| UniProt ID | GBRA3_MOUSE | |
|---|---|---|
| UniProt AC | P26049 | |
| Protein Name | Gamma-aminobutyric acid receptor subunit alpha-3 | |
| Gene Name | Gabra3 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 492 | |
| Subcellular Localization |
Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein. Cell membrane Multi-pass membrane protein. |
|
| Protein Description | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.. | |
| Protein Sequence | MIITQMWHFYVTRVVLLLLISILPGTTSQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPTKKNTTFNIVGTTYPINLAKDTEFSTISKSAAAPSASSTPTAIASPKATYVQDSPAETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 63 | N-linked_Glycosylation | IPDDSTDNITIFTRI CCCCCCCCCHHHHHH | 33.13 | - | |
| 163 | N-linked_Glycosylation | GKKSVAHNMTTPNKL CCCCCCCCCCCCCHH | 21.54 | - | |
| 176 | N-linked_Glycosylation | KLLRLVDNGTLLYTM HHEEEEECCEEEEEE | 37.56 | - | |
| 181 | Phosphorylation | VDNGTLLYTMRLTIH EECCEEEEEEEEEEE | 11.12 | 28576409 | |
| 228 | N-linked_Glycosylation | YSWTLGKNKSVEVAQ EEEECCCCCEEEEEC | 39.78 | - | |
| 418 | Phosphorylation | EFSTISKSAAAPSAS CCEEECCCCCCCCCC | 19.15 | 20415495 | |
| 423 | Phosphorylation | SKSAAAPSASSTPTA CCCCCCCCCCCCCCE | 35.74 | 25521595 | |
| 425 | Phosphorylation | SAAAPSASSTPTAIA CCCCCCCCCCCCEEC | 38.80 | 29899451 | |
| 426 | Phosphorylation | AAAPSASSTPTAIAS CCCCCCCCCCCEECC | 37.82 | 19060867 | |
| 427 | Phosphorylation | AAPSASSTPTAIASP CCCCCCCCCCEECCC | 23.36 | 25521595 | |
| 429 | Phosphorylation | PSASSTPTAIASPKA CCCCCCCCEECCCCC | 30.68 | 20415495 | |
| 433 | Phosphorylation | STPTAIASPKATYVQ CCCCEECCCCCEEEC | 22.33 | 25521595 | |
| 438 | Phosphorylation | IASPKATYVQDSPAE ECCCCCEEECCCCCC | 10.85 | 29899451 | |
| 442 | Phosphorylation | KATYVQDSPAETKTY CCEEECCCCCCCCCC | 14.66 | 25521595 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GBRA3_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GBRA3_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GBRA3_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GBRA3_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-433, AND MASSSPECTROMETRY. | |
