UniProt ID | RED_MOUSE | |
---|---|---|
UniProt AC | Q9Z1M8 | |
Protein Name | Protein Red | |
Gene Name | Ik | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 557 | |
Subcellular Localization | Nucleus . Nucleus, nucleoplasm . Chromosome . Cytoplasm, cytoskeleton, spindle pole . Predominantly present throughout the nucleoplasm during prometaphase, metaphase and anaphase. Is also detected in nuclear foci that are not identical with Cajal bod | |
Protein Description | Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species. Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1.. | |
Protein Sequence | MPERDSEPFSNPLAPDGHDVDDPHSFHQSKLTNEDFRKLLMTPRAAPTSAPPSKSRHHEMPREYNEDEDPAARRRKKKSYYAKLRQQEIERERELAEKYRDRAKERRDGVNKDYEETELISTTANYRAVGPTAEADKSAAEKRRQLIQESKFLGGDMEHTHLVKGLDFALLQKVRAEIASKEKEEEELMEKPQKETKKDEDPENKIEFKTRLGRNVYRMLFKSKSYERNELFLPGRMAYVVDLDDEYADTDIPTTLIRSKADCPTMEAQTTLTTNDIVISKLTQILSYLRQGTRNKKLKKKDKGKLEEKKPPEADMNIFEDIGDYVPSTTKTPRDKERERYRERERDRERDRDRERDRERDRERERERDREREREEEKKRHSYFEKPKVDDEPMDVDKGPGSAKELIKSINEKFAGSAGWEGTESLKKPEDKKQLGDFFGMSNSYAECYPATMDDMAVDSDEEVDYSKMDQGNKKGPLGRWDFDTQEEYSEYMNNKEALPKAAFQYGIKMSEGRKTRRFKETNDKAELDRQWKKISAIIEKRKRMEADGVEVKRPKY | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
6 | Phosphorylation | --MPERDSEPFSNPL --CCCCCCCCCCCCC | 54.08 | 26370283 | |
42 | Phosphorylation | DFRKLLMTPRAAPTS HHHHHHCCCCCCCCC | 15.02 | 26643407 | |
98 | Acetylation | RERELAEKYRDRAKE HHHHHHHHHHHHHHH | 39.72 | - | |
114 | Phosphorylation | RDGVNKDYEETELIS HCCCCCCHHHHHHHE | 19.78 | 25367039 | |
117 | Phosphorylation | VNKDYEETELISTTA CCCCHHHHHHHEEEC | 24.93 | 25367039 | |
137 | Acetylation | GPTAEADKSAAEKRR CCCHHHCHHHHHHHH | 49.38 | 23806337 | |
173 | Ubiquitination | LDFALLQKVRAEIAS HHHHHHHHHHHHHHC | 33.39 | - | |
180 | Phosphorylation | KVRAEIASKEKEEEE HHHHHHHCCHHHHHH | 47.19 | 29514104 | |
223 | Phosphorylation | VYRMLFKSKSYERNE HHHHHHCCCCCCCCC | 21.35 | 26643407 | |
225 | Phosphorylation | RMLFKSKSYERNELF HHHHCCCCCCCCCCC | 39.04 | 25266776 | |
226 | Phosphorylation | MLFKSKSYERNELFL HHHCCCCCCCCCCCC | 23.73 | 29550500 | |
259 | Phosphorylation | IPTTLIRSKADCPTM CCHHHHHCCCCCCCC | 25.79 | 25777480 | |
265 | Phosphorylation | RSKADCPTMEAQTTL HCCCCCCCCCCCCCC | 33.69 | 25777480 | |
270 | Phosphorylation | CPTMEAQTTLTTNDI CCCCCCCCCCCCHHH | 30.71 | 25777480 | |
271 | Phosphorylation | PTMEAQTTLTTNDIV CCCCCCCCCCCHHHH | 15.27 | 25777480 | |
273 | Phosphorylation | MEAQTTLTTNDIVIS CCCCCCCCCHHHHHH | 22.82 | 25777480 | |
274 | Phosphorylation | EAQTTLTTNDIVISK CCCCCCCCHHHHHHH | 33.72 | 25777480 | |
280 | Phosphorylation | TTNDIVISKLTQILS CCHHHHHHHHHHHHH | 15.66 | 25777480 | |
283 | Phosphorylation | DIVISKLTQILSYLR HHHHHHHHHHHHHHH | 19.80 | 25777480 | |
287 | Phosphorylation | SKLTQILSYLRQGTR HHHHHHHHHHHHCCC | 24.61 | 25777480 | |
288 | Phosphorylation | KLTQILSYLRQGTRN HHHHHHHHHHHCCCC | 11.49 | 25777480 | |
325 | Phosphorylation | IFEDIGDYVPSTTKT HHHHHHHCCCCCCCC | 14.73 | 25159016 | |
328 | Phosphorylation | DIGDYVPSTTKTPRD HHHHCCCCCCCCCCH | 38.37 | 25619855 | |
329 | Phosphorylation | IGDYVPSTTKTPRDK HHHCCCCCCCCCCHH | 26.66 | 25619855 | |
330 | Phosphorylation | GDYVPSTTKTPRDKE HHCCCCCCCCCCHHH | 36.94 | 25619855 | |
332 | Phosphorylation | YVPSTTKTPRDKERE CCCCCCCCCCHHHHH | 22.82 | 25619855 | |
402 | Phosphorylation | DVDKGPGSAKELIKS CCCCCCCCHHHHHHH | 39.02 | 25619855 | |
417 | Phosphorylation | INEKFAGSAGWEGTE HHHHHCCCCCCCCHH | 21.85 | 28066266 | |
442 | Phosphorylation | LGDFFGMSNSYAECY HHHHHCCCCCHHHHE | 24.01 | 21149613 | |
444 | Phosphorylation | DFFGMSNSYAECYPA HHHCCCCCHHHHEEC | 20.57 | 21149613 | |
445 | Phosphorylation | FFGMSNSYAECYPAT HHCCCCCHHHHEECC | 15.63 | 21149613 | |
449 | Phosphorylation | SNSYAECYPATMDDM CCCHHHHEECCHHHC | 6.34 | 21149613 | |
452 | Phosphorylation | YAECYPATMDDMAVD HHHHEECCHHHCCCC | 19.34 | 29899451 | |
460 | Phosphorylation | MDDMAVDSDEEVDYS HHHCCCCCCCCCCHH | 40.08 | 21149613 | |
466 | Phosphorylation | DSDEEVDYSKMDQGN CCCCCCCHHHCCCCC | 18.50 | 21149613 | |
467 | Phosphorylation | SDEEVDYSKMDQGNK CCCCCCHHHCCCCCC | 19.62 | 21149613 | |
485 | Phosphorylation | LGRWDFDTQEEYSEY CCCCCCCCHHHHHHH | 37.56 | - | |
489 | Phosphorylation | DFDTQEEYSEYMNNK CCCCHHHHHHHHCCC | 13.17 | 25159016 | |
490 | Phosphorylation | FDTQEEYSEYMNNKE CCCHHHHHHHHCCCC | 26.07 | 25159016 | |
536 | Phosphorylation | DRQWKKISAIIEKRK HHHHHHHHHHHHHHH | 23.46 | 29176673 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RED_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RED_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RED_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of RED_MOUSE !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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