PDD2L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDD2L_HUMAN
• UniProt AC: Q9BRP1
• Protein Name: Programmed cell death protein 2-like
• Gene Name: PDCD2L
• Organism: Homo sapiens (Human).
• Sequence Length: 358
• Protein Description: Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase..
• Protein Sequence: MAAVLKPVLLGLRDAPVHGSPTGPGAWTASKLGGIPDALPTVAAPRPVCQRCGQPLALVVQVYCPLEGSPFHRLLHVFACACPGCSTGGARSWKVFRSQCLQVPEREAQDAQKQGNSLAAEDWCEGADDWGSDTEEGPSPQFTLDFGNDASSAKDVDWTARLQDLRLQDAVLGAAHPVPPGLPLFLPYYICVADEDDYRDFVNLDHAHSLLRDYQQREGIAMDQLLSQSLPNDGDEKYEKTIIKSGDQTFYKFMKRIAACQEQILRYSWSGEPLFLTCPTSEVTELPACSQCGGQRIFEFQLMPALVSMLKSANLGLSVEFGTILVYTCEKSCWPPNHQTPMEEFCIIQEDPDELLFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAVLKPVL ------CCCCCHHHH	13.28	22814378
6	Ubiquitination	--MAAVLKPVLLGLR --CCCCCHHHHHCCC	26.87	21139048
20	Phosphorylation	RDAPVHGSPTGPGAW CCCCCCCCCCCCCCC	12.38	25159151
22	Phosphorylation	APVHGSPTGPGAWTA CCCCCCCCCCCCCCH	58.67	21712546
28	Phosphorylation	PTGPGAWTASKLGGI CCCCCCCCHHHHCCC	22.11	26074081
31	Ubiquitination	PGAWTASKLGGIPDA CCCCCHHHHCCCCCC	49.00	-
94	Ubiquitination	TGGARSWKVFRSQCL CCCHHHHHHHHHHHC	32.51	-
132	Phosphorylation	EGADDWGSDTEEGPS CCCCCCCCCCCCCCC	36.79	25954137
134	Phosphorylation	ADDWGSDTEEGPSPQ CCCCCCCCCCCCCCC	37.32	22210691
209	Phosphorylation	VNLDHAHSLLRDYQQ CCHHHHHHHHHHHHH	29.86	20873877
229	Phosphorylation	MDQLLSQSLPNDGDE HHHHHHCCCCCCCCH	42.28	30576142
238	Phosphorylation	PNDGDEKYEKTIIKS CCCCCHHHHEEEEEC	22.17	29759185
240	Ubiquitination	DGDEKYEKTIIKSGD CCCHHHHEEEEECCC	41.77	27667366
241	Phosphorylation	GDEKYEKTIIKSGDQ CCHHHHEEEEECCCH	18.92	29759185
244	Ubiquitination	KYEKTIIKSGDQTFY HHHEEEEECCCHHHH	44.53	33845483
245	Phosphorylation	YEKTIIKSGDQTFYK HHEEEEECCCHHHHH	36.87	-
249	Phosphorylation	IIKSGDQTFYKFMKR EEECCCHHHHHHHHH	33.40	29759185
251	Phosphorylation	KSGDQTFYKFMKRIA ECCCHHHHHHHHHHH	13.50	29759185
252	Ubiquitination	SGDQTFYKFMKRIAA CCCHHHHHHHHHHHH	34.49	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDD2L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDD2L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDD2L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRP14_HUMAN	SRP14	physical	26186194
ANM3_HUMAN	PRMT3	physical	26186194
SLX4I_HUMAN	SLX4IP	physical	26186194
PCBP3_HUMAN	PCBP3	physical	26186194
ANM3_HUMAN	PRMT3	physical	28514442
PCBP3_HUMAN	PCBP3	physical	28514442
SLX4I_HUMAN	SLX4IP	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.