dbPTM

ENPL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ENPL_MOUSE
UniProt AC	P08113
Protein Name	Endoplasmin
Gene Name	Hsp90b1
Organism	Mus musculus (Mouse).
Sequence Length	802
Subcellular Localization	Endoplasmic reticulum lumen . Melanosome.
Protein Description	Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity)..
Protein Sequence	MRVLWVLGLCCVLLTFGFVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVRKYSQFINFPIYVWSSKTETVEEPLEEDEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHSTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREATEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPEAQVEEEPEEEPEDTSEDAEDSEQDEGEEMDAGTEEEEEETEKESTEKDEL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	VEEDLGKSREGSRTD EECHHCCCCCCCCCC	33.49	27841257
42	Phosphorylation	LGKSREGSRTDDEVV HCCCCCCCCCCHHHH	27.53	27742792
44	Phosphorylation	KSREGSRTDDEVVQR CCCCCCCCCHHHHHH	49.88	27742792
62	N-linked_Glycosylation	AIQLDGLNASQIREL HHHCCCCCHHHHHHH	42.97	-
64	Phosphorylation	QLDGLNASQIRELRE HCCCCCHHHHHHHHH	25.68	27742792
72	Acetylation	QIRELREKSEKFAFQ HHHHHHHHHHHHHHH	58.44	22826441
75	Acetylation	ELREKSEKFAFQAEV HHHHHHHHHHHHHHH	49.43	22826441
75	Ubiquitination	ELREKSEKFAFQAEV HHHHHHHHHHHHHHH	49.43	22790023
87	Acetylation	AEVNRMMKLIINSLY HHHHHHHHHHHHHHH	27.47	22826441
95	Acetylation	LIINSLYKNKEIFLR HHHHHHHCCHHHHHH	67.83	23806337
95	Succinylation	LIINSLYKNKEIFLR HHHHHHHCCHHHHHH	67.83	23806337
95	Ubiquitination	LIINSLYKNKEIFLR HHHHHHHCCHHHHHH	67.83	-
97	Acetylation	INSLYKNKEIFLREL HHHHHCCHHHHHHHH	48.30	23201123
106	Phosphorylation	IFLRELISNASDALD HHHHHHHHCCHHHHH	38.68	18779572
107	N-linked_Glycosylation	FLRELISNASDALDK HHHHHHHCCHHHHHH	36.15	-
109	Phosphorylation	RELISNASDALDKIR HHHHHCCHHHHHHHE	27.89	18779572
114	Ubiquitination	NASDALDKIRLISLT CCHHHHHHHEEEEEC	30.49	22790023
133	Phosphorylation	LAGNEELTVKIKCDK CCCCCEEEEEEEECC	24.04	18779572
138	S-nitrosocysteine	ELTVKIKCDKEKNLL EEEEEEEECCCCCEE	11.71	-
138	S-nitrosylation	ELTVKIKCDKEKNLL EEEEEEEECCCCCEE	11.71	20925432
140	Acetylation	TVKIKCDKEKNLLHV EEEEEECCCCCEEEE	78.89	23201123
148	Phosphorylation	EKNLLHVTDTGVGMT CCCEEEEECCCCCCC	19.66	18779572
150	Phosphorylation	NLLHVTDTGVGMTRE CEEEEECCCCCCCHH	25.13	18779572
161	Acetylation	MTREELVKNLGTIAK CCHHHHHHHHHHHHH	60.11	23864654
161	Ubiquitination	MTREELVKNLGTIAK CCHHHHHHHHHHHHH	60.11	22790023
168	Acetylation	KNLGTIAKSGTSEFL HHHHHHHHHCHHHHH	45.64	23806337
168	Succinylation	KNLGTIAKSGTSEFL HHHHHHHHHCHHHHH	45.64	23806337
168	Ubiquitination	KNLGTIAKSGTSEFL HHHHHHHHHCHHHHH	45.64	-
171	Phosphorylation	GTIAKSGTSEFLNKM HHHHHHCHHHHHHHH	31.97	27841257
172	Phosphorylation	TIAKSGTSEFLNKMT HHHHHCHHHHHHHHH	29.85	24759943
217	N-linked_Glycosylation	IVTSKHNNDTQHIWE EEEECCCCCCCCEEE	54.12	19349973
219	O-linked_Glycosylation	TSKHNNDTQHIWESD EECCCCCCCCEEECC	24.95	30059200
219	Phosphorylation	TSKHNNDTQHIWESD EECCCCCCCCEEECC	24.95	-
231	Phosphorylation	ESDSNEFSVIADPRG ECCCCCEEEEECCCC	13.36	-
248	Phosphorylation	LGRGTTITLVLKEEA CCCCCEEEEEECHHH	14.55	18779572
265	Acetylation	YLELDTIKNLVRKYS CCCHHHHHHHHHHHH	46.45	22826441
265	Ubiquitination	YLELDTIKNLVRKYS CCCHHHHHHHHHHHH	46.45	22790023
270	Acetylation	TIKNLVRKYSQFINF HHHHHHHHHHHHHCC	41.60	22826441
286	Phosphorylation	IYVWSSKTETVEEPL EEEEECCCCCCCCCC	38.54	23984901
288	Phosphorylation	VWSSKTETVEEPLEE EEECCCCCCCCCCCC	38.15	23984901
300	Acetylation	LEEDEAAKEEKEESD CCCCHHHHHHHHHCC	73.74	23864654
303	Acetylation	DEAAKEEKEESDDEA CHHHHHHHHHCCHHH	68.80	23864654
306	Phosphorylation	AKEEKEESDDEAAVE HHHHHHHCCHHHHHH	51.99	25521595
320	Acetylation	EEEEEEKKPKTKKVE HHHHHHHCCCCCCCH	55.84	23201123
340	Acetylation	WELMNDIKPIWQRPS HHHHCCCCCHHCCCC	33.06	23806337
348	Acetylation	PIWQRPSKEVEEDEY CHHCCCCCCCCHHHH	69.34	23954790
348	Succinylation	PIWQRPSKEVEEDEY CHHCCCCCCCCHHHH	69.34	23954790
356	Acetylation	EVEEDEYKAFYKSFS CCCHHHHHHHHHHHC	29.94	22826441
356	Succinylation	EVEEDEYKAFYKSFS CCCHHHHHHHHHHHC	29.94	23954790
360	Acetylation	DEYKAFYKSFSKESD HHHHHHHHHHCCCCC	38.27	23806337
360	Succinylation	DEYKAFYKSFSKESD HHHHHHHHHHCCCCC	38.27	23806337
360	Ubiquitination	DEYKAFYKSFSKESD HHHHHHHHHHCCCCC	38.27	-
392	Phosphorylation	SILFVPTSAPRGLFD EEEEEECCCCCCCCH	30.15	29514104
403	Phosphorylation	GLFDEYGSKKSDYIK CCCHHCCCCHHHHHH	35.69	29514104
404	Acetylation	LFDEYGSKKSDYIKL CCHHCCCCHHHHHHE	52.51	23806337
404	Succinylation	LFDEYGSKKSDYIKL CCHHCCCCHHHHHHE	52.51	-
404	Succinylation	LFDEYGSKKSDYIKL CCHHCCCCHHHHHHE	52.51	23806337
404	Ubiquitination	LFDEYGSKKSDYIKL CCHHCCCCHHHHHHE	52.51	-
408	Phosphorylation	YGSKKSDYIKLYVRR CCCCHHHHHHEEEEE	13.67	-
410	Acetylation	SKKSDYIKLYVRRVF CCHHHHHHEEEEEEE	27.77	22826441
428	Acetylation	DFHDMMPKYLNFVKG CHHHHHHHHHHHHCC	44.46	22826441
434	Acetylation	PKYLNFVKGVVDSDD HHHHHHHCCCCCCCC	41.68	22826441
434	Ubiquitination	PKYLNFVKGVVDSDD HHHHHHHCCCCCCCC	41.68	22790023
439	Phosphorylation	FVKGVVDSDDLPLNV HHCCCCCCCCCCCCC	22.78	28066266
445	N-linked_Glycosylation	DSDDLPLNVSRETLQ CCCCCCCCCCHHHHH	27.98	-
447	Phosphorylation	DDLPLNVSRETLQQH CCCCCCCCHHHHHHH	24.27	27180971
455	Acetylation	RETLQQHKLLKVIRK HHHHHHHHHHHHHHH	51.69	23864654
455	Ubiquitination	RETLQQHKLLKVIRK HHHHHHHHHHHHHHH	51.69	22790023
467	Acetylation	IRKKLVRKTLDMIKK HHHHHHHHHHHHHHH	46.06	22826441
473	Acetylation	RKTLDMIKKIADEKY HHHHHHHHHHHHHHC	31.33	23864654
473	Succinylation	RKTLDMIKKIADEKY HHHHHHHHHHHHHHC	31.33	23954790
479	Acetylation	IKKIADEKYNDTFWK HHHHHHHHCCHHHHH	50.31	23806337
479	Succinylation	IKKIADEKYNDTFWK HHHHHHHHCCHHHHH	50.31	23806337
481	N-linked_Glycosylation	KIADEKYNDTFWKEF HHHHHHCCHHHHHHH	53.57	-
486	Acetylation	KYNDTFWKEFGTNIK HCCHHHHHHHCCCCE	38.69	22826441
486	Succinylation	KYNDTFWKEFGTNIK HCCHHHHHHHCCCCE	38.69	23954790
501	Phosphorylation	LGVIEDHSNRTRLAK EEEEECCCCHHHHHH	40.09	27841257
502	N-linked_Glycosylation	GVIEDHSNRTRLAKL EEEECCCCHHHHHHH	46.02	-
504	Phosphorylation	IEDHSNRTRLAKLLR EECCCCHHHHHHHHH	33.99	26824392
514	Phosphorylation	AKLLRFQSSHHSTDI HHHHHHHCCCCCCCC	29.00	27742792
515	Phosphorylation	KLLRFQSSHHSTDIT HHHHHHCCCCCCCCC	17.90	27742792
518	Phosphorylation	RFQSSHHSTDITSLD HHHCCCCCCCCCHHH	23.50	27742792
519	Phosphorylation	FQSSHHSTDITSLDQ HHCCCCCCCCCHHHH	27.36	27742792
522	Phosphorylation	SHHSTDITSLDQYVE CCCCCCCCHHHHHHH	26.50	27742792
537	Acetylation	RMKEKQDKIYFMAGS HHHHHCCCEEEEECC	36.49	23806337
537	Succinylation	RMKEKQDKIYFMAGS HHHHHCCCEEEEECC	36.49	23806337
547	Acetylation	FMAGSSRKEAESSPF EEECCCCCHHHCCHH	64.32	23806337
547	Succinylation	FMAGSSRKEAESSPF EEECCCCCHHHCCHH	64.32	23806337
552	Phosphorylation	SRKEAESSPFVERLL CCCHHHCCHHHHHHH	17.54	18779572
576	Glutathionylation	TEPVDEYCIQALPEF CCCCCHHHHHHCCCC	1.42	24333276
576	S-palmitoylation	TEPVDEYCIQALPEF CCCCCHHHHHHCCCC	1.42	28526873
586	Acetylation	ALPEFDGKRFQNVAK HCCCCCCHHHHHHHH	52.46	69985
593	Acetylation	KRFQNVAKEGVKFDE HHHHHHHHHCCCCCC	51.20	23806337
593	Succinylation	KRFQNVAKEGVKFDE HHHHHHHHHCCCCCC	51.20	23806337
597	Acetylation	NVAKEGVKFDESEKT HHHHHCCCCCCCHHC	58.93	23864654
597	Succinylation	NVAKEGVKFDESEKT HHHHHCCCCCCCHHC	58.93	24315375
603	Acetylation	VKFDESEKTKESREA CCCCCCHHCHHHHHH	74.34	23201123
613	Acetylation	ESREATEKEFEPLLN HHHHHHHHHHHHHHH	64.45	22826441
623	Acetylation	EPLLNWMKDKALKDK HHHHHHHHHHHHHHH	47.92	22826441
623	Succinylation	EPLLNWMKDKALKDK HHHHHHHHHHHHHHH	47.92	23954790
633	Acetylation	ALKDKIEKAVVSQRL HHHHHHHHHHHHHHC	50.37	23806337
633	Succinylation	ALKDKIEKAVVSQRL HHHHHHHHHHHHHHC	50.37	-
633	Succinylation	ALKDKIEKAVVSQRL HHHHHHHHHHHHHHC	50.37	23806337
637	Phosphorylation	KIEKAVVSQRLTESP HHHHHHHHHHCCCCC	11.72	-
645	Glutathionylation	QRLTESPCALVASQY HHCCCCCCHHHHHHH	6.78	24333276
645	S-palmitoylation	QRLTESPCALVASQY HHCCCCCCHHHHHHH	6.78	28526873
663	Ubiquitination	GNMERIMKAQAYQTG CCHHHHHHHHHHHHC	34.67	22790023
671	Acetylation	AQAYQTGKDISTNYY HHHHHHCCCCCCCCC	56.10	23864654
671	Ubiquitination	AQAYQTGKDISTNYY HHHHHHCCCCCCCCC	56.10	22790023
674	Phosphorylation	YQTGKDISTNYYASQ HHHCCCCCCCCCCCC	22.27	28973931
677	Phosphorylation	GKDISTNYYASQKKT CCCCCCCCCCCCCCE	10.66	22817900
678	Phosphorylation	KDISTNYYASQKKTF CCCCCCCCCCCCCEE	11.22	18779572
682	Acetylation	TNYYASQKKTFEINP CCCCCCCCCEEECCC	51.81	23806337
682	Succinylation	TNYYASQKKTFEINP CCCCCCCCCEEECCC	51.81	23806337
682	Ubiquitination	TNYYASQKKTFEINP CCCCCCCCCEEECCC	51.81	-
683	Acetylation	NYYASQKKTFEINPR CCCCCCCCEEECCCC	51.30	22826441
684	Phosphorylation	YYASQKKTFEINPRH CCCCCCCEEECCCCC	33.27	18779572
702	Succinylation	RDMLRRIKEDEDDKT HHHHHHHHCCCCCCC	58.25	23954790
733	Acetylation	GYLLPDTKAYGDRIE CCCCCCCHHHHHHHH	47.17	23806337
733	Succinylation	GYLLPDTKAYGDRIE CCCCCCCHHHHHHHH	47.17	23806337
766	Phosphorylation	PEEEPEDTSEDAEDS CCCCCCCCCCCCCCC	32.14	23140645
767	Phosphorylation	EEEPEDTSEDAEDSE CCCCCCCCCCCCCCC	45.89	23140645
773	Phosphorylation	TSEDAEDSEQDEGEE CCCCCCCCCCCCCCC	28.76	23140645
785	Phosphorylation	GEEMDAGTEEEEEET CCCCCCCCHHHHHHH	41.78	26525534
792	Phosphorylation	TEEEEEETEKESTEK CHHHHHHHHHHHCCC	56.49	23140645
796	Phosphorylation	EEETEKESTEKDEL- HHHHHHHHCCCCCC-	53.59	23140645
797	Phosphorylation	EETEKESTEKDEL-- HHHHHHHCCCCCC--	48.42	23140645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ENPL_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ENPL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ENPL_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
AF9_MOUSE	Mllt3	physical	20159978
GBRA1_MOUSE	Gabra1	physical	26945068

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ENPL_MOUSE

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-217, AND MASSSPECTROMETRY.	19349973 [Abstract]
Phosphorylation
Reference	PubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306, AND MASSSPECTROMETRY.	17203969 [Abstract]