dbPTM

GBRG1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GBRG1_MOUSE
UniProt AC	Q9R0Y8
Protein Name	Gamma-aminobutyric acid receptor subunit gamma-1
Gene Name	Gabrg1
Organism	Mus musculus (Mouse).
Sequence Length	465
Subcellular Localization	Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein. Cell membrane Multi-pass membrane protein.
Protein Description	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel..
Protein Sequence	MGSGKAFLFSPSLLWSQTRGVRLIFLLLTLHLGNCVDKADDEDDEDLTMNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWSDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEISHTISGDYIIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNNKGKTTRGRKLKNKTSASPGLHAGSTLIPMNSISLPQGEDDYGYQCLEGKDCTSFFCCFDDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	N-linked_Glycosylation	DDEDLTMNKTWVLAP CCCCCCCCCEEEECC	33.11	-
127	N-linked_Glycosylation	FDSRLKFNSTMKVLM HCCCCCCCCHHEEEE	34.68	-
245	N-linked_Glycosylation	FAFVGLRNSTEISHT EEEECCCCCCEEEEE	59.32	-
247	Phosphorylation	FVGLRNSTEISHTIS EECCCCCCEEEEEEC	40.67	-
406	S-palmitoylation	EDDYGYQCLEGKDCT CCCCCCEEECCCCCC	2.55	28680068

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GBRG1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GBRG1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GBRG1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GBRG1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GBRG1_MOUSE

Related Literatures of Post-Translational Modification