| UniProt ID | GBRA1_MOUSE | |
|---|---|---|
| UniProt AC | P62812 | |
| Protein Name | Gamma-aminobutyric acid receptor subunit alpha-1 | |
| Gene Name | Gabra1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 455 | |
| Subcellular Localization |
Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein. Cell membrane Multi-pass membrane protein . Cytoplasmic vesicle membrane . |
|
| Protein Description | Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).. | |
| Protein Sequence | MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 37 | N-linked_Glycosylation | SQDELKDNTTVFTRI CHHHHCCCCHHHHHH | 35.74 | - | |
| 86 | Phosphorylation | VSDHDMEYTIDVFFR CCCCCCEEEEEEEEE | 11.45 | 28059163 | |
| 87 | Phosphorylation | SDHDMEYTIDVFFRQ CCCCCEEEEEEEEEC | 9.44 | 28059163 | |
| 137 | N-linked_Glycosylation | GKKSVAHNMTMPNKL CCCCCCCCCCCCCCE | 20.20 | - | |
| 341 | Phosphorylation | NYFTKRGYAWDGKSV CHHCCCCCCCCCCCC | 14.46 | 19367708 | |
| 347 | Phosphorylation | GYAWDGKSVVPEKPK CCCCCCCCCCCCCCC | 33.60 | 19367708 | |
| 363 | Ubiquitination | VKDPLIKKNNTYAPT CCCCCCCCCCCCCCC | 48.73 | 22790023 | |
| 367 | Phosphorylation | LIKKNNTYAPTATSY CCCCCCCCCCCCCCC | 16.83 | 22817900 | |
| 373 | Phosphorylation | TYAPTATSYTPNLAR CCCCCCCCCCCCCCC | 25.25 | 25521595 | |
| 374 | Phosphorylation | YAPTATSYTPNLARG CCCCCCCCCCCCCCC | 23.12 | 25521595 | |
| 375 | Phosphorylation | APTATSYTPNLARGD CCCCCCCCCCCCCCC | 12.88 | 25521595 | |
| 390 | Ubiquitination | PGLATIAKSATIEPK CCCCHHHHCCCCCCC | 36.45 | 22790023 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GBRA1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GBRA1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GBRA1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| UBP14_MOUSE | Usp14 | physical | 19759851 | |
| GBRG2_MOUSE | Gabrg2 | physical | 12574411 | |
| GBRB2_MOUSE | Gabrb2 | physical | 12574411 | |
| GBRB2_MOUSE | Gabrb2 | physical | 22768092 | |
| GBRB1_MOUSE | Gabrb1 | physical | 22768092 | |
| GBRB3_MOUSE | Gabrb3 | physical | 22768092 | |
| NLGN2_MOUSE | Nlgn2 | physical | 22768092 | |
| GBRA1_MOUSE | Gabra1 | physical | 22768092 | |
| GEPH_MOUSE | Gphn | physical | 22768092 | |
| GBRG2_MOUSE | Gabrg2 | physical | 22768092 | |
| GBRA3_MOUSE | Gabra3 | physical | 22768092 | |
| NLGN3_MOUSE | Nlgn3 | physical | 22768092 | |
| NBEA_MOUSE | Nbea | physical | 22768092 | |
| GBRA4_MOUSE | Gabra4 | physical | 22768092 | |
| GBRA5_MOUSE | Gabra5 | physical | 22768092 | |
| NRX1A_MOUSE | Nrxn1 | physical | 22768092 | |
| GBRG1_MOUSE | Gabrg1 | physical | 22768092 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-374, AND MASSSPECTROMETRY. | |
| "Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-367, AND MASSSPECTROMETRY. | |
