TERF1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TERF1_MOUSE
• UniProt AC: P70371
• Protein Name: Telomeric repeat-binding factor 1
• Gene Name: Terf1
• Organism: Mus musculus (Mouse).
• Sequence Length: 421
• Subcellular Localization: Nucleus . Chromosome, telomere. Cytoplasm, cytoskeleton, spindle. Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle (By similari
• Protein Description: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways..
• Protein Sequence: MAETVSSAARDAPSREGWTDSDSPEQEEVGDDAELLQCQLQLGTPREMENAELVAEVEAVAAGWMLDFLCLSLCRAFRDGRSEDFRRTRDSAEAIIHGLHRLTAYQLKTVYICQFLTRVASGKALDAQFEVDERITPLESALMIWNSIEKEHDKLHDEIKNLIKIQAVAVCMEIGSFKEAEEVFERIFGDPEFYTPLERKLLKIISQKDVFHSLFQHFSYSCMMEKIQSYVGDVLSEKSSTFLMKAATKVVENEKARTQASKDRPDATNTGMDTEVGLNKEKSVNGQQSTETEPLVDTVSSIRSHKNALSQLKHRRAPSDFSRNEARTGTLQCETTMERNRRTSGRNRLCVSENQPDTDDKSGRRKRQTWLWEEDRILKCGVKKYGEGNWAKILSHYKFNNRTSVMLKDRWRTMKRLKLIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAETVSSAA ------CCCCHHHHH	22.59	-
14	Phosphorylation	SAARDAPSREGWTDS HHHHCCCCCCCCCCC	44.69	21183079
19	Phosphorylation	APSREGWTDSDSPEQ CCCCCCCCCCCCHHH	36.16	21149613
21	Phosphorylation	SREGWTDSDSPEQEE CCCCCCCCCCHHHHH	32.39	25293948
23	Phosphorylation	EGWTDSDSPEQEEVG CCCCCCCCHHHHHHC	34.00	21149613
206	Phosphorylation	RKLLKIISQKDVFHS HHHHHHHCCHHHHHH	34.35	-
241	Phosphorylation	VLSEKSSTFLMKAAT HHCHHHHHHHHHHHH	28.07	28576409
261	Phosphorylation	EKARTQASKDRPDAT HHHHHHHHCCCCCCC	25.85	21659604
268	Phosphorylation	SKDRPDATNTGMDTE HCCCCCCCCCCCCCC	40.47	21659604
270	Phosphorylation	DRPDATNTGMDTEVG CCCCCCCCCCCCCCC	29.54	21659604
283	Phosphorylation	VGLNKEKSVNGQQST CCCCCCCCCCCCCCC	23.16	28059163
289	Phosphorylation	KSVNGQQSTETEPLV CCCCCCCCCCCCCCH	21.96	25293948
290	Phosphorylation	SVNGQQSTETEPLVD CCCCCCCCCCCCCHH	42.46	25293948
292	Phosphorylation	NGQQSTETEPLVDTV CCCCCCCCCCCHHHH	42.88	25293948
298	Phosphorylation	ETEPLVDTVSSIRSH CCCCCHHHHHHHHHH	18.14	25293948
300	Phosphorylation	EPLVDTVSSIRSHKN CCCHHHHHHHHHHHH	23.34	25293948
301	Phosphorylation	PLVDTVSSIRSHKNA CCHHHHHHHHHHHHH	20.06	25293948
304	Phosphorylation	DTVSSIRSHKNALSQ HHHHHHHHHHHHHHH	36.82	25293948
310	Phosphorylation	RSHKNALSQLKHRRA HHHHHHHHHHHHCCC	30.93	22006019
319	Phosphorylation	LKHRRAPSDFSRNEA HHHCCCCCCCCCCHH	50.75	28066266
322	Phosphorylation	RRAPSDFSRNEARTG CCCCCCCCCCHHHHC	38.90	28066266
385	Phosphorylation	LKCGVKKYGEGNWAK HCCCCEECCCCCHHH	18.07	-
421	Phosphorylation	MKRLKLIS------- HHHHHCCC-------	44.60	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
206	S	Phosphorylation	Kinase	ATM	Q62388	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	Rlim	Q9WTV7	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
219	S	Phosphorylation	Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TERF1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XRCC6_HUMAN	XRCC6	physical	26496610
PRKDC_HUMAN	PRKDC	physical	26496610
TERF2_HUMAN	TERF2	physical	26496610
POTE1_HUMAN	POT1	physical	26496610
TINF2_HUMAN	TINF2	physical	26496610
TE2IP_HUMAN	TERF2IP	physical	26496610
DCR1B_HUMAN	DCLRE1B	physical	26496610
ACD_HUMAN	ACD	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.