HERC2_MOUSE - dbPTM
HERC2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HERC2_MOUSE
UniProt AC Q4U2R1
Protein Name E3 ubiquitin-protein ligase HERC2
Gene Name Herc2 {ECO:0000312|EMBL:AAD08658.1, ECO:0000312|MGI:MGI:103234}
Organism Mus musculus (Mouse).
Sequence Length 4836
Subcellular Localization Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Nucleus . Recruited to sites of DNA damage in response to ionising radiation (IR) via its interaction with RNF8. May loose association with centrosomes during
Protein Description E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway..
Protein Sequence MPSESFCLAAQSRLDSKWLKTDIQLAFTRDGLCGLWNEMVKDGEIVYTGTELAQNRELPLRKDDGVDAQSGTKKEDLNDKEKKEEEETPAPVYRAKSILESWVWGRQPDVNELKECLSVLVKEQQALAVQSATTTLSALRLKQRLVILERYFIALNRTVFQENVKVKWKSSSISVPPTEKKSARPTGRGVEGLARVGSRAALSFAFAFLRRAWRSGEDADLCSELLQESLDALRALPEASLFDESTVSSVWLEVVERATRFLRSVVTGDVHGTPGTKGPGGVPLQDQHLALAILLELAVQRGTLSQMLSAILLLLQLWDSGAQETDNERSAQGTSAPLLPLLQRFQSIICSKDVPHTESDMHLLSGPLSPNESFLRYLTLPQDNELAIDLRQTAVVVMAHLDRLATPCMPPLCSSPTSHKGSLQEVIGWGLIGWKYYANVIGPIQCEGLASLGVMQVACAEKRFLILSRNGRVYTQAYNSDMLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPTALPGLDSKHIVGIACGPAQSFAWSSCSEWSIGLRVPFVVDICSMTFEQLDLLLRQVSEGMDGTADWPPPQEKECMAVATLNLLRLQLHAAISHQVDPEFLGLGLGSVLLNSLKQTVVTLASSAGVLSTVQSAAQAVLQSGWSVLLPTAEERARALSALLPCTVSGNEVNISPGRRFMIDLLVGSLMADGGLESALNAAITAEIQDIEAKKEAQKEKEIDEQEASASTFHRSRTPLDKDLINTGIYESSGKQCLPLVQLIQQLLRNIASQTVARLKDVARRISSCLDFEQQSCERSASLDLLLRFQRLLISKLYPGEKIGPISDTSSPELMGVGSLLKKYTALVCTHIGDILPVAASIASSSWQHFAEVACVMEGDFTGVLLPELVVSIVLLLSKNASLMQEAGAIPLLGGLLEHLDRFNHLAPGKERDDHEELAWPGIMESFFTGQNCRNNEEVTLIRKADLENHNKDGGFWTVIDGKVYGIKDFQTQSLTGNSILAQFAGEDPVVALEAALQFEDTQESMHAFCVGQYLEPDQEVVTIPDLGSLSSPLIDTERNLGLLLGLHASYLAMSTPLSPVEVECAKWLQSSIFSGGLQTSQIHYSYNEEKDEDHCSSPGGTPISKSRLCSHRWALGDHSQAFLQAIADNNIQDYNVKDFLCQIERYCRQCHLTTPITFPPEHPVEEVGRLLLCCLLKHEDLGHVALSLVHVGTLGIEQVKHRTLPKSVVDVCRVVYQAKCSLIKTHQEQGRSYKEVCAPVIERLRFLFNELRPAVCSDLSIMSKFKLLGSLPRWRRIAQKIIRERRKKRVPKKPESIDSEEKIGNEESDLEEACVLPHSPINVDKRPISMKSPKDKWQPLLNTVTGVHKYKWLKQNVQGLYPQSALLNTIVEFALKEEPVDVEKMRKCLLKQLERAEVRLEGIDTILKLAAKSFLLPSVQYAMFCGWQRLIPEGIDIGEPLTDCLRDVDLIPPFNRMLLEVTFGKLYAWAVQNIRSVLMDASARFKELGIQPVPLQTITNENPAGPSLGTIPQARFLLVMLSMLTLQHGANNLDLLLNSGTLALTQTALRLIGPTCDSVEDDMNASARGASATVLEETRKETAPVQLPVSGPELAAMMKIGTRVMRGVDWKWGDQDGPPPGLGRVIGELGEDGWIRVQWDTGSTNSYRMGKEGKYDLKLVELPVSSQPSAEDSDTEDDSEAEQGERNIHPTAMMLTSVINLLQTLCLSVGVHADIMQSEATKTLCGLLRMLVESGTTDKPAPPDRLVAREQHRSWCTLGFVRSIALTPQACGALSSPRWITLLMKVVEGHAPFTAASLQRQILAVHLLQAVLPSWDKTERARDMKCLVEKLFGFLGSLLTTCSSDVPLLRESTLRKRRARPQASLTATHSSTLAEEVVGLLRTLHSLTQWNGLINKYINSQLCSVTQSYAGKTSERAQLEDYFPDSENLEVGGLMAVLAVIGGIDGRLRLGGQVMHDEFGEGTVTRITPKGRITVQFCDMRMCRVCPLNQLKPLPAVAFSVNNLPFTEPMLSVWAELVNLAGSKLEKHKTKKSAKPAFAGQVDLDLLRSQQLKLYILKAGRALLSHQDKLRQILSQPAVQGTGTLQTDDGAAASPDLGDMSPEGPQPPMILLQQLLSSATQPSPVKAIFDKQELEAAALALCQCLAVESTHPSSPGCEDCSSSEATTPVSVQHIHLARAKKRRQSPAPALPIVVQLMEMGFPRKNIEFALKSLTGTSGNASGLPGVEALVGWLLDHSDVQVTEFSDAETLSDEYSDEEVVEDVDDTPYPVAAGAVVTESQTYKKRADFLSNDDYAVYVRENVQVGMMVRCCRTYEEVCEGDVGKVIKLDRDGLHDLNVQCDWQQKGGTYWVRYIHVELIGYPPPSSSSHIKIGDKVRVKASVTTPKYKWGSVTHQSVGLVKAFSANGKDIIVDFPQQSHWTGLLSEMELVPSIHPGVTCDGCQTFPINGSRFKCRNCDDFDFCETCFKTKKHNTRHTFGRINEPGQSAVFCGRSGKQLKRCHSSQPGMLLDSWSRMVKSLNVSSSVNQASRLIDGSEPCWQSSGSQGKHWIRLEIFPDVLVHRLKMIVDPADSSYMPSLVVVSGGNSLNNLIELKTININQTDTTVPLLSDCAEYHRYIEIAIKQCRSSGIDCKIHGLILLGRIRAEEEDLAAVPFLASDNEEEEDDKGSTGSLIRKKTPGLESTATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYSCGEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDADSSSSSNKISGANNCKPNRPSLAKILLSLEGNLAKQQALSHILTALQIMYARDAVVGALMPAGMLAPVECPSFSSSAPASDVSAMASPMHMEDSTLAADLEDRLSPNLWQEKREIVSSEDAVTPSAVTPSAPSASSRPFIPVTDDPGAASIIAETMTKTKEDVESQNKTSGPEPQSLDEFTSLLIPDDTRVVVELLKLSVCSRAGDKGREVLSAVLSGMGTAYPQVADMLLELCVTELEDVATDSQSGRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLTVMDGVNRIVSVRSGREWSDWSSELRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKDLLSDRCVLSCPSMDLVTCLLDFRLNLTSNRSIVPRLAASLAACAQLSALAASHRMWALQRLRRLLTTEFGQSININRLLGENDGESRALSFTGSALAALVKGLPEALQRQFEYEDPIVRGGKQLLHSPFFKVLVALACDLELDTLPCCAETHKWAWFRRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELMADSESMDVLHESHSIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHISELFCPCIPMFDLEGSLDETGLGPSVGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFSPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLNPATRAPVHCSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLVQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARIALTGEPAADDSSEDSDNEDADSFASDSTQDYLTGH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17AcetylationAQSRLDSKWLKTDIQ
HHHHCCCCCCHHHHH		57.107718545
17UbiquitinationAQSRLDSKWLKTDIQ
HHHHCCCCCCHHHHH		57.1022790023
17 (in isoform 2)Ubiquitination-57.1022790023
62UbiquitinationNRELPLRKDDGVDAQ
CCCCCCCCCCCCCCC		68.7822790023
62 (in isoform 2)Ubiquitination-68.7822790023
73UbiquitinationVDAQSGTKKEDLNDK
CCCCCCCCHHHCCHH		58.6627667366
137PhosphorylationQSATTTLSALRLKQR
HCHHCHHHHHHHHHH		24.1422006019
172PhosphorylationKVKWKSSSISVPPTE
CEEEECCCCCCCCCC		26.4427841257
182O-linked_GlycosylationVPPTEKKSARPTGRG
CCCCCCCCCCCCCCC		40.3530016717
273PhosphorylationVTGDVHGTPGTKGPG
HHCCCCCCCCCCCCC		12.03-
347PhosphorylationPLLQRFQSIICSKDV
HHHHHHHHHHCCCCC		15.9428418008
351PhosphorylationRFQSIICSKDVPHTE
HHHHHHCCCCCCCCC		22.8328418008
548UbiquitinationVISAFSGKQAGKHVV
EEEECCCCCCCCEEE		35.4622790023
548 (in isoform 2)Ubiquitination-35.4622790023
648PhosphorylationGGSDGCKTPKLIEKL
CCCCCCCCHHHHHHH		29.72-
654UbiquitinationKTPKLIEKLQDLDVI
CCHHHHHHHCCCCEE		44.4422790023
654 (in isoform 2)Ubiquitination-44.4422790023
662UbiquitinationLQDLDVIKVRCGSQF
HCCCCEEEEECCCEE		24.3922790023
662 (in isoform 2)Ubiquitination-24.3922790023
750UbiquitinationFDTLRVTKPEPTALP
CCEEEECCCCCCCCC		44.5222790023
750 (in isoform 2)Ubiquitination-44.5222790023
761PhosphorylationTALPGLDSKHIVGIA
CCCCCCCCCCEEEEE		31.0429895711
991UbiquitinationRSRTPLDKDLINTGI
HCCCCCCHHHHHCCC		63.2222790023
991 (in isoform 2)Ubiquitination-63.2222790023
999PhosphorylationDLINTGIYESSGKQC
HHHHCCCCCCCCCCH		15.8822817900
1065UbiquitinationFQRLLISKLYPGEKI
HHHHHHHHHCCCCCC		45.0827667366
1080PhosphorylationGPISDTSSPELMGVG
CCCCCCCCHHHHCHH		25.2028059163
1114PhosphorylationVAASIASSSWQHFAE
HHHHHHCCCHHHHHH		26.95-
1115PhosphorylationAASIASSSWQHFAEV
HHHHHCCCHHHHHHH		28.41-
1366PhosphorylationEKDEDHCSSPGGTPI
CCCCCCCCCCCCCCC		35.8329899451
1367PhosphorylationKDEDHCSSPGGTPIS
CCCCCCCCCCCCCCC		32.7225521595
1371PhosphorylationHCSSPGGTPISKSRL
CCCCCCCCCCCHHHC		24.3023684622
1374PhosphorylationSPGGTPISKSRLCSH
CCCCCCCCHHHCCCC		26.2823984901
1494UbiquitinationQAKCSLIKTHQEQGR
HHHCCHHHHHHHCCC		45.2922790023
1494 (in isoform 2)Ubiquitination-45.2922790023
1540PhosphorylationSKFKLLGSLPRWRRI
HHHHHHCCCHHHHHH		34.8623737553
1566PhosphorylationRVPKKPESIDSEEKI
CCCCCCCCCCCCHHC		39.9826824392
1569PhosphorylationKKPESIDSEEKIGNE
CCCCCCCCCHHCCCC		46.0825521595
1578PhosphorylationEKIGNEESDLEEACV
HHCCCCCCCHHHHHC		41.1227087446
1589PhosphorylationEACVLPHSPINVDKR
HHHCCCCCCCCCCCC		26.0725521595
1601UbiquitinationDKRPISMKSPKDKWQ
CCCCCCCCCCHHCCH		57.7427667366
1602PhosphorylationKRPISMKSPKDKWQP
CCCCCCCCCHHCCHH		28.6528507225
1606UbiquitinationSMKSPKDKWQPLLNT
CCCCCHHCCHHHHHH		54.5822790023
1606 (in isoform 2)Ubiquitination-54.5822790023
1619UbiquitinationNTVTGVHKYKWLKQN
HHHCHHHHHHHHHHH		46.2322790023
1619 (in isoform 2)Ubiquitination-46.2322790023
1678UbiquitinationEGIDTILKLAAKSFL
HCHHHHHHHHHHHCC		32.0322790023
1678 (in isoform 2)Ubiquitination-32.0322790023
1836PhosphorylationVEDDMNASARGASAT
HHHHCCHHHCCCCCE		17.3129899451
1852PhosphorylationLEETRKETAPVQLPV
EHHHHCCCCCEECCC		39.0225159016
1860PhosphorylationAPVQLPVSGPELAAM
CCEECCCCHHHHHHH		46.8425159016
1872PhosphorylationAAMMKIGTRVMRGVD
HHHHHHCCCHHCCCC		24.4625159016
1935PhosphorylationKLVELPVSSQPSAED
EEEECCCCCCCCCCC		22.7025619855
1936PhosphorylationLVELPVSSQPSAEDS
EEECCCCCCCCCCCC		46.4725619855
1939PhosphorylationLPVSSQPSAEDSDTE
CCCCCCCCCCCCCCC		36.3325619855
1943PhosphorylationSQPSAEDSDTEDDSE
CCCCCCCCCCCCHHH		37.6327087446
1945PhosphorylationPSAEDSDTEDDSEAE
CCCCCCCCCCHHHHH		45.3127087446
1949PhosphorylationDSDTEDDSEAEQGER
CCCCCCHHHHHHHCC		51.5321082442
2182UbiquitinationVTQSYAGKTSERAQL
HHHHCCCCCCCCCCH		40.4822790023
2182 (in isoform 2)Ubiquitination-40.4822790023
2323UbiquitinationLLRSQQLKLYILKAG
HHHHCCHHHHHHHHH		34.6022790023
2323 (in isoform 2)Ubiquitination-34.6022790023
2339UbiquitinationALLSHQDKLRQILSQ
HHHHCHHHHHHHHCC		38.7122790023
2339 (in isoform 2)Ubiquitination-38.7122790023
2455PhosphorylationRAKKRRQSPAPALPI
HHHHHCCCCCCCHHH		22.6326745281
2474UbiquitinationMEMGFPRKNIEFALK
HHCCCCHHCHHHHHH		63.6222790023
2474 (in isoform 2)Ubiquitination-63.6222790023
2649UbiquitinationIGDKVRVKASVTTPK
ECCEEEEEEEEECCC		25.1227667366
2661PhosphorylationTPKYKWGSVTHQSVG
CCCCCCCCCCCCCHH		23.80-
2663PhosphorylationKYKWGSVTHQSVGLV
CCCCCCCCCCCHHHH		18.85-
2666PhosphorylationWGSVTHQSVGLVKAF
CCCCCCCCHHHHHHE		15.56-
2774PhosphorylationQLKRCHSSQPGMLLD
CHHCCCCCCCCCHHH		19.4121082442
2788AcetylationDSWSRMVKSLNVSSS
HHHHHHHHHCCCCCC		39.622382945
2788UbiquitinationDSWSRMVKSLNVSSS
HHHHHHHHHCCCCCC		39.6227667366
2929PhosphorylationAAVPFLASDNEEEED
CCCCEECCCCCCCCC		43.0225521595
2940PhosphorylationEEEDDKGSTGSLIRK
CCCCCCCCCCCHHHH		35.0225619855
2941PhosphorylationEEDDKGSTGSLIRKK
CCCCCCCCCCHHHHC		39.1825619855
2943PhosphorylationDDKGSTGSLIRKKTP
CCCCCCCCHHHHCCC		22.2525619855
2961UbiquitinationSTATIRTKVFVWGLN
CCEEEEEEEEEEECC		24.6722790023
2961 (in isoform 2)Ubiquitination-24.6722790023
2977UbiquitinationKDQLGGLKGSKIKVP
HHHCCCCCCCCCCCC		65.5027667366
3030PhosphorylationGRLGLGMSSGTVPIP
CCCCCCCCCCCCCCC		24.6622871156
3031PhosphorylationRLGLGMSSGTVPIPR
CCCCCCCCCCCCCCH		29.5922871156
3033PhosphorylationGLGMSSGTVPIPRQI
CCCCCCCCCCCCHHH		25.6722871156
3142UbiquitinationGDNTTQLKPKMVKVL
CCCCCCCCHHHHHHH		32.5427667366
3276PhosphorylationHCLAVTDSGQVYAWG
EEEEECCCCCEEEEE		23.0425195567
3294PhosphorylationHGQQGNGTTTVNRKP
CCCCCCCCCCCCCCC		24.2425195567
3464PhosphorylationADLEDRLSPNLWQEK
HHHHHHCCCCHHHHH		16.7928066266
3471UbiquitinationSPNLWQEKREIVSSE
CCCHHHHHHHHHCCC		39.9822790023
3471 (in isoform 2)Ubiquitination-39.9822790023
3482PhosphorylationVSSEDAVTPSAVTPS
HCCCCCCCCCCCCCC		17.1626239621
3509PhosphorylationTDDPGAASIIAETMT
CCCCCHHHHHHHHHC		17.6226239621
3633UbiquitinationTSTSGTVKIPGAEGL
CCCCCEEECCCCCCC		42.9222790023
3633 (in isoform 2)Ubiquitination-42.92-
3654UbiquitinationQCSTERRHDPLTVMD
CCCCCCCCCCCEEEC		47.4627667366
3654 (in isoform 2)Ubiquitination-47.46-
3668PhosphorylationDGVNRIVSVRSGREW
CCCCEEEEECCCCCC		14.9424719451
3690UbiquitinationRIPGDELKWKFISDG
ECCCCCCEEEEECCC		46.4122790023
3690 (in isoform 2)Ubiquitination-46.4122790023
3820UbiquitinationSALAALVKGLPEALQ
HHHHHHHCCHHHHHH		56.43-
4031PhosphorylationTESVSTPTLLESIQH
CCCCCCHHHHHHCCE		44.0221454597
4035PhosphorylationSTPTLLESIQHVFIK
CCHHHHHHCCEEEEE		27.7621454597
4122PhosphorylationYTWGKGRYGRLGHSD
CCCCCCCCCCCCCCC		18.4428059163
4130PhosphorylationGRLGHSDSEDQLKPK
CCCCCCCCCHHHCHH		46.1927841257
4362 (in isoform 2)Ubiquitination-3.71-
4398UbiquitinationGILISQGKEAAFRKV
HHHHHCCHHHHHHHH		36.2222790023
4398 (in isoform 2)Ubiquitination-36.2222790023
4409PhosphorylationFRKVVQATMVRDRQH
HHHHHHHHHCCCCCC		10.1028059163
4432PhosphorylationIQVKRSRSKGGLAGP
EEEECCCCCCCCCCC		36.5822942356
4442PhosphorylationGLAGPDGTKSVFGQM
CCCCCCCCHHHHHHH		27.7622942356
4812PhosphorylationGEPAADDSSEDSDNE
CCCCCCCCCCCCCCC		35.8525293948
4813PhosphorylationEPAADDSSEDSDNED
CCCCCCCCCCCCCCC		53.0325293948
4816PhosphorylationADDSSEDSDNEDADS
CCCCCCCCCCCCHHH		37.9825293948
4829PhosphorylationDSFASDSTQDYLTGH
HHHHCHHHHHHHCCC		30.37-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HERC2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
4829TPhosphorylation

-
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HERC2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
P53_MOUSETrp53physical
24722987
1433S_HUMANSFNphysical
26496610
ZBTB5_HUMANZBTB5physical
26496610
SSA27_HUMANSSSCA1physical
26496610
NEUL4_HUMANNEURL4physical
26496610
ESCO1_HUMANESCO1physical
26496610
AKAP9_MOUSEAkap9physical
28671696
ANK2_MOUSEAnk2physical
28671696
ARPC4_MOUSEArpc4physical
28671696
CARM1_MOUSECarm1physical
28671696
CE170_MOUSECep170physical
28671696
CNOT1_MOUSECnot1physical
28671696
COR1C_MOUSECoro1cphysical
28671696
CUX1_MOUSECux1physical
28671696
DREB_MOUSEDbn1physical
28671696
DDX3X_MOUSEDdx3xphysical
28671696
DPYL2_MOUSEDpysl2physical
28671696
DYST_MOUSEDstphysical
28671696
EF1A1_MOUSEEef1a1physical
28671696
FLII_MOUSEFliiphysical
28671696
FXR1_MOUSEFxr1physical
28671696
HDAC2_MOUSEHdac2physical
28671696
SHOT1_MOUSE4930506M07Rikphysical
28671696
KIF11_MOUSEKif11physical
28671696
KIF15_MOUSEKif15physical
28671696
KINH_MOUSEKif5bphysical
28671696
KIF5C_MOUSEKif5cphysical
28671696
MAP6_MOUSEMap6physical
28671696
MATR3_MOUSEMatr3physical
28671696
MCM3_MOUSEMcm3physical
28671696
MA7D1_MOUSEMap7d1physical
28671696
MYH10_MOUSEMyh10physical
28671696
NEUL4_MOUSENeurl4physical
28671696
PP1A_MOUSEPpp1caphysical
28671696
RAI1_MOUSERai1physical
28671696
SC23A_MOUSESec23aphysical
28671696
SRBS1_MOUSESorbs1physical
28671696
SPTB2_MOUSESptbn1physical
28671696
SRGP2_MOUSESrgap2physical
28671696
SYNE2_MOUSESyne2physical
28671696
TNIK_MOUSETnikphysical
28671696
TP53B_MOUSETrp53bp1physical
28671696
TREF1_MOUSETrerf1physical
28671696
TRI67_MOUSETrim67physical
28671696
UBR4_MOUSEUbr4physical
28671696
RENT1_MOUSEUpf1physical
28671696
1433Z_MOUSEYwhazphysical
28671696
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HERC2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2929, AND MASSSPECTROMETRY.

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