CBX8_MOUSE - dbPTM
CBX8_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CBX8_MOUSE
UniProt AC Q9QXV1
Protein Name Chromobox protein homolog 8
Gene Name Cbx8
Organism Mus musculus (Mouse).
Sequence Length 362
Subcellular Localization Nucleus . Chromosome . Localizes to the inactivated X chromosome in females.
Protein Description Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity)..
Protein Sequence MELSAVGERVFAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAFEEREREMELYGPKKRGPKPKTFLLKAQAKAKAKTYEFRSDSTRGIRIPYPGRSPQDLASTSRAREGLRNTGLPPPGSSTSTCRADPPRDRDRERDRGTSRVDDKPSSPGDSSKKRGPKPRKEPLDPSQRPLGEPSAGLGEYLKGRKLDETSSGTGKFPAGHSVIQLARRQDSDLVQYGVTSPSSAEASSKLAVDTFPARVIKHRAAFLEAKGQGALDPGGARVRHSSGTPASVGSLYRDMGAQGGRPSLIARIPVARILGDPEEESWSPSLTNLEKVVVTDVTSNFLTVTIKESNTDQGFFKEKR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
106PhosphorylationTRGIRIPYPGRSPQD
CCCCCCCCCCCCHHH		18.8929472430
110PhosphorylationRIPYPGRSPQDLAST
CCCCCCCCHHHHHHH		32.5926824392
116PhosphorylationRSPQDLASTSRAREG
CCHHHHHHHHHHHHH		33.9225777480
118PhosphorylationPQDLASTSRAREGLR
HHHHHHHHHHHHHHH		22.8025777480
134PhosphorylationTGLPPPGSSTSTCRA
CCCCCCCCCCCCCCC		35.9025619855
135PhosphorylationGLPPPGSSTSTCRAD
CCCCCCCCCCCCCCC		32.0925619855
136PhosphorylationLPPPGSSTSTCRADP
CCCCCCCCCCCCCCC		29.7425619855
137PhosphorylationPPPGSSTSTCRADPP
CCCCCCCCCCCCCCC		27.7025619855
138PhosphorylationPPGSSTSTCRADPPR
CCCCCCCCCCCCCCC		13.1925619855
163PhosphorylationSRVDDKPSSPGDSSK
CCCCCCCCCCCCCCC		55.7123684622
164PhosphorylationRVDDKPSSPGDSSKK
CCCCCCCCCCCCCCC		41.2425521595
168PhosphorylationKPSSPGDSSKKRGPK
CCCCCCCCCCCCCCC		50.3925159016
169PhosphorylationPSSPGDSSKKRGPKP
CCCCCCCCCCCCCCC		47.1125159016
208PhosphorylationGRKLDETSSGTGKFP
CCCCCCCCCCCCCCC		25.4027841257
209PhosphorylationRKLDETSSGTGKFPA
CCCCCCCCCCCCCCC		48.0327841257
213AcetylationETSSGTGKFPAGHSV
CCCCCCCCCCCCCHH		48.2723806337
229PhosphorylationQLARRQDSDLVQYGV
HHHHHCCCCCEECCC		25.2225521595
234PhosphorylationQDSDLVQYGVTSPSS
CCCCCEECCCCCCCH		13.1925619855
237PhosphorylationDLVQYGVTSPSSAEA
CCEECCCCCCCHHHH		30.4725619855
238PhosphorylationLVQYGVTSPSSAEAS
CEECCCCCCCHHHHH		22.0028973931
240PhosphorylationQYGVTSPSSAEASSK
ECCCCCCCHHHHHHH		41.7825619855
241PhosphorylationYGVTSPSSAEASSKL
CCCCCCCHHHHHHHC		33.2525619855
245PhosphorylationSPSSAEASSKLAVDT
CCCHHHHHHHCHHCC		21.3625619855
246PhosphorylationPSSAEASSKLAVDTF
CCHHHHHHHCHHCCC		38.4425619855
283PhosphorylationGGARVRHSSGTPASV
CCCCEECCCCCCCCH		21.6521082442
284PhosphorylationGARVRHSSGTPASVG
CCCEECCCCCCCCHH		40.3325521595
286PhosphorylationRVRHSSGTPASVGSL
CEECCCCCCCCHHHH		20.0322942356
289PhosphorylationHSSGTPASVGSLYRD
CCCCCCCCHHHHHHH		28.3725619855
292PhosphorylationGTPASVGSLYRDMGA
CCCCCHHHHHHHCCC		21.7725619855
294PhosphorylationPASVGSLYRDMGAQG
CCCHHHHHHHCCCCC		13.2825619855
305PhosphorylationGAQGGRPSLIARIPV
CCCCCCCHHEEECCC		30.9227600695
325PhosphorylationDPEEESWSPSLTNLE
CCCCCCCCCCCCCCE		17.5629514104
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CBX8_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CBX8_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CBX8_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AF9_HUMANMLLT3physical
11439343
RING2_HUMANRNF2physical
11439343
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CBX8_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, AND MASSSPECTROMETRY.

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