TNPO1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNPO1_MOUSE
• UniProt AC: Q8BFY9
• Protein Name: Transportin-1
• Gene Name: Tnpo1
• Organism: Mus musculus (Mouse).
• Sequence Length: 898
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. [PubMed: 11493596 Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A (By similarity In vitro, mediates nuclear import of SRP19 (By similarity Mediates the import of histones H2A, H2B, H3 and H4]
• Protein Sequence: MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEAEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHEEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPEQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MVWDRQTKMEYEWK -CCCCCCCCCCCCCC	33.00	28576409
30	Phosphorylation	ILQLLKESQSPDTTI HHHHHHHCCCCCHHH	34.08	23375375
32	Phosphorylation	QLLKESQSPDTTIQR HHHHHCCCCCHHHHH	33.74	28833060
58	Ubiquitination	YPDFNNYLIFVLTKL CCCCCCEEHHHHHCC	2.38	27667366
66	Ubiquitination	IFVLTKLKSEDEPTR HHHHHCCCCCCCCCC	54.04	27667366
73	Ubiquitination	KSEDEPTRSLSGLIL CCCCCCCCCCCHHHH	46.44	27667366
81	Ubiquitination	SLSGLILKNNVKAHF CCCHHHHHCCHHHHH	39.21	27667366
85	Ubiquitination	LILKNNVKAHFQNFP HHHHCCHHHHHHCCC	37.96	22790023
128	Ubiquitination	LITTIASKGELQNWP HHHHHCCCCHHHCCH	47.59	-
164	Glutathionylation	FGALQKICEDSAEIL HHHHHHHHHCHHHHC	6.48	24333276
339	Phosphorylation	EDETIPDSEQDIRPR CCCCCCCCCCCCHHH	31.63	25338131
352	Phosphorylation	PRFHRSRTVAQQHEE HHHHHHHHHHHHHHH	22.80	-
385	Ubiquitination	ISDWNLRKCSAAALD CCHHHHHHHHHHHHH	35.39	22790023
620	Glutathionylation	CEPVYQRCVNLVQKT CHHHHHHHHHHHHHH	1.09	24333276
683	S-palmitoylation	ILTLMYQCMQDKMPE HHHHHHHHHHHCCHH	1.14	28526873

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNPO1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNPO1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNPO1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARBK1_HUMAN	ADRBK1	physical	26496610
AL3A2_HUMAN	ALDH3A2	physical	26496610
AT1A1_HUMAN	ATP1A1	physical	26496610
AT5F1_HUMAN	ATP5F1	physical	26496610
LYST_HUMAN	LYST	physical	26496610
DYN2_HUMAN	DNM2	physical	26496610
ECHB_HUMAN	HADHB	physical	26496610
PYGB_HUMAN	PYGB	physical	26496610
RTKN_HUMAN	RTKN	physical	26496610
GLYM_HUMAN	SHMT2	physical	26496610
TGFI1_HUMAN	TGFB1I1	physical	26496610
SUCB1_HUMAN	SUCLA2	physical	26496610
ATP5H_HUMAN	ATP5H	physical	26496610
SPTC1_HUMAN	SPTLC1	physical	26496610
NS1BP_HUMAN	IVNS1ABP	physical	26496610
ATP5L_HUMAN	ATP5L	physical	26496610
YMEL1_HUMAN	YME1L1	physical	26496610
AFG32_HUMAN	AFG3L2	physical	26496610
SC61B_HUMAN	SEC61B	physical	26496610
S27A2_HUMAN	SLC27A2	physical	26496610
RT27_HUMAN	MRPS27	physical	26496610
ZN281_HUMAN	ZNF281	physical	26496610
ATX10_HUMAN	ATXN10	physical	26496610
CCHCR_HUMAN	CCHCR1	physical	26496610
NDUBB_HUMAN	NDUFB11	physical	26496610
CNTLN_HUMAN	CNTLN	physical	26496610
PCID2_HUMAN	PCID2	physical	26496610
BI2L1_HUMAN	BAIAP2L1	physical	26496610
CCD47_HUMAN	CCDC47	physical	26496610
ESYT2_HUMAN	ESYT2	physical	26496610
SRPRB_HUMAN	SRPRB	physical	26496610
DEFM_HUMAN	PDF	physical	26496610
TFB2M_HUMAN	TFB2M	physical	26496610
RM11_HUMAN	MRPL11	physical	26496610
DDX54_HUMAN	DDX54	physical	26496610
TMM43_HUMAN	TMEM43	physical	26496610
ZN768_HUMAN	ZNF768	physical	26496610
CLP1L_HUMAN	CLPTM1L	physical	26496610
YIPF5_HUMAN	YIPF5	physical	26496610
KLF16_HUMAN	KLF16	physical	26496610
ATD3B_HUMAN	ATAD3B	physical	26496610
MIC25_HUMAN	CHCHD6	physical	26496610
S38A5_HUMAN	SLC38A5	physical	26496610
SGF29_HUMAN	CCDC101	physical	26496610
TOP1M_HUMAN	TOP1MT	physical	26496610
FA83B_HUMAN	FAM83B	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.