DDX3Y_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDX3Y_MOUSE
• UniProt AC: Q62095
• Protein Name: ATP-dependent RNA helicase DDX3Y
• Gene Name: Ddx3y
• Organism: Mus musculus (Mouse).
• Sequence Length: 658
• Subcellular Localization: Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.
• Protein Description: Probable ATP-dependent RNA helicase. May play a role in spermatogenesis..
• Protein Sequence: MSQVAAESTAGLDQQFVGLDLKSSDNQNGGGNTESKGRYIPPHLRNRETSKGVCDKDSSGWSCSKDKDAYSSFGSRDSRGKPNYFSDRGSGSRGRFDDHGRNDYDGIGGRDRTGFGKFERSGHSRWSDRSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIENFSDIEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYTDGPGEALKAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADTVQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEELDKRSFLLDLLNATGKDSLTLVFVETKKGADSLENFLFQERYACTSIHGDRSQKDREEALHQFRSGRKPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNLNITKDLLDLLVEAKQEVPSWLESMAYEHHYKGSSRGRSKSRFSGGFGARDYRQSSGSANAGFNSNRANSSRSSGSSHNRGFGGGGYGGFYNNDGYGGNYNSQAVDWWGN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSQVAAEST ------CCHHHHHCC	33.10	-
2	Phosphorylation	------MSQVAAEST ------CCHHHHHCC	33.10	25266776
56	Acetylation	TSKGVCDKDSSGWSC CCCCCCCCCCCCCCC	55.15	-
65	Acetylation	SSGWSCSKDKDAYSS CCCCCCCCCHHHHHC	73.46	7614285
70	Phosphorylation	CSKDKDAYSSFGSRD CCCCHHHHHCCCCCC	18.25	25159016
71	Phosphorylation	SKDKDAYSSFGSRDS CCCHHHHHCCCCCCC	22.40	25159016
72	Phosphorylation	KDKDAYSSFGSRDSR CCHHHHHCCCCCCCC	22.43	26824392
75	Phosphorylation	DAYSSFGSRDSRGKP HHHHCCCCCCCCCCC	30.79	25159016
78	Phosphorylation	SSFGSRDSRGKPNYF HCCCCCCCCCCCCCC	41.65	29514104
84	Phosphorylation	DSRGKPNYFSDRGSG CCCCCCCCCCCCCCC	17.00	29514104
86	Phosphorylation	RGKPNYFSDRGSGSR CCCCCCCCCCCCCCC	18.95	29514104
90	Phosphorylation	NYFSDRGSGSRGRFD CCCCCCCCCCCCCCC	34.19	25266776
92	Phosphorylation	FSDRGSGSRGRFDDH CCCCCCCCCCCCCCC	33.00	29514104
101	Methylation	GRFDDHGRNDYDGIG CCCCCCCCCCCCCCC	29.44	-
104	Phosphorylation	DDHGRNDYDGIGGRD CCCCCCCCCCCCCCC	21.44	22817900
110	Methylation	DYDGIGGRDRTGFGK CCCCCCCCCCCCCCC	25.65	-
117	Acetylation	RDRTGFGKFERSGHS CCCCCCCCCCCCCCC	41.62	-
130	Phosphorylation	HSRWSDRSDEDDWSK CCCCCCCCCCCCCCC	50.79	23375375
151	Phosphorylation	RLEQELFSGGNTGIN HHHHHHHCCCCCCCC	59.42	29514104
182	Phosphorylation	PPHIENFSDIEMGEI CCCCCCCCCCCCCEE	49.62	-
199	Phosphorylation	GNIELTRYTRPTPVQ ECEEEEEECCCCCCH	11.23	29514104
214	Ubiquitination	KHAIPIIKEKRDLMA HCCCHHHHCHHCHHH	58.88	-
222	S-nitrosylation	EKRDLMACAQTGSGK CHHCHHHHHHCCCCH	1.47	21278135
222	S-nitrosocysteine	EKRDLMACAQTGSGK CHHCHHHHHHCCCCH	1.47	-
225	Phosphorylation	DLMACAQTGSGKTAA CHHHHHHCCCCHHHH	18.13	24759943
227	Phosphorylation	MACAQTGSGKTAAFL HHHHHCCCCHHHHHH	40.27	24759943
263	Ubiquitination	NGRYGRRKQYPISLV HCCCCCCCCCCCEEE	53.47	-
265	Phosphorylation	RYGRRKQYPISLVLA CCCCCCCCCCEEEEC	12.93	29514104
282	Phosphorylation	RELAVQIYEEARKFS HHHHHHHHHHHHHCC	7.22	22817900
292	Phosphorylation	ARKFSYRSRVRPCVV HHHCCHHHCCCCEEE	27.22	-
297	S-nitrosocysteine	YRSRVRPCVVYGGAD HHHCCCCEEEECCCH	1.96	-
297	S-nitrosylation	YRSRVRPCVVYGGAD HHHCCCCEEEECCCH	1.96	21278135
297	S-palmitoylation	YRSRVRPCVVYGGAD HHHCCCCEEEECCCH	1.96	28526873
305	Phosphorylation	VVYGGADTVQQIRDL EEECCCHHHHHHHHH	21.49	25521595
322	Phosphorylation	GCHLLVATPGRLVDM CCEEEEECCCHHHHH	20.85	26824392
334	Ubiquitination	VDMMERGKIGLDFCK HHHHHCCCCCHHHHH	39.56	-
409	Phosphorylation	LAVGRVGSTSENITQ HHCCCCCCCCCCCCE	26.38	30635358
410	Phosphorylation	AVGRVGSTSENITQK HCCCCCCCCCCCCEE	33.85	26745281
411	Phosphorylation	VGRVGSTSENITQKV CCCCCCCCCCCCEEE	30.28	29176673
428	Phosphorylation	VEELDKRSFLLDLLN EEEHHHHHHHHHHHH	26.45	25195567
455	Phosphorylation	ETKKGADSLENFLFQ EECCCHHHHHHHHHH	36.73	27180971
477	Ubiquitination	IHGDRSQKDREEALH CCCCCCHHHHHHHHH	61.06	-
507	Phosphorylation	AARGLDISNVKHVIN HHCCCCCCCCEEEEE	34.93	22006019
510	Ubiquitination	GLDISNVKHVINFDL CCCCCCCEEEEECCC	36.08	-
519	Phosphorylation	VINFDLPSDIEEYVH EEECCCCCCHHHHHH	59.52	26745281
524	Phosphorylation	LPSDIEEYVHRIGRT CCCCHHHHHHHHCCC	6.70	26745281
589	Phosphorylation	SSRGRSKSRFSGGFG CCCCCCCCCCCCCCC	39.54	29514104
590	Methylation	SRGRSKSRFSGGFGA CCCCCCCCCCCCCCC	33.22	-
592	Phosphorylation	GRSKSRFSGGFGARD CCCCCCCCCCCCCCC	36.58	26824392
600	Phosphorylation	GGFGARDYRQSSGSA CCCCCCCCCCCCCCC	12.66	29514104
603	Phosphorylation	GARDYRQSSGSANAG CCCCCCCCCCCCCCC	27.89	22324799
604	Phosphorylation	ARDYRQSSGSANAGF CCCCCCCCCCCCCCC	28.55	22324799
606	Phosphorylation	DYRQSSGSANAGFNS CCCCCCCCCCCCCCC	21.94	22324799
613	Phosphorylation	SANAGFNSNRANSSR CCCCCCCCCCCCCCC	25.98	29899451
615	Methylation	NAGFNSNRANSSRSS CCCCCCCCCCCCCCC	34.66	-
618	Phosphorylation	FNSNRANSSRSSGSS CCCCCCCCCCCCCCC	26.58	29514104
628	Methylation	SSGSSHNRGFGGGGY CCCCCCCCCCCCCCC	36.07	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDX3Y_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDX3Y_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDX3Y_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DDX3Y_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.