LRC49_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRC49_HUMAN
• UniProt AC: Q8IUZ0
• Protein Name: Leucine-rich repeat-containing protein 49
• Gene Name: LRRC49
• Organism: Homo sapiens (Human).
• Sequence Length: 686
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Sequence: MIPGKYRSVSGRAANNVNCGLHLVIQTSSLPEKNKVEFKLNKDTSSFPGRLLQHDLERNYSSRQGDHINLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKKRLTINNVARQWDLQQQRVANIATNEDRKDSDSPQDPCQIDGSTLSAFPEETGPLDSGLNNALQGLSVIDTYLVEVDGDTLSLYGSGALESLDRNWSVQTAGMITTVSFTFIEFDEIVQVLPKLKIKFPNSLHLKFKETNLVMLQQFNALAQLRRIDQLTIDPQGNPVVNFTLWKYYVLFRLSHFSMQKINGTEVTQNDMIMAERLFGILAHVASSELPQYRLISILGDARKKQFRYLLESKGKKPGIINEENNDSKRLVGENTNRATLNYTTRDFYNEKLEEIKEKKKFCKTYIEDLVKEATEINMKNEALQKLWPQMFIELVRDAVIEIRNKNSYMKLCLQQITDQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	EFKLNKDTSSFPGRL EEEECCCCCCCCHHH	28.07	-
60	Phosphorylation	QHDLERNYSSRQGDH HHHHHHCCCCCCCCC	17.78	-
61	Phosphorylation	HDLERNYSSRQGDHI HHHHHCCCCCCCCCE	23.69	-
62	Phosphorylation	DLERNYSSRQGDHIN HHHHCCCCCCCCCEE	20.47	-
78	Ubiquitination	VSSSLSSFPILQRSS HHHHHHCCCCCCCCC	3.81	-
88	Ubiquitination	LQRSSEEKILYSDRL CCCCCCCCCCCCCCC	33.68	21906983
168	Ubiquitination	LLLGKNRIKKISNLE HHHCCCHHHHCCCCC	8.13	-
169	Ubiquitination	LLGKNRIKKISNLEN HHCCCHHHHCCCCCC	40.60	-
178	Ubiquitination	ISNLENLKSLDVLDL CCCCCCCCCCCEEEC	61.63	21906983
307	Phosphorylation	QLDMKRITEEERRMA CCCHHHCCHHHHHHH	41.18	26437602
332	Phosphorylation	KRESHKQSLLKEKKR HHHHHHHHHHHHHHH	40.24	24719451
562	Phosphorylation	LPQYRLISILGDARK CCHHHHHHHHHHHHH	19.16	29214152
574	Phosphorylation	ARKKQFRYLLESKGK HHHHHHHHHHHCCCC	19.54	20049867
614	Phosphorylation	NYTTRDFYNEKLEEI ECHHHHHHHHHHHHH	27.05	-
631	Phosphorylation	KKKFCKTYIEDLVKE HHHHHHHHHHHHHHH	6.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRC49_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRC49_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRC49_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPGS1_HUMAN	TPGS1	physical	28514442
K1841_HUMAN	KIAA1841	physical	28514442
TBC19_HUMAN	TBC1D19	physical	28514442
TPGS2_HUMAN	TPGS2	physical	28514442
PCM1_HUMAN	PCM1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.