dbPTM

LMNA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LMNA_MOUSE
UniProt AC	P48678
Protein Name	Prelamin-A/C
Gene Name	Lmna
Organism	Mus musculus (Mouse).
Sequence Length	665
Subcellular Localization	Nucleus . Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then b
Protein Description	Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone. Required for cardiac homeostasis. [PubMed: 26436652 Isoform C2 may have a role in determining the organization of nuclear and chromosomal structures during spermatogenesis.; Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (By similarity]
Protein Sequence	METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLLAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTLKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQSQGGGSVTKKRKLESSESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIRRQNGDDPLMTYRFPPKFTLKAGQVVTIWASGAGATHSPPTDLVWKAQNTWGCGSSLRTALINSTGEEVAMRKLVRSLTMVEDNEDDDEDGEELLHHHRGSHCSGSGDPAEYNLRSRTVLCGTCGQPADKAAGGAGAQVGGSISSGSSASSVTVTRSFRSVGGSGGGSFGDNLVTRSYLLGNSSPRSQSSQNCSIM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------METPSQRR -------CCCHHHHH	13.44	-
3	Phosphorylation	-----METPSQRRAT -----CCCHHHHHHC	27.26	27717184
5	Phosphorylation	---METPSQRRATRS ---CCCHHHHHHCCC	43.68	28507225
10	Phosphorylation	TPSQRRATRSGAQAS CHHHHHHCCCCCCCC	24.45	26160508
12	Phosphorylation	SQRRATRSGAQASST HHHHHCCCCCCCCCC	33.84	27087446
17	Phosphorylation	TRSGAQASSTPLSPT CCCCCCCCCCCCCCC	23.75	27087446
18	Phosphorylation	RSGAQASSTPLSPTR CCCCCCCCCCCCCCH	36.74	27087446
19	Phosphorylation	SGAQASSTPLSPTRI CCCCCCCCCCCCCHH	26.25	27087446
22	Phosphorylation	QASSTPLSPTRITRL CCCCCCCCCCHHHHC	25.98	27087446
23	Ubiquitination	ASSTPLSPTRITRLQ CCCCCCCCCHHHHCH	33.12	27667366
24	Phosphorylation	SSTPLSPTRITRLQE CCCCCCCCHHHHCHH	31.18	25521595
27	Phosphorylation	PLSPTRITRLQEKED CCCCCHHHHCHHHHH	23.26	24453211
32	Ubiquitination	RITRLQEKEDLQELN HHHHCHHHHHHHHHH	43.50	22790023
32	Acetylation	RITRLQEKEDLQELN HHHHCHHHHHHHHHH	43.50	23806337
32	Succinylation	RITRLQEKEDLQELN HHHHCHHHHHHHHHH	43.50	-
32	Succinylation	RITRLQEKEDLQELN HHHHCHHHHHHHHHH	43.50	23806337
32	Ubiquitination	RITRLQEKEDLQELN HHHHCHHHHHHHHHH	43.50	-
45	Phosphorylation	LNDRLAVYIDRVRSL HHHHHHHHHHHHHHH	7.47	25367039
51	Phosphorylation	VYIDRVRSLETENAG HHHHHHHHHCCCCCC	27.92	27180971
54	Phosphorylation	DRVRSLETENAGLRL HHHHHHCCCCCCEEE	39.57	28066266
59	Ubiquitination	LETENAGLRLRITES HCCCCCCEEEEEECC	4.30	27667366
66	Phosphorylation	LRLRITESEEVVSRE EEEEEECCHHHHHHH	30.33	27180971
68	Ubiquitination	LRITESEEVVSREVS EEEECCHHHHHHHHH	58.46	27667366
69	Ubiquitination	RITESEEVVSREVSG EEECCHHHHHHHHHC	4.09	27667366
71	Phosphorylation	TESEEVVSREVSGIK ECCHHHHHHHHHCHH	28.09	26824392
75	Phosphorylation	EVVSREVSGIKAAYE HHHHHHHHCHHHHHH	30.01	26060331
78	Ubiquitination	SREVSGIKAAYEAEL HHHHHCHHHHHHHHH	30.41	22790023
78	Ubiquitination	SREVSGIKAAYEAEL HHHHHCHHHHHHHHH	30.41	-
89	Ubiquitination	EAELGDARKTLDSVA HHHHCCHHHHHHHHH	36.91	27667366
90	Acetylation	AELGDARKTLDSVAK HHHCCHHHHHHHHHH	55.98	23806337
90	Malonylation	AELGDARKTLDSVAK HHHCCHHHHHHHHHH	55.98	32601280
90	Succinylation	AELGDARKTLDSVAK HHHCCHHHHHHHHHH	55.98	23806337
94	Phosphorylation	DARKTLDSVAKERAR CHHHHHHHHHHHHHH	27.38	-
96	Ubiquitination	RKTLDSVAKERARLQ HHHHHHHHHHHHHHH	16.37	27667366
97	Ubiquitination	KTLDSVAKERARLQL HHHHHHHHHHHHHHH	45.65	22790023
97	Acetylation	KTLDSVAKERARLQL HHHHHHHHHHHHHHH	45.65	23954790
97	Malonylation	KTLDSVAKERARLQL HHHHHHHHHHHHHHH	45.65	26073543
97	Ubiquitination	KTLDSVAKERARLQL HHHHHHHHHHHHHHH	45.65	27667366
107	Phosphorylation	ARLQLELSKVREEFK HHHHHHHHHHHHHHH	21.52	26824392
108	Ubiquitination	RLQLELSKVREEFKE HHHHHHHHHHHHHHH	58.92	22790023
108	Acetylation	RLQLELSKVREEFKE HHHHHHHHHHHHHHH	58.92	22826441
108	Malonylation	RLQLELSKVREEFKE HHHHHHHHHHHHHHH	58.92	26320211
108	Ubiquitination	RLQLELSKVREEFKE HHHHHHHHHHHHHHH	58.92	-
114	Ubiquitination	SKVREEFKELKARNT HHHHHHHHHHHHHCC	66.47	22790023
114	Acetylation	SKVREEFKELKARNT HHHHHHHHHHHHHCC	66.47	23236377
114	Malonylation	SKVREEFKELKARNT HHHHHHHHHHHHHCC	66.47	26320211
114	Ubiquitination	SKVREEFKELKARNT HHHHHHHHHHHHHCC	66.47	27667366
121	Ubiquitination	KELKARNTKKEGDLL HHHHHHCCHHHHHHH	37.63	27667366
123	Acetylation	LKARNTKKEGDLLAA HHHHCCHHHHHHHHH	65.96	23806337
123	Malonylation	LKARNTKKEGDLLAA HHHHCCHHHHHHHHH	65.96	26320211
135	Ubiquitination	LAAQARLKDLEALLN HHHHHHHHHHHHHHC	55.50	22790023
135	Acetylation	LAAQARLKDLEALLN HHHHHHHHHHHHHHC	55.50	23806337
135	Malonylation	LAAQARLKDLEALLN HHHHHHHHHHHHHHC	55.50	26320211
135	Ubiquitination	LAAQARLKDLEALLN HHHHHHHHHHHHHHC	55.50	27667366
143	Phosphorylation	DLEALLNSKEAALST HHHHHHCCHHHHHHH	31.66	29514104
144	Ubiquitination	LEALLNSKEAALSTA HHHHHCCHHHHHHHH	50.75	22790023
144	Acetylation	LEALLNSKEAALSTA HHHHHCCHHHHHHHH	50.75	23806337
144	Succinylation	LEALLNSKEAALSTA HHHHHCCHHHHHHHH	50.75	23806337
144	Ubiquitination	LEALLNSKEAALSTA HHHHHCCHHHHHHHH	50.75	-
153	Phosphorylation	AALSTALSEKRTLEG HHHHHHHHHCCHHHH	38.31	28464351
155	Ubiquitination	LSTALSEKRTLEGEL HHHHHHHCCHHHHHH	47.51	22790023
155	Acetylation	LSTALSEKRTLEGEL HHHHHHHCCHHHHHH	47.51	23806337
155	Malonylation	LSTALSEKRTLEGEL HHHHHHHCCHHHHHH	47.51	26320211
155	Ubiquitination	LSTALSEKRTLEGEL HHHHHHHCCHHHHHH	47.51	-
158	Ubiquitination	ALSEKRTLEGELHDL HHHHCCHHHHHHHHH	10.39	27667366
171	Ubiquitination	DLRGQVAKLEAALGE HHHHHHHHHHHHHHH	48.26	22790023
171	Acetylation	DLRGQVAKLEAALGE HHHHHHHHHHHHHHH	48.26	23806337
171	Succinylation	DLRGQVAKLEAALGE HHHHHHHHHHHHHHH	48.26	-
171	Succinylation	DLRGQVAKLEAALGE HHHHHHHHHHHHHHH	48.26	23806337
171	Ubiquitination	DLRGQVAKLEAALGE HHHHHHHHHHHHHHH	48.26	27667366
180	Ubiquitination	EAALGEAKKQLQDEM HHHHHHHHHHHHHHH	36.43	22790023
180	Acetylation	EAALGEAKKQLQDEM HHHHHHHHHHHHHHH	36.43	7668129
180	Malonylation	EAALGEAKKQLQDEM HHHHHHHHHHHHHHH	36.43	26320211
180	Ubiquitination	EAALGEAKKQLQDEM HHHHHHHHHHHHHHH	36.43	27667366
181	Ubiquitination	AALGEAKKQLQDEML HHHHHHHHHHHHHHH	64.39	22790023
181	Malonylation	AALGEAKKQLQDEML HHHHHHHHHHHHHHH	64.39	26320211
181	Ubiquitination	AALGEAKKQLQDEML HHHHHHHHHHHHHHH	64.39	27667366
199	Phosphorylation	DAENRLQTLKEELDF CHHHHHHHHHHHHHH	44.37	8477740
199	Ubiquitination	DAENRLQTLKEELDF CHHHHHHHHHHHHHH	44.37	27667366
201	Ubiquitination	ENRLQTLKEELDFQK HHHHHHHHHHHHHHH	53.16	22790023
201	Acetylation	ENRLQTLKEELDFQK HHHHHHHHHHHHHHH	53.16	23806337
201	Malonylation	ENRLQTLKEELDFQK HHHHHHHHHHHHHHH	53.16	26320211
201	Succinylation	ENRLQTLKEELDFQK HHHHHHHHHHHHHHH	53.16	23806337
201	Sumoylation	ENRLQTLKEELDFQK HHHHHHHHHHHHHHH	53.16	-
201	Ubiquitination	ENRLQTLKEELDFQK HHHHHHHHHHHHHHH	53.16	27667366
208	Ubiquitination	KEELDFQKNIYSEEL HHHHHHHHHHCCHHH	45.35	22790023
208	Acetylation	KEELDFQKNIYSEEL HHHHHHHHHHCCHHH	45.35	23954790
208	Ubiquitination	KEELDFQKNIYSEEL HHHHHHHHHHCCHHH	45.35	27667366
211	Phosphorylation	LDFQKNIYSEELRET HHHHHHHCCHHHHHH	21.30	23984901
212	Phosphorylation	DFQKNIYSEELRETK HHHHHHCCHHHHHHH	22.31	26824392
218	Phosphorylation	YSEELRETKRRHETR CCHHHHHHHHHHCCE	24.34	23984901
219	Ubiquitination	SEELRETKRRHETRL CHHHHHHHHHHCCEE	42.56	22790023
219	Ubiquitination	SEELRETKRRHETRL CHHHHHHHHHHCCEE	42.56	-
224	Phosphorylation	ETKRRHETRLVEIDN HHHHHHCCEEEEECC	24.15	-
233	Ubiquitination	LVEIDNGKQREFESR EEEECCCCHHHHHHH	53.06	22790023
233	Acetylation	LVEIDNGKQREFESR EEEECCCCHHHHHHH	53.06	23236377
233	Ubiquitination	LVEIDNGKQREFESR EEEECCCCHHHHHHH	53.06	27667366
239	Phosphorylation	GKQREFESRLADALQ CCHHHHHHHHHHHHH	37.60	25338131
260	Acetylation	EDQVEQYKKELEKTY HHHHHHHHHHHHHHH	39.19	23806337
261	Acetylation	DQVEQYKKELEKTYS HHHHHHHHHHHHHHH	63.70	129605
265	Acetylation	QYKKELEKTYSAKLD HHHHHHHHHHHHHHH	66.44	23954790
265	Malonylation	QYKKELEKTYSAKLD HHHHHHHHHHHHHHH	66.44	26320211
266	Phosphorylation	YKKELEKTYSAKLDN HHHHHHHHHHHHHHH	17.21	20469934
267	Phosphorylation	KKELEKTYSAKLDNA HHHHHHHHHHHHHHH	20.07	20469934
268	Phosphorylation	KELEKTYSAKLDNAR HHHHHHHHHHHHHHH	24.94	20469934
270	Ubiquitination	LEKTYSAKLDNARQS HHHHHHHHHHHHHHH	50.89	22790023
270	Acetylation	LEKTYSAKLDNARQS HHHHHHHHHHHHHHH	50.89	23806337
270	Malonylation	LEKTYSAKLDNARQS HHHHHHHHHHHHHHH	50.89	26320211
270	Succinylation	LEKTYSAKLDNARQS HHHHHHHHHHHHHHH	50.89	23806337
270	Ubiquitination	LEKTYSAKLDNARQS HHHHHHHHHHHHHHH	50.89	27667366
277	Phosphorylation	KLDNARQSAERNSNL HHHHHHHHHHHHHCH	26.92	26824392
282	Phosphorylation	RQSAERNSNLVGAAH HHHHHHHHCHHHHHH	37.45	24453211
301	Phosphorylation	QSRIRIDSLSAQLSQ HHCHHHHHHHHHHHH	23.11	25521595
303	Phosphorylation	RIRIDSLSAQLSQLQ CHHHHHHHHHHHHHH	20.23	27742792
307	Phosphorylation	DSLSAQLSQLQKQLA HHHHHHHHHHHHHHH	19.43	29472430
311	Ubiquitination	AQLSQLQKQLAAKEA HHHHHHHHHHHHHHH	56.74	22790023
311	Acetylation	AQLSQLQKQLAAKEA HHHHHHHHHHHHHHH	56.74	23806337
311	Ubiquitination	AQLSQLQKQLAAKEA HHHHHHHHHHHHHHH	56.74	27667366
316	Malonylation	LQKQLAAKEAKLRDL HHHHHHHHHHHHHHH	53.23	26320211
319	Ubiquitination	QLAAKEAKLRDLEDS HHHHHHHHHHHHHHH	45.18	22790023
319	Acetylation	QLAAKEAKLRDLEDS HHHHHHHHHHHHHHH	45.18	23236377
319	Ubiquitination	QLAAKEAKLRDLEDS HHHHHHHHHHHHHHH	45.18	-
326	Phosphorylation	KLRDLEDSLARERDT HHHHHHHHHHHHHHH	17.98	19367708
345	Ubiquitination	LAEKEREMAEMRARM HHHHHHHHHHHHHHH	4.85	27667366
378	Ubiquitination	MEIHAYRKLLEGEEE HHHHHHHHHHCCHHH	44.76	22790023
378	Acetylation	MEIHAYRKLLEGEEE HHHHHHHHHHCCHHH	44.76	22631205
378	Ubiquitination	MEIHAYRKLLEGEEE HHHHHHHHHHCCHHH	44.76	-
390	Phosphorylation	EEERLRLSPSPTSQR HHHHHCCCCCCCCCC	19.52	27087446
392	Phosphorylation	ERLRLSPSPTSQRSR HHHCCCCCCCCCCCC	37.12	27087446
392 (in isoform 2)	Phosphorylation	-	37.12	1959608
394	Phosphorylation	LRLSPSPTSQRSRGR HCCCCCCCCCCCCCC	41.66	27087446
395	Phosphorylation	RLSPSPTSQRSRGRA CCCCCCCCCCCCCCC	27.29	25521595
398	Phosphorylation	PSPTSQRSRGRASSH CCCCCCCCCCCCCCC	31.30	26824392
403	Phosphorylation	QRSRGRASSHSSQSQ CCCCCCCCCCCCCCC	27.50	27087446
404	Phosphorylation	RSRGRASSHSSQSQG CCCCCCCCCCCCCCC	26.80	27087446
406	Phosphorylation	RGRASSHSSQSQGGG CCCCCCCCCCCCCCC	31.83	27087446
407	Phosphorylation	GRASSHSSQSQGGGS CCCCCCCCCCCCCCC	28.55	27087446
407 (in isoform 2)	Phosphorylation	-	28.55	1959608
409	Phosphorylation	ASSHSSQSQGGGSVT CCCCCCCCCCCCCCC	32.51	27087446
409 (in isoform 2)	Phosphorylation	-	32.51	1959608
414	Phosphorylation	SQSQGGGSVTKKRKL CCCCCCCCCCCCHHC	29.86	27087446
416	Phosphorylation	SQGGGSVTKKRKLES CCCCCCCCCCHHCCC	32.33	27087446
417	Acetylation	QGGGSVTKKRKLESS CCCCCCCCCHHCCCC	48.72	109369
418	Acetylation	GGGSVTKKRKLESSE CCCCCCCCHHCCCCC	45.45	7338331
420	Acetylation	GSVTKKRKLESSESR CCCCCCHHCCCCCCH	66.54	23806337
423	Phosphorylation	TKKRKLESSESRSSF CCCHHCCCCCCHHHH	50.25	26824392
424	Phosphorylation	KKRKLESSESRSSFS CCHHCCCCCCHHHHH	30.16	26824392
426	Phosphorylation	RKLESSESRSSFSQH HHCCCCCCHHHHHHH	39.14	26824392
428	Phosphorylation	LESSESRSSFSQHAR CCCCCCHHHHHHHHH	45.04	23684622
429	Phosphorylation	ESSESRSSFSQHART CCCCCHHHHHHHHHH	28.01	27087446
431	Phosphorylation	SESRSSFSQHARTSG CCCHHHHHHHHHHHC	24.01	24899341
450	Ubiquitination	EEVDEEGKFVRLRNK EEECCCCCEEEEECC	43.92	22790023
450	Acetylation	EEVDEEGKFVRLRNK EEECCCCCEEEEECC	43.92	23806337
450	Succinylation	EEVDEEGKFVRLRNK EEECCCCCEEEEECC	43.92	23806337
450	Ubiquitination	EEVDEEGKFVRLRNK EEECCCCCEEEEECC	43.92	-
457	Acetylation	KFVRLRNKSNEDQSM CEEEEECCCCCCCCC	48.50	23806337
457	Malonylation	KFVRLRNKSNEDQSM CEEEEECCCCCCCCC	48.50	26320211
457	Ubiquitination	KFVRLRNKSNEDQSM CEEEEECCCCCCCCC	48.50	27667366
458	Phosphorylation	FVRLRNKSNEDQSMG EEEEECCCCCCCCCC	49.34	25521595
458 (in isoform 3)	Phosphorylation	-	49.34	28507225
460 (in isoform 3)	Phosphorylation	-	65.60	29514104
463	Phosphorylation	NKSNEDQSMGNWQIR CCCCCCCCCCCCCHH	40.76	27742792
480	Phosphorylation	NGDDPLMTYRFPPKF CCCCCCEEEECCCCE	21.16	8477740
496	Phosphorylation	LKAGQVVTIWASGAG EECCCEEEEEECCCC	16.37	23984901
500	Phosphorylation	QVVTIWASGAGATHS CEEEEEECCCCCCCC	17.74	23984901
505	Phosphorylation	WASGAGATHSPPTDL EECCCCCCCCCCCCC	23.20	23984901
507	Phosphorylation	SGAGATHSPPTDLVW CCCCCCCCCCCCCEE	28.37	23984901
510	Phosphorylation	GATHSPPTDLVWKAQ CCCCCCCCCCEEECC	45.40	23984901
522	Glutathionylation	KAQNTWGCGSSLRTA ECCCCCCCCHHHHHH	3.44	24333276
522	S-palmitoylation	KAQNTWGCGSSLRTA ECCCCCCCCHHHHHH	3.44	28526873
524	Phosphorylation	QNTWGCGSSLRTALI CCCCCCCHHHHHHHH	30.21	29514104
525	Phosphorylation	NTWGCGSSLRTALIN CCCCCCHHHHHHHHC	13.73	8477740
528	Phosphorylation	GCGSSLRTALINSTG CCCHHHHHHHHCCCC	30.98	28066266
533	Phosphorylation	LRTALINSTGEEVAM HHHHHHCCCCHHHHH	30.69	26824392
534	Phosphorylation	RTALINSTGEEVAMR HHHHHCCCCHHHHHH	44.09	25521595
546	Phosphorylation	AMRKLVRSLTMVEDN HHHHHHHHCCCCCCC	22.25	27087446
548	Phosphorylation	RKLVRSLTMVEDNED HHHHHHCCCCCCCCC	22.03	26824392
570	Phosphorylation	LLHHHRGSHCSGSGD HHHHCCCCCCCCCCC	22.68	27087446
570 (in isoform 2)	Phosphorylation	-	22.68	28507225
572	Glutathionylation	HHHRGSHCSGSGDPA HHCCCCCCCCCCCHH	5.44	24333276
572 (in isoform 2)	Phosphorylation	-	5.44	29514104
573	Phosphorylation	HHRGSHCSGSGDPAE HCCCCCCCCCCCHHH	30.48	25521595
575	Phosphorylation	RGSHCSGSGDPAEYN CCCCCCCCCCHHHHC	24.59	26824392
581	Phosphorylation	GSGDPAEYNLRSRTV CCCCHHHHCCCCCEE	22.92	25619855
585	Phosphorylation	PAEYNLRSRTVLCGT HHHHCCCCCEEEECC	35.15	25619855
587	Phosphorylation	EYNLRSRTVLCGTCG HHCCCCCEEEECCCC	21.05	25619855
592	Phosphorylation	SRTVLCGTCGQPADK CCEEEECCCCCCCHH	16.68	25619855
611	O-linked_Glycosylation	AGAQVGGSISSGSSA CCCCCCCCCCCCCCC	17.23	21540332
611	Phosphorylation	AGAQVGGSISSGSSA CCCCCCCCCCCCCCC	17.23	25619855
613	O-linked_Glycosylation	AQVGGSISSGSSASS CCCCCCCCCCCCCCE	30.28	21540332
613	Phosphorylation	AQVGGSISSGSSASS CCCCCCCCCCCCCCE	30.28	25619855
614	O-linked_Glycosylation	QVGGSISSGSSASSV CCCCCCCCCCCCCEE	40.81	21540332
614	Phosphorylation	QVGGSISSGSSASSV CCCCCCCCCCCCCEE	40.81	25619855
616	Phosphorylation	GGSISSGSSASSVTV CCCCCCCCCCCEEEE	25.36	26824392
617	Phosphorylation	GSISSGSSASSVTVT CCCCCCCCCCEEEEE	35.38	27087446
619	Phosphorylation	ISSGSSASSVTVTRS CCCCCCCCEEEEEEE	27.56	25619855
620	Phosphorylation	SSGSSASSVTVTRSF CCCCCCCEEEEEEEE	22.86	27087446
622	Phosphorylation	GSSASSVTVTRSFRS CCCCCEEEEEEEECC	20.36	25619855
624	Phosphorylation	SASSVTVTRSFRSVG CCCEEEEEEEECCCC	15.95	25619855
626	Phosphorylation	SSVTVTRSFRSVGGS CEEEEEEEECCCCCC	18.69	26643407
629	Phosphorylation	TVTRSFRSVGGSGGG EEEEEECCCCCCCCC	24.09	25521595
633	Phosphorylation	SFRSVGGSGGGSFGD EECCCCCCCCCCCCC	28.47	25521595
637	Phosphorylation	VGGSGGGSFGDNLVT CCCCCCCCCCCCHHH	29.36	27087446
644	O-linked_Glycosylation	SFGDNLVTRSYLLGN CCCCCHHHHHHHCCC	19.64	21540332
644	Phosphorylation	SFGDNLVTRSYLLGN CCCCCHHHHHHHCCC	19.64	25619855
646	Phosphorylation	GDNLVTRSYLLGNSS CCCHHHHHHHCCCCC	15.69	27717184
647	Phosphorylation	DNLVTRSYLLGNSSP CCHHHHHHHCCCCCC	11.58	22802335
652	Phosphorylation	RSYLLGNSSPRSQSS HHHHCCCCCCCCCCC	39.66	22802335
653	Phosphorylation	SYLLGNSSPRSQSSQ HHHCCCCCCCCCCCC	28.47	26824392
662	Farnesylation	RSQSSQNCSIM---- CCCCCCCCCCC----	1.95	-
662	Methylation	RSQSSQNCSIM---- CCCCCCCCCCC----	1.95	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
5	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
5	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
5	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
22	S	Phosphorylation	Kinase	MAPK1	P63085	GPS
199	T	Phosphorylation	Kinase	PRKCA	P20444	GPS
199	T	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
199	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
390	S	Phosphorylation	Kinase	CDK1	P06493	PSP
390	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
390	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
392	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
392	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
392	S	Phosphorylation	Kinase	CDK1	P06493	PSP
392	S	Phosphorylation	Kinase	CDK1	P11440	PSP
404	S	Phosphorylation	Kinase	P70-SUBFAMILY	-	GPS
404	S	Phosphorylation	Kinase	P70S6K_GROUP	-	PhosphoELM
416	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
416	T	Phosphorylation	Kinase	PRKCA	P20444	GPS
416	T	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
480	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
480	T	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
480	T	Phosphorylation	Kinase	PRKCA	P20444	GPS
525	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
575	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
652	S	Phosphorylation	Kinase	PRKCA	P20444	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
392	S	Phosphorylation	1959608
Isoform C is phosphorylated on Ser-392, Ser-407 and Ser-409 at interphase.
407	S	Phosphorylation	1959608
Isoform C is phosphorylated on Ser-392, Ser-407 and Ser-409 at interphase.
409	S	Phosphorylation	1959608
Isoform C is phosphorylated on Ser-392, Ser-407 and Ser-409 at interphase.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LMNA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LMNB1_MOUSE	Lmnb1	physical	21327095
LMNB2_MOUSE	Lmnb2	physical	21327095
HNRH2_MOUSE	Hnrnph2	physical	21327095
DX39B_MOUSE	Ddx39b	physical	21327095
LBR_MOUSE	Lbr	physical	21327095
TOIP1_MOUSE	Tor1aip1	physical	21327095
SUN2_MOUSE	Sun2	physical	21327095
SUN1_MOUSE	Sun1	physical	21327095
HNRL1_MOUSE	Hnrnpul1	physical	21327095
MYH9_MOUSE	Myh9	physical	21327095
1433G_MOUSE	Ywhag	physical	21327095
RAB5A_MOUSE	Rab5a	physical	21327095
EMD_MOUSE	Emd	physical	21327095
DDX3Y_MOUSE	Ddx3y	physical	21327095
RBM10_MOUSE	Rbm10	physical	21327095
1433S_MOUSE	Sfn	physical	21327095
RED_MOUSE	Ik	physical	21327095
UBC9_MOUSE	Ube2i	physical	21327095
PPIL1_MOUSE	Ppil1	physical	21327095
TOP2A_MOUSE	Top2a	physical	21327095
RAB2A_MOUSE	Rab2a	physical	21327095
ENPL_MOUSE	Hsp90b1	physical	21327095
MAN1_MOUSE	Lemd3	physical	21327095
TNPO1_MOUSE	Tnpo1	physical	21327095
SYNE2_MOUSE	Syne2	physical	21327095
RAB5C_MOUSE	Rab5c	physical	21327095
ACTG_MOUSE	Actg1	physical	21327095
RAB7A_MOUSE	Rab7	physical	21327095
H14_MOUSE	Hist1h1e	physical	21327095
ANXA3_MOUSE	Anxa3	physical	21327095
EIF3I_MOUSE	Eif3i	physical	21327095
RAB10_MOUSE	Rab10	physical	21327095
LUC7L_MOUSE	Luc7l	physical	21327095
CBX5_MOUSE	Cbx5	physical	21327095
ARC1B_MOUSE	Arpc1b	physical	21327095
RAB6B_MOUSE	Rab6b	physical	21327095
PIPNB_MOUSE	Pitpnb	physical	21327095
TIF1B_MOUSE	Trim28	physical	21327095
SC22B_MOUSE	Sec22b	physical	21327095
PAIRB_MOUSE	Serbp1	physical	21327095
STRAP_MOUSE	Strap	physical	21327095
MTAP_MOUSE	Mtap	physical	21327095
LAR4B_MOUSE	Larp4b	physical	21327095
CNN3_MOUSE	Cnn3	physical	21327095
PSB5_MOUSE	Psmb5	physical	21327095
GT251_MOUSE	Glt25d1	physical	21327095
ESTD_MOUSE	Esd	physical	21327095
XRCC6_MOUSE	Xrcc6	physical	21327095
DESP_HUMAN	DSP	physical	26496610
DNJB1_HUMAN	DNAJB1	physical	26496610
LMNB1_HUMAN	LMNB1	physical	26496610
MTDC_HUMAN	MTHFD2	physical	26496610
HAUS5_HUMAN	HAUS5	physical	26496610
DCAF8_HUMAN	DCAF8	physical	26496610
LMNB2_HUMAN	LMNB2	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LMNA_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-390 AND SER-392,AND MASS SPECTROMETRY.	19131326 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301; SER-390; SER-392;SER-398; SER-406; SER-407; SER-409; SER-414; SER-573; SER-575; SER-629AND SER-633, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; THR-19; SER-22;SER-633 AND SER-637, AND MASS SPECTROMETRY.	17242355 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-390 AND SER-392, ANDMASS SPECTROMETRY.	16452087 [Abstract]
"Identification of phosphorylation sites on murine nuclear lamin C byRP-HPLC and microsequencing."; Eggert M., Radomski N., Tripier D., Traub P., Jost E.; FEBS Lett. 292:205-209(1991). Cited for: PARTIAL PROTEIN SEQUENCE, AND PHOSPHORYLATION AT SER-392; SER-407 ANDSER-409.	1959608 [Abstract]

show

show

show