GBRA3_MOUSE - dbPTM
GBRA3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GBRA3_MOUSE
UniProt AC P26049
Protein Name Gamma-aminobutyric acid receptor subunit alpha-3
Gene Name Gabra3
Organism Mus musculus (Mouse).
Sequence Length 492
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein. Cell membrane
Multi-pass membrane protein.
Protein Description GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel..
Protein Sequence MIITQMWHFYVTRVVLLLLISILPGTTSQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPTKKNTTFNIVGTTYPINLAKDTEFSTISKSAAAPSASSTPTAIASPKATYVQDSPAETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
63N-linked_GlycosylationIPDDSTDNITIFTRI
CCCCCCCCCHHHHHH
33.13-
163N-linked_GlycosylationGKKSVAHNMTTPNKL
CCCCCCCCCCCCCHH
21.54-
176N-linked_GlycosylationKLLRLVDNGTLLYTM
HHEEEEECCEEEEEE
37.56-
181PhosphorylationVDNGTLLYTMRLTIH
EECCEEEEEEEEEEE
11.1228576409
228N-linked_GlycosylationYSWTLGKNKSVEVAQ
EEEECCCCCEEEEEC
39.78-
418PhosphorylationEFSTISKSAAAPSAS
CCEEECCCCCCCCCC
19.1520415495
423PhosphorylationSKSAAAPSASSTPTA
CCCCCCCCCCCCCCE
35.7425521595
425PhosphorylationSAAAPSASSTPTAIA
CCCCCCCCCCCCEEC
38.8029899451
426PhosphorylationAAAPSASSTPTAIAS
CCCCCCCCCCCEECC
37.8219060867
427PhosphorylationAAPSASSTPTAIASP
CCCCCCCCCCEECCC
23.3625521595
429PhosphorylationPSASSTPTAIASPKA
CCCCCCCCEECCCCC
30.6820415495
433PhosphorylationSTPTAIASPKATYVQ
CCCCEECCCCCEEEC
22.3325521595
438PhosphorylationIASPKATYVQDSPAE
ECCCCCEEECCCCCC
10.8529899451
442PhosphorylationKATYVQDSPAETKTY
CCEEECCCCCCCCCC
14.6625521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GBRA3_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GBRA3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GBRA3_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GBRA3_MOUSE !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GBRA3_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-433, AND MASSSPECTROMETRY.

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