TBC19_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBC19_HUMAN
• UniProt AC: Q8N5T2
• Protein Name: TBC1 domain family member 19
• Gene Name: TBC1D19
• Organism: Homo sapiens (Human).
• Sequence Length: 526
• Protein Description: May act as a GTPase-activating protein for Rab family protein(s)..
• Protein Sequence: MLQEESDLSLIIAQIVQKLKGSNLYSQLERQAWASLQRPEIKLESLKEDIKEFFKISGWEKKLQNAVYSELSVFPLPSHPAAPPEHLKEPLVYMRKAQGSWEKRILKSLNSMCTELSIPLARKRPVGEQKELLNKWNEMGTDEPDLSLFRPVYAPKDFLEVLINLRNPNYENGDSLSFRTHLGLIQVPLKVKDIPELKECFVELGLNIGQLGIDDSTQVPPELFENEHVRIGQKVLAEQDSAAAQQYIRQGSPTALRAELWALILNISSQPEDVLYYEQLKTNVIQHDLLVDSLIYKDVKLTASNDDYYFVFEDYLYQVLLCFSRDTSVLSHFAFNSASPPKSYIRGKLGLEEYAVFYPPNGVIPFHGFSMYVAPLCFLYHEPSKLYQIFREMYVRFFFRLHSISSHPSGIVSLCLLFETLLQTYLPQLFYHLREIGAQPLRISFKWMVRAFSGYLATDQLLLLWDRILGYNSLEILAVLAAAVFAFRAVNLMEVTSLAAAEAVLADLSTLKVMPLLQIFLFATVT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Acetylation	IIAQIVQKLKGSNLY HHHHHHHHHCCCCHH	41.07	11794941
20	Acetylation	AQIVQKLKGSNLYSQ HHHHHHHCCCCHHHH	68.29	11794951
25	Phosphorylation	KLKGSNLYSQLERQA HHCCCCHHHHHHHHH	9.91	22817900
45	Phosphorylation	RPEIKLESLKEDIKE CCCCCHHHHHHHHHH	56.00	22496350
47	Ubiquitination	EIKLESLKEDIKEFF CCCHHHHHHHHHHHH	63.72	29967540
65	Ubiquitination	GWEKKLQNAVYSELS CHHHHHHHHHHCCCC	41.64	22817900
68	Phosphorylation	KKLQNAVYSELSVFP HHHHHHHHCCCCCCC	8.26	-
70	Ubiquitination	LQNAVYSELSVFPLP HHHHHHCCCCCCCCC	27.63	-
70	Ubiquitination	LQNAVYSELSVFPLP HHHHHHCCCCCCCCC	27.63	22817900
93	Phosphorylation	HLKEPLVYMRKAQGS HHCCCHHHHHHCCCH	10.01	29449344
130	Ubiquitination	KRPVGEQKELLNKWN CCCCHHHHHHHHHHH	46.13	22817900
135	Ubiquitination	EQKELLNKWNEMGTD HHHHHHHHHHHCCCC	51.90	22817900
147	Phosphorylation	GTDEPDLSLFRPVYA CCCCCCHHHCCCCCC	32.61	24719451
169	Ubiquitination	LINLRNPNYENGDSL HHHCCCCCCCCCCCC	61.37	-
169	Ubiquitination	LINLRNPNYENGDSL HHHCCCCCCCCCCCC	61.37	22817900
177	Phosphorylation	YENGDSLSFRTHLGL CCCCCCCCEEEEEEE	19.34	24719451
234	Ubiquitination	EHVRIGQKVLAEQDS CCCCCCCHHHHHCCH	33.72	22817900
324	Phosphorylation	YQVLLCFSRDTSVLS HHHHHHHCCCCHHHH	28.40	24719451
327	Phosphorylation	LLCFSRDTSVLSHFA HHHHCCCCHHHHHHH	21.45	-
328	Phosphorylation	LCFSRDTSVLSHFAF HHHCCCCHHHHHHHC	25.91	-
337	Phosphorylation	LSHFAFNSASPPKSY HHHHHCCCCCCCHHH	24.54	24706070
339	Phosphorylation	HFAFNSASPPKSYIR HHHCCCCCCCHHHHC	41.37	29900121
354	Phosphorylation	GKLGLEEYAVFYPPN CCCCCEEEEEEECCC	9.93	-
358	Phosphorylation	LEEYAVFYPPNGVIP CEEEEEEECCCCCCC	15.92	-
387	Phosphorylation	YHEPSKLYQIFREMY HCCHHHHHHHHHHHH	11.87	-
444	Phosphorylation	GAQPLRISFKWMVRA CCCCCEEEHHHHHHH	17.84	24719451
509	Phosphorylation	EAVLADLSTLKVMPL HHHHHCHHHCCHHHH	32.04	-
510	Phosphorylation	AVLADLSTLKVMPLL HHHHCHHHCCHHHHH	37.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBC19_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBC19_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBC19_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TBC19_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-25, AND MASSSPECTROMETRY.
PubMed: 15592455