SYNE2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYNE2_MOUSE
• UniProt AC: Q6ZWQ0
• Protein Name: Nesprin-2
• Gene Name: Syne2
• Organism: Mus musculus (Mouse).
• Sequence Length: 6874
• Subcellular Localization: Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Cell membrane; Single-pass membrane protein. Cytoplasm, cytoskeleton. Mitochondrion. Nucleus, nucleoplas
• Protein Description: Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 seem to act redundantly in cerebellum, midbrain, brain stem, and other brain regions except cerebral cortex and hippocampus. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis..
• Protein Sequence: MAASPVLPTEDGEGFLGIDDLHFSLQAEQEDTQKKTFTCWINSQLAKHTPPSVVSDLFADIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLKNRSIKLINIHVADIVEGNPSIILGLIWTIILHFHIEKLAQTLSCDYNQPSPEVVSVAASSPTSSPPTKKCSKAQAQARWQWSAKKALLQWAQEQCARSESVNVTDFKSSWRNGMAFLAVIHALRPDLIDMDSMRHRSNKDNLKEAFRIAEHELKIPKLLEPEDVDVVNPDEKSIMTYVAQFLKYSKDAPGPGDSTQAKVRDALVWLTLQEKRFQKMLKDSASETYCNKYHSLLSFMESLNEEKESFIDVLSLKGRMGELNEDESRLRQGWTSLMHQVAAWRAQLDDALPSPLKETEAWLKDIEGVVQEGVPTSQSYSEARTLIQGKLSSFKSLMGSFDYHSDVLMAFQSNAEKSLPAVPPVKLEEMTRRINNVLGKNFIPLLEFHDSKCSVLALLDEAKAKLDVWNGTYESKESVEVLLEDWHKFTGEKKFLIQLDASFQKCEEMYKNSARECESIREEYMMLEKNVHSCRQYIHNTKATLQRALMSWATFEEDLALLKASFDLTKKEQIKEVPVETLLQWNTKHTSLNEVGSFLIGVSSREVAASISKELRRLNKRWRKFITKTPLLKLPLVKIQDQPPGNSSGTSLSKESAMAAEPGGSRGEDVKAAEKQEVEDEESAGQLKVNEEVEGLIKQVTIWESQTKSILDLLQHGDHADGSSADTLQHLIAKGSVYEELLARTEDTLQMDVQSPSNLEPFQNVLRAGLQAKIQEAKQGVQITMVELSAVLKNLSDEPLELDLGLKVEEAQKELEVSILRAEQLLGQRERPGGFLLKYKEALEILNTNSLAKYLRAVEELKRTVPGGAKLQLEEQSRVASAKWEPLRHEISLYLQQLKIAIEEEKLRDNIARLEKQINKEKKLIRRGRTRGLRKEHEACLSPESIKCQLEHHVGVLRVLCEELTSPEDQQELKRALRDYEQKIARLLKCASEIHTTLQSSQGGALEERSALITTENGRRDADGEVPLEIPDNQLSTEKAMEPIKNFSQTSELKPQQEESIMEKEGKDCSASLSDLQERYDTQRGLLEQHLQDSKSRVTSDFASEQERSSACLQSKLAELQVLLADTDAHWEKFEITSLNLRRLMSDAEKPVLNQERDLLKGNEQVLHGLLNTRMESLEMALQIVLPLEKECSLLCASDLPLCTVAVQDLHPVEIDGVYQNLRDIRDSIAKQIRVCTSLEEPSNSVPRELHTLDQCAIQDIVLKCRLQLETMNQKVEMREDALDALEGFLASLRAAKLSAELPADRPAPKAPEVLSEDILLMKEKAGPLDERLRTLGINIKDAEGGENTTCERLVGALSVNLVAMDGQSKEEGPPEDKKLLEACSSKNLELFKNIQDLQNQISKIGLKDPTAPAVKHRKKSLLRLDKDLDGLEEEKVRIQKIAGSLPRFKDGSEKNVIQQCEDTAALWESTKASVTESLEQCGSALELLRQYQNIKNNLTALIQKEEGIISQQASYMGKDNLKKKIAEIETVKEEFSDHLEVVDKINQICKNLQYHLNKMKTFEDPPFEKEANAIVDRWLDINEKTEEYGENLGRALALWDKLFIIKNNIDEWTEQILGKAESHELTEEDRGRLKEELKVLEEQSAEFSRRVADIQSLLQSNEKPLELQVMESSVLSKMKDVKTHVAGGSNSYAPSGSTAELREDLDQAKTQMGMTESLLNALSPSDSLEIFTKLEEIQQQIFQQKHSMTVLENQIGCLTPELSELKRQYASVSNLFNTKKNALQDHFATFLNEQCKNFNDWFSNVKTNLQECFEPPETKLSLEQRLQKLSDFLTLGGGNSKIQQVETVLQHVKMLLPKAHVKELDSWLRSQELELENMESICQARAGELNNSFQQLLRLEDDCRSLSKWLTNQEENWGKMEVSGERMDLFSQALTRKREQFETVAQLSDSLKEHGLTEGEETIKESTHLIDRYQALWRQLHEIEEEDKLPAAEDQSFNDLADDVIHWIKEIKESLMALNSSEGKMPLEERIQKIKEIIALKPEGDAKIQMVMRQAEHCEAPLAQETFTDLSNQWDSTLHLANTYLSHQEKLVLEGEKYLQSKEDLRLMLTELKKQQEAGFALQPGLPEKQAQLKIYKKFLQKAQDLTSLLEELKSQGNYLLECTKNPSFSEEPWLEVKHLHESLLQQLQDSVQKLEGHVQEHSSYQVCLTDLSSTLDDISKEYFSLCDGSKDQIMAKERMQKLQELESRLRFQGGALKKASALAKSIKQNTSSVGQKIIKDDIRSLKYKQKDLENRIESAKQETENGLNSILKSKSSTEKHVKFSLPVEEMPATSEVPKPTRESAAVGESGGARETNTNSAVEMILSKQLSLNVQESMQNAQDEREVNELQNQPLELDIMLRNEQLKGMEELSTHLEARRAAIELLEQSQHLNQTEEQALVLPAARPSVCHLGSLQQELHTLKKTKERQYGLLSGFQDQLVMAEASLNTSLAEVESLKIGSLDSATYLGKIKKFLGSVENQQGSLSKLRTEWAHLSSLLAAADQKLVESQMKHLEHGWELVEQLAHRKCFQQATEHSELTCLLEKLQDLKVSLHQQQQRLTLSLNSPGQQAAIVDMVTPAAELQAIKCEFSGLKWQAELHMKRLWGEKDKKTLEDAINNLNKQMEALEPLNREVENRIKKCELQNRIKETLSWVKNTMAELVVPIALLPDNILSQIRKCKLIHDGILGNQQAVELLVEEVRGITPSLAPCEGDGLNALLEDLQSQHQALLLKSTERSQQLELKLEEKSKLFAIIGKVQLTLEESETLMSPTGDRASTEAELERRLAILKASQQQLQDTESALSAHLQELTNAYKDANVFERLFLDDQLKNLKARTNRTQRFLQNNGSELKQKMESYREFHDKAAVLQKEAECILHGGLLPLRQELEQDAKEQLGNLRDKLAAIRGSLSQVLTSEEVFDTIGLSWDGSLLARLQTQVLEREREVEGKIKQLDTFLIARDRHQASISKIRAVDLQIKKGAESLLKVPSMSPESTLLNAQTLIQKIEKSKRLRDEIIRKLSKNEAFDDSFKESEMQRLKLCAEENSRLQEALQNMLLELQPREMGEKEFREKLENALHVLKQIQSRLQQPLCVNLGVQHIQHEKETWEAFGEQVEAEMCGLRAVRITEEQREENDSGTGGMEAKLRDIEGLHMELSKSISLRADVLNDAYDSANRYDELVAGALRIITSLEATLLSYRVDLHNPQKTLELAHLKQEELQSSVADLRSLTETLGAISSPEAKEQLRCTLEVLAAKNSALKAGLEAQEAEEERCLENYKCFRKMKEEICSRLRKMEMDLGQSIFPLPRSYKEALARLEQSKALTSNLLSTKEDLVKLRQLLRHLRCRSTENDATCALGVASALWEKWLSLLEAAREWQQWGGELKREWKFISEEIEREAIILETLQEDLPEISKTNAAPTEELWQLLDSLCQHQESVEKQQLLLALLLQRVRSIQNIPEGTETGETIPALQEIGSMQERCDRLLHTTRKNKDLVQAEIQAQQSFLKEIKDVKRVFEQISTSFPNLAPEGHPERAEQFEELRSILQKGKLSFENIMEKLRIKYSEMYSIVPAEIGSQVEECRSALEDAEEKMSSEVSKSSPSSIMRRKIERINNGLHCVEKMLQQKSRNIEEAHEIQKKIWDELDLWHSKLNELDSEVQDFVEQDPGQAQEWMDNLMAPFQQHQQVSQRAESRTSQLNKATIKMEEYNDLLKSTEVWIEKTSCLLANPACYDSSRTLSHRASTLQMALEDSEQKHSLLHSIFTDLEDLSIIFETDDLIQTIHELSDQVAALQQQIMEALPHVQQVADDVVAIESEVKAMEKKVAKIKAILLSKEIFDFPPEEHLKHGEVILENIHPMKKTIAEIMTYQVELRLPQTGTKPLPVFQRTSQLLQDVKLLENVTQEQNELLKVVIKQTAECDEEIDSLKQMLTNYSAEISPEHVSQNQVADLPSLQGEMERLEKQILNLNQKKEDLLVDLKTAVLNLHEHLKQEQQEVGDKPSAGASECTVAERDASERKLSRTNSMSFLPVVKEEAEESSVKSEDGRRRTEPPSASWSFLGKHSKDLEGDGASSSSSATIVQDADGRISTCDSSMVHIIAPDSGSTEEGPAPSPRLSQTDEGATPPIEAALLDFPREQGAFESTVERSRPRPADILRVCKTQVAKLELWLQQANVAFEPETVDADMQQVVEEELAGCQAMLTEIEYKVASLLETCKDQGLGDCGTTQQEAEALSWKLKTVKCNLEKVQMVLQEKFSEDQHPSTLKKPSEPHDVDQPAGLSELDSVLTERPQFSRQKDAPQPQILELKPSEQKDLIKFTELNAKKTWLQGHQENEDANRQSASSSKVPSPGNAASDSTLPLQAQSGDKWQYLHHELTSRPNPSVPQLVEPQVALTTSTLPSVSVYNFRCPTADELQAYTTQLEELRQEANTIQTQGSMTEETYISLDKRLFELFLSLSRCLGSVEGLLQRPGLLREDACAQQVFFQKLALELKKLYLALGDKKDDFLKAVTWPGKEATLLPECIDALTVSLESVQSRAAWRDASLKAGLEHSRSYQNEVKRLYSQLIKKKTALQQSLNEISGQSISKQLQKADVHTAELQNSEKQVAKLRDEGERLRFPHGLLQDVYKLEDVLDSMWGILRARYLELSSPFLSKSLQTLLQGMAELVSIGKGKLAADPLQHAKSKAALQAQLQDHKAFFQKLVADMLLIQTYSATMFPPSLQKGEGFGAEQVAEVRALEEEACLRGAQLQSMLQKWEEFDDNYASLEKDLEALISSLPSVSLVEETEERLLERISFYQQIKRNIDGKHARLCQTLNEGRQLAASVSCPEPEGQIARLEEQWLSLNKRIDQELHRLQTLLKHLLSYSRDSDELTRWLETSQQTLNYWKEQSLNVSQDLNTIRSNIDRFFKFSKEVDERSSLKSAVMSTGNQLLHLKEADTATLRASLAQFEQKWTVLITQLPDIQEKLHQLQMEKLPSREAISEMISWMNAVEPQAAGKDTELSKSSASQVKHLLQKLKEFRMEMDYKQWVVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWQRVHGTLNRKIQHLEQLLESITENENKVQNLNSWLEAQEERLKMLQKPESAVSMEKLLLDCQDIENQLALKSKALDELRQSSLTMDGGDVPLLEDMASGIVELFQKKNNVTSQVHQLRASVQSVLQEWKACDKLYDEATMRTTQLTYSMEHSKPAVLSLQALACQVQNLEALQDEAENGERSWEKLQEVIGRLKASCPSMAGIIEEKCQDAHSRWTQVNQDLADQLQEARGQLQLWKAPHNAHAEAAAWLQQQEAKFQQLANTNLSGDNLADILPRALKDIKGLQSDLQKTKEAFLENSTLSDQLPQPEERSTPGLHSGQRHSLQTAAYLEKMLLAKSNEFEIVLAQFKDFTDRLAYSKDLIVHKEENLNKLYHEEKEEVPDLFLNHVLALTAQSPDIERLNEESLRLPLSDVTIKTLQSLNRQWIRATATALDHYSELQGNGLNEKFLHYCERWIQVLEKIQESLSVEVAHSLPALLEQQKTYEILEAEVSTNQAVADAYVTQSLQLLDTAEIEKRPEFVSEFSKLSDQWQRAARGVRQRKCDISRLVTQWRFFTTSVEDLLRFLADTSQLLSAVKEQDCYSLCQTRRLVHELKSKEIHLQRWRTTYALALEAGEKLRNTPSPETREFVDGQISRLQESWKDTELSLGEVISRLQSTAETWDQCKKKIKKLKKRLQALKAQSEDPLPELHEALHEEKELIKEVEKSLANWTHSLKELQTMKADLSQHILAEDVTVLKEQIQLLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADVSIEEMIEKLQKDCMEEISLFTENKLQLKQMGDQLIKASSKAKAAELEEKLSKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDNQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASKLKQMVHEGNQRWDNLQKRVTAILRRLRYFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAEDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSHTPGLDDEKEASENETDIEDPREIQADSWRKRRESEEPTSPQSLCHLVPPALGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEDDEEGPFYSALSGKSISEGHPWHVPDSPSHSKHHYKHMEGDRTEAPVPTDASTPFKSDYVKLLLRQGTDDSKEGLKEAQQEDEQLATLTGQQPGAFDRWELIQAQELHSKLRLKQTVQQLKSDIGSIAAWLGKTEAELEALKLAEPPSDIQEIALRVKRLQEILKAFDTYKALMVSVNVSHKEYLPSQSPEATELQNRLHQLSLSWDSVQGVLDSWRGDLRQSLMQCQDFHQLSQDLLLWLATAESRRQKAHVTSPEADRQVLLECQKDLMRLEKELVARQPQVSSLREISSSLLVKGQGEDYIEAEEKVHVIEKKLKQLQEQVAQDLMSLQRSLDPDASLTSFDEVDSGEQLPAAFAKSPRPRWTFLEEEEEEEETDSRMPHLDSPGSSQPRRSFLSRVIRAALPLQLLLLLLLLLACLLPASEDDYSCTQANNFARSFYPMLRYTNGPPPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Phosphorylation	LAKHTPPSVVSDLFA HHHCCCCHHHHHHHC	36.03	-
55	Phosphorylation	HTPPSVVSDLFADIK CCCCHHHHHHHCCCC	26.83	-
143	Phosphorylation	HIEKLAQTLSCDYNQ HHHHHHHHHCCCCCC	18.29	-
152	Phosphorylation	SCDYNQPSPEVVSVA CCCCCCCCCCEEEEE	24.75	28066266
157	Phosphorylation	QPSPEVVSVAASSPT CCCCCEEEEEECCCC	15.94	26643407
161	Phosphorylation	EVVSVAASSPTSSPP CEEEEEECCCCCCCC	27.41	26643407
162	Phosphorylation	VVSVAASSPTSSPPT EEEEEECCCCCCCCC	27.72	21082442
164	Phosphorylation	SVAASSPTSSPPTKK EEEECCCCCCCCCCC	43.73	20139300
165	Phosphorylation	VAASSPTSSPPTKKC EEECCCCCCCCCCCC	44.20	27087446
166	Phosphorylation	AASSPTSSPPTKKCS EECCCCCCCCCCCCC	37.06	27087446
169	Phosphorylation	SPTSSPPTKKCSKAQ CCCCCCCCCCCCHHH	46.66	26643407
322	Phosphorylation	FQKMLKDSASETYCN HHHHHCCCCCHHHHH	31.91	25521595
331	Phosphorylation	SETYCNKYHSLLSFM CHHHHHHHHHHHHHH	5.22	29550500
333	Phosphorylation	TYCNKYHSLLSFMES HHHHHHHHHHHHHHH	28.10	29550500
336	Phosphorylation	NKYHSLLSFMESLNE HHHHHHHHHHHHHCH	28.04	29550500
340	Phosphorylation	SLLSFMESLNEEKES HHHHHHHHHCHHHHH	25.38	29550500
353	Phosphorylation	ESFIDVLSLKGRMGE HHHHHHHHHCCCCCC	28.08	30387612
392	Phosphorylation	QLDDALPSPLKETEA HHCCCCCCCCHHHHH	43.65	28973931
589	Phosphorylation	TLQRALMSWATFEED HHHHHHHHHHCHHHH	17.89	26643407
592	Phosphorylation	RALMSWATFEEDLAL HHHHHHHCHHHHHHH	25.89	26643407
685	Phosphorylation	QDQPPGNSSGTSLSK CCCCCCCCCCCCCCH	35.74	28973931
691	Phosphorylation	NSSGTSLSKESAMAA CCCCCCCCHHHHCCC	33.86	25338131
703	Phosphorylation	MAAEPGGSRGEDVKA CCCCCCCCCCCHHHH	42.92	28973931
783	Phosphorylation	YEELLARTEDTLQMD HHHHHHCCCCCCCCC	32.38	27087446
793	Phosphorylation	TLQMDVQSPSNLEPF CCCCCCCCCCCCHHH	30.09	26239621
795	Phosphorylation	QMDVQSPSNLEPFQN CCCCCCCCCCHHHHH	60.33	25293948
980	Phosphorylation	KEHEACLSPESIKCQ HHHHHHCCHHHHHHH	26.89	28973931
1110	Phosphorylation	EGKDCSASLSDLQER HCCCCCCCHHHHHHH	16.47	28973931
1184	Phosphorylation	LNLRRLMSDAEKPVL HHHHHHHCCCCCCCC	37.96	28973931
1459	Phosphorylation	AVKHRKKSLLRLDKD HHHHHHHHHHHHCCC	35.35	26239621
1589	Ubiquitination	DKINQICKNLQYHLN HHHHHHHHHHHHHHH	63.42	-
1600	Phosphorylation	YHLNKMKTFEDPPFE HHHHCCCCCCCCCCH	28.85	28973931
1608	Ubiquitination	FEDPPFEKEANAIVD CCCCCCHHHHHHHHH	63.61	-
1886	Phosphorylation	SKIQQVETVLQHVKM HHHHHHHHHHHHHHH	27.88	-
1944	Phosphorylation	RLEDDCRSLSKWLTN HCHHHHHHHHHHHHC	43.24	28973931
1970	Phosphorylation	GERMDLFSQALTRKR HHHHHHHHHHHHHCH	23.11	24719451
2137	Phosphorylation	LVLEGEKYLQSKEDL HHHCCHHHHCCHHHH	12.98	29514104
2207	Phosphorylation	LECTKNPSFSEEPWL EEECCCCCCCCCCCH	51.29	26643407
2264	Phosphorylation	DISKEYFSLCDGSKD HHCHHHHHCCCCCHH	27.47	22871156
2269	Phosphorylation	YFSLCDGSKDQIMAK HHHCCCCCHHHHHHH	21.58	22871156
2338	Phosphorylation	DLENRIESAKQETEN HHHHHHHHHHHHHHH	38.09	26239621
2349	Phosphorylation	ETENGLNSILKSKSS HHHHHHHHHHHCCCC	34.05	25266776
2389	Phosphorylation	ESAAVGESGGARETN HCCCCCCCCCCCCCC	36.28	-
2407	Acetylation	AVEMILSKQLSLNVQ HHHHHHHHCCCCCHH	52.38	15614197
2410	Phosphorylation	MILSKQLSLNVQESM HHHHHCCCCCHHHHH	18.53	28973931
2816	Phosphorylation	LLKSTERSQQLELKL HHHCCHHHHHHHHHH	18.95	28973931
2848	Phosphorylation	EESETLMSPTGDRAS HHHCCCCCCCCCCCC	23.56	28973931
2978	Acetylation	QLGNLRDKLAAIRGS HHHCHHHHHHHHHHC	33.32	22902405
3234	Phosphorylation	LHMELSKSISLRADV HHHHHHHHHHHHHHH	17.65	24719451
3236	Phosphorylation	MELSKSISLRADVLN HHHHHHHHHHHHHHH	20.92	24719451
3666	Phosphorylation	EDAEEKMSSEVSKSS HHHHHHHHHHHHHCC	34.12	26643407
3667	Phosphorylation	DAEEKMSSEVSKSSP HHHHHHHHHHHHCCH	38.22	26643407
3670	Phosphorylation	EKMSSEVSKSSPSSI HHHHHHHHHCCHHHH	23.83	26239621
3672	Phosphorylation	MSSEVSKSSPSSIMR HHHHHHHCCHHHHHH	39.72	28066266
3673	Phosphorylation	SSEVSKSSPSSIMRR HHHHHHCCHHHHHHH	32.32	26239621
3675	Phosphorylation	EVSKSSPSSIMRRKI HHHHCCHHHHHHHHH	34.15	26643407
3676	Phosphorylation	VSKSSPSSIMRRKIE HHHCCHHHHHHHHHH	24.64	26643407
4092	Phosphorylation	DASERKLSRTNSMSF CCCCCCCCCCCCCCC	39.84	29550500
4094	Phosphorylation	SERKLSRTNSMSFLP CCCCCCCCCCCCCCH	28.41	27087446
4096	Phosphorylation	RKLSRTNSMSFLPVV CCCCCCCCCCCCHHC	18.39	25521595
4098	Phosphorylation	LSRTNSMSFLPVVKE CCCCCCCCCCHHCHH	24.37	26239621
4110	Phosphorylation	VKEEAEESSVKSEDG CHHHHHHCCCCCCCC	31.75	28066266
4111	Phosphorylation	KEEAEESSVKSEDGR HHHHHHCCCCCCCCC	36.52	20139300
4114	Phosphorylation	AEESSVKSEDGRRRT HHHCCCCCCCCCCCC	38.47	26239621
4121	Phosphorylation	SEDGRRRTEPPSASW CCCCCCCCCCCCCCH	51.54	23984901
4125	Phosphorylation	RRRTEPPSASWSFLG CCCCCCCCCCHHHCC	45.72	23984901
4127	Phosphorylation	RTEPPSASWSFLGKH CCCCCCCCHHHCCCC	27.82	23984901
4129	Phosphorylation	EPPSASWSFLGKHSK CCCCCCHHHCCCCCC	14.22	23984901
4135	Phosphorylation	WSFLGKHSKDLEGDG HHHCCCCCCCCCCCC	31.20	23984901
4144	Phosphorylation	DLEGDGASSSSSATI CCCCCCCCCCCCEEE	35.96	26239621
4145	Phosphorylation	LEGDGASSSSSATIV CCCCCCCCCCCEEEE	33.43	28973931
4146	Phosphorylation	EGDGASSSSSATIVQ CCCCCCCCCCEEEEE	26.30	28973931
4147	Phosphorylation	GDGASSSSSATIVQD CCCCCCCCCEEEEEC	26.41	26239621
4148	Phosphorylation	DGASSSSSATIVQDA CCCCCCCCEEEEECC	31.23	26239621
4176	Phosphorylation	IIAPDSGSTEEGPAP EECCCCCCCCCCCCC	36.28	25619855
4177	Phosphorylation	IAPDSGSTEEGPAPS ECCCCCCCCCCCCCC	41.40	25619855
4184	Phosphorylation	TEEGPAPSPRLSQTD CCCCCCCCCCCCCCC	25.43	25619855
4188	Phosphorylation	PAPSPRLSQTDEGAT CCCCCCCCCCCCCCC	32.11	19060867
4190	Phosphorylation	PSPRLSQTDEGATPP CCCCCCCCCCCCCCC	32.42	26239621
4195	Phosphorylation	SQTDEGATPPIEAAL CCCCCCCCCCHHHHH	40.22	26239621
4419	Phosphorylation	ASSSKVPSPGNAASD CCCCCCCCCCCCCCC	48.72	26643407
4656	Phosphorylation	EISGQSISKQLQKAD HHCCCHHHHHHHHCC	21.42	28973931
4718	Phosphorylation	RARYLELSSPFLSKS HHHHHHHCCHHHHHH	26.96	26026062
4719	Phosphorylation	ARYLELSSPFLSKSL HHHHHHCCHHHHHHH	32.09	26026062
4725	Phosphorylation	SSPFLSKSLQTLLQG CCHHHHHHHHHHHHH	23.49	19854140
4738	Phosphorylation	QGMAELVSIGKGKLA HHHHHHHHCCCCCCC	37.94	19854140
5190	Phosphorylation	QKPESAVSMEKLLLD CCHHHCCCHHHHHHH	22.42	19854140
5243	Ubiquitination	GIVELFQKKNNVTSQ HHHHHHHHHCCCCHH	50.57	-
5744	Phosphorylation	HLQRWRTTYALALEA HHHHHHHHHHHHHHH	9.75	21454597
5760	Phosphorylation	EKLRNTPSPETREFV HHHCCCCCHHHHHHH	33.07	24719451
5763	Phosphorylation	RNTPSPETREFVDGQ CCCCCHHHHHHHHHH	38.59	24719451
5772	Phosphorylation	EFVDGQISRLQESWK HHHHHHHHHHHHHHC	21.03	-
5985	Ubiquitination	ELEEKLSKINDRWQH HHHHHHHHHHHHHHH	56.84	-
6301	Phosphorylation	GEQLIQKSEPLDAVL HHHHHHCCCCCCEEE	28.24	-
6335	Phosphorylation	SRFHRRLTSHTPGLD HHHHHHHHCCCCCCC	19.36	26239621
6336	Phosphorylation	RFHRRLTSHTPGLDD HHHHHHHCCCCCCCC	29.92	26239621
6338	Phosphorylation	HRRLTSHTPGLDDEK HHHHHCCCCCCCCHH	20.86	25619855
6348	Phosphorylation	LDDEKEASENETDIE CCCHHHHCCCCCCCC	41.88	27087446
6352	Phosphorylation	KEASENETDIEDPRE HHHCCCCCCCCCHHH	54.59	27742792
6364	Phosphorylation	PREIQADSWRKRRES HHHHCHHHHHHHHHC	31.62	28066266
6371	Phosphorylation	SWRKRRESEEPTSPQ HHHHHHHCCCCCCCH	45.51	26824392
6375	Phosphorylation	RRESEEPTSPQSLCH HHHCCCCCCCHHHHH	57.21	25619855
6376	Phosphorylation	RESEEPTSPQSLCHL HHCCCCCCCHHHHHC	31.49	25619855
6379	Phosphorylation	EEPTSPQSLCHLVPP CCCCCCHHHHHCCCC	36.03	25619855
6400	Phosphorylation	SGCETPVSVDSIPLE CCCCCCCCCCCCCCC	22.78	21183079
6403	Phosphorylation	ETPVSVDSIPLEWDH CCCCCCCCCCCCCCC	24.77	21183079
6411	Phosphorylation	IPLEWDHTGDVGGSS CCCCCCCCCCCCCCC	32.38	25293948
6417	Phosphorylation	HTGDVGGSSSHEDDE CCCCCCCCCCCCCCC	23.80	21183079
6418	Phosphorylation	TGDVGGSSSHEDDEE CCCCCCCCCCCCCCC	38.70	21183079
6419	Phosphorylation	GDVGGSSSHEDDEEG CCCCCCCCCCCCCCC	32.37	21183079
6429	Phosphorylation	DDEEGPFYSALSGKS CCCCCCCCCCCCCCC	9.00	25293948
6430	Phosphorylation	DEEGPFYSALSGKSI CCCCCCCCCCCCCCC	24.10	25293948
6433	Phosphorylation	GPFYSALSGKSISEG CCCCCCCCCCCCCCC	43.84	25293948
6436	Phosphorylation	YSALSGKSISEGHPW CCCCCCCCCCCCCCC	34.57	23375375
6438	Phosphorylation	ALSGKSISEGHPWHV CCCCCCCCCCCCCCC	44.62	28973931
6448	Phosphorylation	HPWHVPDSPSHSKHH CCCCCCCCCCCCCCC	23.41	23684622
6450	Phosphorylation	WHVPDSPSHSKHHYK CCCCCCCCCCCCCCC	44.32	25266776
6452	Phosphorylation	VPDSPSHSKHHYKHM CCCCCCCCCCCCCCC	37.71	25266776
6470	Phosphorylation	RTEAPVPTDASTPFK CCCCCCCCCCCCCCC	44.42	28066266
6473	Phosphorylation	APVPTDASTPFKSDY CCCCCCCCCCCCHHH	39.15	28066266
6474	Phosphorylation	PVPTDASTPFKSDYV CCCCCCCCCCCHHHH	34.17	28066266
6489	Phosphorylation	KLLLRQGTDDSKEGL HHHHHCCCCCCHHHH	28.44	22324799
6492	Phosphorylation	LRQGTDDSKEGLKEA HHCCCCCCHHHHHHH	35.10	26643407
6610	Phosphorylation	KEYLPSQSPEATELQ HHHCCCCCHHHHHHH	29.10	28973931
6761	Phosphorylation	RSLDPDASLTSFDEV HHCCCCCCCCCCCCC	39.29	22006019
6763	Phosphorylation	LDPDASLTSFDEVDS CCCCCCCCCCCCCCC	25.50	25338131
6764	Phosphorylation	DPDASLTSFDEVDSG CCCCCCCCCCCCCCC	35.67	25338131
6787	Phosphorylation	KSPRPRWTFLEEEEE CCCCCCCCCCCCHHH	21.44	25266776
6807	Phosphorylation	SRMPHLDSPGSSQPR CCCCCCCCCCCCCCC	37.20	28973931
6816	Phosphorylation	GSSQPRRSFLSRVIR CCCCCCHHHHHHHHH	31.64	23737553
6819	Phosphorylation	QPRRSFLSRVIRAAL CCCHHHHHHHHHHHH	23.61	23737553

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYNE2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYNE2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYNE2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUN1_MOUSE	Sun1	physical	16079285
BRAP_MOUSE	Brap	physical	23707952

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.