| UniProt ID | TPGS1_HUMAN | |
|---|---|---|
| UniProt AC | Q6ZTW0 | |
| Protein Name | Tubulin polyglutamylase complex subunit 1 | |
| Gene Name | TPGS1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 290 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, axon. Cell projection, dendrite. Cytoplasm, cytoskeleton, micr | |
| Protein Description | May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity).. | |
| Protein Sequence | MAAVEKRRQAVPPPAGFTDSGRQSVSRAAGAAESEEDFLRQVGVTEMLRAALLKVLEARPEEPIAFLAHYFENMGLRSPVNGGAGEPPGQLLLQQQRLGRALWHLRLAHHSQRAAFNNNVSVAYECLSAGGRRKRPGLDGRTYSELLRRICRDGQAPEEVVAPLLRKVQCRDHEAVPLSVFRAGTLTCFVLLEFVARAGALFQLLEDSAAAVADRRVGQAVLDTLEGALQASDAAAPARFLEAGSRLGPDSLALALDRAVGGRRPSAPMTREEFLERAAALFIAKVKPVG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Ubiquitination | --MAAVEKRRQAVPP --CCHHHHHHHCCCC | 46.40 | - | |
| 20 | Phosphorylation | PPAGFTDSGRQSVSR CCCCCCCHHHHHHHH | 32.58 | 28555341 | |
| 24 | Phosphorylation | FTDSGRQSVSRAAGA CCCHHHHHHHHHHCC | 22.24 | 27251275 | |
| 26 | Phosphorylation | DSGRQSVSRAAGAAE CHHHHHHHHHHCCCC | 22.81 | 27251275 | |
| 34 | Phosphorylation | RAAGAAESEEDFLRQ HHHCCCCCHHHHHHH | 41.37 | 30001349 | |
| 54 | Ubiquitination | MLRAALLKVLEARPE HHHHHHHHHHHHCCC | 45.70 | 21890473 | |
| 66 (in isoform 1) | Ubiquitination | - | 6.83 | 21890473 | |
| 66 (in isoform 2) | Ubiquitination | - | 6.83 | 21890473 | |
| 251 | Phosphorylation | GSRLGPDSLALALDR CHHCCHHHHHHHHHH | 20.76 | 27251275 | |
| 266 | Phosphorylation | AVGGRRPSAPMTREE HHCCCCCCCCCCHHH | 43.10 | 30266825 | |
| 270 | Phosphorylation | RRPSAPMTREEFLER CCCCCCCCHHHHHHH | 33.59 | 23403867 | |
| 285 | Ubiquitination | AAALFIAKVKPVG-- HHHHHHHHCCCCC-- | 46.07 | 21963094 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TPGS1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TPGS1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TPGS1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TPGS1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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