GBRG2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBRG2_MOUSE
• UniProt AC: P22723
• Protein Name: Gamma-aminobutyric acid receptor subunit gamma-2
• Gene Name: Gabrg2
• Organism: Mus musculus (Mouse).
• Sequence Length: 474
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cytoplasmic vesicle membrane .
• Protein Description: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel..
• Protein Sequence: MSSPNTWSIGSSVYSPVFSQKMTLWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MSSPNTWSIGSSVYS CCCCCCCCCCCCCCC	18.29	28576409
51	N-linked_Glycosylation	DYEDYASNKTWVLTP CHHHHHHCCEEEECC	37.29	-
128	N-linked_Glycosylation	YDRRLKFNSTIKVLR HHHHHHCCCEEEEEE	36.33	-
203	Ubiquitination	FPMDEHSCPLEFSSY CCCCCCCCCCCCCCC	4.87	27667366
204	Ubiquitination	PMDEHSCPLEFSSYG CCCCCCCCCCCCCCC	37.63	27667366
222	Ubiquitination	EEIVYQWKRSSVEVG HHHEEEEECCCCCCC	27.20	27667366
246	N-linked_Glycosylation	FSFVGLRNTTEVVKT EEEECCCCCEEEEEE	57.29	-
363	Ubiquitination	HYFVSNRKPSKDKDK HHHHCCCCCCCCCCC	58.87	-
365	Phosphorylation	FVSNRKPSKDKDKKK HHCCCCCCCCCCCCC	57.43	17875639
366	Ubiquitination	VSNRKPSKDKDKKKK HCCCCCCCCCCCCCC	76.85	-
368	Ubiquitination	NRKPSKDKDKKKKNP CCCCCCCCCCCCCCH	75.16	-
370	Ubiquitination	KPSKDKDKKKKNPLL CCCCCCCCCCCCHHH	72.70	-
371	Ubiquitination	PSKDKDKKKKNPLLR CCCCCCCCCCCHHHH	78.20	-
372	Ubiquitination	SKDKDKKKKNPLLRM CCCCCCCCCCHHHHH	64.62	-
373	Ubiquitination	KDKDKKKKNPLLRMF CCCCCCCCCHHHHHH	73.08	-
381	Phosphorylation	NPLLRMFSFKAPTID CHHHHHHEEECCCCE	19.25	22817900
386	Phosphorylation	MFSFKAPTIDIRPRS HHEEECCCCEECCCC	35.82	21082442
393	Phosphorylation	TIDIRPRSATIQMNN CCEECCCCEEEEECC	32.23	25521595
395	Phosphorylation	DIRPRSATIQMNNAT EECCCCEEEEECCCC	17.00	22817900
411	Phosphorylation	LQERDEEYGYECLDG CCCCHHHHCCCCCCC	23.98	20233604
413	Phosphorylation	ERDEEYGYECLDGKD CCHHHHCCCCCCCCC	11.54	20233604
415	S-palmitoylation	DEEYGYECLDGKDCA HHHHCCCCCCCCCCE	2.94	28680068
421	S-palmitoylation	ECLDGKDCASFFCCF CCCCCCCCEEEEEEE	3.78	28680068
426	S-palmitoylation	KDCASFFCCFEDCRT CCCEEEEEEEHHCCC	2.15	28680068
427	S-palmitoylation	DCASFFCCFEDCRTG CCEEEEEEEHHCCCC	3.37	28680068
431	S-palmitoylation	FFCCFEDCRTGAWRH EEEEEHHCCCCCCHH	3.10	28680068

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
365	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
365	S	Phosphorylation	Kinase	PRKCE	P16054	GPS
365	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
381	S	Phosphorylation	Kinase	PKC	-	Uniprot
381	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
381	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
381	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
381	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
381	S	Phosphorylation	Kinase	KCC2A	P11798	PhosphoELM
393	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
393	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
393	S	Phosphorylation	Kinase	KCC2A	P11798	PhosphoELM
395	T	Phosphorylation	Kinase	CAMK2A	P11275	PSP
395	T	Phosphorylation	Kinase	KCC2A	P11798	PhosphoELM
395	T	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
411	Y	Phosphorylation	Kinase	SRC	P12931	PSP
411	Y	Phosphorylation	Kinase	FYN	P06241	PSP
413	Y	Phosphorylation	Kinase	SRC	P12931	PSP
413	Y	Phosphorylation	Kinase	FYN	P39688	PSP
413	Y	Phosphorylation	Kinase	FYN	P06241	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBRG2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBRG2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GBRG2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.