MYCB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYCB2_MOUSE
• UniProt AC: Q7TPH6
• Protein Name: E3 ubiquitin-protein ligase MYCBP2 {ECO:0000305}
• Gene Name: Mycbp2 {ECO:0000312|MGI:MGI:2179432}
• Organism: Mus musculus (Mouse).
• Sequence Length: 4749
• Subcellular Localization: Nucleus . Cell projection, axon . Cytoplasm, cytoskeleton . Localizes to axon shafts and associates with microtubule cytoskeleton (PubMed:18031680). Translocates to the nucleus following interaction with sumoylated RANGAP1 (PubMed:26304119).
• Protein Description: Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (By similarity). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (By similarity). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration. [PubMed: 14729956]
• Protein Sequence: MMMCAATASPAAASSGPGGDGFFAAATISSSPAPGALFMPVPDGSVAAAGLGLGLPTTDSRGHYQLLLSGRALADRYRRIYTTALSDRDQAGSSTGHPASRNKKILNKKKLKRKQKSKSKVKTRSKSENVENTVIIPDIKLHSNPSAFNIYCNVRHCVLEWQKKETSLAAASKNSVQSGESDSDEEEESREPPIKLPKIIEVGLCEVFELIKETRFSHPSLCLRSLQALLNVLQGQQPEGLQSEPPEVLESLFQLLLEITVRSTGMNDSTGQSLTALSCACLFSLVASWGETGRTLQAISAILTNNGSHACQTIQVPTILNSLQRSVQAVLVGKIQVQDWFSNGIKKAALMHKWPLKEVSVDEDDQCLLQNDGFFLYLLCKDGLYKIGSGYSGTVRGHIYNSTSRIRNRKEKKSWLGYAQGYLLYRDLNNHSMTAIRISPETLEQDGTVLLPDCHTEGQNILFTDGEYINQIAASRDDGFVVRIFATSTEPVLQQELQLKLARKCLHACGISLFDLEKDLHIISTGFDEESAILGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITKSPKIVHFSVGHDGSHALLVAEDGSVFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKDAIYSDSSSLVSDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMDEDLEEELDEKDEKSMMCPPGMHKWKLEQCMVCTVCGDCTGYGASCVSSGRPDRVPGGICGCGSGESGCAVCGCCKACARELDGQEARQRGILDAVKEMIPLDLLLAVPVPGVNIEEHLQLRQEEKRQRVIRRHRLEDGRGPLVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDGSGDRGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLGRPILDIPYWNAKPAPMPNIGSKYGRKATWIGASGDQTFLRIDEALINSHVLATSEIFASKHIIGLVPASISEPPPFKCLLINKVDGSCKTFNDSEQEDLQGFGVCLDPVYDVLWRFRPSTRELWCYNAVVADARLPSATDMQSRCSILSPELALPTGSRALTTRSHAALHILGCLDTLAAMQDLKMGIASTEEETQAVMKVYSKEDYSVVNRFESHGGGWGYSAHSVEAIRFSADTDILLGGLGLFGGRGEYTAKIKLFELGPDGGDHETDGDLLAETDVLAYDCAAREKYAMMFDEPVLLQAGWWYVAWARVSGPSSDCGSHGQASITTDDGVIFQFKSSKKSNNGTDVNAGQIPQLLYRLPTSDGSTSKGKQQTSEPVHILKRSFARTVSVECFESLLSILHWSWTTLVLGVEELRGLKGFQFTATLLDLERLRFVGTCCLRLLRVYTCEIYPVSATGKAVVEETSKLAECIGKTRTLLRKILSEGVDHCMVKLDNDPQGYLSQPLRLLEAVLQECHNTFTACFHSFYPTPALQWACLCDLLNCLDQEANFKTSSSRLLAAVMSALCHTSVKLTSLFPIAYDGEVLLRSIVKQVSTENDSTLVHRFPLLVGHMEKLSQSEENISGMTSFREVLEKMLVIVVLPVRNSLRRESELFSSHLVSNTCGLLASIVSELTASALGSEVDGLNSLHSVKASANRFTKTSQGRSWNTGNGSPDAICFAVDKPGIVVVGFAVYGGGGIHEYELEVLVDDSEHAGDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNYGSRTANGDGGMTTVQCPDGVTFTFSTCSLSSNGTNQTRGQIPQILYYRSEFDGDLQSQLLSKANEEDKNCSRALSVVSTVVRAAKDLLHRALAVDADDIPELLSSSSLFSMLLPLIIAYIGPVAAAIPKVAVEVFGLVQQLLPSVAILNQKYAPPAFNPNQSTDSTTGNQPEQGLSACTTSNHYAVIESEHPYKPACVMHYKVTFPECVRWMTIEFDPQCGTAQSEDVIRLLIPVRTIQNSGYGAKLTSVHENLNSWVELKKYSGSSGWPTMVLVLPGNEALFSLETASDYVKDDKASFYGFKCFAIGYEFSPGPDEGVIQLEKELANLGGVCAAALMKKDLALPVGNELEEDLEILEEAALQVCKTHSGILGKGLALSHSPTILEALEGNLPLQIQSNEQSFLDDFIACVPGSSGGRLARWLQPDSYADPQKTSLILNKDDIRCGWPTTITVQTKDQYGDVVHVPNMKVEVKAVPVSQKKTSLQQDQGKKCQRIPGSPSAAASSADMTFGGLASPKLDVSYEPMIVKEARYIAITMMKVYENYSFEELRFASPTPKRPSENMLIRVNNDGTYCANWTPGAIGLYTVHVTIDGIEIDAGLEVKVKDPPKGMIPPGTQLVKPKADPQPNKIRKFVAKDSAGLRIRSHPSLQSEQIGIVRVNGTITFIDEIHNDDGVWLRLNEETIKKYVPNMNGYTEAWCLSFNQHLGKSLLVPVDNIFNASQGVRDLDVFSWTSKAFFPQEPKTNTDDFFKDMNSCGPQEATMQERDHPFLRGGPGMYKVVKTGPSGHNIRSCPNLRGIPIGMLVLGNKVKAVGEVTNSEGAWVQLDKNSMVEFCESDEGEAWSLARDRGGNQYLRHEDEQVLLDQNSQPPPPSPFSVQAFNKGASCSAQGFDYGLGNNKGDQLSAILNSIQSRPNLPAPSIFDQAAKPPSSLVHSPFVFGQPLSFQQRQLQSDRGTISTSSRPVSTSGKSELPSKHSRSVKPDGHVSRTPADQKKPRGTEGLSASESLMLKSDAAKLRSDSHSRSLSPNHNTLQTLKSDGRTSSGFRAESPGPGSRSSSPKPKPLPTPRSSPSGASSPRSSSPQDKNLPQKSTAPAKTKLDPPRERSKSDSYTLDPDTLRKKKMPLTEPLRGRSTSPKPKPVPKDPKDSPGSENRAPSPHVVQENLHSEVVEVCTSSTLKTNGVTDSTCDDSGDLKSVDEGSNKVHFSIGKAPLKDEQEMRASPKISRKCANRHTRPKKEKSNFLFKGDGTKSLEPAKQAMSPSVAECARAVFASFLWHEGIVHDAMACSSFLKFNPDLSKEHAPIRSSLNSQPPTEEKEIKLKNRHSLEISSALNMFNIAPHGPDISKMGSINKNKVLSMLKEPPLHEKCEDGKSEATFEMSMHHTMKSKSPLPLTLQHLVAFWEDISLATIKAASQNMIFPSPGSCAVLKKKECEKENKKTKKEKKKKEKTEIRPRGNLFGEMAQLAVGGPEKDTICELCGESHPYPVTYHMRQAHPGCGRYAGGQGYNSIGHFCGGWAGNCGDGGMGGSTWYLVCDRCREKYLREKQAAAREKVKQSRRKPMQVKTPRALPTMEAHQVIKANALFLLSLSSAAEPSILCYHPAKPFQSQLPIVKEGVSEDLPVKMPCLYLQTLARHHHENFVGYQDDNLFQDEMRYLRSTSVPAPYISVTPDASPNVFEEPESNMKSMPPSLETSPITDTDLAKRTVFQRSYSVVASEYDKQHSILPARVKAIPRRRVNSGDTVGSSLLRHPSPELSRLISAHSSLSKGERNFQWPVLAFVIQHHDLEGLEIAMKQALRKSACRVFAMEAFNWLLCNVIQTTSLHDILWHFVAALTPSPVEAEEDEDEDNKSNKENAEQEKDTRVCEHPLSDIVIAGEAAHPLPHTFHRLLQTISDLMMSLPSGSSLQQMALRCWSLKFKQSDHQFLHQSNVFHHINNILSKSDDGDSEESFSISVQSGFEAMSQELCIVMCLKDLTSIVDIKTSSRPAMIGSLTDGSTETFWESGDEDKNKTKNITINCVKGINARYVSVHVDNSRDLGNKVTSMTFLTGKAVEELCRIKQVDLDSRHIGWVTSELPGGDNQIIKIELKGPENTLRVRQVKVLGWKDGESTKIAGQISASVAQQRSCEAETLRVFRLITSQVFGKLISGDAEPTPEQEEKALLSSPEGEEKVYNATSDADLKEHMVGIIFSRSKLTNLQKQVCAHIVQAIRMEATRVREEWEHAISSKENANSQPSDEDASSDAYCFELLSMVLALSGSNVGRQYLAQQLTLLQDLFSLLHTASPRVQRQVTSLLRRVLPEVTPNRLASIIGVKSLPPADISDIIHSTEKGDWNKLGILDMFLGCIAKALTVQLKAKGTTITGTAGTTVGKGVTTVTLPMIFNSSYLRRGESHWWMKGSTPTQISEIIIRLIKDMAAGHLSEAWSRVTKNAIAETIIALTKMEEEFRSPVRCIATTRLWLALASLCVLDQDHVDRLSSGRWMGKDGQQKQMPMCDNHDDGETAAIILCNICGNLCTDCDRFLHLHRRTKTHQRQVFKEEEEAIKVDLHEGCGRTKLFWLMALADSKTMKAMVEFREHTGKPTTSSSEACRFCGSRSGTELSAVGSVCSDADCQEYAKIACSKTHPCGHPCGGVRNEEHCLPCLHGCDKSATTLKQDADDMCMICFTEALSAAPAIQLDCSHVFHLQCCRRVLENRWLGPRITFGFISCPICKNKINHIVLKDLLDPIKELYEDVRRKALMRLEYEGLHKSEAITTPGVRFYNDAAGYAMNRYAYYVCYKCRKAYFGGEARCDAEAGQGDDYDPRELICGACSDVSRAQMCPKHGTDFLEYKCRYCCSVAVFFCFGTTHFCNACHDDFQRMTSIPKEELPHCPAGPKGKQLEGTECPLHVVHPPTGEEFALGCGVCRNAHTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	VPDGSVAAAGLGLGL CCCCCCCCCCCCCCC	28.30	29514104
55	Phosphorylation	AAGLGLGLPTTDSRG CCCCCCCCCCCCCCC	27.95	25338131
89	Phosphorylation	TTALSDRDQAGSSTG HHHCCCHHHCCCCCC	35.33	-
127	Phosphorylation	KVKTRSKSENVENTV CCCCCCCCCCCCCEE	51.14	-
137	Phosphorylation	VENTVIIPDIKLHSN CCCEEECCCCCCCCC	25.85	29899451
140	Phosphorylation	TVIIPDIKLHSNPSA EEECCCCCCCCCCHH	42.23	23684622
143	Phosphorylation	IPDIKLHSNPSAFNI CCCCCCCCCCHHHHE	46.04	23684622
145	Phosphorylation	DIKLHSNPSAFNIYC CCCCCCCCHHHHEEE	57.09	23684622
151	Phosphorylation	NPSAFNIYCNVRHCV CCHHHHEEEEHEEHH	45.27	29899451
178	Phosphorylation	ASKNSVQSGESDSDE HHHCCCCCCCCCCCC	11.68	21183079
181	Phosphorylation	NSVQSGESDSDEEEE CCCCCCCCCCCCHHH	28.00	21183079
183	Phosphorylation	VQSGESDSDEEEESR CCCCCCCCCCHHHHC	3.62	21183079
513	Phosphorylation	LHACGISLFDLEKDL HHHCCCCHHHHCCCE	9.84	22802335
514	Phosphorylation	HACGISLFDLEKDLH HHCCCCHHHHCCCEE	16.70	22802335
518	Phosphorylation	ISLFDLEKDLHIIST CCHHHHCCCEEEEEC	12.51	22802335
520	Phosphorylation	LFDLEKDLHIISTGF HHHHCCCEEEEECCC	26.02	22802335
529	Phosphorylation	IISTGFDEESAILGA EEECCCCHHHHHHCC	53.59	22802335
713	Phosphorylation	GVNNKGQCGRDTGAM EECCCCCCCCCCCCC	15.09	26643407
872	Acetylation	RVIRRHRLEDGRGPL HHHHHHCCCCCCCCE	57.49	7744257
874	Acetylation	IRRHRLEDGRGPLVF HHHHCCCCCCCCEEE	70.31	7744267
994	Phosphorylation	QALPGPSTQVTAGSN HCCCCCCCEECCCCC	16.19	-
1008	Methylation	NHTAVLLMDGQVFTF CCEEEEEECCEEEEE	46.65	-
1009	Phosphorylation	HTAVLLMDGQVFTFG CEEEEEECCEEEEEE	24.70	-
1148	Phosphorylation	RPSTRELWCYNAVVA CCCCCHHCEEEEEEE	21.12	28973931
1149	Phosphorylation	PSTRELWCYNAVVAD CCCCHHCEEEEEEEC	30.90	28973931
1583	Phosphorylation	NFKTSSSRLLAAVMS CCCCCHHHHHHHHHH	27.75	25521595
1584	Phosphorylation	FKTSSSRLLAAVMSA CCCCHHHHHHHHHHH	39.69	25521595
1588	Phosphorylation	SSRLLAAVMSALCHT HHHHHHHHHHHHHCC	34.91	28833060
1589	Phosphorylation	SRLLAAVMSALCHTS HHHHHHHHHHHHCCC	35.35	28833060
1605	Phosphorylation	KLTSLFPIAYDGEVL CHHHCCCCCCCHHHH	42.61	28066266
1607	Phosphorylation	TSLFPIAYDGEVLLR HHCCCCCCCHHHHHH	43.43	28066266
1612	Phosphorylation	IAYDGEVLLRSIVKQ CCCCHHHHHHHHHHH	33.81	28066266
1621	Phosphorylation	RSIVKQVSTENDSTL HHHHHHHCCCCCCCH	4.48	-
2084	Phosphorylation	GAKLTSVHENLNSWV CHHCEEHHHCHHHHE	36.57	28059163
2086	Phosphorylation	KLTSVHENLNSWVEL HCEEHHHCHHHHEEH	13.60	28059163
2278	Phosphorylation	LNKDDIRCGWPTTIT EECCCCCCCCCEEEE	32.82	27841257
2293	Phosphorylation	VQTKDQYGDVVHVPN EEEECCCCCEEECCC	15.44	26824392
2295	Phosphorylation	TKDQYGDVVHVPNMK EECCCCCEEECCCCE	32.03	25266776
2299	Phosphorylation	YGDVVHVPNMKVEVK CCCEEECCCCEEEEE	22.72	26643407
2300	Phosphorylation	GDVVHVPNMKVEVKA CCEEECCCCEEEEEE	24.46	26643407
2304	Phosphorylation	HVPNMKVEVKAVPVS ECCCCEEEEEEEECC	21.48	20415495
2310	Phosphorylation	VEVKAVPVSQKKTSL EEEEEEECCCCCCCC	27.84	27841257
2331	Phosphorylation	KCQRIPGSPSAAASS CCCCCCCCHHHHHHC	11.37	24719451
2336	Phosphorylation	PGSPSAAASSADMTF CCCHHHHHHCCCCCC	7.92	28285833
2348	Phosphorylation	MTFGGLASPKLDVSY CCCCCCCCCCCCCCC	26.96	28285833
2557	Phosphorylation	IFNASQGVRDLDVFS HCCCCCCCCCCCCEE	20.73	-
2614	Phosphorylation	GPGMYKVVKTGPSGH CCCCEEEEECCCCCC	28.21	22871156
2669	Phosphorylation	NSMVEFCESDEGEAW CCCEEEEECCCCCHH	44.33	30352176
2672	Phosphorylation	VEFCESDEGEAWSLA EEEEECCCCCHHHHH	19.39	25266776
2757	Phosphorylation	LPAPSIFDQAAKPPS CCCCCHHHCCCCCCH	40.46	25338131
2761	Phosphorylation	SIFDQAAKPPSSLVH CHHHCCCCCCHHHCC	21.38	25338131
2803	Phosphorylation	RPVSTSGKSELPSKH CCCCCCCCCCCCCCC	19.31	-
2817	Phosphorylation	HSRSVKPDGHVSRTP CCCCCCCCCCCCCCC	25.30	29514104
2821	Phosphorylation	VKPDGHVSRTPADQK CCCCCCCCCCCCCCC	35.89	27742792
2823	Phosphorylation	PDGHVSRTPADQKKP CCCCCCCCCCCCCCC	25.54	25521595
2828	Phosphorylation	SRTPADQKKPRGTEG CCCCCCCCCCCCCCC	16.82	28833060
2838	Phosphorylation	RGTEGLSASESLMLK CCCCCCCHHHHHHCC	32.54	23527152
2840	Phosphorylation	TEGLSASESLMLKSD CCCCCHHHHHHCCCC	41.14	24759943
2841	Phosphorylation	EGLSASESLMLKSDA CCCCHHHHHHCCCCH	18.81	-
2846	Phosphorylation	SESLMLKSDAAKLRS HHHHHCCCCHHHHCC	33.88	23527152
2851	Phosphorylation	LKSDAAKLRSDSHSR CCCCHHHHCCCCCCC	31.93	23737553
2853	Phosphorylation	SDAAKLRSDSHSRSL CCHHHHCCCCCCCCC	36.54	25266776
2854	Phosphorylation	DAAKLRSDSHSRSLS CHHHHCCCCCCCCCC	49.93	25266776
2855	Phosphorylation	AAKLRSDSHSRSLSP HHHHCCCCCCCCCCC	37.88	27742792
2859	Phosphorylation	RSDSHSRSLSPNHNT CCCCCCCCCCCCCCH	66.37	-
2861	Phosphorylation	DSHSRSLSPNHNTLQ CCCCCCCCCCCCHHH	10.34	-
2863	Phosphorylation	HSRSLSPNHNTLQTL CCCCCCCCCCHHHHH	38.73	27149854
2866	Phosphorylation	SLSPNHNTLQTLKSD CCCCCCCHHHHHHHC	48.05	27087446
2867	Phosphorylation	LSPNHNTLQTLKSDG CCCCCCHHHHHHHCC	25.10	26160508
2869	Phosphorylation	PNHNTLQTLKSDGRT CCCCHHHHHHHCCCC	49.27	26160508
2872	Phosphorylation	NTLQTLKSDGRTSSG CHHHHHHHCCCCCCC	44.38	27087446
2873	Phosphorylation	TLQTLKSDGRTSSGF HHHHHHHCCCCCCCC	24.65	27087446
2876	Phosphorylation	TLKSDGRTSSGFRAE HHHHCCCCCCCCEEC	38.25	26160508
2877	Phosphorylation	LKSDGRTSSGFRAES HHHCCCCCCCCEECC	47.52	25266776
2878	Phosphorylation	KSDGRTSSGFRAESP HHCCCCCCCCEECCC	28.03	22942356
2884	Phosphorylation	SSGFRAESPGPGSRS CCCCEECCCCCCCCC	6.15	24719451
2893	Phosphorylation	GPGSRSSSPKPKPLP CCCCCCCCCCCCCCC	45.17	24719451
2902	Methylation	KPKPLPTPRSSPSGA CCCCCCCCCCCCCCC	51.14	30988173
2903	Phosphorylation	PKPLPTPRSSPSGAS CCCCCCCCCCCCCCC	31.58	25521595
2905	Phosphorylation	PLPTPRSSPSGASSP CCCCCCCCCCCCCCC	32.79	25521595
2907	Phosphorylation	PTPRSSPSGASSPRS CCCCCCCCCCCCCCC	27.40	27742792
2908	Phosphorylation	TPRSSPSGASSPRSS CCCCCCCCCCCCCCC	19.13	26239621
2909	Phosphorylation	PRSSPSGASSPRSSS CCCCCCCCCCCCCCC	28.74	26239621
2911	Phosphorylation	SSPSGASSPRSSSPQ CCCCCCCCCCCCCCC	31.09	-
2914	Phosphorylation	SGASSPRSSSPQDKN CCCCCCCCCCCCCCC	33.57	28833060
2916	Phosphorylation	ASSPRSSSPQDKNLP CCCCCCCCCCCCCCC	51.33	24719451
2930	Phosphorylation	PQKSTAPAKTKLDPP CCCCCCCCCCCCCCC	35.74	23684622
2931	Phosphorylation	QKSTAPAKTKLDPPR CCCCCCCCCCCCCCC	47.92	23684622
2932	Phosphorylation	KSTAPAKTKLDPPRE CCCCCCCCCCCCCCC	31.97	26824392
2941	Phosphorylation	LDPPRERSKSDSYTL CCCCCCCCCCCCCCC	49.78	21183079
2943	Phosphorylation	PPRERSKSDSYTLDP CCCCCCCCCCCCCCH	79.54	-
2945	Phosphorylation	RERSKSDSYTLDPDT CCCCCCCCCCCCHHH	36.97	26643407
2948	Phosphorylation	SKSDSYTLDPDTLRK CCCCCCCCCHHHHHC	34.77	25367039
2954	Phosphorylation	TLDPDTLRKKKMPLT CCCHHHHHCCCCCCC	27.01	25521595
2964	Phosphorylation	KMPLTEPLRGRSTSP CCCCCCCCCCCCCCC	34.94	25293948
2968	Phosphorylation	TEPLRGRSTSPKPKP CCCCCCCCCCCCCCC	36.73	24719451
2970	Phosphorylation	PLRGRSTSPKPKPVP CCCCCCCCCCCCCCC	1.61	24719451
2992	Phosphorylation	GSENRAPSPHVVQEN CCCCCCCCCCHHCCC	53.85	21183079
3019	Phosphorylation	TLKTNGVTDSTCDDS CCCCCCCCCCCCCCC	19.16	26824392
3022	Phosphorylation	TNGVTDSTCDDSGDL CCCCCCCCCCCCCCC	5.67	24719451
3057	Phosphorylation	DEQEMRASPKISRKC CHHHHHCCHHHHHHH	5.84	-
3104	Phosphorylation	PSVAECARAVFASFL HHHHHHHHHHHHHHH	39.64	25338131
3105	Phosphorylation	SVAECARAVFASFLW HHHHHHHHHHHHHHC	23.01	25338131
3124	Phosphorylation	VHDAMACSSFLKFNP CCHHHHHHHHHHCCC	25.18	25266776
3128	Phosphorylation	MACSSFLKFNPDLSK HHHHHHHHCCCCCCH	10.53	25266776
3162	Phosphorylation	IKLKNRHSLEISSAL HHCCCCHHHHHHHHH	47.65	-
3365	Phosphorylation	CGDGGMGGSTWYLVC CCCCCCCCCCEEEEE	21.10	28059163
3458	Phosphorylation	KEGVSEDLPVKMPCL CCCCCCCCCCCCHHH	23.57	26026062
3460	Phosphorylation	GVSEDLPVKMPCLYL CCCCCCCCCCHHHHH	27.61	22942356
3469	Phosphorylation	MPCLYLQTLARHHHE CHHHHHHHHHHHCHH	14.52	25338131
3473	Phosphorylation	YLQTLARHHHENFVG HHHHHHHHCHHCCCC	25.12	22942356
3493	Phosphorylation	LFQDEMRYLRSTSVP CCHHHHHHHHCCCCC	45.13	26643407
3494	Phosphorylation	FQDEMRYLRSTSVPA CHHHHHHHHCCCCCC	12.62	26643407
3497	Phosphorylation	EMRYLRSTSVPAPYI HHHHHHCCCCCCCEE	35.91	26643407
3510	Phosphorylation	YISVTPDASPNVFEE EEECCCCCCCCCCCC	15.81	25619855
3511	Phosphorylation	ISVTPDASPNVFEEP EECCCCCCCCCCCCC	13.99	25619855
3512	Phosphorylation	SVTPDASPNVFEEPE ECCCCCCCCCCCCCC	16.03	25521595
3516	Phosphorylation	DASPNVFEEPESNMK CCCCCCCCCCCHHCC	25.69	28285833
3539	Phosphorylation	SPITDTDLAKRTVFQ CCCCCHHHHHHHHHH	34.88	26824392
3542	Phosphorylation	TDTDLAKRTVFQRSY CCHHHHHHHHHHCCC	30.23	23970565
3545	Phosphorylation	DLAKRTVFQRSYSVV HHHHHHHHHCCCEEE	17.30	25266776
3550	Phosphorylation	TVFQRSYSVVASEYD HHHHCCCEEECCHHH	27.45	17242355
3552	Phosphorylation	FQRSYSVVASEYDKQ HHCCCEEECCHHHHC	25.53	28066266
3556	Phosphorylation	YSVVASEYDKQHSIL CEEECCHHHHCCCCC	24.31	28066266
3577	Phosphorylation	IPRRRVNSGDTVGSS CCCCCCCCCCCCCHH	2.41	-
3752	Phosphorylation	QQMALRCWSLKFKQS HHHHHHHHHCEECCC	24.19	-
3954	Phosphorylation	ESTKIAGQISASVAQ CCCEEEEEEEHHHHH	30.84	25521595
3964	Phosphorylation	ASVAQQRSCEAETLR HHHHHHHCCHHHHHH	44.70	26824392
3964 (in isoform 2)	Phosphorylation	-	44.70	25521595
3965	Phosphorylation	SVAQQRSCEAETLRV HHHHHHCCHHHHHHH	27.26	26824392
3965 (in isoform 2)	Phosphorylation	-	27.26	25521595
3992	Phosphorylation	ISGDAEPTPEQEEKA HCCCCCCCHHHHHHH	27.36	21183079
4002	Phosphorylation	QEEKALLSSPEGEEK HHHHHHHCCCCCCHH	3.92	25521595
4002	Phosphorylation	QEEKALLSSPEGEEK HHHHHHHCCCCCCHH	3.92	-
4003	Phosphorylation	EEKALLSSPEGEEKV HHHHHHCCCCCCHHH	1.80	25521595
4003	Phosphorylation	EEKALLSSPEGEEKV HHHHHHCCCCCCHHH	1.80	-
4086	Methylation	SSDAYCFELLSMVLA CCHHHHHHHHHHHHH	34.40	16188229
4092	Phosphorylation	FELLSMVLALSGSNV HHHHHHHHHHCCCCH	12.81	21454597
4103	Phosphorylation	GSNVGRQYLAQQLTL CCCHHHHHHHHHHHH	17.12	21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYCB2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYCB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYCB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPNE1_HUMAN	CPNE1	physical	12522145
CPNE4_HUMAN	CPNE4	physical	12522145
RAGP1_MOUSE	Rangap1	physical	26304119
RAN_MOUSE	Ran	physical	26304119
AKA12_MOUSE	Akap12	physical	28671696
KCC2A_MOUSE	Camk2a	physical	28671696
KCC2B_MOUSE	Camk2b	physical	28671696
CYFP2_MOUSE	Cyfip2	physical	28671696
FBSP1_MOUSE	Fbxo45	physical	28671696
G3BP2_MOUSE	G3bp2	physical	28671696
IQEC3_MOUSE	Iqsec3	physical	28671696
MATR3_MOUSE	Matr3	physical	28671696
MTOR_MOUSE	Mtor	physical	28671696
PDE1B_MOUSE	Pde1b	physical	28671696
PKN1_MOUSE	Pkn1	physical	28671696
SYT3_MOUSE	Syt3	physical	28671696
TNIK_MOUSE	Tnik	physical	28671696
UNC79_MOUSE	Unc79	physical	28671696
WIPI4_MOUSE	Wdr45	physical	28671696
DLG2_MOUSE	Dlg2	physical	28671696
SYGP1_MOUSE	Syngap1	physical	28671696
ABLM1_MOUSE	Ablim1	physical	28671696
ABLM3_MOUSE	Ablim3	physical	28671696
ANK2_MOUSE	Ank2	physical	28671696
RHG21_MOUSE	Arhgap21	physical	28671696
ARHG2_MOUSE	Arhgef2	physical	28671696
ARPC2_MOUSE	Arpc2	physical	28671696
ARPC3_MOUSE	Arpc3	physical	28671696
BCLF1_MOUSE	Bclaf1	physical	28671696
PYR1_MOUSE	Cad	physical	28671696
CAPR1_MOUSE	Caprin1	physical	28671696
CARM1_MOUSE	Carm1	physical	28671696
CCAR1_MOUSE	Ccar1	physical	28671696
CC177_MOUSE	Ccdc177	physical	28671696
TCPG_MOUSE	Cct3	physical	28671696
TCPD_MOUSE	Cct4	physical	28671696
CLAP1_MOUSE	Clasp1	physical	28671696
CLAP2_MOUSE	Clasp2	physical	28671696
COR1B_MOUSE	Coro1b	physical	28671696
COR1C_MOUSE	Coro1c	physical	28671696
KC1A_MOUSE	Csnk1a1	physical	28671696
SRC8_MOUSE	Cttn	physical	28671696
DAPK1_MOUSE	Dapk1	physical	28671696
DREB_MOUSE	Dbn1	physical	28671696
DCLK1_MOUSE	Dclk1	physical	28671696
DCTN1_MOUSE	Dctn1	physical	28671696
DCX_MOUSE	Dcx	physical	28671696
DDX3X_MOUSE	Ddx3x	physical	28671696
DYST_MOUSE	Dst	physical	28671696
DYHC1_MOUSE	Dync1h1	physical	28671696
EF2_MOUSE	Eef2	physical	28671696
IF4A1_MOUSE	Eif4a1	physical	28671696
ELAV1_MOUSE	Elavl1	physical	28671696
EPMIP_MOUSE	Epm2aip1	physical	28671696
EWS_MOUSE	Ewsr1	physical	28671696
FUS_MOUSE	Fus	physical	28671696
FXR1_MOUSE	Fxr1	physical	28671696
G3BP1_MOUSE	G3bp1	physical	28671696
RACK1_MOUSE	Gnb2l1	physical	28671696
GELS_MOUSE	Gsn	physical	28671696
HDAC2_MOUSE	Hdac2	physical	28671696
HERC2_MOUSE	Herc2	physical	28671696
H2A1H_MOUSE	Hist1h2ah	physical	28671696
GRP75_MOUSE	Hspa9	physical	28671696
HUWE1_MOUSE	Huwe1	physical	28671696
IQGA1_MOUSE	Iqgap1	physical	28671696
SHOT1_MOUSE	4930506M07Rik	physical	28671696
KI21B_MOUSE	Kif21b	physical	28671696
IMA5_MOUSE	Kpna1	physical	28671696
KTN1_MOUSE	Ktn1	physical	28671696
LIMA1_MOUSE	Lima1	physical	28671696
LIMC1_MOUSE	Limch1	physical	28671696
LMNB1_MOUSE	Lmnb1	physical	28671696
LRCH2_MOUSE	Lrch2	physical	28671696
LRRF1_MOUSE	Lrrfip1	physical	28671696
LRRF2_MOUSE	Lrrfip2	physical	28671696
M4K4_MOUSE	Map4k4	physical	28671696
MPRIP_MOUSE	Mprip	physical	28671696
MBB1A_MOUSE	Mybbp1a	physical	28671696
MYEF2_MOUSE	Myef2	physical	28671696
NEST_MOUSE	Nes	physical	28671696
NOL9_MOUSE	Nol9	physical	28671696
PCM1_MOUSE	Pcm1	physical	28671696
PELP1_MOUSE	Pelp1	physical	28671696
PAG15_MOUSE	Pla2g15	physical	28671696
PP1A_MOUSE	Ppp1ca	physical	28671696
PP1B_MOUSE	Ppp1cb	physical	28671696
MYPT1_MOUSE	Ppp1r12a	physical	28671696
NEB2_MOUSE	Ppp1r9b	physical	28671696
2AAA_MOUSE	Ppp2r1a	physical	28671696
PRC2C_MOUSE	Prrc2c	physical	28671696
RFA1_MOUSE	Rpa1	physical	28671696
SCRIB_MOUSE	Scrib	physical	28671696
SC23A_MOUSE	Sec23a	physical	28671696
SC31A_MOUSE	Sec31a	physical	28671696
SENP3_MOUSE	Senp3	physical	28671696
SKP1_MOUSE	Skp1a	physical	28671696
SMRC1_MOUSE	Smarcc1	physical	28671696
SMRC2_MOUSE	Smarcc2	physical	28671696
SRBS1_MOUSE	Sorbs1	physical	28671696
SRBS2_MOUSE	Sorbs2	physical	28671696
CYTSA_MOUSE	Specc1l	physical	28671696
SPTB2_MOUSE	Sptbn1	physical	28671696
SSH1_MOUSE	Ssh1	physical	28671696
SSH2_MOUSE	Ssh2	physical	28671696
SVIL_MOUSE	Svil	physical	28671696
SYNE2_MOUSE	Syne2	physical	28671696
TAGL3_MOUSE	Tagln3	physical	28671696
TBCD5_MOUSE	Tbc1d5	physical	28671696
TEX10_MOUSE	Tex10	physical	28671696
TR150_MOUSE	Thrap3	physical	28671696
ZO1_MOUSE	Tjp1	physical	28671696
TPR_MOUSE	Tpr	physical	28671696
TIF1B_MOUSE	Trim28	physical	28671696
TWF1_MOUSE	Twf1	physical	28671696
UACA_MOUSE	Uaca	physical	28671696
UBR4_MOUSE	Ubr4	physical	28671696
RENT1_MOUSE	Upf1	physical	28671696
UBP10_MOUSE	Usp10	physical	28671696
WDR1_MOUSE	Wdr1	physical	28671696
WDR18_MOUSE	Wdr18	physical	28671696
1433Z_MOUSE	Ywhaz	physical	28671696

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1583 AND THR-3954, ANDMASS SPECTROMETRY.
PubMed: 17114649