TFB2M_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TFB2M_HUMAN
• UniProt AC: Q9H5Q4
• Protein Name: Dimethyladenosine transferase 2, mitochondrial
• Gene Name: TFB2M
• Organism: Homo sapiens (Human).
• Sequence Length: 396
• Subcellular Localization: Mitochondrion.
• Protein Description: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity..
• Protein Sequence: MWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLAQIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKNLGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKLMADPGNPDLYHVLSVIWQLACEIKVLHMEPWSSFDIYTRKGPLENPKRRELLDQLQQKLYLIQMIPRQNLFTKNLTPMNYNIFFHLLKHCFGRRSATVIDHLRSLTPLDARDILMQIGKQEDEKVVNMHPQDFKTLFETIERSKDCAYKWLYDETLEDR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Phosphorylation	RNPPRKASKASLDFK CCCCCCCHHHCCCHH	31.61	26074081
66	Ubiquitination	NPPRKASKASLDFKR CCCCCCHHHCCCHHH	47.02	24816145
68	Phosphorylation	PRKASKASLDFKRYV CCCCHHHCCCHHHHH	32.01	24719451
72	2-Hydroxyisobutyrylation	SKASLDFKRYVTDRR HHHCCCHHHHHHHHH	42.35	-
91	Ubiquitination	LAQIYLGKPSRPPHL HHHHHCCCCCCCCCE	36.91	24816145
127	Acetylation	VVALESDKTFIPHLE EEEECCCCCCHHHHH	55.40	26051181
127	Ubiquitination	VVALESDKTFIPHLE EEEECCCCCCHHHHH	55.40	29967540
138	Ubiquitination	PHLESLGKNLDGKLR HHHHHCCCCCCCCEE	60.68	21890473
153	Acetylation	VIHCDFFKLDPRSGG EEECEEEECCCCCCC	52.56	25953088
163	Ubiquitination	PRSGGVIKPPAMSSR CCCCCCCCCCCCCCC	42.41	29967540
178	Ubiquitination	GLFKNLGIEAVPWTA CCHHHCCCCCCCCCC	3.28	21890473
183	Ubiquitination	LGIEAVPWTADIPLK CCCCCCCCCCCCCEE	9.53	24816145
184	Phosphorylation	GIEAVPWTADIPLKV CCCCCCCCCCCCEEE	14.37	-
194	Sulfoxidation	IPLKVVGMFPSRGEK CCEEEEEECCCCHHH	2.78	21406390
197	Phosphorylation	KVVGMFPSRGEKRAL EEEEECCCCHHHHHH	41.47	-
201	Succinylation	MFPSRGEKRALWKLA ECCCCHHHHHHHHHH	45.88	23954790
270	Ubiquitination	LHMEPWSSFDIYTRK EECCCCCCCCEEECC	24.06	21890473
277	Ubiquitination	SFDIYTRKGPLENPK CCCEEECCCCCCCHH	58.02	29967540
284	Ubiquitination	KGPLENPKRRELLDQ CCCCCCHHHHHHHHH	75.55	24816145
284	2-Hydroxyisobutyrylation	KGPLENPKRRELLDQ CCCCCCHHHHHHHHH	75.55	-
313	Phosphorylation	NLFTKNLTPMNYNIF CCCCCCCCCCCHHHH	29.86	-
361	Ubiquitination	IGKQEDEKVVNMHPQ HCCCCCCHHHCCCHH	64.90	29967540
371	Ubiquitination	NMHPQDFKTLFETIE CCCHHHHHHHHHHHH	53.24	22817900
386	Ubiquitination	RSKDCAYKWLYDETL HCCCCHHHHHHHHCC	16.52	29967540
396	Methylation	YDETLEDR------- HHHCCCCC-------	38.78	115918381

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TFB2M_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TFB2M_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TFB2M_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MCATL_HUMAN	SLC25A29	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.