TPGS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPGS2_HUMAN
• UniProt AC: Q68CL5
• Protein Name: Tubulin polyglutamylase complex subunit 2
• Gene Name: TPGS2
• Organism: Homo sapiens (Human).
• Sequence Length: 300
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Sequence: MEEEASSPGLGCSKPHLEKLTLGITRILESSPGVTEVTIIEKPPAERHMISSWEQKNNCVMPEDVKNFYLMTNGFHMTWSVKLDEHIIPLGSMAINSISKLTQLTQSSMYSLPNAPTLADLEDDTHEASDDQPEKPHFDSRSVIFELDSCNGSGKVCLVYKSGKPALAEDTEIWFLDRALYWHFLTDTFTAYYRLLITHLGLPQWQYAFTSYGISPQAKQWFSMYKPITYNTNLLTEETDSFVNKLDPSKVFKSKNKIVIPKKKGPVQPAGGQKGPSGPSGPSTSSTSKSSSGSGNPTRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MEEEASSPGLGCSK -CCCCCCCCCCCCCH	29.99	25627689
14	Ubiquitination	SPGLGCSKPHLEKLT CCCCCCCHHHHHHHH	40.30	-
14	Ubiquitination	SPGLGCSKPHLEKLT CCCCCCCHHHHHHHH	40.30	-
19	Ubiquitination	CSKPHLEKLTLGITR CCHHHHHHHHHHHHH	53.80	-
19	Ubiquitination	CSKPHLEKLTLGITR CCHHHHHHHHHHHHH	53.80	-
42 (in isoform 3)	Ubiquitination	-	45.98	21906983
42 (in isoform 2)	Ubiquitination	-	45.98	21906983
42 (in isoform 1)	Ubiquitination	-	45.98	21906983
42	Ubiquitination	TEVTIIEKPPAERHM EEEEEEECCHHHHCC	45.98	21906983
42	Ubiquitination	TEVTIIEKPPAERHM EEEEEEECCHHHHCC	45.98	-
56	Ubiquitination	MISSWEQKNNCVMPE CCCCHHHHCCCCCCH	38.32	-
56	Ubiquitination	MISSWEQKNNCVMPE CCCCHHHHCCCCCCH	38.32	-
82	Ubiquitination	FHMTWSVKLDEHIIP CEEEEEEECCCCEEE	44.71	21906983
82	Ubiquitination	FHMTWSVKLDEHIIP CEEEEEEECCCCEEE	44.71	21906983
129 (in isoform 1)	Ubiquitination	-	38.44	21906983
129	Ubiquitination	EDDTHEASDDQPEKP CCCCCCCCCCCCCCC	38.44	-
135 (in isoform 3)	Ubiquitination	-	50.94	21906983
135 (in isoform 2)	Ubiquitination	-	50.94	21906983
135	Ubiquitination	ASDDQPEKPHFDSRS CCCCCCCCCCCCCCE	50.94	21906983
135	Ubiquitination	ASDDQPEKPHFDSRS CCCCCCCCCCCCCCE	50.94	21906983
164	Ubiquitination	CLVYKSGKPALAEDT EEEEECCCCCCCCCC	33.92	21906983
164 (in isoform 3)	Ubiquitination	-	33.92	21906983
164 (in isoform 2)	Ubiquitination	-	33.92	21906983
164	Ubiquitination	CLVYKSGKPALAEDT EEEEECCCCCCCCCC	33.92	2190698
229	Phosphorylation	FSMYKPITYNTNLLT HHCCCCCEECCCCCC	21.17	23663014
230	Phosphorylation	SMYKPITYNTNLLTE HCCCCCEECCCCCCC	22.25	23663014
232	Phosphorylation	YKPITYNTNLLTEET CCCCEECCCCCCCCC	19.48	23663014
236	Phosphorylation	TYNTNLLTEETDSFV EECCCCCCCCCHHHH	34.64	23663014
239	Phosphorylation	TNLLTEETDSFVNKL CCCCCCCCHHHHHHC	30.61	23663014
241	Phosphorylation	LLTEETDSFVNKLDP CCCCCCHHHHHHCCH	38.21	23663014
254	Phosphorylation	DPSKVFKSKNKIVIP CHHHHCCCCCEEEEC	29.96	-
274	Acetylation	VQPAGGQKGPSGPSG CCCCCCCCCCCCCCC	75.87	8242855
285	Phosphorylation	GPSGPSTSSTSKSSS CCCCCCCCCCCCCCC	35.64	22817900
286	Phosphorylation	PSGPSTSSTSKSSSG CCCCCCCCCCCCCCC	36.47	22817900
288	Phosphorylation	GPSTSSTSKSSSGSG CCCCCCCCCCCCCCC	32.27	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPGS2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPGS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPGS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTBL_HUMAN	ACTBL2	physical	28514442
ZMYM6_HUMAN	ZMYM6	physical	28514442
ACTB_HUMAN	ACTB	physical	28514442
UBR4_HUMAN	UBR4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.