| UniProt ID | GBRA4_MOUSE | |
|---|---|---|
| UniProt AC | Q9D6F4 | |
| Protein Name | Gamma-aminobutyric acid receptor subunit alpha-4 | |
| Gene Name | Gabra4 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 552 | |
| Subcellular Localization |
Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein. Cell membrane Multi-pass membrane protein. |
|
| Protein Description | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.. | |
| Protein Sequence | MVSVQKVPAIALCSGVSLALLHFLCLAACLNESPGQNSKDEKLCPENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMQKAKKKISKPPPEVPAAPVLKEKHTETSLQNTHANLNMRKRTNALVHSESDVKSRTEVGNHSSKTSAVQESSEATPKAHLASSPNPFSRANAAETMSAAARGLSSAASPSPHGTLRPASLGSASTRPAFGSRLGRIKTTVNTTGAAGNVSATPPPPAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKSESLM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 33 | Phosphorylation | LAACLNESPGQNSKD HHHHHCCCCCCCCCC | 33.00 | - | |
| 47 | N-linked_Glycosylation | DEKLCPENFTRILDS CCCCCHHHHHHHHHH | 28.82 | - | |
| 140 | Phosphorylation | FFRNGKKSVSHNMTA CCCCCCCCCCCCCCC | 32.13 | 17693683 | |
| 142 | Phosphorylation | RNGKKSVSHNMTAPN CCCCCCCCCCCCCCC | 19.08 | 17693683 | |
| 144 | N-linked_Glycosylation | GKKSVSHNMTAPNKL CCCCCCCCCCCCCHH | 23.22 | - | |
| 157 | N-linked_Glycosylation | KLFRIMRNGTILYTM HHHHHHCCCEEEEEE | 34.28 | - | |
| 390 | Phosphorylation | NLNMRKRTNALVHSE HHHHHHHHCCEECCH | 28.07 | 30482847 | |
| 398 | Phosphorylation | NALVHSESDVKSRTE CCEECCHHHCCCCCC | 51.20 | 29899451 | |
| 423 | Phosphorylation | VQESSEATPKAHLAS CCCCCCCCCCHHHCC | 22.67 | 25521595 | |
| 431 | Phosphorylation | PKAHLASSPNPFSRA CCHHHCCCCCCCHHH | 24.08 | 29899451 | |
| 472 | Phosphorylation | PASLGSASTRPAFGS CCCCCCCCCCCCCHH | 27.01 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GBRA4_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GBRA4_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GBRA4_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GBRA4_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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