MYH9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYH9_MOUSE
• UniProt AC: Q8VDD5
• Protein Name: Myosin-9
• Gene Name: Myh9
• Organism: Mus musculus (Mouse).
• Sequence Length: 1960
• Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (By similarity). In retinal pigment epithelial cells, predominantly localized to stress fiber-like
• Protein Description: During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping..
• Protein Sequence: MAQQAADKYLYVDKNFINNPLAQADWAAKKLVWVPSSKNGFEPASLKEEVGEEAIVELVENGKKVKVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEDEQMGLLRVISGVLQLGNIAFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDKSFVEKVVQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLRLRNWQWWRLFTKVKPLLNSIRHEDELLAKEAELTKVREKHLAAENRLTEMETMQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQYLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEDQIIMEDQNCKLAKEKKLLEDRVAEFTTNLMEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELETQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVSILKKTLEDEAKTHEAQIQEMRQKHSQAVEELADQLEQTKRVKATLEKAKQTLENERGELANEVKALLQGKGDSEHKRKKVEAQLQELQVKFSEGERVRTELADKVTKLQVELDSVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQMEDEKNSFREQLEEEEEAKRNLEKQIATLHAQVTDMKKKMEDGVGCLETAEEAKRRLQKDLEGLSQRLEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAMAARKKLEMDLKDLEAHIDTANKNREEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKAKLQEMESAVKSKYKASIAALEAKIAQLEEQLDNETKERQAASKQVRRTEKKLKDVLLQVEDERRNAEQFKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVTRRIVRKGTGDCSDEEVDGKADGADAKAAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAQQAADKY ------CCHHHHHHH	22.84	23806337
8	Acetylation	MAQQAADKYLYVDKN CCHHHHHHHEEECCC	32.21	23806337
8	Malonylation	MAQQAADKYLYVDKN CCHHHHHHHEEECCC	32.21	26320211
8	Succinylation	MAQQAADKYLYVDKN CCHHHHHHHEEECCC	32.21	23806337
9	Phosphorylation	AQQAADKYLYVDKNF CHHHHHHHEEECCCC	12.10	22499769
11	Phosphorylation	QAADKYLYVDKNFIN HHHHHHEEECCCCCC	11.96	22499769
29	Acetylation	AQADWAAKKLVWVPS HHCHHHHHHCEEECC	38.60	22826441
29	Ubiquitination	AQADWAAKKLVWVPS HHCHHHHHHCEEECC	38.60	22790023
30	Acetylation	QADWAAKKLVWVPSS HCHHHHHHCEEECCC	43.47	7614475
30	Malonylation	QADWAAKKLVWVPSS HCHHHHHHCEEECCC	43.47	26320211
30	Ubiquitination	QADWAAKKLVWVPSS HCHHHHHHCEEECCC	43.47	-
36	Phosphorylation	KKLVWVPSSKNGFEP HHCEEECCCCCCCCC	44.30	23984901
37	Phosphorylation	KLVWVPSSKNGFEPA HCEEECCCCCCCCCC	24.87	26745281
38	Ubiquitination	LVWVPSSKNGFEPAS CEEECCCCCCCCCCC	66.48	27667366
63	Acetylation	VELVENGKKVKVNKD HHHHHCCCEEECCHH	67.01	7744409
64	Acetylation	ELVENGKKVKVNKDD HHHHCCCEEECCHHH	49.00	19851077
69	Acetylation	GKKVKVNKDDIQKMN CCEEECCHHHHHHCC	60.82	23806337
74	Malonylation	VNKDDIQKMNPPKFS CCHHHHHHCCCCCCC	40.76	26320211
79	Malonylation	IQKMNPPKFSKVEDM HHHCCCCCCCCHHHH	64.62	26320211
79	Ubiquitination	IQKMNPPKFSKVEDM HHHCCCCCCCCHHHH	64.62	22790023
81	Phosphorylation	KMNPPKFSKVEDMAE HCCCCCCCCHHHHHH	41.75	29550500
91	S-nitrosocysteine	EDMAELTCLNEASVL HHHHHHHHCCHHHHH	6.33	-
91	Glutathionylation	EDMAELTCLNEASVL HHHHHHHHCCHHHHH	6.33	24333276
91	S-nitrosylation	EDMAELTCLNEASVL HHHHHHHHCCHHHHH	6.33	20925432
91	S-palmitoylation	EDMAELTCLNEASVL HHHHHHHHCCHHHHH	6.33	28526873
102	Acetylation	ASVLHNLKERYYSGL HHHHHHHHHHHCCCE	45.52	22826441
139	Acetylation	EEIVEMYKGKKRHEM HHHHHHHCCCCCCCC	64.04	22826441
139	Ubiquitination	EEIVEMYKGKKRHEM HHHHHHHCCCCCCCC	64.04	22790023
151	Phosphorylation	HEMPPHIYAITDTAY CCCCCCEEEECHHHH	6.74	18563927
158	Phosphorylation	YAITDTAYRSMMQDR EEECHHHHHHHCCCC	12.81	-
172	S-palmitoylation	REDQSILCTGESGAG CCCCCEEEECCCCCC	4.35	28526873
181	Phosphorylation	GESGAGKTENTKKVI CCCCCCCCCCHHHHH	33.28	17203969
184	Phosphorylation	GAGKTENTKKVIQYL CCCCCCCHHHHHHHH	26.47	17203969
186	Ubiquitination	GKTENTKKVIQYLAH CCCCCHHHHHHHHHH	42.40	22790023
190	Phosphorylation	NTKKVIQYLAHVASS CHHHHHHHHHHHHHH	8.50	-
196	Phosphorylation	QYLAHVASSHKSKKD HHHHHHHHHCCCCCC	31.70	26824392
197	Phosphorylation	YLAHVASSHKSKKDQ HHHHHHHHCCCCCCH	25.79	26824392
225	Ubiquitination	LEAFGNAKTVKNDNS HHHHCCCEECCCCCC	58.83	22790023
233	Phosphorylation	TVKNDNSSRFGKFIR ECCCCCCCCCEEEEE	37.57	26824392
237	Acetylation	DNSSRFGKFIRINFD CCCCCCEEEEEEEEE	34.60	133205
262	Phosphorylation	ETYLLEKSRAIRQAK HHHHHHHHHHHHHHH	19.98	18779572
278	Phosphorylation	ERTFHIFYYLLSGAG HCHHHHHHHHHCCCC	7.81	-
299	Acetylation	LLLEPYNKYRFLSNG EECCCCCCCEECCCC	31.77	23806337
299	Malonylation	LLLEPYNKYRFLSNG EECCCCCCCEECCCC	31.77	26320211
299	Succinylation	LLLEPYNKYRFLSNG EECCCCCCCEECCCC	31.77	-
299	Ubiquitination	LLLEPYNKYRFLSNG EECCCCCCCEECCCC	31.77	27667366
316	Acetylation	TIPGQQDKDMFQETM CCCCCCCHHHHHHHH	46.91	23954790
316	Ubiquitination	TIPGQQDKDMFQETM CCCCCCCHHHHHHHH	46.91	22790023
355	Acetylation	QLGNIAFKKERNTDQ HHCCEEEECCCCCCC	44.71	23954790
355	Ubiquitination	QLGNIAFKKERNTDQ HHCCEEEECCCCCCC	44.71	22790023
356	Acetylation	LGNIAFKKERNTDQA HCCEEEECCCCCCCC	56.29	19851087
356	Ubiquitination	LGNIAFKKERNTDQA HCCEEEECCCCCCCC	56.29	-
364	Phosphorylation	ERNTDQASMPDNTAA CCCCCCCCCCCCHHH	25.80	26824392
373	Ubiquitination	PDNTAAQKVSHLLGI CCCHHHHHHHHHHCC	40.76	22790023
400	Phosphorylation	RIKVGRDYVQKAQTK CHHCCHHHHHHHCCH	11.92	25195567
403	Malonylation	VGRDYVQKAQTKEQA CCHHHHHHHCCHHHH	32.20	26320211
403	Ubiquitination	VGRDYVQKAQTKEQA CCHHHHHHHCCHHHH	32.20	-
435	Acetylation	WLVLRINKALDKTKR HHHHHHHHHHHHHHH	48.21	-
435	Malonylation	WLVLRINKALDKTKR HHHHHHHHHHHHHHH	48.21	26320211
540	Malonylation	WFPKATDKSFVEKVV CCCCCCCHHHHHHHH	41.25	26320211
540	Ubiquitination	WFPKATDKSFVEKVV CCCCCCCHHHHHHHH	41.25	22790023
541	Phosphorylation	FPKATDKSFVEKVVQ CCCCCCHHHHHHHHH	37.02	29176673
545	Acetylation	TDKSFVEKVVQEQGT CCHHHHHHHHHHCCC	42.26	22826441
545	Ubiquitination	TDKSFVEKVVQEQGT CCHHHHHHHHHHCCC	42.26	22790023
552	Phosphorylation	KVVQEQGTHPKFQKP HHHHHCCCCCCCCCC	34.40	26824392
555	Ubiquitination	QEQGTHPKFQKPKQL HHCCCCCCCCCCHHH	53.47	22790023
558	Ubiquitination	GTHPKFQKPKQLKDK CCCCCCCCCHHHCCC	58.26	-
569	S-nitrosocysteine	LKDKADFCIIHYAGK HCCCCCEEEEECCCC	2.69	-
569	S-nitrosylation	LKDKADFCIIHYAGK HCCCCCEEEEECCCC	2.69	20925432
580	Acetylation	YAGKVDYKADEWLMK CCCCCCCCHHHHHHH	44.92	66700217
580	Ubiquitination	YAGKVDYKADEWLMK CCCCCCCCHHHHHHH	44.92	22790023
606	Ubiquitination	LLHQSSDKFVSELWK HHHHCHHHHHHHHHH	50.00	-
613	Acetylation	KFVSELWKDVDRIIG HHHHHHHHCHHHHCC	61.57	23806337
628	Phosphorylation	LDQVAGMSETALPGA HHHHCCCCCCCCCCC	30.77	-
637	Acetylation	TALPGAFKTRKGMFR CCCCCCHHHCCCCCH	47.05	19854395
637	Ubiquitination	TALPGAFKTRKGMFR CCCCCCHHHCCCCCH	47.05	22790023
638	Phosphorylation	ALPGAFKTRKGMFRT CCCCCHHHCCCCCHH	31.03	26824392
651	Acetylation	RTVGQLYKEQLAKLM HHHHHHHHHHHHHHH	47.80	23806337
651	Succinylation	RTVGQLYKEQLAKLM HHHHHHHHHHHHHHH	47.80	23806337
656	Acetylation	LYKEQLAKLMATLRN HHHHHHHHHHHHHHH	47.60	23806337
656	Succinylation	LYKEQLAKLMATLRN HHHHHHHHHHHHHHH	47.60	23806337
664	Phosphorylation	LMATLRNTNPNFVRC HHHHHHHCCCCCEEE	45.69	28059163
682	Ubiquitination	NHEKKAGKLDPHLVL CCHHHCCCCCHHHHH	55.35	22790023
721	Phosphorylation	FQEFRQRYEILTPNS HHHHHHHHCCCCCCC	10.05	21183079
725	Phosphorylation	RQRYEILTPNSIPKG HHHHCCCCCCCCCCC	26.53	26745281
728	Phosphorylation	YEILTPNSIPKGFMD HCCCCCCCCCCCCCC	41.28	23984901
737	Acetylation	PKGFMDGKQACVLMI CCCCCCHHHHHHHHH	30.38	22826441
740	S-palmitoylation	FMDGKQACVLMIKAL CCCHHHHHHHHHHHE	1.93	28526873
751	Phosphorylation	IKALELDSNLYRIGQ HHHEECCCCCCCCCC	41.16	26824392
754	Phosphorylation	LELDSNLYRIGQSKV EECCCCCCCCCCCHH	12.39	26824392
759	Phosphorylation	NLYRIGQSKVFFRAG CCCCCCCCHHHHHHH	26.10	-
760	Ubiquitination	LYRIGQSKVFFRAGV CCCCCCCHHHHHHHH	34.86	22790023
816	S-palmitoylation	MKVLQRNCAAYLRLR HHHHHHHHHHHHHHH	2.20	28526873
835	Ubiquitination	WRLFTKVKPLLNSIR HHHHHHHHHHHHHCC	31.35	22790023
840	Phosphorylation	KVKPLLNSIRHEDEL HHHHHHHHCCCHHHH	22.44	26824392
850	Acetylation	HEDELLAKEAELTKV CHHHHHHHHHHHHHH	58.38	23806337
850	Succinylation	HEDELLAKEAELTKV CHHHHHHHHHHHHHH	58.38	-
850	Succinylation	HEDELLAKEAELTKV CHHHHHHHHHHHHHH	58.38	23806337
850	Ubiquitination	HEDELLAKEAELTKV CHHHHHHHHHHHHHH	58.38	-
860	Acetylation	ELTKVREKHLAAENR HHHHHHHHHHHHHHH	33.10	23806337
860	Ubiquitination	ELTKVREKHLAAENR HHHHHHHHHHHHHHH	33.10	22790023
869	Phosphorylation	LAAENRLTEMETMQS HHHHHHHHHHHHHHH	30.01	23608596
907	Phosphorylation	EELRARLTAKKQELE HHHHHHHHHHHHHHH	30.77	27149854
910	Acetylation	RARLTAKKQELEEIC HHHHHHHHHHHHHHH	46.68	23806337
917	S-nitrosocysteine	KQELEEICHDLEARV HHHHHHHHHHHHHHH	2.01	-
917	S-nitrosylation	KQELEEICHDLEARV HHHHHHHHHHHHHHH	2.01	20925432
917	S-palmitoylation	KQELEEICHDLEARV HHHHHHHHHHHHHHH	2.01	28526873
933	Phosphorylation	EEEERCQYLQAEKKK HHHHHHHHHHHHHHH	12.38	22499769
966	Ubiquitination	RQKLQLEKVTTEAKL HHHHHHHHHHHHHHH	54.17	27667366
975	Acetylation	TTEAKLKKLEEDQII HHHHHHHHHHHCCCC	72.12	23806337
992	Acetylation	DQNCKLAKEKKLLED CCCCHHHHHHHHHHH	79.21	133225
1014	Acetylation	NLMEEEEKSKSLAKL HHHHHHHHHHHHHHH	67.47	23806337
1015	Phosphorylation	LMEEEEKSKSLAKLK HHHHHHHHHHHHHHH	30.65	21082442
1017	Phosphorylation	EEEEKSKSLAKLKNK HHHHHHHHHHHHHHH	40.42	24719451
1024	Acetylation	SLAKLKNKHEAMITD HHHHHHHHHHHHHHH	41.03	23806337
1048	Acetylation	KQRQELEKTRRKLEG HHHHHHHHHHHHHHC	61.01	23954790
1057	Phosphorylation	RRKLEGDSTDLSDQI HHHHHCCCCCHHHHH	34.38	26643407
1058	Phosphorylation	RKLEGDSTDLSDQIA HHHHCCCCCHHHHHH	45.78	23984901
1061	Phosphorylation	EGDSTDLSDQIAELQ HCCCCCHHHHHHHHH	30.22	23984901
1099	Acetylation	VEEEAAQKNMALKKI HHHHHHHHHHHHHHH	43.92	23806337
1099	Succinylation	VEEEAAQKNMALKKI HHHHHHHHHHHHHHH	43.92	23806337
1105	Acetylation	QKNMALKKIRELETQ HHHHHHHHHHHHHHH	48.09	19860209
1111	Phosphorylation	KKIRELETQISELQE HHHHHHHHHHHHHHH	43.77	23984901
1114	Phosphorylation	RELETQISELQEDLE HHHHHHHHHHHHHHH	23.57	26824392
1122	Phosphorylation	ELQEDLESERASRNK HHHHHHHHHHHHHHH	39.41	26824392
1126	Phosphorylation	DLESERASRNKAEKQ HHHHHHHHHHHHHHH	42.48	26824392
1146	Phosphorylation	EELEALKTELEDTLD HHHHHHHHHHHHHHC	46.80	26239621
1151	Phosphorylation	LKTELEDTLDSTAAQ HHHHHHHHHCHHHHH	24.08	26239621
1154	Phosphorylation	ELEDTLDSTAAQQEL HHHHHHCHHHHHHHH	24.06	26745281
1155	Phosphorylation	LEDTLDSTAAQQELR HHHHHCHHHHHHHHH	26.19	28066266
1170	Phosphorylation	SKREQEVSILKKTLE HHHHHHHHHHHHHHH	22.81	26824392
1181	Acetylation	KTLEDEAKTHEAQIQ HHHHHHHHHHHHHHH	48.65	22826441
1182	Phosphorylation	TLEDEAKTHEAQIQE HHHHHHHHHHHHHHH	31.81	-
1193	Acetylation	QIQEMRQKHSQAVEE HHHHHHHHHHHHHHH	34.55	22826441
1195	Phosphorylation	QEMRQKHSQAVEELA HHHHHHHHHHHHHHH	27.20	26370283
1209	Acetylation	ADQLEQTKRVKATLE HHHHHHHHHHHHHHH	55.69	23806337
1209	Succinylation	ADQLEQTKRVKATLE HHHHHHHHHHHHHHH	55.69	23806337
1212	Malonylation	LEQTKRVKATLEKAK HHHHHHHHHHHHHHH	39.42	26320211
1234	Acetylation	GELANEVKALLQGKG HHHHHHHHHHHCCCC	27.43	22826441
1243	Phosphorylation	LLQGKGDSEHKRKKV HHCCCCCHHHHHHHH	50.71	26824392
1249	Acetylation	DSEHKRKKVEAQLQE CHHHHHHHHHHHHHH	49.71	23806337
1249	Malonylation	DSEHKRKKVEAQLQE CHHHHHHHHHHHHHH	49.71	26320211
1249	Succinylation	DSEHKRKKVEAQLQE CHHHHHHHHHHHHHH	49.71	23806337
1260	Acetylation	QLQELQVKFSEGERV HHHHHHHHCCCCCHH	30.16	23954790
1274	Ubiquitination	VRTELADKVTKLQVE HHHHHHHHHHHHHHH	46.31	22790023
1277	Ubiquitination	ELADKVTKLQVELDS HHHHHHHHHHHHHHH	39.65	-
1284	Phosphorylation	KLQVELDSVTGLLSQ HHHHHHHHHHHHHCC	33.91	26824392
1290	Phosphorylation	DSVTGLLSQSDSKSS HHHHHHHCCCCCCCC	32.45	26745281
1292	Phosphorylation	VTGLLSQSDSKSSKL HHHHHCCCCCCCCCC	40.24	26745281
1294	Phosphorylation	GLLSQSDSKSSKLTK HHHCCCCCCCCCCHH	39.42	26745281
1301	Acetylation	SKSSKLTKDFSALES CCCCCCHHHHHHHHH	68.18	23954790
1301	Ubiquitination	SKSSKLTKDFSALES CCCCCCHHHHHHHHH	68.18	-
1304	Phosphorylation	SKLTKDFSALESQLQ CCCHHHHHHHHHHHH	41.92	23649490
1308	Phosphorylation	KDFSALESQLQDTQE HHHHHHHHHHHHHHH	36.72	23649490
1313	Phosphorylation	LESQLQDTQELLQEE HHHHHHHHHHHHHHH	15.81	26745281
1326	Phosphorylation	EENRQKLSLSTKLKQ HHHHHHCCHHHHHHH	27.58	26745281
1328	Phosphorylation	NRQKLSLSTKLKQME HHHHCCHHHHHHHHH	21.81	26745281
1329	Phosphorylation	RQKLSLSTKLKQMED HHHCCHHHHHHHHHH	45.77	23737553
1330	Acetylation	QKLSLSTKLKQMEDE HHCCHHHHHHHHHHH	50.76	23806337
1330	Malonylation	QKLSLSTKLKQMEDE HHCCHHHHHHHHHHH	50.76	26320211
1330	Succinylation	QKLSLSTKLKQMEDE HHCCHHHHHHHHHHH	50.76	23806337
1340	Phosphorylation	QMEDEKNSFREQLEE HHHHHHHHHHHHHHH	36.43	29550500
1352	Acetylation	LEEEEEAKRNLEKQI HHHHHHHHHHHHHHH	45.13	23954790
1357	Acetylation	EAKRNLEKQIATLHA HHHHHHHHHHHHHHH	50.61	23806337
1357	Succinylation	EAKRNLEKQIATLHA HHHHHHHHHHHHHHH	50.61	23806337
1370	Acetylation	HAQVTDMKKKMEDGV HHHHHHHHHHHHCCC	52.64	130343
1371	Acetylation	AQVTDMKKKMEDGVG HHHHHHHHHHHCCCC	51.20	15609065
1372	Acetylation	QVTDMKKKMEDGVGC HHHHHHHHHHCCCCH	41.84	23806337
1372	Succinylation	QVTDMKKKMEDGVGC HHHHHHHHHHCCCCH	41.84	23806337
1379	Glutathionylation	KMEDGVGCLETAEEA HHHCCCCHHHHHHHH	2.63	24333276
1392	Acetylation	EAKRRLQKDLEGLSQ HHHHHHHHHHHHHHH	69.72	23806337
1392	Malonylation	EAKRRLQKDLEGLSQ HHHHHHHHHHHHHHH	69.72	26320211
1392	Succinylation	EAKRRLQKDLEGLSQ HHHHHHHHHHHHHHH	69.72	-
1392	Ubiquitination	EAKRRLQKDLEGLSQ HHHHHHHHHHHHHHH	69.72	-
1398	Phosphorylation	QKDLEGLSQRLEEKV HHHHHHHHHHHHHHH	24.90	24899341
1404	Acetylation	LSQRLEEKVAAYDKL HHHHHHHHHHHHHHH	28.00	22826441
1404	Succinylation	LSQRLEEKVAAYDKL HHHHHHHHHHHHHHH	28.00	23806337
1408	Phosphorylation	LEEKVAAYDKLEKTK HHHHHHHHHHHHHHH	12.13	20116462
1410	Acetylation	EKVAAYDKLEKTKTR HHHHHHHHHHHHHHH	45.96	23806337
1410	Succinylation	EKVAAYDKLEKTKTR HHHHHHHHHHHHHHH	45.96	23806337
1413	Ubiquitination	AAYDKLEKTKTRLQQ HHHHHHHHHHHHHHH	66.80	22790023
1435	Phosphorylation	DLDHQRQSVSNLEKK HHHHHHHHHHHHHHH	29.69	26824392
1437	Phosphorylation	DHQRQSVSNLEKKQK HHHHHHHHHHHHHHH	40.73	26745281
1445	Malonylation	NLEKKQKKFDQLLAE HHHHHHHHHHHHHHH	52.24	26320211
1454	Acetylation	DQLLAEEKTISAKYA HHHHHHHHHHHHHHH	42.54	23806337
1454	Succinylation	DQLLAEEKTISAKYA HHHHHHHHHHHHHHH	42.54	23806337
1457	Phosphorylation	LAEEKTISAKYAEER HHHHHHHHHHHHHHH	24.76	-
1459	Acetylation	EEKTISAKYAEERDR HHHHHHHHHHHHHHH	37.90	23806337
1459	Malonylation	EEKTISAKYAEERDR HHHHHHHHHHHHHHH	37.90	26320211
1460	Phosphorylation	EKTISAKYAEERDRA HHHHHHHHHHHHHHH	20.97	-
1477	Malonylation	EAREKETKALSLARA HHHHHHHHHHHHHHH	48.71	26320211
1477	Ubiquitination	EAREKETKALSLARA HHHHHHHHHHHHHHH	48.71	27667366
1480	Phosphorylation	EKETKALSLARALEE HHHHHHHHHHHHHHH	25.50	27149854
1492	Acetylation	LEEAMEQKAELERLN HHHHHHHHHHHHHHH	30.44	22826441
1500	Ubiquitination	AELERLNKQFRTEME HHHHHHHHHHHHHHH	56.24	27667366
1513	Acetylation	MEDLMSSKDDVGKSV HHHHHCCCCHHHHHH	51.12	23806337
1525	Acetylation	KSVHELEKSKRALEQ HHHHHHHHHHHHHHH	74.11	23806337
1525	Ubiquitination	KSVHELEKSKRALEQ HHHHHHHHHHHHHHH	74.11	-
1539	Phosphorylation	QQVEEMKTQLEELED HHHHHHHHHHHHHHH	36.76	26239621
1580	Phosphorylation	LQGRDEQSEEKKKQL HCCCCCCCHHHHHHH	45.75	26824392
1584	Acetylation	DEQSEEKKKQLVRQV CCCCHHHHHHHHHHH	49.37	7610181
1638	Acetylation	KNREEAIKQLRKLQA CCHHHHHHHHHHHHH	50.78	22826441
1642	Malonylation	EAIKQLRKLQAQMKD HHHHHHHHHHHHHHH	54.25	26320211
1648	Malonylation	RKLQAQMKDCMRELD HHHHHHHHHHHHHCH	35.38	26320211
1657	Phosphorylation	CMRELDDTRASREEI HHHHCHHHHHCHHHH	28.00	25195567
1660	Phosphorylation	ELDDTRASREEILAQ HCHHHHHCHHHHHHH	36.61	26824392
1669	Acetylation	EEILAQAKENEKKLK HHHHHHHHHHHHHHH	49.33	23806337
1669	Succinylation	EEILAQAKENEKKLK HHHHHHHHHHHHHHH	49.33	-
1669	Succinylation	EEILAQAKENEKKLK HHHHHHHHHHHHHHH	49.33	23806337
1713	Phosphorylation	LADEIANSSGKGALA HHHHHHHCCCCCHHH	31.29	26824392
1714	Phosphorylation	ADEIANSSGKGALAL HHHHHHCCCCCHHHH	44.31	25521595
1754	Acetylation	LINDRLKKANLQIDQ HHHHHHHHCCCCHHH	47.28	23806337
1754	Succinylation	LINDRLKKANLQIDQ HHHHHHHHCCCCHHH	47.28	23806337
1775	Acetylation	LERSHAQKNENARQQ HHHHHHHHHHHHHHH	67.99	23864654
1793	Acetylation	QNKELKAKLQEMESA HHHHHHHHHHHHHHH	49.46	23806337
1793	Succinylation	QNKELKAKLQEMESA HHHHHHHHHHHHHHH	49.46	23806337
1799	Phosphorylation	AKLQEMESAVKSKYK HHHHHHHHHHHHHHH	36.73	26824392
1802	Acetylation	QEMESAVKSKYKASI HHHHHHHHHHHHHHH	40.73	23806337
1802	Malonylation	QEMESAVKSKYKASI HHHHHHHHHHHHHHH	40.73	26320211
1802	Succinylation	QEMESAVKSKYKASI HHHHHHHHHHHHHHH	40.73	23806337
1803	Phosphorylation	EMESAVKSKYKASIA HHHHHHHHHHHHHHH	34.32	22817900
1805	Phosphorylation	ESAVKSKYKASIAAL HHHHHHHHHHHHHHH	20.91	18779572
1806	Acetylation	SAVKSKYKASIAALE HHHHHHHHHHHHHHH	39.12	23806337
1806	Malonylation	SAVKSKYKASIAALE HHHHHHHHHHHHHHH	39.12	26320211
1806	Succinylation	SAVKSKYKASIAALE HHHHHHHHHHHHHHH	39.12	23806337
1845	Acetylation	RRTEKKLKDVLLQVE HHHHHHHHHHHHHHH	55.46	23806337
1892	Phosphorylation	EAQRANASRRKLQRE HHHHHHHHHHHHHHH	32.21	29514104
1904	Phosphorylation	QRELEDATETADAMN HHHHHHHHHHHHHHH	46.30	30635358
1906	Phosphorylation	ELEDATETADAMNRE HHHHHHHHHHHHHHH	26.03	26643407
1915	Phosphorylation	DAMNREVSSLKNKLR HHHHHHHHHHHHHHH	25.79	25266776
1916	Phosphorylation	AMNREVSSLKNKLRR HHHHHHHHHHHHHHC	48.84	18779572
1918	Malonylation	NREVSSLKNKLRRGD HHHHHHHHHHHHCCC	54.72	26320211
1923	Methylation	SLKNKLRRGDLPFVV HHHHHHHCCCCCEEE	54.11	-
1931	Phosphorylation	GDLPFVVTRRIVRKG CCCCEEEEEEEECCC	14.66	18394644
1939	Phosphorylation	RRIVRKGTGDCSDEE EEEECCCCCCCCHHH	32.65	27087446
1943	Phosphorylation	RKGTGDCSDEEVDGK CCCCCCCCHHHCCCC	53.44	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1799	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1803	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1931	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYH9_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYH9_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI72_MOUSE	Trim72	physical	22253476
ACTS_HUMAN	ACTA1	physical	26496610
ACTG_HUMAN	ACTG1	physical	26496610
ACTN4_HUMAN	ACTN4	physical	26496610
ACTN1_HUMAN	ACTN1	physical	26496610
ADDA_HUMAN	ADD1	physical	26496610
ADDG_HUMAN	ADD3	physical	26496610
AP2A1_HUMAN	AP2A1	physical	26496610
AP2B1_HUMAN	AP2B1	physical	26496610
ANXA2_HUMAN	ANXA2	physical	26496610
BCS1_HUMAN	BCS1L	physical	26496610
DYST_HUMAN	DST	physical	26496610
CALD1_HUMAN	CALD1	physical	26496610
CAZA1_HUMAN	CAPZA1	physical	26496610
CAZA2_HUMAN	CAPZA2	physical	26496610
CAPZB_HUMAN	CAPZB	physical	26496610
CD44_HUMAN	CD44	physical	26496610
CD59_HUMAN	CD59	physical	26496610
SEPT7_HUMAN	SEPT7	physical	26496610
COF1_HUMAN	CFL1	physical	26496610
COF2_HUMAN	CFL2	physical	26496610
AP2M1_HUMAN	AP2M1	physical	26496610
CLCA_HUMAN	CLTA	physical	26496610
CLCB_HUMAN	CLTB	physical	26496610
CLH1_HUMAN	CLTC	physical	26496610
CBPM_HUMAN	CPM	physical	26496610
CSTF3_HUMAN	CSTF3	physical	26496610
DAB2_HUMAN	DAB2	physical	26496610
DAPK3_HUMAN	DAPK3	physical	26496610
DREB_HUMAN	DBN1	physical	26496610
DSG2_HUMAN	DSG2	physical	26496610
E41L2_HUMAN	EPB41L2	physical	26496610
EPS15_HUMAN	EPS15	physical	26496610
FLII_HUMAN	FLII	physical	26496610
FLNA_HUMAN	FLNA	physical	26496610
FLNB_HUMAN	FLNB	physical	26496610
FYN_HUMAN	FYN	physical	26496610
PUR2_HUMAN	GART	physical	26496610
GNAI3_HUMAN	GNAI3	physical	26496610
GELS_HUMAN	GSN	physical	26496610
H33_HUMAN	H3F3A	physical	26496610
HMGB2_HUMAN	HMGB2	physical	26496610
ITPR1_HUMAN	ITPR1	physical	26496610
ITPR3_HUMAN	ITPR3	physical	26496610
PLAK_HUMAN	JUP	physical	26496610
ABLM1_HUMAN	ABLIM1	physical	26496610
LMO7_HUMAN	LMO7	physical	26496610
MARK3_HUMAN	MARK3	physical	26496610
MYO1B_HUMAN	MYO1B	physical	26496610
MOES_HUMAN	MSN	physical	26496610
MYL6_HUMAN	MYL6	physical	26496610
MYLK_HUMAN	MYLK	physical	26496610
MYO1C_HUMAN	MYO1C	physical	26496610
MYO1E_HUMAN	MYO1E	physical	26496610
MYO6_HUMAN	MYO6	physical	26496610
MYPT1_HUMAN	PPP1R12A	physical	26496610
MYPT2_HUMAN	PPP1R12B	physical	26496610
MERL_HUMAN	NF2	physical	26496610
PALM_HUMAN	PALM	physical	26496610
PLEC_HUMAN	PLEC	physical	26496610
PLSI_HUMAN	PLS1	physical	26496610
PP1A_HUMAN	PPP1CA	physical	26496610
PP1B_HUMAN	PPP1CB	physical	26496610
PP1G_HUMAN	PPP1CC	physical	26496610
TWF1_HUMAN	TWF1	physical	26496610
CTIP_HUMAN	RBBP8	physical	26496610
RL6_HUMAN	RPL6	physical	26496610
S10AA_HUMAN	S100A10	physical	26496610
SIPA1_HUMAN	SIPA1	physical	26496610
SOAT1_HUMAN	SOAT1	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
SPTB2_HUMAN	SPTBN1	physical	26496610
SPTN2_HUMAN	SPTBN2	physical	26496610
SRPK1_HUMAN	SRPK1	physical	26496610
SSFA2_HUMAN	SSFA2	physical	26496610
SSRP1_HUMAN	SSRP1	physical	26496610
ST5_HUMAN	ST5	physical	26496610
SPT5H_HUMAN	SUPT5H	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
ZO1_HUMAN	TJP1	physical	26496610
TMOD1_HUMAN	TMOD1	physical	26496610
BACD2_HUMAN	TNFAIP1	physical	26496610
TPM1_HUMAN	TPM1	physical	26496610
TPM2_HUMAN	TPM2	physical	26496610
TPM3_HUMAN	TPM3	physical	26496610
TPM4_HUMAN	TPM4	physical	26496610
TBB2A_HUMAN	TUBB2A	physical	26496610
COR2A_HUMAN	CORO2A	physical	26496610
LUZP1_HUMAN	LUZP1	physical	26496610
BAG6_HUMAN	BAG6	physical	26496610
IFT88_HUMAN	IFT88	physical	26496610
UBL4A_HUMAN	UBL4A	physical	26496610
PICAL_HUMAN	PICALM	physical	26496610
SRBS2_HUMAN	SORBS2	physical	26496610
LIPB1_HUMAN	PPFIBP1	physical	26496610
RAI3_HUMAN	GPRC5A	physical	26496610
LRRF2_HUMAN	LRRFIP2	physical	26496610
NOLC1_HUMAN	NOLC1	physical	26496610
DLG5_HUMAN	DLG5	physical	26496610
PDLI7_HUMAN	PDLIM7	physical	26496610
ZO2_HUMAN	TJP2	physical	26496610
CDYL_HUMAN	CDYL	physical	26496610
GOSR1_HUMAN	GOSR1	physical	26496610
MTFR1_HUMAN	MTFR1	physical	26496610
EPN4_HUMAN	CLINT1	physical	26496610
RHGBA_HUMAN	ARHGAP11A	physical	26496610
SC16A_HUMAN	SEC16A	physical	26496610
WDR1_HUMAN	WDR1	physical	26496610
ATP9A_HUMAN	ATP9A	physical	26496610
PDCD7_HUMAN	PDCD7	physical	26496610
ARPC4_HUMAN	ARPC4	physical	26496610
ARC1B_HUMAN	ARPC1B	physical	26496610
ARP3_HUMAN	ACTR3	physical	26496610
ARP2_HUMAN	ACTR2	physical	26496610
ARPC2_HUMAN	ARPC2	physical	26496610
FARP1_HUMAN	FARP1	physical	26496610
FLOT1_HUMAN	FLOT1	physical	26496610
BASP1_HUMAN	BASP1	physical	26496610
ML12A_HUMAN	MYL12A	physical	26496610
GA2L1_HUMAN	GAS2L1	physical	26496610
CELF1_HUMAN	CELF1	physical	26496610
SC61B_HUMAN	SEC61B	physical	26496610
DEST_HUMAN	DSTN	physical	26496610
TARA_HUMAN	TRIOBP	physical	26496610
SP16H_HUMAN	SUPT16H	physical	26496610
AKAP2_HUMAN	AKAP2	physical	26496610
SYNPO_HUMAN	SYNPO	physical	26496610
RRAS2_HUMAN	RRAS2	physical	26496610
CE162_HUMAN	CEP162	physical	26496610
AAK1_HUMAN	AAK1	physical	26496610
LIMC1_HUMAN	LIMCH1	physical	26496610
RB6I2_HUMAN	ERC1	physical	26496610
SI1L3_HUMAN	SIPA1L3	physical	26496610
MPRIP_HUMAN	MPRIP	physical	26496610
COBL_HUMAN	COBL	physical	26496610
MCF2L_HUMAN	MCF2L	physical	26496610
CYTSA_HUMAN	SPECC1L	physical	26496610
FBX46_HUMAN	FBXO46	physical	26496610
COR1C_HUMAN	CORO1C	physical	26496610
ZDHC5_HUMAN	ZDHHC5	physical	26496610
PKHG3_HUMAN	PLEKHG3	physical	26496610
SI1L1_HUMAN	SIPA1L1	physical	26496610
DECR2_HUMAN	DECR2	physical	26496610
RAI14_HUMAN	RAI14	physical	26496610
TES_HUMAN	TES	physical	26496610
ZBT20_HUMAN	ZBTB20	physical	26496610
PACN3_HUMAN	PACSIN3	physical	26496610
TMOD3_HUMAN	TMOD3	physical	26496610
RMD1_HUMAN	RMDN1	physical	26496610
LIMA1_HUMAN	LIMA1	physical	26496610
BMP2K_HUMAN	BMP2K	physical	26496610
UN45A_HUMAN	UNC45A	physical	26496610
MYO5C_HUMAN	MYO5C	physical	26496610
MUC13_HUMAN	MUC13	physical	26496610
COR1B_HUMAN	CORO1B	physical	26496610
K1211_HUMAN	KIAA1211	physical	26496610
CING_HUMAN	CGN	physical	26496610
MICA3_HUMAN	MICAL3	physical	26496610
RHG21_HUMAN	ARHGAP21	physical	26496610
AFAP1_HUMAN	AFAP1	physical	26496610
RBM26_HUMAN	RBM26	physical	26496610
INF2_HUMAN	INF2	physical	26496610
EFHD2_HUMAN	EFHD2	physical	26496610
GCC1_HUMAN	GCC1	physical	26496610
CYBR1_HUMAN	CYBRD1	physical	26496610
WDCP_HUMAN	C2orf44	physical	26496610
ARP5L_HUMAN	ARPC5L	physical	26496610
EPIPL_HUMAN	EPPK1	physical	26496610
BACD3_HUMAN	KCTD10	physical	26496610
LZTS2_HUMAN	LZTS2	physical	26496610
NEB2_HUMAN	PPP1R9B	physical	26496610
TBA1C_HUMAN	TUBA1C	physical	26496610
STON2_HUMAN	STON2	physical	26496610
DIXC1_HUMAN	DIXDC1	physical	26496610
SSH2_HUMAN	SSH2	physical	26496610
PHLB2_HUMAN	PHLDB2	physical	26496610
NEXN_HUMAN	NEXN	physical	26496610
CYTSB_HUMAN	SPECC1	physical	26496610
TM10A_HUMAN	TRMT10A	physical	26496610
FCHO2_HUMAN	FCHO2	physical	26496610
FGD4_HUMAN	FGD4	physical	26496610
MISP_HUMAN	MISP	physical	26496610
CD109_HUMAN	CD109	physical	26496610
MYL6B_HUMAN	MYL6B	physical	26496610
RHG42_HUMAN	ARHGAP42	physical	26496610
PPR18_HUMAN	PPP1R18	physical	26496610
GA2L3_HUMAN	GAS2L3	physical	26496610
TPRN_HUMAN	TPRN	physical	26496610
ACTBL_HUMAN	ACTBL2	physical	26496610
MY18A_HUMAN	MYO18A	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1939 AND SER-1943, ANDMASS SPECTROMETRY.
PubMed: 19131326

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1943, AND MASSSPECTROMETRY.
PubMed: 19144319

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1939 AND SER-1943, ANDMASS SPECTROMETRY.
PubMed: 19367708

"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis.";
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
J. Proteome Res. 7:3957-3967(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1943, AND MASSSPECTROMETRY.
PubMed: 18630941

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1939 AND SER-1943, ANDMASS SPECTROMETRY.
PubMed: 17242355

"Mitochondrial phosphoproteome revealed by an improved IMAC method andMS/MS/MS.";
Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y.;
Mol. Cell. Proteomics 6:669-676(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1943, AND MASSSPECTROMETRY.
PubMed: 17208939

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-181 AND SER-1943, ANDMASS SPECTROMETRY.
PubMed: 17203969

"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1943, AND MASSSPECTROMETRY.
PubMed: 16452087

"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling.";
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.;
J. Immunol. 179:5864-5876(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-754, AND MASSSPECTROMETRY.
PubMed: 17947660