 | 30177828 | |
| 466 | Phosphorylation | GYSRNTSSVSPRGYV CCCCCCCCCCCCCCC | 25.28 | 30177828 | |
| 468 | Phosphorylation | SRNTSSVSPRGYVPS CCCCCCCCCCCCCCC | 15.72 | 30177828 | |
| 527 | Phosphorylation | GIVPSSPTMAASSVT CCCCCCCCCCCCCCC | 22.76 | 32142685 | |
| 572 | Phosphorylation | PVVRPQASPPPSCTS CCCCCCCCCCCCCCC | 32.46 | 28348404 | |
| 576 | Phosphorylation | PQASPPPSCTSANGN CCCCCCCCCCCCCCC | 35.48 | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of COE3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of COE3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of COE3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MARF1_HUMAN | KIAA0430 | physical | 27173435 | |
| PAN2_HUMAN | PAN2 | physical | 27173435 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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