COE3_HUMAN - dbPTM
COE3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID COE3_HUMAN
UniProt AC Q9H4W6
Protein Name Transcription factor COE3
Gene Name EBF3
Organism Homo sapiens (Human).
Sequence Length 596
Subcellular Localization Nucleus .
Protein Description Transcriptional activator. [PubMed: 28017373]
Protein Sequence MFGIQENIPRGGTTMKEEPLGSGMNPVRSWMHTAGVVDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNEKTNNGIHYKLQLLYSNGVRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTAPSYLENATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQIPTLGNNPAHTGMMGVNSFSSQLAVNVSETSQANDQVGYSRNTSSVSPRGYVPSSTPQQSNYNTVSTSMNGYGSGAMASLGVPGSPGFLNGSSANSPYGIVPSSPTMAASSVTLPSNCSSTHGIFSFSPANVISAVKQKSAFAPVVRPQASPPPSCTSANGNGLQAMSGLVVPPM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
10MethylationGIQENIPRGGTTMKE
CCCCCCCCCCCCCCC
52.99-
45PhosphorylationDANTAAQSGVGLARA
CHHHHHHHCCCHHHH
30.6224719451
56UbiquitinationLARAHFEKQPPSNLR
HHHHHHHCCCCCCCC
68.1332142685
65PhosphorylationPPSNLRKSNFFHFVL
CCCCCCCCCHHHHHH
32.22-
111MethylationTNNGIHYKLQLLYSN
CCCHHHHHHHHHHHC
18.65-
331UbiquitinationVEVTLSYKSKQFCKG
EEEEEEECCHHHCCC
48.04-
337PhosphorylationYKSKQFCKGAPGRFV
ECCHHHCCCCCCCEE
60.4424719451
346PhosphorylationAPGRFVYTALNEPTI
CCCCEEEEECCCCCC
21.2624719451
353UbiquitinationTALNEPTIDYGFQRL
EECCCCCCCHHHHHH
5.8632142685
355PhosphorylationLNEPTIDYGFQRLQK
CCCCCCCHHHHHHHH
18.9124719451
413PhosphorylationADIAEALYSVPRNHN
HHHHHHHHCCCCCCC
18.0525884760
414PhosphorylationDIAEALYSVPRNHNQ
HHHHHHHCCCCCCCC
26.8829978859
465PhosphorylationVGYSRNTSSVSPRGY
CCCCCCCCCCCCCCC
32.0930177828
466PhosphorylationGYSRNTSSVSPRGYV
CCCCCCCCCCCCCCC
25.2830177828
468PhosphorylationSRNTSSVSPRGYVPS
CCCCCCCCCCCCCCC
15.7230177828
527PhosphorylationGIVPSSPTMAASSVT
CCCCCCCCCCCCCCC
22.7632142685
572PhosphorylationPVVRPQASPPPSCTS
CCCCCCCCCCCCCCC
32.4628348404
576PhosphorylationPQASPPPSCTSANGN
CCCCCCCCCCCCCCC
35.4827251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of COE3_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of COE3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of COE3_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MARF1_HUMANKIAA0430physical
27173435
PAN2_HUMANPAN2physical
27173435

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of COE3_HUMAN

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Related Literatures of Post-Translational Modification

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