RAB5A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB5A_MOUSE
• UniProt AC: Q9CQD1
• Protein Name: Ras-related protein Rab-5A
• Gene Name: Rab5a
• Organism: Mus musculus (Mouse).
• Sequence Length: 215
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side . Early endosome membrane ; Lipid-anchor . Melanosome . Cytoplasmic vesicle . Cell projection, ruffle . Membrane . Cytoplasm, cytosol . Cytoplasmic vesicle, phagosome membrane . Endosome membrane . Enri
• Protein Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (By similarity). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3. [PubMed: 18425118]
• Protein Sequence: MANRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEPAQPARSQCCSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MANRGATRPNGPNT -CCCCCCCCCCCCCC	49.86	29514104
14	Phosphorylation	TRPNGPNTGNKICQF CCCCCCCCCCCCCEE	45.31	29899451
29	Phosphorylation	KLVLLGESAVGKSSL EEEEECCCCCCCCHH	26.84	22817900
33	Ubiquitination	LGESAVGKSSLVLRF ECCCCCCCCHHHHHH	30.21	-
34	Phosphorylation	GESAVGKSSLVLRFV CCCCCCCCHHHHHHH	23.99	23737553
35	Phosphorylation	ESAVGKSSLVLRFVK CCCCCCCHHHHHHHC	26.44	23737553
82	Phosphorylation	DTAGQERYHSLAPMY CCCCCCCCHHHCCCH	8.60	25367039
84	Phosphorylation	AGQERYHSLAPMYYR CCCCCCHHHCCCHHC	19.79	25367039
89	Phosphorylation	YHSLAPMYYRGAQAA CHHHCCCHHCCCCEE	6.75	29514104
116	Ubiquitination	ARAKNWVKELQRQAS HHHHHHHHHHHHHCC	44.30	27667366
123	Phosphorylation	KELQRQASPNIVIAL HHHHHHCCCCEEEEE	15.33	25195567
134	Ubiquitination	VIALSGNKADLANKR EEEECCCHHHHCCCC	46.96	22790023
134	Ubiquitination	VIALSGNKADLANKR EEEECCCHHHHCCCC	46.96	22790023
140	Ubiquitination	NKADLANKRAVDFQE CHHHHCCCCCCCHHH	35.81	22790023
140	Ubiquitination	NKADLANKRAVDFQE CHHHHCCCCCCCHHH	35.81	22790023
183	Ubiquitination	AIAKKLPKNEPQNPG HHHHHCCCCCCCCCC	81.84	27667366
193	Phosphorylation	PQNPGANSARGRGVD CCCCCCCCCCCCCCC	20.86	23684622
212	Geranylgeranylation	AQPARSQCCSN---- CCHHHHHHCCC----	2.64	-
213	Geranylgeranylation	QPARSQCCSN----- CHHHHHHCCC-----	3.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAB5A_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
84	S	Phosphorylation	Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including RAB GDP dissociation inhibitors GDI1 and GDI2.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB5A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYUA_HUMAN	SNCA	physical	15099020

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.