| UniProt ID | CNTRB_HUMAN | |
|---|---|---|
| UniProt AC | Q8N137 | |
| Protein Name | Centrobin | |
| Gene Name | CNTROB | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 903 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Centriole-associated, asymmetrically localizes to the daughter centriole. | |
| Protein Description | Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.. | |
| Protein Sequence | MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDLTSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETVPQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSHSQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKTEKPPARKKSGHPAPSSMRSRGGVWR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MATSADSPSSPLGA -CCCCCCCCCCCCCH | 26.80 | 28348404 | |
| 9 | Phosphorylation | ATSADSPSSPLGAED CCCCCCCCCCCCHHH | 48.84 | 28348404 | |
| 10 | Phosphorylation | TSADSPSSPLGAEDL CCCCCCCCCCCHHHH | 27.77 | 28348404 | |
| 19 | Phosphorylation | LGAEDLLSDSSEPPG CCHHHHCCCCCCCCC | 42.62 | 23401153 | |
| 21 | Phosphorylation | AEDLLSDSSEPPGLN HHHHCCCCCCCCCHH | 32.97 | 28348404 | |
| 22 | Phosphorylation | EDLLSDSSEPPGLNQ HHHCCCCCCCCCHHH | 60.14 | 28348404 | |
| 31 | Phosphorylation | PPGLNQVSSEVTSQL CCCHHHCCHHHHHHH | 15.83 | 23401153 | |
| 32 | Phosphorylation | PGLNQVSSEVTSQLY CCHHHCCHHHHHHHH | 36.91 | 23401153 | |
| 35 | Phosphorylation | NQVSSEVTSQLYASL HHCCHHHHHHHHHHH | 13.50 | - | |
| 36 | Phosphorylation | QVSSEVTSQLYASLR HCCHHHHHHHHHHHH | 24.30 | - | |
| 41 | Phosphorylation | VTSQLYASLRLSRQA HHHHHHHHHHHHHHH | 10.64 | 23909892 | |
| 45 | Phosphorylation | LYASLRLSRQAEATA HHHHHHHHHHHHHHH | 18.86 | 23909892 | |
| 51 | Phosphorylation | LSRQAEATARAQLYL HHHHHHHHHHEEEEC | 14.26 | 26074081 | |
| 57 | Phosphorylation | ATARAQLYLPSTSPP HHHHEEEECCCCCCC | 12.41 | 25850435 | |
| 60 | Phosphorylation | RAQLYLPSTSPPHEG HEEEECCCCCCCCCC | 38.63 | 24972180 | |
| 61 | Phosphorylation | AQLYLPSTSPPHEGL EEEECCCCCCCCCCH | 43.23 | 30183078 | |
| 62 | Phosphorylation | QLYLPSTSPPHEGLD EEECCCCCCCCCCHH | 40.55 | 23401153 | |
| 76 | Phosphorylation | DGFAQELSRSLSVGL HHHHHHHHHHHHHHH | 21.04 | 22617229 | |
| 78 | Phosphorylation | FAQELSRSLSVGLEK HHHHHHHHHHHHHHH | 22.94 | 26657352 | |
| 80 | Phosphorylation | QELSRSLSVGLEKNL HHHHHHHHHHHHHHC | 18.52 | 23401153 | |
| 88 (in isoform 2) | Ubiquitination | - | 68.14 | - | |
| 94 | Ubiquitination | LKKKDGSKHIFEMES CCCCCCCCEEEEHHH | 46.37 | - | |
| 108 | Phosphorylation | SVRGQLQTMLQTSRD HHHHHHHHHHHHCCC | 28.57 | 30242111 | |
| 112 | Phosphorylation | QLQTMLQTSRDTAYR HHHHHHHHCCCCCCC | 23.05 | 30242111 | |
| 113 | Phosphorylation | LQTMLQTSRDTAYRD HHHHHHHCCCCCCCC | 18.39 | 30242111 | |
| 128 | Phosphorylation | PLIPGAGSERREEDS CCCCCCCCCCCCCCC | 27.65 | 28985074 | |
| 135 | Phosphorylation | SERREEDSFDSDSTA CCCCCCCCCCCCCHH | 33.94 | 27732954 | |
| 138 | Phosphorylation | REEDSFDSDSTATLL CCCCCCCCCCHHHHC | 31.30 | 27732954 | |
| 140 | Phosphorylation | EDSFDSDSTATLLNT CCCCCCCCHHHHCCC | 24.72 | 27732954 | |
| 141 | Phosphorylation | DSFDSDSTATLLNTR CCCCCCCHHHHCCCC | 28.75 | 27732954 | |
| 143 | Phosphorylation | FDSDSTATLLNTRPL CCCCCHHHHCCCCCH | 31.69 | 27732954 | |
| 147 | Phosphorylation | STATLLNTRPLQDLS CHHHHCCCCCHHHCC | 33.36 | 26657352 | |
| 154 | Phosphorylation | TRPLQDLSPSSSAQA CCCHHHCCCCCHHHH | 30.90 | 27732954 | |
| 156 | Phosphorylation | PLQDLSPSSSAQALE CHHHCCCCCHHHHHH | 33.28 | 27732954 | |
| 157 | Phosphorylation | LQDLSPSSSAQALEE HHHCCCCCHHHHHHH | 32.83 | 27732954 | |
| 158 | Phosphorylation | QDLSPSSSAQALEEL HHCCCCCHHHHHHHH | 28.83 | 27732954 | |
| 169 | Phosphorylation | LEELFPRYTSLRPGP HHHHCHHCCCCCCCC | 10.83 | 27642862 | |
| 170 | Phosphorylation | EELFPRYTSLRPGPP HHHCHHCCCCCCCCC | 23.67 | 27251275 | |
| 171 | Phosphorylation | ELFPRYTSLRPGPPL HHCHHCCCCCCCCCC | 17.28 | 27251275 | |
| 227 | Methylation | VAVAADRKKDTMIEQ HHHHHHHCHHHHHHH | 56.39 | 115972531 | |
| 227 (in isoform 2) | Ubiquitination | - | 56.39 | - | |
| 228 | Methylation | AVAADRKKDTMIEQL HHHHHHCHHHHHHHH | 60.36 | 115972539 | |
| 230 | Phosphorylation | AADRKKDTMIEQLDK HHHHCHHHHHHHHHH | 29.00 | 20068231 | |
| 237 | Ubiquitination | TMIEQLDKTLARVVE HHHHHHHHHHHHHHC | 54.77 | 29967540 | |
| 258 | Methylation | AERTEVLRGLQEEHQ HHHHHHHHHHHHHHH | 49.29 | 115482163 | |
| 308 | Phosphorylation | LQQRERETLEEERQA HHHHHHHHHHHHHHH | 45.77 | 22210691 | |
| 322 | Ubiquitination | ALTLRLEAEQQRCCV HHHHHHHHHHHHHEE | 25.21 | 21963094 | |
| 380 | Ubiquitination | YQALQEESQAQLERE HHHHHHHHHHHHHHH | 30.02 | 21963094 | |
| 424 | Ubiquitination | GELDTARRERDALQL CCHHHHHHHHHHHHH | 40.62 | 21963094 | |
| 460 | Phosphorylation | VQLEQRVTERLAQAQ HHHHHHHHHHHHHHH | 19.99 | 24719451 | |
| 469 | Phosphorylation | RLAQAQESSLRQAAS HHHHHHHHHHHHHHH | 23.69 | 24719451 | |
| 473 | Ubiquitination | AQESSLRQAASLREH HHHHHHHHHHHHHHH | 46.72 | 22505724 | |
| 504 | Ubiquitination | ASQLAQFKVEMAERE HHHHHHHHHHHHHHH | 25.79 | 29967540 | |
| 521 | Phosphorylation | QQQVAEDYELRLARE HHHHHHHHHHHHHHH | 14.36 | 27642862 | |
| 521 | Ubiquitination | QQQVAEDYELRLARE HHHHHHHHHHHHHHH | 14.36 | 21963094 | |
| 531 | Ubiquitination | RLAREQARVCELQSG HHHHHHHHHHHCCCC | 33.06 | 22505724 | |
| 544 | Ubiquitination | SGNQQLEEQRVELVE CCCHHHHHHHHHHHH | 52.89 | 21963094 | |
| 569 | Phosphorylation | DEANQLLSTTLPPPN HHHHHHHHCCCCCCC | 28.12 | 26074081 | |
| 570 | Phosphorylation | EANQLLSTTLPPPNP HHHHHHHCCCCCCCC | 32.11 | 26074081 | |
| 571 | Phosphorylation | ANQLLSTTLPPPNPP HHHHHHCCCCCCCCC | 33.61 | 26074081 | |
| 575 | Ubiquitination | LSTTLPPPNPPAPPA HHCCCCCCCCCCCCC | 65.11 | 22505724 | |
| 585 | Phosphorylation | PAPPAGPSSPGPQEP CCCCCCCCCCCCCCC | 48.52 | 26074081 | |
| 586 | Phosphorylation | APPAGPSSPGPQEPE CCCCCCCCCCCCCCC | 36.69 | 26074081 | |
| 602 | Phosphorylation | EERRVWTMPPMAVAL HHCCCCCCCHHHHHH | 1.74 | 32142685 | |
| 602 | Ubiquitination | EERRVWTMPPMAVAL HHCCCCCCCHHHHHH | 1.74 | 21963094 | |
| 610 | Ubiquitination | PPMAVALKPVLQQSR CHHHHHHHHHHHHHH | 24.28 | 21963094 | |
| 610 (in isoform 2) | Ubiquitination | - | 24.28 | - | |
| 646 | Ubiquitination | LLLGPSFQSQHSFQP HHHCCCCCCCCCCCC | 46.66 | 21963094 | |
| 672 | Ubiquitination | AGAFSALGAFHPDHR HHHHHHHCCCCCCCC | 26.39 | 22505724 | |
| 698 | Ubiquitination | PDGEGLLKQGLPPAQ CCCCCHHHCCCCHHH | 47.57 | 2190698 | |
| 698 (in isoform 1) | Ubiquitination | - | 47.57 | 21906983 | |
| 698 (in isoform 2) | Ubiquitination | - | 47.57 | 21906983 | |
| 698 (in isoform 3) | Ubiquitination | - | 47.57 | 21906983 | |
| 698 (in isoform 5) | Ubiquitination | - | 47.57 | 21906983 | |
| 699 | Phosphorylation | DGEGLLKQGLPPAQL CCCCHHHCCCCHHHH | 59.64 | 32142685 | |
| 743 | Phosphorylation | SGPLTVPSWEEAPQV CCCCCCCCHHHCCCC | 42.66 | 26471730 | |
| 743 | Ubiquitination | SGPLTVPSWEEAPQV CCCCCCCCHHHCCCC | 42.66 | 21963094 | |
| 761 | Ubiquitination | PPPVHKTKVPLAMAS CCCCCCCCCCHHHHH | 46.81 | 22505724 | |
| 761 (in isoform 2) | Ubiquitination | - | 46.81 | - | |
| 769 | Phosphorylation | VPLAMASSLFRVPEP CCHHHHHHHCCCCCC | 23.22 | 24719451 | |
| 778 | Phosphorylation | FRVPEPPSSHSQGSG CCCCCCCCCCCCCCC | 51.93 | 30108239 | |
| 779 | Phosphorylation | RVPEPPSSHSQGSGP CCCCCCCCCCCCCCC | 32.69 | 23663014 | |
| 781 | Phosphorylation | PEPPSSHSQGSGPSS CCCCCCCCCCCCCCC | 37.88 | 17525332 | |
| 784 | Phosphorylation | PSSHSQGSGPSSGSP CCCCCCCCCCCCCCC | 39.63 | 23663014 | |
| 787 | Phosphorylation | HSQGSGPSSGSPERG CCCCCCCCCCCCCCC | 51.35 | 29255136 | |
| 788 | Phosphorylation | SQGSGPSSGSPERGG CCCCCCCCCCCCCCC | 46.56 | 29255136 | |
| 790 | Phosphorylation | GSGPSSGSPERGGDG CCCCCCCCCCCCCCC | 26.07 | 29255136 | |
| 799 | Phosphorylation | ERGGDGLTFPRQLME CCCCCCCCHHHHHHH | 36.80 | 27174698 | |
| 808 | Phosphorylation | PRQLMEVSQLLRLYQ HHHHHHHHHHHHHHH | 11.21 | 24043423 | |
| 814 | Phosphorylation | VSQLLRLYQARGWGA HHHHHHHHHHCCCCC | 8.16 | - | |
| 832 | Ubiquitination | EDLLLYLKRLEHSGT HHHHHHHHHHHHCCC | 41.18 | 21963094 | |
| 832 (in isoform 2) | Ubiquitination | - | 41.18 | - | |
| 837 | Phosphorylation | YLKRLEHSGTDGRGD HHHHHHHCCCCCCCC | 33.73 | - | |
| 853 | Phosphorylation | VPRRNTDSRLGEIPR CCCCCCCCCCCCCCH | 27.63 | 20860994 | |
| 861 | Ubiquitination | RLGEIPRKEIPSQAV CCCCCCHHHCCCCCC | 55.42 | 29967540 | |
| 862 | Ubiquitination | LGEIPRKEIPSQAVP CCCCCHHHCCCCCCC | 62.50 | 29967540 | |
| 865 | Phosphorylation | IPRKEIPSQAVPRRL CCHHHCCCCCCCHHH | 36.11 | 26074081 | |
| 883 | Ubiquitination | PKTEKPPARKKSGHP CCCCCCCCCCCCCCC | 44.44 | 29967540 | |
| 883 (in isoform 2) | Ubiquitination | - | 44.44 | - | |
| 887 | Phosphorylation | KPPARKKSGHPAPSS CCCCCCCCCCCCCCH | 45.42 | 24719451 | |
| 909 | Phosphorylation | WR------------- CC------------- | 24719451 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CNTRB_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CNTRB_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-781, AND MASSSPECTROMETRY. | |
