FGD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FGD4_HUMAN
• UniProt AC: Q96M96
• Protein Name: FYVE, RhoGEF and PH domain-containing protein 4
• Gene Name: FGD4
• Organism: Homo sapiens (Human).
• Sequence Length: 766
• Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, filopodium. Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity)..
• Protein Description: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)..
• Protein Sequence: MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	ASCVSKEKPSKVSDL CHHCCCCCCCHHHHH	59.33	-
34	Phosphorylation	FEGGSSLSNYSDLKK CCCCCCCCCHHHHHH	35.35	29978859
36	Phosphorylation	GGSSLSNYSDLKKES CCCCCCCHHHHHHHH	10.53	25394399
37	Phosphorylation	GSSLSNYSDLKKESA CCCCCCHHHHHHHHC	40.49	25106551
40	Ubiquitination	LSNYSDLKKESAVNL CCCHHHHHHHHCCCC	60.53	-
43	Phosphorylation	YSDLKKESAVNLNAP HHHHHHHHCCCCCCC	46.53	28348404
52	Phosphorylation	VNLNAPRTPGRHGLT CCCCCCCCCCCCCCC	29.09	29214152
59	Phosphorylation	TPGRHGLTTTPQQKL CCCCCCCCCCHHHHH	32.96	29396449
60	Phosphorylation	PGRHGLTTTPQQKLL CCCCCCCCCHHHHHH	41.33	29496963
61	Phosphorylation	GRHGLTTTPQQKLLS CCCCCCCCHHHHHHH	17.54	28985074
68	Phosphorylation	TPQQKLLSQHLPQRQ CHHHHHHHCCCCCCC	26.45	28857561
119	Phosphorylation	SDTSIQASEPLLDTH CCCCCCCCCCCCCEE	24.30	28348404
125	Phosphorylation	ASEPLLDTHIVNGER CCCCCCCEEEECCCC	17.30	28348404
135	Phosphorylation	VNGERDETATAPASP ECCCCCCCCCCCCCC	33.33	24275569
137	Phosphorylation	GERDETATAPASPTT CCCCCCCCCCCCCCC	40.36	27732954
141	Phosphorylation	ETATAPASPTTDSCD CCCCCCCCCCCCCCC	23.01	30206219
143	Phosphorylation	ATAPASPTTDSCDGN CCCCCCCCCCCCCCC	40.51	23663014
144	Phosphorylation	TAPASPTTDSCDGNA CCCCCCCCCCCCCCC	29.33	23663014
146	Phosphorylation	PASPTTDSCDGNASD CCCCCCCCCCCCCCC	16.41	23663014
152	Phosphorylation	DSCDGNASDSSYRTP CCCCCCCCCCCCCCC	41.86	27732954
154	Phosphorylation	CDGNASDSSYRTPGI CCCCCCCCCCCCCCC	27.12	27732954
155	Phosphorylation	DGNASDSSYRTPGIG CCCCCCCCCCCCCCC	24.51	27732954
156	Phosphorylation	GNASDSSYRTPGIGP CCCCCCCCCCCCCCC	23.58	27732954
158	Phosphorylation	ASDSSYRTPGIGPVL CCCCCCCCCCCCCCC	20.03	21815630
186	Phosphorylation	QERENGESPLELEQL HHHHCCCCCCHHHHH	35.86	25849741
255	Phosphorylation	EMVNKIFSNISSINA HHHHHHHHCHHHHHH	36.41	21406692
258	Phosphorylation	NKIFSNISSINAFHS HHHHHCHHHHHHHHH	29.43	21406692
259	Phosphorylation	KIFSNISSINAFHSK HHHHCHHHHHHHHHH	18.96	21406692
265	Phosphorylation	SSINAFHSKFLLPEL HHHHHHHHHHHHHHH	20.74	21406692
281	Phosphorylation	KRMQEWETTPRIGDI HHHHHHHCCCCHHHH	43.08	22210691
282	Phosphorylation	RMQEWETTPRIGDIL HHHHHHCCCCHHHHH	10.08	22210691
291	Ubiquitination	RIGDILQKLAPFLKM CHHHHHHHHHHHHHH	43.07	-
299	Phosphorylation	LAPFLKMYGEYVKGF HHHHHHHHHHHHCCH	12.76	22210691
302	Phosphorylation	FLKMYGEYVKGFDNA HHHHHHHHHCCHHHH	11.78	22210691
355	Phosphorylation	PVQRIPRYEMLLKDY HHHHCCHHHHHHHHH	10.59	20068231
362	Phosphorylation	YEMLLKDYLRKLPPD HHHHHHHHHHHCCCC	13.56	20068231
370	Phosphorylation	LRKLPPDSLDWNDAK HHHCCCCCCCHHHHH	33.72	20068231
379	Phosphorylation	DWNDAKKSLEIISTA CHHHHHHHHHHHHHH	30.44	21406692
384	Phosphorylation	KKSLEIISTAASHSN HHHHHHHHHHHHCCH	20.04	30576142
385	Phosphorylation	KSLEIISTAASHSNS HHHHHHHHHHHCCHH	18.81	26657352
388	Phosphorylation	EIISTAASHSNSAIR HHHHHHHHCCHHHHH	25.61	21406692
390	Phosphorylation	ISTAASHSNSAIRKM HHHHHHCCHHHHHHH	29.95	21406692
392	Phosphorylation	TAASHSNSAIRKMEN HHHHCCHHHHHHHHH	28.25	25849741
407	Phosphorylation	LKKLLEIYEMLGEEE HHHHHHHHHHHCCCC	5.96	-
443	Phosphorylation	NTSAQERYLFLFNNM CCCHHHHHHHHHCCC	10.89	-
453	Phosphorylation	LFNNMLLYCVPKFSL HHCCCHHHHHCCCEE	6.35	-
463	Phosphorylation	PKFSLVGSKFTVRTR CCCEECCCCEEEEEE	19.67	20068231
563	Phosphorylation	WIRDNEVTMCMKCKE CHHCCCCEEEEECCC	9.85	28857561
602	Phosphorylation	DYKAQLEYDGGKLSK CCEEEEEECCCHHHH	28.60	-
606	Acetylation	QLEYDGGKLSKVCKD EEEECCCHHHHHHHH	55.93	26051181
615	Phosphorylation	SKVCKDCYQIISGFT HHHHHHHHHHHHCCC	16.93	-
619	Phosphorylation	KDCYQIISGFTDSEE HHHHHHHHCCCCCHH	29.50	27251275
622	Phosphorylation	YQIISGFTDSEEKKR HHHHHCCCCCHHHHH	41.98	27251275
624	Phosphorylation	IISGFTDSEEKKRKG HHHCCCCCHHHHHCC	44.60	27251275
694	Phosphorylation	ATIPLLGYVVDEMPR HHHCCCCEECCCCCC	9.40	23090842
702	Phosphorylation	VVDEMPRSADLPHSF ECCCCCCCCCCCCEE	21.92	29255136
708	Phosphorylation	RSADLPHSFKLTQSK CCCCCCCEEEECCCC	23.33	22199227
716	Phosphorylation	FKLTQSKSVHSFAAD EEECCCCCCCCCCCC	30.24	23312004
719	Phosphorylation	TQSKSVHSFAADSEE CCCCCCCCCCCCHHH	17.90	23312004
724	Phosphorylation	VHSFAADSEELKQKW CCCCCCCHHHHHHHH	28.39	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FGD4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FGD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FGD4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FGD3_HUMAN	FGD3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 609311: Charcot-Marie-Tooth disease 4H (CMT4H)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.