LYST_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LYST_HUMAN
• UniProt AC: Q99698
• Protein Name: Lysosomal-trafficking regulator
• Gene Name: LYST
• Organism: Homo sapiens (Human).
• Sequence Length: 3801
• Subcellular Localization: Cytoplasm .
• Protein Description: May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules..
• Protein Sequence: MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQEEKATDFNLPLSADIILTKEKNSSSQRSTQEKLHLEGSALSSQVSAKVNVFRKSRRQRKITHRYSVRDARKTQLSTSDSEANSDEKGIAMNKHRRPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPPDAMALENSREIIPRQGSNTDILSEPAALSVISNMNNSPFDLCHVLLSLLEKVCKFDVTLNHNSPLAASVVPTLTEFLAGFGDCCSLSDNLESRVVSAGWTEEPVALIQRMLFRTVLHLLSVDVSTAEMMPENLRKNLTELLRAALKIRICLEKQPDPFAPRQKKTLQEVQEDFVFSKYRHRALLLPELLEGVLQILICCLQSAASNPFYFSQAMDLVQEFIQHHGFNLFETAVLQMEWLVLRDGVPPEASEHLKALINSVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGDVYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVHNIGICCCMDPKSVIIPLLHAFKLPALKNFQQHILNILNKLILDQLGGAEISPKIKKAACNICTVDSDQLAQLEETLQGNLCDAELSSSLSSPSYRFQGILPSSGSEDLLWKWDALKAYQNFVFEEDRLHSIQIANHICNLIQKGNIVVQWKLYNYIFNPVLQRGVELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQIYVKTLPILLKSRVIRDLFLSCNGVSQIIELNCLNGIRSHSLKAFETLIISLGEQQKDASVPDIDGIDIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYPKRRKTVNQDVHINTINLFLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLSHMLPCISLESLVLPSPEHMHQAADIWSMCRWIYMLSSVFQKQFYRLGGFRVCHKLIFMIIQKLFRSHKEEQGKKEGDTSVNENQDLNRISQPKRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVSATEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILFEMRDHLSQSKVIETQLAKPLFDALLRVALGNYSADFEHNDAMTEKSHQSAEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLENLTQGEIIYPEICMLELNLLSASKAKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTVKNLLGGFLSILTQDDSDFQACQRVLVDLLVSLMSSRTCSEELTLLLRIFLEKSPCTKILLLGILKIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSRSKKEADRESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKRNKSLILPDSSFDGTESDRPEGAEYINPGERLIEEGCIHIISLGSKALMIQVWADPHNATLIFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKRRIHGKISIWVSGQRKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLGNLLLFNGAKVGSQEAFYLYACGPNHTSVMPCKYGKPVNDYSKYINKEILRCEQIRELFMTKKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHHLKNLQPTEYKTIQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRVHELENCNGLSMIHQVLIKQKCIVGFYILKTLLEGCCGEDIIYMNENGEFKLDVDSNAIIQDVKLLEELLLDWKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQLTPMPREVCRSFVKIIAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVRSIMYLRHSSSGGRSLMSPGFMVISPSGFTASPYEGENSSNIIPQQMAAHMLRSRSLPAFPTSSLLTQSQKLTGSLGCSIDRLQNIADTYVATQSKKQNSLGSSDTLKKGKEDAFISSCESAKTVCEMEAVLSAQVSVSDVPKGVLGFPVVKADHKQLGAEPRSEDDSPGDESCPRRPDYLKGLASFQRSHSTIASLGLAFPSQNGSAAVGRWPSLVDRNTDDWENFAYSLGYEPNYNRTASAHSVTEDCLVPICCGLYELLSGVLLILPDVLLEDVMDKLIQADTLLVLVNHPSPAIQQGVIKLLDAYFARASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMFFGRHIGLDEEFDLEDVRNMGLFQKWSVIPILGLIETSLYDNILLHNALLLLLQILNSCSKVADMLLDNGLLYVLCNTVAALNGLEKNIPMSEYKLLACDIQQLFIAVTIHACSSSGSQYFRVIEDLIVMLGYLQNSKNKRTQNMAVALQLRVLQAAMEFIRTTANHDSENLTDSLQSPSAPHHAVVQKRKSIAGPRKFPLAQTESLLMKMRSVANDELHVMMQRRMSQENPSQATETELAQRLQRLTVLAVNRIIYQEFNSDIIDILRTPENVTQSKTSVFQTEISEENIHHEQSSVFNPFQKEIFTYLVEGFKVSIGSSKASGSKQQWTKILWSCKETFRMQLGRLLVHILSPAHAAQERKQIFEIVHEPNHQEILRDCLSPSLQHGAKLVLYLSELIHNHQGELTEEELGTAELLMNALKLCGHKCIPPSASTKADLIKMIKEEQKKYETEEGVNKAAWQKTVNNNQQSLFQRLDSKSKDISKIAADITQAVSLSQGNERKKVIQHIRGMYKVDLSASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCYLTIPNKYLLRDRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVESSSLQGELEPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFDNTKVRDDVYHNILTNNLPNLLEYGNITALTNLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGAKLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYADNILRLKSKQSEPPVNFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGVSINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAWCRKDQQRLKQPMFYSFLSSYAAG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Phosphorylation	ELLTLLLSLLPLVWK HHHHHHHHHHHHHHC	28.03	30177828
112	Phosphorylation	ILTKEKNSSSQRSTQ EEECCCCCCCCCCHH	42.29	22468782
113	Phosphorylation	LTKEKNSSSQRSTQE EECCCCCCCCCCHHH	39.62	29083192
114	Phosphorylation	TKEKNSSSQRSTQEK ECCCCCCCCCCHHHH	29.45	29083192
117	Phosphorylation	KNSSSQRSTQEKLHL CCCCCCCCHHHHHHH	27.14	29083192
118	Phosphorylation	NSSSQRSTQEKLHLE CCCCCCCHHHHHHHC	42.83	22468782
134	Phosphorylation	SALSSQVSAKVNVFR HHHHHHHHHHHHHHH	18.09	28857561
153	Phosphorylation	QRKITHRYSVRDARK HHCCCCCCCHHHHHH	12.15	27080861
154	Phosphorylation	RKITHRYSVRDARKT HCCCCCCCHHHHHHH	15.61	27080861
161	Phosphorylation	SVRDARKTQLSTSDS CHHHHHHHCCCCCCC	29.23	-
164	Phosphorylation	DARKTQLSTSDSEAN HHHHHCCCCCCCCCC	18.95	28450419
165	Phosphorylation	ARKTQLSTSDSEANS HHHHCCCCCCCCCCC	45.18	28450419
166	Phosphorylation	RKTQLSTSDSEANSD HHHCCCCCCCCCCCC	35.45	28450419
168	Phosphorylation	TQLSTSDSEANSDEK HCCCCCCCCCCCCCC	38.07	28450419
172	Phosphorylation	TSDSEANSDEKGIAM CCCCCCCCCCCCCCC	54.95	23312004
193	Phosphorylation	HLLHHFLTSFPKQDH HHHHHHHHCCCCCCC	27.64	-
214	Phosphorylation	RLATKEQTPPDAMAL HHCCCCCCCCCHHHH	37.57	23403867
224	Phosphorylation	DAMALENSREIIPRQ CHHHHHCCCCCCCCC	23.16	23403867
233	Phosphorylation	EIIPRQGSNTDILSE CCCCCCCCCCCCCCC	28.37	27251275
235	Phosphorylation	IPRQGSNTDILSEPA CCCCCCCCCCCCCHH	26.55	27251275
263	Phosphorylation	DLCHVLLSLLEKVCK HHHHHHHHHHHHHHC	27.09	24719451
316	Phosphorylation	RVVSAGWTEEPVALI CCCCCCCCHHHHHHH	29.56	-
351	Acetylation	MMPENLRKNLTELLR CCCHHHHHHHHHHHH	60.52	30590209
380	Ubiquitination	PFAPRQKKTLQEVQE CCCCHHCCCHHHHHH	46.24	29967540
466	Phosphorylation	DGVPPEASEHLKALI CCCCHHHHHHHHHHH	24.72	21949786
475	Phosphorylation	HLKALINSVMKIMST HHHHHHHHHHHHHHH	19.32	21949786
488	Phosphorylation	STVKKVKSEQLHHSM HHHHHHCHHHHHHCH	33.30	29116813
494	Phosphorylation	KSEQLHHSMCTRKRH CHHHHHHCHHHHHHH	12.57	29116813
517	Phosphorylation	MHHHRDLSGLLVSAF HHCCCCHHHHHHHHH	31.51	25850435
526	Ubiquitination	LLVSAFKNQVSKNPF HHHHHHHCCCCCCCC	40.82	21890473
780	Phosphorylation	VLQIYVKTLPILLKS HHHHHHHHHHHHHHH	27.94	21815630
864	Phosphorylation	SFHHQQAYSDSPQSL CCCCCCCCCCCHHHH	14.52	27080861
865	Phosphorylation	FHHQQAYSDSPQSLS CCCCCCCCCCHHHHH	34.33	27080861
867	Phosphorylation	HQQAYSDSPQSLSKF CCCCCCCCHHHHHHH	20.92	27080861
870	Phosphorylation	AYSDSPQSLSKFYAG CCCCCHHHHHHHHHH	37.69	27080861
872	Phosphorylation	SDSPQSLSKFYAGLK CCCHHHHHHHHHHHH	26.43	27080861
882	Phosphorylation	YAGLKEAYPKRRKTV HHHHHHHCCCCCCCC	15.46	28509920
971	Phosphorylation	WSMCRWIYMLSSVFQ HHHHHHHHHHHHHHH	5.76	27732954
974	Phosphorylation	CRWIYMLSSVFQKQF HHHHHHHHHHHHHHH	14.13	27732954
975	Phosphorylation	RWIYMLSSVFQKQFY HHHHHHHHHHHHHHH	24.00	27732954
979	Methylation	MLSSVFQKQFYRLGG HHHHHHHHHHHHHCC	30.80	-
1017	Phosphorylation	GKKEGDTSVNENQDL CCCCCCCCCCCCCHH	27.90	25627689
1054	Phosphorylation	PIPSELGSLKKSADS CCCHHHHHHHHHHHH	50.03	24719451
1061	Phosphorylation	SLKKSADSLGKLELQ HHHHHHHHCCCHHHE	38.44	24275569
1072	Phosphorylation	LELQHISSINVEEVS HHHEEEECCCCEECC	19.99	30576142
1081	Phosphorylation	NVEEVSATEAAPEEA CCEECCCCCCCHHHH	20.74	30576142
1093	Phosphorylation	EEAKLFTSQESETSL HHHCCCCCCCCHHHH	25.31	30576142
1119	Phosphorylation	ICLHGARTSQQKMEL HHHHCCCCCHHHCCC	30.28	-
1186	Phosphorylation	NDAMTEKSHQSAEEL CHHHCHHHHHCHHHH	22.11	28450419
1189	Phosphorylation	MTEKSHQSAEELSSQ HCHHHHHCHHHHHCC	32.02	28450419
1194	Phosphorylation	HQSAEELSSQPGDFS HHCHHHHHCCCCCCC	30.15	28450419
1195	Phosphorylation	QSAEELSSQPGDFSE HCHHHHHCCCCCCCH	53.68	27251789
1201	Phosphorylation	SSQPGDFSEEAEDSQ HCCCCCCCHHHCCCC	38.99	27251789
1207	Phosphorylation	FSEEAEDSQCCSFKL CCHHHCCCCCCEEEE	19.34	28450419
1211	Phosphorylation	AEDSQCCSFKLLVEE HCCCCCCEEEEEEEE	32.80	28450419
1225	Phosphorylation	EEGYEADSESNPEDG ECCCCCCCCCCCCCC	50.39	28634120
1227	Phosphorylation	GYEADSESNPEDGET CCCCCCCCCCCCCCC	62.73	28634120
1280	Phosphorylation	MLELNLLSASKAKLD HHHHHHHHHCHHHHH	33.39	23312004
1295	Phosphorylation	VLAHVFESFLKIIRQ HHHHHHHHHHHHHHH	25.14	24719451
1305	Ubiquitination	KIIRQKEKNVFLLMQ HHHHHHHCCEEEEEC	66.50	21890473
1305 (in isoform 1)	Ubiquitination	-	66.50	21890473
1305 (in isoform 2)	Ubiquitination	-	66.50	21890473
1305 (in isoform 3)	Ubiquitination	-	66.50	21890473
1489	Phosphorylation	ECIHEAESTTEKGKK EEEECCCCCCHHCCC	47.91	-
1490	Phosphorylation	CIHEAESTTEKGKKI EEECCCCCCHHCCCC	30.40	-
1491	Phosphorylation	IHEAESTTEKGKKIK EECCCCCCHHCCCCH	45.00	-
1503	Phosphorylation	KIKKRNKSLILPDSS CCHHCCCCCCCCCCC	24.96	28450419
1509	Phosphorylation	KSLILPDSSFDGTES CCCCCCCCCCCCCCC	30.85	26657352
1510	Phosphorylation	SLILPDSSFDGTESD CCCCCCCCCCCCCCC	34.43	29507054
1514	Phosphorylation	PDSSFDGTESDRPEG CCCCCCCCCCCCCCC	33.87	28450419
1516	Phosphorylation	SSFDGTESDRPEGAE CCCCCCCCCCCCCCC	38.46	27251789
1524	Phosphorylation	DRPEGAEYINPGERL CCCCCCCCCCCCCHH	12.88	27642862
1590	Phosphorylation	QENIFLPSKWQHLVL CCCCCCCHHHHHHHH	48.99	24719451
1622	Acetylation	IWVSGQRKPDVTLDF EEECCCCCCCEEEEE	37.37	7696093
1635	Phosphorylation	DFMLPRKTSLSSDSN EEECCCCCCCCCCCC	35.86	26657352
1703	Acetylation	VMPCKYGKPVNDYSK CCCCCCCCCCCCHHH	42.58	20167786
1710	Acetylation	KPVNDYSKYINKEIL CCCCCHHHHCCHHHH	43.87	20167786
1791	Ubiquitination	LLEPHHLKNLQPTEY HHCHHHHCCCCCCCH	51.78	29967540
1811	Phosphorylation	ILHEIGGTGIFVFLF HHHHHCCCCHHHHEE	23.14	22210691
1830	Phosphorylation	ELSSCEETQALALRV HHCCCHHHHHHHHHH	9.24	22210691
1840	Phosphorylation	LALRVILSLIKYNQQ HHHHHHHHHHHHCHH	19.54	24719451
1982	Phosphorylation	EYKEGQLTPMPREVC HHHCCCCCCCCHHHH	15.06	24719451
1999 (in isoform 2)	Phosphorylation	-	5.61	30631047
2051	Phosphorylation	IFQEKVRSIMYLRHS HHHHHHHHHHEEEEC	18.07	28450419
2058	Phosphorylation	SIMYLRHSSSGGRSL HHHEEEECCCCCCCC	21.55	28450419
2059	Phosphorylation	IMYLRHSSSGGRSLM HHEEEECCCCCCCCC	27.20	28450419
2060	Phosphorylation	MYLRHSSSGGRSLMS HEEEECCCCCCCCCC	48.56	28450419
2074	Phosphorylation	SPGFMVISPSGFTAS CCCEEEECCCCCCCC	11.12	22210691
2103	Phosphorylation	MAAHMLRSRSLPAFP HHHHHHHHCCCCCCC	23.43	23401153
2105	Phosphorylation	AHMLRSRSLPAFPTS HHHHHHCCCCCCCCH	39.69	29255136
2111	Phosphorylation	RSLPAFPTSSLLTQS CCCCCCCCHHHHHHH	25.21	23927012
2112	Phosphorylation	SLPAFPTSSLLTQSQ CCCCCCCHHHHHHHH	21.16	24702127
2113	Phosphorylation	LPAFPTSSLLTQSQK CCCCCCHHHHHHHHH	29.85	23403867
2116	Phosphorylation	FPTSSLLTQSQKLTG CCCHHHHHHHHHHHH	31.31	23403867
2118	Phosphorylation	TSSLLTQSQKLTGSL CHHHHHHHHHHHHCC	24.85	23403867
2122	Phosphorylation	LTQSQKLTGSLGCSI HHHHHHHHHCCCCCH	31.59	30266825
2124	Phosphorylation	QSQKLTGSLGCSIDR HHHHHHHCCCCCHHH	19.16	23401153
2128	Phosphorylation	LTGSLGCSIDRLQNI HHHCCCCCHHHHHHH	26.23	29255136
2138	Phosphorylation	RLQNIADTYVATQSK HHHHHHHHHHHCCCC	15.75	-
2139	Phosphorylation	LQNIADTYVATQSKK HHHHHHHHHHCCCCC	6.66	-
2142	Phosphorylation	IADTYVATQSKKQNS HHHHHHHCCCCCCCC	24.27	27251275
2149	Phosphorylation	TQSKKQNSLGSSDTL CCCCCCCCCCCCHHH	31.45	29255136
2152	Phosphorylation	KKQNSLGSSDTLKKG CCCCCCCCCHHHHCC	30.27	29255136
2153	O-linked_Glycosylation	KQNSLGSSDTLKKGK CCCCCCCCHHHHCCC	32.58	30379171
2153	Phosphorylation	KQNSLGSSDTLKKGK CCCCCCCCHHHHCCC	32.58	29255136
2155	O-linked_Glycosylation	NSLGSSDTLKKGKED CCCCCCHHHHCCCHH	42.28	30379171
2155	Phosphorylation	NSLGSSDTLKKGKED CCCCCCHHHHCCCHH	42.28	29255136
2166	Phosphorylation	GKEDAFISSCESAKT CCHHHCHHHCCCCHH	23.60	26657352
2167	Phosphorylation	KEDAFISSCESAKTV CHHHCHHHCCCCHHH	19.65	29255136
2170	Phosphorylation	AFISSCESAKTVCEM HCHHHCCCCHHHHHH	39.12	29255136
2173	Phosphorylation	SSCESAKTVCEMEAV HHCCCCHHHHHHHHH	30.06	28555341
2182	Phosphorylation	CEMEAVLSAQVSVSD HHHHHHHHCEEEHHH	15.28	28555341
2186	Phosphorylation	AVLSAQVSVSDVPKG HHHHCEEEHHHCCCC	12.11	28555341
2213	Phosphorylation	QLGAEPRSEDDSPGD HCCCCCCCCCCCCCC	56.97	29255136
2217	Phosphorylation	EPRSEDDSPGDESCP CCCCCCCCCCCCCCC	43.00	27251789
2235	Phosphorylation	DYLKGLASFQRSHST HHHHHHHHHHHCCCH	27.27	24719451
2239	Phosphorylation	GLASFQRSHSTIASL HHHHHHHCCCHHHHH	15.82	28450419
2241	Phosphorylation	ASFQRSHSTIASLGL HHHHHCCCHHHHHCE	23.82	26657352
2242	Phosphorylation	SFQRSHSTIASLGLA HHHHCCCHHHHHCEE	18.35	28450419
2245	Phosphorylation	RSHSTIASLGLAFPS HCCCHHHHHCEECCC	21.08	28450419
2252	Phosphorylation	SLGLAFPSQNGSAAV HHCEECCCCCCCCCC	29.80	27080861
2256	Phosphorylation	AFPSQNGSAAVGRWP ECCCCCCCCCCCCCC	22.17	27080861
2264	Phosphorylation	AAVGRWPSLVDRNTD CCCCCCCCCCCCCCC	33.78	21815630
2270	Phosphorylation	PSLVDRNTDDWENFA CCCCCCCCCCHHHHH	35.91	29507054
2358	Phosphorylation	VIKLLDAYFARASKE HHHHHHHHHHHCCHH	9.46	22673903
2466	Ubiquitination	SKVADMLLDNGLLYV HHHHHHHHCCCHHHH	3.74	21890473
2563	Phosphorylation	AMEFIRTTANHDSEN HHHHHHHHCCCCCCC	18.66	27080861
2568	Phosphorylation	RTTANHDSENLTDSL HHHCCCCCCCCCHHC	22.34	27080861
2572	Phosphorylation	NHDSENLTDSLQSPS CCCCCCCCHHCCCCC	34.81	27080861
2574	Phosphorylation	DSENLTDSLQSPSAP CCCCCCHHCCCCCCC	24.07	27080861
2577	Phosphorylation	NLTDSLQSPSAPHHA CCCHHCCCCCCCCCH	26.56	28555341
2591	Phosphorylation	AVVQKRKSIAGPRKF HHHHCCCCCCCCCCC	23.00	24719451
2603	Phosphorylation	RKFPLAQTESLLMKM CCCCHHHHHHHHHHH	23.18	23909892
2605	Phosphorylation	FPLAQTESLLMKMRS CCHHHHHHHHHHHHH	30.14	23909892
2612	Phosphorylation	SLLMKMRSVANDELH HHHHHHHHHHHHHHH	23.29	23909892
2627	Phosphorylation	VMMQRRMSQENPSQA HHHHHHHHCCCCCCC	32.31	26657352
2632	Phosphorylation	RMSQENPSQATETEL HHHCCCCCCCHHHHH	43.99	29255136
2635	Phosphorylation	QENPSQATETELAQR CCCCCCCHHHHHHHH	35.48	28450419
2637	Phosphorylation	NPSQATETELAQRLQ CCCCCHHHHHHHHHH	31.76	23312004
2674	Phosphorylation	LRTPENVTQSKTSVF HCCCCCCCCCCCEEE	38.41	28348404
2676	Phosphorylation	TPENVTQSKTSVFQT CCCCCCCCCCEEEEE	28.65	25850435
2707	Phosphorylation	PFQKEIFTYLVEGFK HHHHHHHHHHHHCEE	22.93	-
2708	Phosphorylation	FQKEIFTYLVEGFKV HHHHHHHHHHHCEEE	9.67	-
2726	Ubiquitination	SSKASGSKQQWTKIL CCCCCCCHHHHHHHH	50.46	29967540
2731	Acetylation	GSKQQWTKILWSCKE CCHHHHHHHHHHCHH	32.61	24889131
2878	Phosphorylation	SLFQRLDSKSKDISK HHHHHHHHCCCCHHH	43.34	30177828
2880	Phosphorylation	FQRLDSKSKDISKIA HHHHHHCCCCHHHHH	39.24	30177828
2884	Phosphorylation	DSKSKDISKIAADIT HHCCCCHHHHHHHHH	28.30	30177828
3011	Phosphorylation	TVKDKAASESIRVNR HHCCHHHHCCCEECC	36.41	23403867
3013	Phosphorylation	KDKAASESIRVNRRC CCHHHHCCCEECCEE	17.13	23403867
3022	Phosphorylation	RVNRRCISVAPSRET EECCEEEEECCCHHH	18.82	22617229
3026	Phosphorylation	RCISVAPSRETAGEL EEEEECCCHHHHHHH	32.77	22617229
3191	Ubiquitination	LIYRNLSKPIAVQYK HHHCCCCCCEEEEEC	43.54	21890473
3191 (in isoform 1)	Ubiquitination	-	43.54	21890473
3199	Ubiquitination	PIAVQYKEKEDRYVD CEEEEECCCCCCHHH	57.66	21890473
3204	Phosphorylation	YKEKEDRYVDTYKYL ECCCCCCHHHHHHHH	18.26	26552605
3207	Phosphorylation	KEDRYVDTYKYLEEE CCCCHHHHHHHHHHH	16.33	23401153
3208	Phosphorylation	EDRYVDTYKYLEEEY CCCHHHHHHHHHHHH	7.99	26552605
3210	Phosphorylation	RYVDTYKYLEEEYRK CHHHHHHHHHHHHHC	14.66	26552605
3215	Phosphorylation	YKYLEEEYRKGARED HHHHHHHHHCCCCCC	22.39	23401153
3245	Ubiquitination	SNSGTVLHFLVRMPP CCCCCEEEEEEECCC	15.06	21890473
3299	Phosphorylation	ELIPEFFYLPEFLVN HHCHHHHCCHHHHHC	27.03	-
3457	Phosphorylation	EQVKEITYPSPLSWI HHHHHCCCCCCCHHH	13.84	-
3633	Phosphorylation	KPYSILISVSRDGTC CCEEEEEEECCCCCE	15.59	24719451
3659	Phosphorylation	QSLAGHKSPVTAVSA HHHCCCCCCCEEEEC	20.94	-
3662	Phosphorylation	AGHKSPVTAVSASET CCCCCCCEEEECCCC	25.40	-
3749	Acetylation	VREITFPKSNKPIIS EEEEECCCCCCCEEE	63.57	30590203
3756	Phosphorylation	KSNKPIISLTFSCDG CCCCCEEEEEEEECC	23.29	30576142
3771	Phosphorylation	HHLYTANSDGTVIAW CCEEECCCCCCEEEE	34.65	30576142
3774	Phosphorylation	YTANSDGTVIAWCRK EECCCCCCEEEEECC	17.46	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LYST_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LYST_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LYST_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1433T_HUMAN	YWHAQ	physical	11984006
CSK2B_HUMAN	CSNK2B	physical	11984006
TNNI3_HUMAN	TNNI3	physical	11984006
HGS_HUMAN	HGS	physical	11984006
1433B_HUMAN	YWHAB	physical	11984006
ERR1_HUMAN	ESRRA	physical	11984006
IMB1_HUMAN	KPNB1	physical	11984006
RT31_HUMAN	MRPS31	physical	11984006
DGC14_HUMAN	DGCR14	physical	11984006
NCDN_HUMAN	NCDN	physical	11984006
PCBP4_HUMAN	PCBP4	physical	11984006
VTA1_HUMAN	VTA1	physical	11984006
DJC14_HUMAN	DNAJC14	physical	11984006
CNTRB_HUMAN	CNTROB	physical	11984006
ATN1_HUMAN	ATN1	physical	11984006
EFS_HUMAN	EFS	physical	11984006
MED12_HUMAN	MED12	physical	11984006
HNRPM_HUMAN	HNRNPM	physical	11984006
CENPJ_HUMAN	CENPJ	physical	11984006
RM17_HUMAN	MRPL17	physical	11984006
ZN521_HUMAN	ZNF521	physical	11984006
CELF4_HUMAN	CELF4	physical	11984006
1433Z_HUMAN	YWHAZ	physical	11984006

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 214500: Chediak-Higashi syndrome (CHS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2103; SER-2105 ANDSER-2124, AND MASS SPECTROMETRY.
PubMed: 19369195