GBRB2_MOUSE - dbPTM
GBRB2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GBRB2_MOUSE
UniProt AC P63137
Protein Name Gamma-aminobutyric acid receptor subunit beta-2
Gene Name Gabrb2
Organism Mus musculus (Mouse).
Sequence Length 512
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein . Cell membrane
Multi-pass membrane protein . Cytoplasmic vesicle .
Protein Description Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel..
Protein Sequence MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAANANNEKMRLDVNKMFYKDIKQNGTQYRSLWDPTGDLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
32N-linked_GlycosylationQSVNDPSNMSLVKET
HHCCCCCHHHHHHHH		29.47-
45UbiquitinationETVDRLLKGYDIRLR
HHHHHHHCCCCEEEC		61.0822790023
45 (in isoform 2)Ubiquitination-61.0822790023
104N-linked_GlycosylationSYNVIPLNLTLDNRV
CEEEEECEEEECCCH		26.14-
126UbiquitinationDTYFLNDKKSFVHGV
CEEECCCCCCEEEEE		49.6022790023
126 (in isoform 2)Ubiquitination-49.6022790023
155PhosphorylationVLYGLRITTTAACMM
EEEEEEEEHHHHHHH		16.20-
156PhosphorylationLYGLRITTTAACMMD
EEEEEEEHHHHHHHH		16.44-
157PhosphorylationYGLRITTTAACMMDL
EEEEEEHHHHHHHHH		12.01-
173N-linked_GlycosylationRYPLDEQNCTLEIES
CCCCCCCCCEEEEEE		20.77-
215PhosphorylationPQFSIVDYKLITKKV
CCCEEEEEEEEEEEE		9.2221538884
280PhosphorylationARVALGITTVLTMTT
HHHHHCCCEEEHHHH		14.7326060331
281PhosphorylationRVALGITTVLTMTTI
HHHHCCCEEEHHHHH		16.1726060331
284PhosphorylationLGITTVLTMTTINTH
HCCCEEEHHHHHCHH		14.2426060331
286PhosphorylationITTVLTMTTINTHLR
CCEEEHHHHHCHHHH		21.2026060331
287PhosphorylationTTVLTMTTINTHLRE
CEEEHHHHHCHHHHH		11.0426060331
290PhosphorylationLTMTTINTHLRETLP
EHHHHHCHHHHHHCC		20.5926060331
352UbiquitinationAANANNEKMRLDVNK
HHHCCCHHHHCCHHH		31.2927667366
359 (in isoform 2)Ubiquitination-30.18-
383PhosphorylationWDPTGDLSPTRRTTN
CCCCCCCCCCCCCCC		29.0321082442
396PhosphorylationTNYDFSLYTMDPHEN
CCCCEEEEECCCCCC		9.9818034455
405UbiquitinationMDPHENILLSTLEIK
CCCCCCEEEEEEEHH		4.6927667366
407PhosphorylationPHENILLSTLEIKNE
CCCCEEEEEEEHHCC		27.7421538884
408PhosphorylationHENILLSTLEIKNEM
CCCEEEEEEEHHCCC		28.5121538884
434PhosphorylationPRSTMLAYDASSIQY
CHHHHEEEEHHHHHH		14.2121538884
437PhosphorylationTMLAYDASSIQYRKA
HHEEEEHHHHHHHHC		25.6928059163
438PhosphorylationMLAYDASSIQYRKAG
HEEEEHHHHHHHHCC		18.5521538884
441PhosphorylationYDASSIQYRKAGLPR
EEHHHHHHHHCCCCC		16.6516141072
443UbiquitinationASSIQYRKAGLPRHS
HHHHHHHHCCCCCCC		41.7027667366
450PhosphorylationKAGLPRHSFGRNALE
HCCCCCCCHHHHHHH		30.5822324799
472PhosphorylationSRLRRRASQLKITIP
HHHHHHHHHCCCCCC		33.9529899451
477PhosphorylationRASQLKITIPDLTDV
HHHHCCCCCCCCCCC		25.5221538884
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
472SPhosphorylationKinaseCAMK2-FAMILY-GPS
472SPhosphorylationKinasePKA-FAMILY-GPS
472SPhosphorylationKinasePKC-FAMILY-GPS
472SPhosphorylationKinasePKG-FAMILY-GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GBRB2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GBRB2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GBRB2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GBRB2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-434 AND TYR-441, ANDMASS SPECTROMETRY.

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