TP53B_MOUSE - dbPTM
TP53B_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TP53B_MOUSE
UniProt AC P70399
Protein Name TP53-binding protein 1 {ECO:0000305}
Gene Name Tp53bp1 {ECO:0000250|UniProtKB:Q12888}
Organism Mus musculus (Mouse).
Sequence Length 1969
Subcellular Localization Nucleus . Chromosome . Chromosome, centromere, kinetochore . Localizes to the nucleus in absence of DNA damage (PubMed:11801725). Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs) (PubMed:11673449, PubMed:2320
Protein Description Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. [PubMed: 15159415]
Protein Sequence MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEEDAGSHFSVLSRHLPNLQMHKENPVLDIVSNPEQSAVEQGDSNSSFNEHLKEKKASDPVESSHLGTSGSISQVIERLPQPNRTSSALAVTVEAASLPEEEKEEEELEEEKEGVGANAPGADSLAAEDSASSQLGFGVLELSQSQDVEEHTVPYDVNQEHLQLVTTNSGSSPLSDVDASTAIKCEEQPTEDIAMIEQPSKDIPVTVQPGKGIHVVEEQNLPLVRSEDRPSSPQVSVAAVETKEQVPARELLEEGPQVQPSSEPEVSSTQEDLFDQSSKTASDGCSTPSREEGGCSPVSTPATTLQLLQLSGQKPLVQESLSTNSSDLVAPSPDAFRSTPFIVPSSPTEQGGRKDEPMDMSVIPVGGEPFQKLHDDEAMETEKPLLPSQPAVSPQASTPVSRSTPVFTPGSLPIPSQPEFSHDIFIPSPSLEEPSDDVKKGGGLHSSSLTVECSKTSESEPKNFTDDLGLSMTGDSCKLMLSTSEYSQSSKMESLGSPRTEEDRENTQIDDTEPLSPVSNSKLPADSENVLVTPSQDDQVEMSQNVDKAKEDETEDRGDCKGREDAVAEDVCIDLTCDSGSQAVPSPATRSEALSSVLDQEEAMDTKEHHPEEGFSGSEVEEVPETPCGSHREEPKEEPMESIPLHLSLTETQSEALCLQKEAPKEECPEAMEVETSVISIDSPQKLQVLDQELEHKDPDTWEEATSEDSSVVIVDVKEPSPRADVSCEPLEEVEKCSDSQSWEGVAPEEEPCAENRLDTPEEKRIECDGDSKAETTEKDAVTEDSPQPPLPSVRDEPVRPDQETQQPQVQEKESPVTVDAEVADDKQLGPEGACQQLEKAPACASQSFCESSSETPFHFTLPKEGDIIPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDVTSESMVEINDPLLGNEKGDSESAPEMDGKLSLKMKLVSPETEASEESLQFSLEKPTTAERKNGSTAIAEPVASLQKPVPVFGCIYEAQQEKEAQSEAPPSAPDRANLLHFPSAQEEDKERPDVTPKLRQSEQPVKPVGPVMDDAAPEDSASPVSQQRASQEQRASQEPFSPAEDVMETDLLEGLAANQDRPSKMLMDRPTQSNIGIQTVDHSLCAPETVSAATQTVKSVCEQGTSTAEQNSGKQDATVQTERGSGEKPASAPVDDTESLHSQGEEEFEMPQPPHGHVLHRHMRTIREVRTLVTRVITDVYYVDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSSHHTSSGTSLSAIHSSGSSGRGAGPLKGKASGTEAADFALPSSRGGPGKLSPRKGISQTGAPVCEEDGDAGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETVVSGPLGVEDISPSMSPDDKSFTRIMPRVPDSTKRTDASSSTLRRSDSPEIPFQAATGSSDGLDSSSSGNSFVGLRVVAKWSSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSAGVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTKAADISLDNLVEGKRKRRSNISSPVTPTAASSSSTTPTRKATESPRASTGVPSGKRKLPTSEEERSPAKRGRKSATVKPGTVGAAEFVSPCETGDNIGEPSVLEEPRGPLPLNKTLFLGYAFLLTMATTSDKLASRSKLLDGPTGSSEEEEEFLEIPPFNKQYTECQLRAGAGYILEDFNEAQCNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLEEQRILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALGVFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYKHDYVSH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
25PhosphorylationSQQDTPCLIIEDSQP
CCCCCCEEEEECCCC
34.54-
30PhosphorylationPCLIIEDSQPESQVL
CEEEEECCCCHHHHH
42.00-
63PhosphorylationQMHKENPVLDIVSNP
CCCCCCCCEEECCCH
47.1823567750
68PhosphorylationNPVLDIVSNPEQSAV
CCCEEECCCHHHHHH
32.4027087446
73PhosphorylationIVSNPEQSAVEQGDS
ECCCHHHHHHHCCCC
27.1522802335
75PhosphorylationSNPEQSAVEQGDSNS
CCHHHHHHHCCCCCC
45.4921659605
77PhosphorylationPEQSAVEQGDSNSSF
HHHHHHHCCCCCCHH
40.0121659605
78PhosphorylationEQSAVEQGDSNSSFN
HHHHHHCCCCCCHHH
36.0221659605
80PhosphorylationSAVEQGDSNSSFNEH
HHHHCCCCCCHHHHH
37.4127087446
82PhosphorylationVEQGDSNSSFNEHLK
HHCCCCCCHHHHHHH
43.2227087446
83PhosphorylationEQGDSNSSFNEHLKE
HCCCCCCHHHHHHHH
6.6327087446
104PhosphorylationVESSHLGTSGSISQV
CCCCCCCCCCCHHHH
21.79-
109PhosphorylationLGTSGSISQVIERLP
CCCCCCHHHHHHCCC
40.31-
116PhosphorylationSQVIERLPQPNRTSS
HHHHHCCCCCCCCCC
33.4025338131
121PhosphorylationRLPQPNRTSSALAVT
CCCCCCCCCCEEEEE
8.4729899451
122PhosphorylationLPQPNRTSSALAVTV
CCCCCCCCCEEEEEE
6.8329899451
123PhosphorylationPQPNRTSSALAVTVE
CCCCCCCCEEEEEEH
13.6625521595
128PhosphorylationTSSALAVTVEAASLP
CCCEEEEEEHHHCCC
52.0525338131
133PhosphorylationAVTVEAASLPEEEKE
EEEEHHHCCCHHHHH
65.1925338131
145 (in isoform 6)Phosphorylation-7.4025266776
147 (in isoform 6)Phosphorylation-13.4527818261
150 (in isoform 6)Phosphorylation-38.0121659605
155 (in isoform 6)Phosphorylation-5.5721659605
160 (in isoform 6)Phosphorylation-22.8921659605
163PhosphorylationPGADSLAAEDSASSQ
CCHHHCCCCCHHHHC
29.19-
169PhosphorylationAAEDSASSQLGFGVL
CCCCHHHHCCCCCEE
3.33-
179PhosphorylationGFGVLELSQSQDVEE
CCCEEECCCCCCCCC
52.96-
181PhosphorylationGVLELSQSQDVEEHT
CEEECCCCCCCCCCC
20.75-
241AcetylationQPSKDIPVTVQPGKG
CCCCCCCEEECCCCC
62.4722826441
247AcetylationPVTVQPGKGIHVVEE
CEEECCCCCEEEEEE
53.42-
256PhosphorylationIHVVEEQNLPLVRSE
EEEEEECCCCEECCC
36.0525266776
261PhosphorylationEQNLPLVRSEDRPSS
ECCCCEECCCCCCCC
56.3925521595
262PhosphorylationQNLPLVRSEDRPSSP
CCCCEECCCCCCCCC
23.2625521595
267PhosphorylationVRSEDRPSSPQVSVA
ECCCCCCCCCCEEEE
4.1024925903
268PhosphorylationRSEDRPSSPQVSVAA
CCCCCCCCCCEEEEE
9.7824925903
272PhosphorylationRPSSPQVSVAAVETK
CCCCCCEEEEEEECC
33.0324925903
278PhosphorylationVSVAAVETKEQVPAR
EEEEEEECCCCCCHH
20.8025619855
291PhosphorylationARELLEEGPQVQPSS
HHHHHHHCCCCCCCC
30.1825338131
292PhosphorylationRELLEEGPQVQPSSE
HHHHHHCCCCCCCCC
64.9525338131
297PhosphorylationEGPQVQPSSEPEVSS
HCCCCCCCCCCCCCC
26.4625266776
298PhosphorylationGPQVQPSSEPEVSST
CCCCCCCCCCCCCCC
39.0127087446
299PhosphorylationPQVQPSSEPEVSSTQ
CCCCCCCCCCCCCCH
28.5923984901
303PhosphorylationPSSEPEVSSTQEDLF
CCCCCCCCCCHHHHC
5.1227087446
304PhosphorylationSSEPEVSSTQEDLFD
CCCCCCCCCHHHHCC
14.3726643407
305PhosphorylationSEPEVSSTQEDLFDQ
CCCCCCCCHHHHCCC
55.5427087446
308PhosphorylationEVSSTQEDLFDQSSK
CCCCCHHHHCCCCCC
28.5225338131
310PhosphorylationSSTQEDLFDQSSKTA
CCCHHHHCCCCCCCC
33.0823984901
312PhosphorylationTQEDLFDQSSKTASD
CHHHHCCCCCCCCCC
39.5025266776
313PhosphorylationQEDLFDQSSKTASDG
HHHHCCCCCCCCCCC
60.7025293948
314PhosphorylationEDLFDQSSKTASDGC
HHHCCCCCCCCCCCC
12.5525777480
316PhosphorylationLFDQSSKTASDGCST
HCCCCCCCCCCCCCC
49.2125266776
317PhosphorylationFDQSSKTASDGCSTP
CCCCCCCCCCCCCCC
29.3819060867
318PhosphorylationDQSSKTASDGCSTPS
CCCCCCCCCCCCCCC
18.3325266776
319PhosphorylationQSSKTASDGCSTPSR
CCCCCCCCCCCCCCC
53.0323984901
322PhosphorylationKTASDGCSTPSREEG
CCCCCCCCCCCCCCC
60.8325266776
323PhosphorylationTASDGCSTPSREEGG
CCCCCCCCCCCCCCC
37.3425266776
325PhosphorylationSDGCSTPSREEGGCS
CCCCCCCCCCCCCCC
6.46101545
326PhosphorylationDGCSTPSREEGGCSP
CCCCCCCCCCCCCCC
31.4521743459
332PhosphorylationSREEGGCSPVSTPAT
CCCCCCCCCCCCCHH
17.1925266776
333PhosphorylationREEGGCSPVSTPATT
CCCCCCCCCCCCHHH
29.2825266776
335PhosphorylationEGGCSPVSTPATTLQ
CCCCCCCCCCHHHHH
2.6826643407
336PhosphorylationGGCSPVSTPATTLQL
CCCCCCCCCHHHHHH
37.7326643407
339PhosphorylationSPVSTPATTLQLLQL
CCCCCCHHHHHHHHH
42.0225266776
340PhosphorylationPVSTPATTLQLLQLS
CCCCCHHHHHHHHHH
6.6523984901
353PhosphorylationLSGQKPLVQESLSTN
HHCCCCCEEECCCCC
44.4025338131
355PhosphorylationGQKPLVQESLSTNSS
CCCCCEEECCCCCCC
25.8925338131
356PhosphorylationQKPLVQESLSTNSSD
CCCCEEECCCCCCCC
36.7124759943
358PhosphorylationPLVQESLSTNSSDLV
CCEEECCCCCCCCCC
3.7029472430
359PhosphorylationLVQESLSTNSSDLVA
CEEECCCCCCCCCCC
9.8827841257
361PhosphorylationQESLSTNSSDLVAPS
EECCCCCCCCCCCCC
38.6329472430
362PhosphorylationESLSTNSSDLVAPSP
ECCCCCCCCCCCCCC
26.1925266776
368PhosphorylationSSDLVAPSPDAFRST
CCCCCCCCCCHHHCC
33.7026824392
374PhosphorylationPSPDAFRSTPFIVPS
CCCCHHHCCCEECCC
25.0325619855
375PhosphorylationSPDAFRSTPFIVPSS
CCCHHHCCCEECCCC
37.7525521595
376PhosphorylationPDAFRSTPFIVPSSP
CCHHHCCCEECCCCC
29.7625521595
378PhosphorylationAFRSTPFIVPSSPTE
HHHCCCEECCCCCCC
42.7720139300
381PhosphorylationSTPFIVPSSPTEQGG
CCCEECCCCCCCCCC
31.4725521595
382PhosphorylationTPFIVPSSPTEQGGR
CCEECCCCCCCCCCC
32.9124925903
384PhosphorylationFIVPSSPTEQGGRKD
EECCCCCCCCCCCCC
70.4925521595
391PhosphorylationTEQGGRKDEPMDMSV
CCCCCCCCCCCCCEE
16.78-
397PhosphorylationKDEPMDMSVIPVGGE
CCCCCCCEEEECCCC
41.3226239621
421PhosphorylationAMETEKPLLPSQPAV
HHHCCCCCCCCCCCC
26.4421659605
423PhosphorylationETEKPLLPSQPAVSP
HCCCCCCCCCCCCCC
17.4821659605
424PhosphorylationTEKPLLPSQPAVSPQ
CCCCCCCCCCCCCCC
29.4424704852
427PhosphorylationPLLPSQPAVSPQAST
CCCCCCCCCCCCCCC
28.1719060867
428PhosphorylationLLPSQPAVSPQASTP
CCCCCCCCCCCCCCC
30.6321183079
429PhosphorylationLPSQPAVSPQASTPV
CCCCCCCCCCCCCCC
21.4218846507
429PhosphorylationLPSQPAVSPQASTPV
CCCCCCCCCCCCCCC
21.4226824392
431PhosphorylationSQPAVSPQASTPVSR
CCCCCCCCCCCCCCC
23.0125338131
433PhosphorylationPAVSPQASTPVSRST
CCCCCCCCCCCCCCC
29.5618846507
433PhosphorylationPAVSPQASTPVSRST
CCCCCCCCCCCCCCC
29.5625159016
434PhosphorylationAVSPQASTPVSRSTP
CCCCCCCCCCCCCCC
23.5118846507
434PhosphorylationAVSPQASTPVSRSTP
CCCCCCCCCCCCCCC
23.511029903829
437PhosphorylationPQASTPVSRSTPVFT
CCCCCCCCCCCCCCC
7.8025159016
439PhosphorylationASTPVSRSTPVFTPG
CCCCCCCCCCCCCCC
20.9325159016
440PhosphorylationSTPVSRSTPVFTPGS
CCCCCCCCCCCCCCC
38.4626643407
444PhosphorylationSRSTPVFTPGSLPIP
CCCCCCCCCCCCCCC
6.5925159016
446PhosphorylationSTPVFTPGSLPIPSQ
CCCCCCCCCCCCCCC
60.1225338131
447PhosphorylationTPVFTPGSLPIPSQP
CCCCCCCCCCCCCCC
35.8726643407
451PhosphorylationTPGSLPIPSQPEFSH
CCCCCCCCCCCCCCC
20.7019060867
452PhosphorylationPGSLPIPSQPEFSHD
CCCCCCCCCCCCCCC
37.1925159016
457PhosphorylationIPSQPEFSHDIFIPS
CCCCCCCCCCEECCC
29.4625159016
458PhosphorylationPSQPEFSHDIFIPSP
CCCCCCCCCEECCCC
23.4625266776
460PhosphorylationQPEFSHDIFIPSPSL
CCCCCCCEECCCCCC
53.3921659605
464PhosphorylationSHDIFIPSPSLEEPS
CCCEECCCCCCCCCC
33.4127087446
466PhosphorylationDIFIPSPSLEEPSDD
CEECCCCCCCCCCCC
75.3721149613
471PhosphorylationSPSLEEPSDDVKKGG
CCCCCCCCCCCCCCC
29.6821149613
484PhosphorylationGGGLHSSSLTVECSK
CCCCCCCCEEEEEEC
26.0128418008
487PhosphorylationLHSSSLTVECSKTSE
CCCCCEEEEEECCCC
42.7525266776
490PhosphorylationSSLTVECSKTSESEP
CCEEEEEECCCCCCC
57.1325266776
493PhosphorylationTVECSKTSESEPKNF
EEEEECCCCCCCCCC
56.6225266776
501PhosphorylationESEPKNFTDDLGLSM
CCCCCCCCCCCCCCC
16.7025266776
503PhosphorylationEPKNFTDDLGLSMTG
CCCCCCCCCCCCCCC
34.17-
506PhosphorylationNFTDDLGLSMTGDSC
CCCCCCCCCCCCCCE
17.94-
507PhosphorylationFTDDLGLSMTGDSCK
CCCCCCCCCCCCCEE
4.7028066266
509PhosphorylationDDLGLSMTGDSCKLM
CCCCCCCCCCCEEEE
4.9828833060
512PhosphorylationGLSMTGDSCKLMLST
CCCCCCCCEEEEEEC
18.8728833060
513PhosphorylationLSMTGDSCKLMLSTS
CCCCCCCEEEEEECC
22.93-
517PhosphorylationGDSCKLMLSTSEYSQ
CCCEEEEEECCCCCC
21.3825338131
518PhosphorylationDSCKLMLSTSEYSQS
CCEEEEEECCCCCCC
51.3128833060
519PhosphorylationSCKLMLSTSEYSQSS
CEEEEEECCCCCCCH
26.4528833060
520PhosphorylationCKLMLSTSEYSQSSK
EEEEEECCCCCCCHH
28.5228833060
522PhosphorylationLMLSTSEYSQSSKME
EEEECCCCCCCHHCH
4.5828833060
523PhosphorylationMLSTSEYSQSSKMES
EEECCCCCCCHHCHH
46.6928833060
524PhosphorylationLSTSEYSQSSKMESL
EECCCCCCCHHCHHC
34.2321659605
525PhosphorylationSTSEYSQSSKMESLG
ECCCCCCCHHCHHCC
5.1228833060
526PhosphorylationTSEYSQSSKMESLGS
CCCCCCCHHCHHCCC
44.9028833060
527PhosphorylationSEYSQSSKMESLGSP
CCCCCCHHCHHCCCC
19.2625521595
530PhosphorylationSQSSKMESLGSPRTE
CCCHHCHHCCCCCCH
47.309423481
533PhosphorylationSKMESLGSPRTEEDR
HHCHHCCCCCCHHHH
57.8927087446
536PhosphorylationESLGSPRTEEDRENT
HHCCCCCCHHHHHCC
37.8725619855
537PhosphorylationSLGSPRTEEDRENTQ
HCCCCCCHHHHHCCC
23.34-
542PhosphorylationRTEEDRENTQIDDTE
CCHHHHHCCCCCCCC
35.44-
543PhosphorylationTEEDRENTQIDDTEP
CHHHHHCCCCCCCCC
51.7625619855
546PhosphorylationDRENTQIDDTEPLSP
HHHCCCCCCCCCCCC
33.6925521595
548PhosphorylationENTQIDDTEPLSPVS
HCCCCCCCCCCCCCC
8.3225619855
549PhosphorylationNTQIDDTEPLSPVSN
CCCCCCCCCCCCCCC
38.4819060867
551PhosphorylationQIDDTEPLSPVSNSK
CCCCCCCCCCCCCCC
28.2325338131
552PhosphorylationIDDTEPLSPVSNSKL
CCCCCCCCCCCCCCC
63.8424925903
555PhosphorylationTEPLSPVSNSKLPAD
CCCCCCCCCCCCCCC
43.3225521595
557PhosphorylationPLSPVSNSKLPADSE
CCCCCCCCCCCCCCC
32.9324925903
563PhosphorylationNSKLPADSENVLVTP
CCCCCCCCCCEEECC
17.0425293948
565PhosphorylationKLPADSENVLVTPSQ
CCCCCCCCEEECCCH
36.5525338131
569PhosphorylationDSENVLVTPSQDDQV
CCCCEEECCCHHHCE
41.1628066266
571PhosphorylationENVLVTPSQDDQVEM
CCEEECCCHHHCEEH
27.7327180971
573PhosphorylationVLVTPSQDDQVEMSQ
EEECCCHHHCEEHHH
12.7125338131
579PhosphorylationQDDQVEMSQNVDKAK
HHHCEEHHHCHHHHH
18.9226643407
612PhosphorylationEDVCIDLTCDSGSQA
CCEEEEEEECCCCCC
50.3225293948
615PhosphorylationCIDLTCDSGSQAVPS
EEEEEECCCCCCCCC
37.3025293948
616PhosphorylationIDLTCDSGSQAVPSP
EEEEECCCCCCCCCC
22.1425266776
617PhosphorylationDLTCDSGSQAVPSPA
EEEECCCCCCCCCCC
31.4230635358
621PhosphorylationDSGSQAVPSPATRSE
CCCCCCCCCCCCHHH
23.9021743459
622PhosphorylationSGSQAVPSPATRSEA
CCCCCCCCCCCHHHH
50.7925521595
625PhosphorylationQAVPSPATRSEALSS
CCCCCCCCHHHHHHH
26.0021659605
626PhosphorylationAVPSPATRSEALSSV
CCCCCCCHHHHHHHH
27.7821659605
627PhosphorylationVPSPATRSEALSSVL
CCCCCCHHHHHHHHC
6.4921082442
631PhosphorylationATRSEALSSVLDQEE
CCHHHHHHHHCCHHH
47.6021082442
632PhosphorylationTRSEALSSVLDQEEA
CHHHHHHHHCCHHHH
43.6025521595
646PhosphorylationAMDTKEHHPEEGFSG
HCCCCCCCCCCCCCC
52.8719060867
648PhosphorylationDTKEHHPEEGFSGSE
CCCCCCCCCCCCCCC
36.9521659605
652PhosphorylationHHPEEGFSGSEVEEV
CCCCCCCCCCCCEEC
69.4225521595
654PhosphorylationPEEGFSGSEVEEVPE
CCCCCCCCCCEECCC
42.9225521595
660PhosphorylationGSEVEEVPETPCGSH
CCCCEECCCCCCCCC
26.5319854140
662PhosphorylationEVEEVPETPCGSHRE
CCEECCCCCCCCCCC
52.2325159016
666PhosphorylationVPETPCGSHREEPKE
CCCCCCCCCCCCCCC
72.0425159016
678PhosphorylationPKEEPMESIPLHLSL
CCCCCCCCCCCEEEC
23.62-
684PhosphorylationESIPLHLSLTETQSE
CCCCCEEECCHHHHH
32.05-
710PhosphorylationECPEAMEVETSVISI
HCCCCCEEEEEEEEC
20.4225266776
712PhosphorylationPEAMEVETSVISIDS
CCCCEEEEEEEECCC
47.6925619855
713PhosphorylationEAMEVETSVISIDSP
CCCEEEEEEEECCCH
27.7927087446
716PhosphorylationEVETSVISIDSPQKL
EEEEEEEECCCHHHH
44.2524925903
719PhosphorylationTSVISIDSPQKLQVL
EEEEECCCHHHHHHH
10.3625521595
742PhosphorylationPDTWEEATSEDSSVV
CCCHHHHCCCCCCEE
3.8429899451
743PhosphorylationDTWEEATSEDSSVVI
CCHHHHCCCCCCEEE
3.6929899451
747PhosphorylationEATSEDSSVVIVDVK
HHCCCCCCEEEEECC
5.3929899451
751PhosphorylationEDSSVVIVDVKEPSP
CCCCEEEEECCCCCC
28.2720469934
757PhosphorylationIVDVKEPSPRADVSC
EEECCCCCCCCCCCC
17.2021659605
763PhosphorylationPSPRADVSCEPLEEV
CCCCCCCCCCCHHHH
64.7526824392
768PhosphorylationDVSCEPLEEVEKCSD
CCCCCCHHHHHHCCC
51.9021659605
770PhosphorylationSCEPLEEVEKCSDSQ
CCCCHHHHHHCCCCC
15.1521659605
772PhosphorylationEPLEEVEKCSDSQSW
CCHHHHHHCCCCCCC
30.9221659605
774PhosphorylationLEEVEKCSDSQSWEG
HHHHHHCCCCCCCCC
49.3835815
776PhosphorylationEVEKCSDSQSWEGVA
HHHHCCCCCCCCCCC
5.6421659605
778PhosphorylationEKCSDSQSWEGVAPE
HHCCCCCCCCCCCCC
47.3111721371
790PhosphorylationAPEEEPCAENRLDTP
CCCCCCCHHCCCCCC
36.8721183079
796PhosphorylationCAENRLDTPEEKRIE
CHHCCCCCCHHHCCC
10.2726745281
802PhosphorylationDTPEEKRIECDGDSK
CCCHHHCCCCCCCCC
39.0225266776
806PhosphorylationEKRIECDGDSKAETT
HHCCCCCCCCCCCCC
45.1525266776
808PhosphorylationRIECDGDSKAETTEK
CCCCCCCCCCCCCCC
57.251031628229
812PhosphorylationDGDSKAETTEKDAVT
CCCCCCCCCCCCCCC
9.6225619855
813PhosphorylationGDSKAETTEKDAVTE
CCCCCCCCCCCCCCC
35.4825619855
816PhosphorylationKAETTEKDAVTEDSP
CCCCCCCCCCCCCCC
21.1425521595
819PhosphorylationTTEKDAVTEDSPQPP
CCCCCCCCCCCCCCC
35.4625619855
822PhosphorylationKDAVTEDSPQPPLPS
CCCCCCCCCCCCCCC
36.2325521595
823PhosphorylationDAVTEDSPQPPLPSV
CCCCCCCCCCCCCCC
37.1525266776
829PhosphorylationSPQPPLPSVRDEPVR
CCCCCCCCCCCCCCC
15.1525619855
841PhosphorylationPVRPDQETQQPQVQE
CCCCCCCCCCCCCCC
51.2829899451
845PhosphorylationDQETQQPQVQEKESP
CCCCCCCCCCCCCCC
35.4223684622
851PhosphorylationPQVQEKESPVTVDAE
CCCCCCCCCCEECEE
14.6125521595
854PhosphorylationQEKESPVTVDAEVAD
CCCCCCCEECEECCC
15.7025619855
876PhosphorylationGACQQLEKAPACASQ
CHHHHHHHCCCCCCC
26.66-
878PhosphorylationCQQLEKAPACASQSF
HHHHHHCCCCCCCCH
29.3925266776
882PhosphorylationEKAPACASQSFCESS
HHCCCCCCCCHHCCC
40.1026160508
884PhosphorylationAPACASQSFCESSSE
CCCCCCCCHHCCCCC
55.5625266776
888PhosphorylationASQSFCESSSETPFH
CCCCHHCCCCCCCCE
10.9126643407
889PhosphorylationSQSFCESSSETPFHF
CCCHHCCCCCCCCEE
18.9126643407
890PhosphorylationQSFCESSSETPFHFT
CCHHCCCCCCCCEEE
8.4226643407
892PhosphorylationFCESSSETPFHFTLP
HHCCCCCCCCEEECC
5.8026643407
903PhosphorylationFTLPKEGDIIPPLTG
EECCCCCCCCCCCCC
30.4623984901
906PhosphorylationPKEGDIIPPLTGATP
CCCCCCCCCCCCCCC
27.1221659605
909PhosphorylationGDIIPPLTGATPPLI
CCCCCCCCCCCCCCC
8.4626745281
912PhosphorylationIPPLTGATPPLIGHL
CCCCCCCCCCCCCEE
16.8826824392
959PhosphorylationEINDPLLGNEKGDSE
EECCCCCCCCCCCCC
41.96-
965PhosphorylationLGNEKGDSESAPEMD
CCCCCCCCCCCCCCC
8.8424899341
967PhosphorylationNEKGDSESAPEMDGK
CCCCCCCCCCCCCCC
31.3424899341
977PhosphorylationEMDGKLSLKMKLVSP
CCCCCEEEEEEEECC
27.7021659605
983PhosphorylationSLKMKLVSPETEASE
EEEEEEECCCCCCCH
35.3521659605
986PhosphorylationMKLVSPETEASEESL
EEEECCCCCCCHHHH
24.3426745281
989PhosphorylationVSPETEASEESLQFS
ECCCCCCCHHHHHHC
12.49110709
992PhosphorylationETEASEESLQFSLEK
CCCCCHHHHHHCCCC
56.6528066266
996PhosphorylationSEESLQFSLEKPTTA
CHHHHHHCCCCCCCC
34.7428066266
1001PhosphorylationQFSLEKPTTAERKNG
HHCCCCCCCCCCCCC
56.7325293948
1002PhosphorylationFSLEKPTTAERKNGS
HCCCCCCCCCCCCCC
29.4325293948
1012PhosphorylationRKNGSTAIAEPVASL
CCCCCCEECCCHHHC
31.41-
1018PhosphorylationAIAEPVASLQKPVPV
EECCCHHHCCCCCCE
25.01-
1034PhosphorylationGCIYEAQQEKEAQSE
EEEEHHHHHHHHHCC
42.65-
1040PhosphorylationQQEKEAQSEAPPSAP
HHHHHHHCCCCCCCC
18.7852836237
1057PhosphorylationANLLHFPSAQEEDKE
HHHCCCCCCCHHHHC
59.9229899451
1069PhosphorylationDKERPDVTPKLRQSE
HHCCCCCCHHHHHCC
31.59-
1075PhosphorylationVTPKLRQSEQPVKPV
CCHHHHHCCCCCCCC
36.2125619855
1088PhosphorylationPVGPVMDDAAPEDSA
CCCCCCCCCCCCCCC
29.0521659605
1090PhosphorylationGPVMDDAAPEDSASP
CCCCCCCCCCCCCCH
29.7720139300
1093PhosphorylationMDDAAPEDSASPVSQ
CCCCCCCCCCCHHHH
24.7921659605
1094PhosphorylationDDAAPEDSASPVSQQ
CCCCCCCCCCHHHHH
36.6924925903
1094 (in isoform 5)Phosphorylation-36.6925266776
1096PhosphorylationAAPEDSASPVSQQRA
CCCCCCCCHHHHHHH
28.6825521595
1096 (in isoform 5)Phosphorylation-28.6827818261
1098PhosphorylationPEDSASPVSQQRASQ
CCCCCCHHHHHHHHH
36.9521659605
1099PhosphorylationEDSASPVSQQRASQE
CCCCCHHHHHHHHHH
62.494689495
1099 (in isoform 5)Phosphorylation-62.4921659605
1103PhosphorylationSPVSQQRASQEQRAS
CHHHHHHHHHHHHHH
33.6421659605
1104PhosphorylationPVSQQRASQEQRASQ
HHHHHHHHHHHHHHC
39.7926160508
1104 (in isoform 5)Phosphorylation-39.7921659605
1109 (in isoform 5)Phosphorylation-7.6921659605
1110PhosphorylationASQEQRASQEPFSPA
HHHHHHHHCCCCCHH
38.7321183079
1110PhosphorylationASQEQRASQEPFSPA
HHHHHHHHCCCCCHH
38.7324925903
1111PhosphorylationSQEQRASQEPFSPAE
HHHHHHHCCCCCHHH
17.53-
1115PhosphorylationRASQEPFSPAEDVME
HHHCCCCCHHHHHHH
60.5025266776
1115PhosphorylationRASQEPFSPAEDVME
HHHCCCCCHHHHHHH
60.5024925903
1123PhosphorylationPAEDVMETDLLEGLA
HHHHHHHCCHHHHHH
27.8524925903
1137PhosphorylationAANQDRPSKMLMDRP
HHCCCCCCHHCCCCC
6.6125619855
1193PhosphorylationSGKQDATVQTERGSG
CCCCCEEEEECCCCC
41.4519854140
1199PhosphorylationTVQTERGSGEKPASA
EEEECCCCCCCCCCC
24.0219060867
1201PhosphorylationQTERGSGEKPASAPV
EECCCCCCCCCCCCC
33.2125266776
1204PhosphorylationRGSGEKPASAPVDDT
CCCCCCCCCCCCCCC
45.2125266776
1205PhosphorylationGSGEKPASAPVDDTE
CCCCCCCCCCCCCCH
53.2026643407
1211PhosphorylationASAPVDDTESLHSQG
CCCCCCCCHHHHHCC
53.9121082442
1213PhosphorylationAPVDDTESLHSQGEE
CCCCCCHHHHHCCCH
36.0127087446
1216PhosphorylationDDTESLHSQGEEEFE
CCCHHHHHCCCHHCC
40.6227087446
1253UbiquitinationLVTRVITDVYYVDGT
HHHHHHEEEEEECCC
39.75-
1270PhosphorylationERKVTEETEEPIVEC
EEECCCCCCCCCEEE
54.0325338131
1282PhosphorylationVECQECETEVSPSQT
EEEEECEEEECHHHC
35.5425293948
1285PhosphorylationQECETEVSPSQTGGS
EECEEEECHHHCCCC
34.6425195567
1287PhosphorylationCETEVSPSQTGGSSG
CEEEECHHHCCCCCC
3.3625293948
1289PhosphorylationTEVSPSQTGGSSGDL
EEECHHHCCCCCCCC
29.4925293948
1292PhosphorylationSPSQTGGSSGDLGDI
CHHHCCCCCCCCCCH
30.1725293948
1293PhosphorylationPSQTGGSSGDLGDIS
HHHCCCCCCCCCCHH
51.6025293948
1302PhosphorylationDLGDISSFSSKASSS
CCCCHHHHCCCCCCC
47.4425338131
1314PhosphorylationSSSHHTSSGTSLSAI
CCCCCCCCCCCEEEH
31.4125338131
1317MethylationHHTSSGTSLSAIHSS
CCCCCCCCEEEHHCC
33.46-
1327PhosphorylationAIHSSGSSGRGAGPL
EHHCCCCCCCCCCCC
50.13-
1329MethylationHSSGSSGRGAGPLKG
HCCCCCCCCCCCCCC
21.6924129315
1339PhosphorylationGPLKGKASGTEAADF
CCCCCCCCCCCHHHH
32.7628066266
1340MethylationPLKGKASGTEAADFA
CCCCCCCCCCHHHHC
59.43-
1341PhosphorylationLKGKASGTEAADFAL
CCCCCCCCCHHHHCC
48.9028066266
1347PhosphorylationGTEAADFALPSSRGG
CCCHHHHCCCCCCCC
26.5825266776
1352MethylationDFALPSSRGGPGKLS
HHCCCCCCCCCCCCC
2.8624129315
1353PhosphorylationFALPSSRGGPGKLSP
HCCCCCCCCCCCCCC
30.29-
1359PhosphorylationRGGPGKLSPRKGISQ
CCCCCCCCCCCCCCC
6.7725521595
1365PhosphorylationLSPRKGISQTGAPVC
CCCCCCCCCCCCCCC
50.19-
1373PhosphorylationQTGAPVCEEDGDAGL
CCCCCCCCCCCCCCC
29.7125266776
1373PhosphorylationQTGAPVCEEDGDAGL
CCCCCCCCCCCCCCC
29.7125266776
1403PhosphorylationGRRGRPPSRTTGTRE
CCCCCCCCCCCCCCC
15.1619854140
1405PhosphorylationRGRPPSRTTGTRETV
CCCCCCCCCCCCCEE
15.9319854140
1411PhosphorylationRTTGTRETVVSGPLG
CCCCCCCEEEECCCC
24.2028833060
1413PhosphorylationTGTRETVVSGPLGVE
CCCCCEEEECCCCCC
25.7125266776
1414PhosphorylationGTRETVVSGPLGVED
CCCCEEEECCCCCCC
8.3925619855
1415PhosphorylationTRETVVSGPLGVEDI
CCCEEEECCCCCCCC
29.5221659605
1420PhosphorylationVSGPLGVEDISPSMS
EECCCCCCCCCCCCC
38.5519060867
1422PhosphorylationGPLGVEDISPSMSPD
CCCCCCCCCCCCCCC
26.7819060867
1423PhosphorylationPLGVEDISPSMSPDD
CCCCCCCCCCCCCCC
22.6221082442
1425PhosphorylationGVEDISPSMSPDDKS
CCCCCCCCCCCCCCC
1.2427087446
1427PhosphorylationEDISPSMSPDDKSFT
CCCCCCCCCCCCCCC
34.9127087446
1432PhosphorylationSMSPDDKSFTRIMPR
CCCCCCCCCCEECCC
31.7428833060
1434PhosphorylationSPDDKSFTRIMPRVP
CCCCCCCCEECCCCC
37.6228833060
1445PhosphorylationPRVPDSTKRTDASSS
CCCCCCCCCCCCCCC
35.6925266776
1447PhosphorylationVPDSTKRTDASSSTL
CCCCCCCCCCCCCCC
26.1925521595
1456PhosphorylationASSSTLRRSDSPEIP
CCCCCCCCCCCCCCC
40.3821659604
1457PhosphorylationSSSTLRRSDSPEIPF
CCCCCCCCCCCCCCC
22.0424925903
1458PhosphorylationSSTLRRSDSPEIPFQ
CCCCCCCCCCCCCCC
22.3919060867
1459PhosphorylationSTLRRSDSPEIPFQA
CCCCCCCCCCCCCCC
36.7225521595
1468PhosphorylationEIPFQAATGSSDGLD
CCCCCCCCCCCCCCC
35.4324925903
1470PhosphorylationPFQAATGSSDGLDSS
CCCCCCCCCCCCCCC
25.4924925903
1471PhosphorylationFQAATGSSDGLDSSS
CCCCCCCCCCCCCCC
6.1525619855
1476PhosphorylationGSSDGLDSSSSGNSF
CCCCCCCCCCCCCCE
6.2025619855
1477PhosphorylationSSDGLDSSSSGNSFV
CCCCCCCCCCCCCEE
3.5225619855
1478PhosphorylationSDGLDSSSSGNSFVG
CCCCCCCCCCCCEEE
12.5425619855
1479PhosphorylationDGLDSSSSGNSFVGL
CCCCCCCCCCCEEEE
35.6825619855
1482PhosphorylationDSSSSGNSFVGLRVV
CCCCCCCCEEEEEEE
32.9125619855
1533PhosphorylationGKDILLCDPIPLDTE
CCEEEEECCCCCCCC
40.30-
1545PhosphorylationDTEVTALSEDEYFSA
CCCEEECCCCCCCCC
17.7751456787
1573AcetylationYYSIEKEGQRKWYKR
EEEEEEHHCHHHHHH
3.72-
1594PhosphorylationLEQGNRLREQYGLGP
HHHHCHHHHHHCCCC
21.4523984901
1602PhosphorylationEQYGLGPYEAVTPLT
HHHCCCCHHHCCCHH
3.6523984901
1603PhosphorylationQYGLGPYEAVTPLTK
HHCCCCHHHCCCHHH
30.1623984901
1606PhosphorylationLGPYEAVTPLTKAAD
CCCHHHCCCHHHHHC
51.8126745281
1609PhosphorylationYEAVTPLTKAADISL
HHHCCCHHHHHCCCH
63.2623984901
1611AcetylationAVTPLTKAADISLDN
HCCCHHHHHCCCHHH
41.0423806337
1615PhosphorylationLTKAADISLDNLVEG
HHHHHCCCHHHHHCC
36.776459625
1616PhosphorylationTKAADISLDNLVEGK
HHHHCCCHHHHHCCC
42.4125266776
1619PhosphorylationADISLDNLVEGKRKR
HCCCHHHHHCCCHHC
32.6025338131
1620PhosphorylationDISLDNLVEGKRKRR
CCCHHHHHCCCHHCC
21.4225266776
1623PhosphorylationLDNLVEGKRKRRSNI
HHHHHCCCHHCCCCC
20.5025338131
1628PhosphorylationEGKRKRRSNISSPVT
CCCHHCCCCCCCCCC
28.4323527152
1629PhosphorylationGKRKRRSNISSPVTP
CCHHCCCCCCCCCCC
24.4721183079
1630PhosphorylationKRKRRSNISSPVTPT
CHHCCCCCCCCCCCC
29.2525338131
1631PhosphorylationRKRRSNISSPVTPTA
HHCCCCCCCCCCCCC
37.9425619855
1632PhosphorylationKRRSNISSPVTPTAA
HCCCCCCCCCCCCCC
38.4555991
1633PhosphorylationRRSNISSPVTPTAAS
CCCCCCCCCCCCCCC
25.3025266776
1635PhosphorylationSNISSPVTPTAASSS
CCCCCCCCCCCCCCC
42.5925619855
1637PhosphorylationISSPVTPTAASSSST
CCCCCCCCCCCCCCC
63.2425619855
1640PhosphorylationPVTPTAASSSSTTPT
CCCCCCCCCCCCCCC
64.7025619855
1641PhosphorylationVTPTAASSSSTTPTR
CCCCCCCCCCCCCCC
18.4825619855
1642PhosphorylationTPTAASSSSTTPTRK
CCCCCCCCCCCCCCC
29.6225619855
1643PhosphorylationPTAASSSSTTPTRKA
CCCCCCCCCCCCCCC
50.9125619855
1644PhosphorylationTAASSSSTTPTRKAT
CCCCCCCCCCCCCCC
18.1525619855
1645PhosphorylationAASSSSTTPTRKATE
CCCCCCCCCCCCCCC
27.2923527152
1646PhosphorylationASSSSTTPTRKATES
CCCCCCCCCCCCCCC
41.01-
1647PhosphorylationSSSSTTPTRKATESP
CCCCCCCCCCCCCCC
27.1825619855
1651PhosphorylationTTPTRKATESPRAST
CCCCCCCCCCCCCCC
27.9326745281
1653PhosphorylationPTRKATESPRASTGV
CCCCCCCCCCCCCCC
49.6326745281
1657PhosphorylationATESPRASTGVPSGK
CCCCCCCCCCCCCCC
60.2426745281
1658PhosphorylationTESPRASTGVPSGKR
CCCCCCCCCCCCCCC
40.8625266776
1662PhosphorylationRASTGVPSGKRKLPT
CCCCCCCCCCCCCCC
51.7428066266
1663PhosphorylationASTGVPSGKRKLPTS
CCCCCCCCCCCCCCC
32.2725521595
1669PhosphorylationSGKRKLPTSEEERSP
CCCCCCCCCHHHCCC
33.5125159016
1670PhosphorylationGKRKLPTSEEERSPA
CCCCCCCCHHHCCCC
47.46169385
1675PhosphorylationPTSEEERSPAKRGRK
CCCHHHCCCCCCCCC
33.1225521595
1686PhosphorylationRGRKSATVKPGTVGA
CCCCCCCCCCCCCCC
29.20-
1698PhosphorylationVGAAEFVSPCETGDN
CCCEEEECCCCCCCC
34.72-
1741PhosphorylationTMATTSDKLASRSKL
HHHHCHHHHHHHHHH
56.0521743459
1743PhosphorylationATTSDKLASRSKLLD
HHCHHHHHHHHHHCC
36.7321743459
1744PhosphorylationTTSDKLASRSKLLDG
HCHHHHHHHHHHCCC
50.8221659605
1753PhosphorylationSKLLDGPTGSSEEEE
HHHCCCCCCCCHHHH
5.9727600695
1755PhosphorylationLLDGPTGSSEEEEEF
HCCCCCCCCHHHHHH
51.62169389
1756PhosphorylationLDGPTGSSEEEEEFL
CCCCCCCCHHHHHHH
17.4823984901
1962PhosphorylationGFKQHPKYKHDYVSH
CCCCCCCCCCCCCCC
27717184
1968PhosphorylationKYKHDYVSH------
CCCCCCCCC------
101544641

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
382SPhosphorylationKinaseCDK1P06493
PSP

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
1606TPhosphorylation

23333305
1615SPhosphorylation

23333305

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TP53B_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
P53_MOUSETrp53genetic
18931658
NBN_MOUSENbngenetic
18931658
TERF1_MOUSETerf1genetic
22556254
TERF2_MOUSETerf2genetic
22556254
TERF1_MOUSETerf1genetic
22508511
LMNA_MOUSELmnagenetic
21701264
RN168_MOUSERnf168physical
24324146
MDC1_MOUSEMdc1physical
24324146
CENPF_HUMANCENPFphysical
26496610
PSMD2_HUMANPSMD2physical
26496610
TAF1_HUMANTAF1physical
26496610
TYK2_HUMANTYK2physical
26496610
ARK72_HUMANAKR7A2physical
26496610
ZN281_HUMANZNF281physical
26496610
WBP2_HUMANWBP2physical
26496610
ZBT11_HUMANZBTB11physical
26496610
RHG17_HUMANARHGAP17physical
26496610
ERGI1_HUMANERGIC1physical
26496610
UBP28_HUMANUSP28physical
26496610
RM11_HUMANMRPL11physical
26496610
P5CR3_HUMANPYCRLphysical
26496610
TIRR_HUMANNUDT16L1physical
26496610
CHAP1_HUMANCHAMP1physical
26496610
ZSWM9_HUMANC19orf68physical
26496610

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TP53B_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1103, AND MASSSPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-546 AND SER-1347, ANDMASS SPECTROMETRY.

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