DJC14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DJC14_HUMAN
• UniProt AC: Q6Y2X3
• Protein Name: DnaJ homolog subfamily C member 14
• Gene Name: DNAJC14
• Organism: Homo sapiens (Human).
• Sequence Length: 702
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface..
• Protein Sequence: MAQKHPGERGLYGAHHSGGASLRTLGPSVDPEIPSFSGLRDSAGTAPNGTRCLTEHSGPKHTQHPNPAHWLDPSHGPPGGPGPPRDAEDPDQSETSSEEESGVDQELSKENETGNQKDGNSFLSIPSACNCQGTPGIPEGPYSEGGNGSSSNFCHHCTSPALGEDELEEEYDDEESLKFPSDFSRVSSGKKPPSRRQRHRFPTKEDTREGGRRDPRSPGRHRLGRKRSQADKRKGLGLWGAEELCQLGQAGFWWLIELLVLVGEYVETCGHLIYACRQLKSSDLDLFRVWMGVWTGRLGGWAQVMFQFLSQGFYCGVGLFTRFLKLLGALLLLALALFLGFLQLGWRFLVGLGDRLGWRDKATWLFSWLDSPALQRCLTLLRDSRPWQRLVRIVQWGWLELPWVKQNINRQGNAPVASGRYCQPEEEVARLLTMAGVPEDELNPFHVLGVEATASDVELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNAEKRKEYEMKRMAENELSRSVNEFLSKLQDDLKEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPYHISFGSRIPGTRGRQRATPDAPPADLQDFLSRIFQVPPGQMPNGNFFAAPQPAPGAAAASKPNSTVPKGEAKPKRRKKVRRPFQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	HPGERGLYGAHHSGG CCCCCCCCCCCCCCC	18.32	27080861
17	Phosphorylation	GLYGAHHSGGASLRT CCCCCCCCCCCCCCC	29.11	25159151
21	Phosphorylation	AHHSGGASLRTLGPS CCCCCCCCCCCCCCC	22.97	27080861
28	Phosphorylation	SLRTLGPSVDPEIPS CCCCCCCCCCCCCCC	37.04	27251275
54	Phosphorylation	PNGTRCLTEHSGPKH CCCCCEECCCCCCCC	34.97	26330541
57	Phosphorylation	TRCLTEHSGPKHTQH CCEECCCCCCCCCCC	51.03	26330541
93	Phosphorylation	DAEDPDQSETSSEEE CCCCCCCCCCCCHHH	50.66	27732954
95	Phosphorylation	EDPDQSETSSEEESG CCCCCCCCCCHHHHC	42.68	27732954
96	Phosphorylation	DPDQSETSSEEESGV CCCCCCCCCHHHHCC	31.53	27732954
97	Phosphorylation	PDQSETSSEEESGVD CCCCCCCCHHHHCCC	57.35	27732954
101	Phosphorylation	ETSSEEESGVDQELS CCCCHHHHCCCHHHH	47.61	27732954
142	Phosphorylation	PGIPEGPYSEGGNGS CCCCCCCCCCCCCCC	30.15	24275569
143	Phosphorylation	GIPEGPYSEGGNGSS CCCCCCCCCCCCCCC	32.66	24275569
187	Phosphorylation	PSDFSRVSSGKKPPS CCCHHHCCCCCCCCC	32.06	25159151
188	Phosphorylation	SDFSRVSSGKKPPSR CCHHHCCCCCCCCCH	52.34	25159151
203	Phosphorylation	RQRHRFPTKEDTREG HHHCCCCCHHHCCCC	44.33	-
204	Acetylation	QRHRFPTKEDTREGG HHCCCCCHHHCCCCC	54.56	7976075
232	Ubiquitination	RKRSQADKRKGLGLW CCCCHHHHHCCCCCC	60.05	-
361	Ubiquitination	DRLGWRDKATWLFSW CCCCCCHHHHHHHHH	38.86	-
433	Phosphorylation	EEVARLLTMAGVPED HHHHHHHHHHCCCHH	15.01	22210691
516	Phosphorylation	AENELSRSVNEFLSK HHHHHHHHHHHHHHH	26.39	25159151
523	Ubiquitination	SVNEFLSKLQDDLKE HHHHHHHHHHHHHHH	52.92	-
585	Phosphorylation	SMLGLKITYFALMDG HHHCCEEEEEEECCC	15.82	30576142
586	Phosphorylation	MLGLKITYFALMDGK HHCCEEEEEEECCCE	7.13	30576142
609	Phosphorylation	GCQRVGISPDTHRVP CCCEEECCCCCCCCC	15.70	28674419
612	O-linked_Glycosylation	RVGISPDTHRVPYHI EEECCCCCCCCCCEE	18.24	29351928
612	Phosphorylation	RVGISPDTHRVPYHI EEECCCCCCCCCCEE	18.24	29396449
635	Phosphorylation	TRGRQRATPDAPPAD CCCCCCCCCCCCCHH	24.72	25850435
681	Phosphorylation	AAASKPNSTVPKGEA CCCCCCCCCCCCCCC	39.03	27251275
682	Phosphorylation	AASKPNSTVPKGEAK CCCCCCCCCCCCCCC	47.68	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DJC14_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DJC14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DJC14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DRD1_HUMAN	DRD1	physical	11331877
SARNP_HUMAN	SARNP	physical	26186194
CPVL_HUMAN	CPVL	physical	26186194
SARNP_HUMAN	SARNP	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.