GBRB3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBRB3_MOUSE
• UniProt AC: P63080
• Protein Name: Gamma-aminobutyric acid receptor subunit beta-3
• Gene Name: Gabrb3
• Organism: Mus musculus (Mouse).
• Sequence Length: 473
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane .
• Protein Description: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel..
• Protein Sequence: MWGFAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSEINRVDAHGNILLAPMDVHNEMNEVAGSVGDTRNSAISFDNSGIQYRKQSMPKEGHGRYMGDRSIPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	N-linked_Glycosylation	QSVNDPGNMSFVKET HCCCCCCCCHHHHHH	28.45	-
46	Ubiquitination	ETVDKLLKGYDIRLR HHHHHHHCCCCEECC	66.90	-
105	N-linked_Glycosylation	AYSGIPLNLTLDNRV CCCCCCCEEEECCCH	26.14	-
127	Ubiquitination	DTYFLNDKKSFVHGV CEEECCCCCCEEEEE	49.60	-
156	Phosphorylation	VLYGLRITTTAACMM EEEEEEEEHHHHHHH	16.20	-
157	Phosphorylation	LYGLRITTTAACMMD EEEEEEEHHHHHHHH	16.44	-
158	Phosphorylation	YGLRITTTAACMMDL EEEEEEHHHHHHHHH	12.01	-
174	N-linked_Glycosylation	RYPLDEQNCTLEIES CCCCCCCCCEEEEEE	20.77	-
234	Phosphorylation	TGAYPRLSLSFRLKR CCCCCCEEEEEEEHH	24.21	26370283
236	Phosphorylation	AYPRLSLSFRLKRNI CCCCEEEEEEEHHHH	12.63	26370283
281	Phosphorylation	ARVALGITTVLTMTT HHHHHCCCEEEHHHH	14.73	26060331
282	Phosphorylation	RVALGITTVLTMTTI HHHHCCCEEEHHHHH	16.17	26060331
285	Phosphorylation	LGITTVLTMTTINTH HCCCEEEHHHHHCHH	14.24	26060331
287	Phosphorylation	ITTVLTMTTINTHLR CCEEEHHHHHCHHHH	21.20	26060331
288	Phosphorylation	TTVLTMTTINTHLRE CEEEHHHHHCHHHHH	11.04	26060331
291	Phosphorylation	LTMTTINTHLRETLP EHHHHHCHHHHHHCC	20.59	26060331
354	Phosphorylation	AKAKNDRSKSEINRV HHHCCCCCHHHHCEE	43.31	29899451
384	Phosphorylation	EMNEVAGSVGDTRNS HHHHHCCCCCCCCCC	17.12	-
388	Phosphorylation	VAGSVGDTRNSAISF HCCCCCCCCCCCEEE	26.31	-
391	Phosphorylation	SVGDTRNSAISFDNS CCCCCCCCCEEECCC	24.56	-
394	Phosphorylation	DTRNSAISFDNSGIQ CCCCCCEEECCCCCC	26.68	29899451
406	Phosphorylation	GIQYRKQSMPKEGHG CCCEEECCCCCCCCC	39.84	22324799
432	Phosphorylation	KTHLRRRSSQLKIKI HHHHHHHHHCCEEEC	22.18	16854455
433	Phosphorylation	THLRRRSSQLKIKIP HHHHHHHHCCEEECC	37.41	16854455

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
406	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
406	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
432	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
432	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
433	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
433	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
433	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
433	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
433	S	Phosphorylation	Kinase	PKG-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBRB3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBRB3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GBRB3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.