NBEA_MOUSE - dbPTM
NBEA_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NBEA_MOUSE
UniProt AC Q9EPN1
Protein Name Neurobeachin
Gene Name Nbea
Organism Mus musculus (Mouse).
Sequence Length 2936
Subcellular Localization Membrane
Peripheral membrane protein . Endomembrane system
Peripheral membrane protein . Cell junction, synapse, postsynaptic cell membrane
Peripheral membrane protein . Associated with pleomorphic tubulovesicular endomembranes near the trans s
Protein Description Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. May have a role in membrane trafficking..
Protein Sequence MASDKPGPGLEPQPVALLAVGAGGGAGGGGAMGEPRGAAGSGPVVLPAGMINPSVPIRNIRMKFAVLIGLIQVGEVSNRDIVETVLNLLVGGEFDLEMNFIIQDAESITCMTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEVGLIEQVLLKMSAVDDMIADLLVDMLGVLASYSITVKELKLLFSMLRGESGIWPRHAVKLLSVLNQMPQRHGPDTFFNFPGCSAAAIALPPIAKWPYQNGFTLNTWFRMDPLNNINVDKDKPYLYCFRTSKGVGYSAHFVGNCLIVTSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYNRWRNSEIRCYVNGQLVSYGDMAWHVNTNDSYDKCFLGSSETADANRVFCGQLGAVYVFSEALNPAQIFAVHQLGPGYKSTFKFKSESDIHLAEHHKQVLYDGKLASSIAFSYNAKATDAQLCLESSPKENASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLNDSQVETTVCATLLAFLVELLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQLCDHILFNPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVINPADSSGIAPKGLDGPRPSQKEIISLRAFMLLFLKQLILKDRGVKEDELQSILNYLLTMHEDENIHDVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIWVQALKVLGYFLKHLGHKRKVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQVCTQVVHKPHPEPDSTVKIQNPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLGYINPKSSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLAKMYEEYQRQEEENIKKGKKGNVSTISGLSSQTAGAKGGMEIREIEDLSQSQSPESETDYPVSTDTRDLLMSTKVSDDILGSSDRPGSGVHVEVHDLLVDIKAEKVEATEVKLDDMDLSPETLVGGENGALVEVESLLDNVYSAAVEKLQNNVHGSVGIIKKNEEKDNGPLITLADEKEELPNSSTPFLFDKIPRQEEKLLPELSSNHIIPNIQDTQVHLGVSDDLGLLAHMTASVELTCTSSIMEEKDFRIHTTSDGVSSVSERELASSTKGLDYAEMTATTLETESSNSKAVPNVDAGSIISDTERSDDGKESGKEIRKIQTTATTQAVQGRSSTQQDRDLRVDLGFRGMPMTEEQRRQFSPGPRTTMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENIIFVHNTIHLISQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGSKSSHGSSKPQEAPHSVTAASASKTPLENVPGNLSPIKDPDRLLQDVDINRLRAVVFRDVDDSKQAQFLALAVVYFISVLMVSKYRDILEPQRETARTGSQPGRNIRQEINSPTSTVVVIPSIPHPSLNHGLLAKLMPEQSFAHSFYKETPATFPDTVKEKETPTPGEDIQLESSVPHTDSGMGEEQVASILDGAELEPAAGPDAMSELLSTLSSEVKKSQESLTEHPSEMLKPAPSISSISQTKGINVKEILKSLVAAPVEIAECGPEPIPYPDPALKREAHAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVGATAAGSGLPTGSTSSIFAAPGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQELLIEGLVCMKSSTSVVELVMLLCSQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKSAVEYGTEEDVVKSKKAFRSQAIVNQNSETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQLIAPVVVAKGTLSITTTEIYFEVDEDDAAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWEEDQSPPFHYNTHYSTATSALSWLVRIEPFTTFFLNANDGKFDHPDRTFSSIARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYHLGVREDEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHYEHQNRY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
251UbiquitinationQNGFTLNTWFRMDPL
CCCCEECEEEECCCC		29.1527667366
271PhosphorylationDKDKPYLYCFRTSKG
CCCCCEEEEEECCCC		5.4525293948
275PhosphorylationPYLYCFRTSKGVGYS
CEEEEEECCCCCCCC		17.9725293948
276PhosphorylationYLYCFRTSKGVGYSA
EEEEEECCCCCCCCE		24.1325293948
352UbiquitinationDMAWHVNTNDSYDKC
CEEEEEECCCCCCCC		39.0427667366
473UbiquitinationLMLQDVKAIVTHSIH
HHHHCHHHHHHHCHH		11.0027667366
527PhosphorylationFLVELLKSSVAMQEQ
HHHHHHHHHHHHHHH		29.98-
742UbiquitinationNGIRVIYKLLASKSE
CCHHHHHHHHHCCCC		26.3727667366
843UbiquitinationKVVATLLKNSTPSAE
HHHHHHHHCCCCCHH		52.5522790023
950UbiquitinationAHKEYLAKMYEEYQR
HHHHHHHHHHHHHHH		39.1422790023
964UbiquitinationRQEEENIKKGKKGNV
HHHHHHHHCCCCCCC		68.0327667366
975PhosphorylationKGNVSTISGLSSQTA
CCCCEEECCCCCCCC		33.50-
997PhosphorylationIREIEDLSQSQSPES
EEEEHHHHCCCCCCC		39.8621183079
999PhosphorylationEIEDLSQSQSPESET
EEHHHHCCCCCCCCC		29.2919060867
1001PhosphorylationEDLSQSQSPESETDY
HHHHCCCCCCCCCCC		35.5625521595
1004PhosphorylationSQSQSPESETDYPVS
HCCCCCCCCCCCCCC		49.5325521595
1006PhosphorylationSQSPESETDYPVSTD
CCCCCCCCCCCCCCC		50.5421183079
1008PhosphorylationSPESETDYPVSTDTR
CCCCCCCCCCCCCHH		16.9825293948
1067PhosphorylationKLDDMDLSPETLVGG
ECCCCCCCHHHCCCC		19.2020415495
1070PhosphorylationDMDLSPETLVGGENG
CCCCCHHHCCCCCCC		30.0820415495
1134PhosphorylationEELPNSSTPFLFDKI
CCCCCCCCCCCCCCC		20.2025338131
1238UbiquitinationTLETESSNSKAVPNV
EEEECCCCCCCCCCC		57.7327667366
1249PhosphorylationVPNVDAGSIISDTER
CCCCCCCCCCCCCCC		20.6125521595
1252PhosphorylationVDAGSIISDTERSDD
CCCCCCCCCCCCCCC		36.4925521595
1254PhosphorylationAGSIISDTERSDDGK
CCCCCCCCCCCCCCC		26.8925521595
1257PhosphorylationIISDTERSDDGKESG
CCCCCCCCCCCCCCC		33.5525521595
1263PhosphorylationRSDDGKESGKEIRKI
CCCCCCCCCHHHHHH		59.6623684622
1276O-linked_GlycosylationKIQTTATTQAVQGRS
HHHHHCCHHHHCCCC		16.4422645316
1303PhosphorylationGFRGMPMTEEQRRQF
ECCCCCCCHHHHHCC		30.4223140645
1311PhosphorylationEEQRRQFSPGPRTTM
HHHHHCCCCCCCCCC		22.1725521595
1509PhosphorylationTAASASKTPLENVPG
CCCCCCCCCCCCCCC		30.5223527152
1519PhosphorylationENVPGNLSPIKDPDR
CCCCCCCCCCCCHHH		28.6925521595
1596PhosphorylationNIRQEINSPTSTVVV
CHHHHCCCCCCEEEE		34.9026060331
1598PhosphorylationRQEINSPTSTVVVIP
HHHCCCCCCEEEEEC		36.5326060331
1599PhosphorylationQEINSPTSTVVVIPS
HHCCCCCCEEEEECC		23.6926060331
1600PhosphorylationEINSPTSTVVVIPSI
HCCCCCCEEEEECCC		21.5726060331
1606PhosphorylationSTVVVIPSIPHPSLN
CEEEEECCCCCCCCC		37.3120415495
1611PhosphorylationIPSIPHPSLNHGLLA
ECCCCCCCCCCCHHH		38.4820415495
1625PhosphorylationAKLMPEQSFAHSFYK
HHHCCCCHHCCCCCC		23.8029899451
1704PhosphorylationLSSEVKKSQESLTEH
HCHHHHHHHHHHHCC		33.2019060867
1704O-linked_GlycosylationLSSEVKKSQESLTEH
HCHHHHHHHHHHHCC		33.209554483
1707PhosphorylationEVKKSQESLTEHPSE
HHHHHHHHHHCCHHH		32.7119060867
1709PhosphorylationKKSQESLTEHPSEML
HHHHHHHHCCHHHHC		41.3425293948
1726UbiquitinationAPSISSISQTKGINV
CCCCHHHHCCCCCCH		33.4727667366
1729UbiquitinationISSISQTKGINVKEI
CHHHHCCCCCCHHHH		50.5922790023
1776PhosphorylationILPMQFHSFDRSVVV
EEEECCCCCCCEEEE		30.0822324799
1796O-linked_GlycosylationPPGSLAVTTVGATAA
CCCCEEEEEECCCCC		15.3422645316
1797O-linked_GlycosylationPGSLAVTTVGATAAG
CCCEEEEEECCCCCC		15.4422645316
1805PhosphorylationVGATAAGSGLPTGST
ECCCCCCCCCCCCCC		32.2229899451
1852UbiquitinationSFVNGATSKNLPAVQ
CCCCCCCCCCCCCEE		21.0027667366
2106PhosphorylationKSKKAFRSQAIVNQN
HCCHHHHCCEEECCC		19.9425619855
2114PhosphorylationQAIVNQNSETELMLE
CEEECCCCCCEEEEE		35.8125619855
2116PhosphorylationIVNQNSETELMLEGD
EECCCCCCEEEEECC		33.9525619855
2128PhosphorylationEGDDDAVSLLQEKEI
ECCCCHHHHHHHHCC		25.6925619855
2265PhosphorylationARRISLATPRQLYKS
HHCCEECCHHHHHHC		25.0523567750
2334UbiquitinationPGNFRDLSKPIGALN
CCCHHHCCCCCCCCC		40.4527667366
2335UbiquitinationGNFRDLSKPIGALNP
CCHHHCCCCCCCCCH		48.21-
2337UbiquitinationFRDLSKPIGALNPKR
HHHCCCCCCCCCHHH		6.0727667366
2340UbiquitinationLSKPIGALNPKRAVF
CCCCCCCCCHHHEEE		10.7227667366
2343UbiquitinationPIGALNPKRAVFYAE
CCCCCCHHHEEEEEE		52.4927667366
2377PhosphorylationSTATSALSWLVRIEP
HHHHHHHHHHHCCCC		20.34-
2403PhosphorylationKFDHPDRTFSSIARS
CCCCCCCCHHHHHHH		34.9422871156
2405PhosphorylationDHPDRTFSSIARSWR
CCCCCCHHHHHHHHC		21.8824704852
2406PhosphorylationHPDRTFSSIARSWRT
CCCCCHHHHHHHHCC		18.9724704852
2413PhosphorylationSIARSWRTSQRDTSD
HHHHHHCCCCCCCHH		23.9722871156
2541PhosphorylationQIQNFGQTPSQLLIE
HHHHCCCCHHHEEEC		25.8623140645
2543PhosphorylationQNFGQTPSQLLIEPH
HHCCCCHHHEEECCC		36.5323140645
2554PhosphorylationIEPHPPRSSAMHLCF
ECCCCCCCCCCEEEE		28.3723140645
2555PhosphorylationEPHPPRSSAMHLCFL
CCCCCCCCCCEEEEC		30.7823140645
2565PhosphorylationHLCFLPQSPLMFKDQ
EEEECCCCCCCCCHH		20.3316141072
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NBEA_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NBEA_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NBEA_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NBEA_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NBEA_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1519, AND MASSSPECTROMETRY.

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