AF9_MOUSE - dbPTM
AF9_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AF9_MOUSE
UniProt AC A2AM29
Protein Name Protein AF-9
Gene Name Mllt3
Organism Mus musculus (Mouse).
Sequence Length 569
Subcellular Localization Nucleus . Chromosome . Colocalizes with acylated histone H3. H3 Colocalizes with histone H3 crotonylated at 'Lys-18' (H3K18cr).
Protein Description Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr). Also recognizes and binds histone H3 acetylated at 'Lys-9' (H3K9ac), but with lower affinity than crotonylated histone H3. In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones..
Protein Sequence MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPKKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKDSSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKADSNLLTVTSGQQDKKAPSKRPPASDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSMLPPFDDIVDPNDSDVEENMSSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEAEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
76PhosphorylationPPYKVEESGYAGFIL
CCCCCCCCCCCEEEE		24.4925338131
78PhosphorylationYKVEESGYAGFILPI
CCCCCCCCCEEEEEE		16.9025338131
88PhosphorylationFILPIEVYFKNKEEP
EEEEEEEEECCCCCC		8.9525338131
123PhosphorylationHLRCEKLTFNNPTED
CEEEEECCCCCCCHH		35.0727180971
149PhosphorylationPNRSIHTSSSSSSSS
CCCCCCCCCCCCCCC		17.67-
150PhosphorylationNRSIHTSSSSSSSSS
CCCCCCCCCCCCCCC		35.08-
151PhosphorylationRSIHTSSSSSSSSSS
CCCCCCCCCCCCCCC		33.72-
152PhosphorylationSIHTSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
153PhosphorylationIHTSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
154PhosphorylationHTSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
155PhosphorylationTSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.8721183079
156PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
157PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
158PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
159PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
160PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
161PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
162PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
163PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
164PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
165PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
166PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
167PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
168PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
169PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
170PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
171PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
172PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
173PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
174PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
175PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
176PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
177PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
178PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
179PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
180PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
181PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
182PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
183PhosphorylationSSSSSSSSSSSSSSS
CCCCCCCCCCCCCCC		35.87-
219AcetylationREHKSAFKEPSRDHN
HHHHHHHCCCCCCCC		69.3223806337
254AcetylationIVPKMAFKEPKPMSK
CCCCCCCCCCCCCCC		64.6723806337
289PhosphorylationPSKRPPASDSEELSA
CCCCCCCCCHHHHHH		47.6627149854
291PhosphorylationKRPPASDSEELSAKK
CCCCCCCHHHHHHHH		30.4024759943
295PhosphorylationASDSEELSAKKRKKS
CCCHHHHHHHHHHCC		41.1224759943
302PhosphorylationSAKKRKKSSSEALFK
HHHHHHCCCHHHHHH		41.9728833060
303PhosphorylationAKKRKKSSSEALFKS
HHHHHCCCHHHHHHH		40.8728833060
304PhosphorylationKKRKKSSSEALFKSF
HHHHCCCHHHHHHHH		33.7029514104
325AcetylationILTCSADKKQIKDKS
EEEEECCHHHHCCHH		46.4223806337
365PhosphorylationDIVDPNDSDVEENMS
CCCCCCCHHHHHHHC		50.6329514104
413PhosphorylationSIMKDLHSDDNEEES
HHHHHHHCCCCHHHC		54.6927087446
420PhosphorylationSDDNEEESDEAEDND
CCCCHHHCHHCCCCC		43.9927087446
430PhosphorylationAEDNDNDSEMERPVN
CCCCCCHHHCCCCCC		45.1327087446
447PhosphorylationGSRSRRVSLSDGSDS
CCCCCEEECCCCCCC		21.9729514104
454PhosphorylationSLSDGSDSESSSASS
ECCCCCCCCCCCCCC		40.8725338131
474PhosphorylationPPPPLLKTNNNQILE
CCCCCCCCCCCCEEE		43.0525619855
484PhosphorylationNQILEVKSPIKQSKS
CCEEEECCCCCCCCC		36.7126824392
489PhosphorylationVKSPIKQSKSDKQIK
ECCCCCCCCCHHHCC		29.1725619855
569PhosphorylationYLETSGTS-------
HHHHCCCC-------		41.5729514104
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AF9_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AF9_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AF9_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BCOR_MOUSEBcorphysical
12776190
CBX8_MOUSECbx8physical
11439343
RING2_MOUSERnf2physical
24070375
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AF9_MOUSE

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory