GBRB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBRB1_MOUSE
• UniProt AC: P50571
• Protein Name: Gamma-aminobutyric acid receptor subunit beta-1
• Gene Name: Gabrb1
• Organism: Mus musculus (Mouse).
• Sequence Length: 474
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .
• Protein Description: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel..
• Protein Sequence: MWTVQNRESLGLLSFPVMVAMVCCAHSSNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNRLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTGVSDPKATMYSYDSASIQYRKPLSSREGFGRGLDRHGVPGKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	N-linked_Glycosylation	HSSNEPSNMSYVKET HCCCCCCCHHHHHHH	33.85	-
46	Ubiquitination	ETVDRLLKGYDIRLR HHHHHHHCCCCEEEC	61.08	-
105	N-linked_Glycosylation	SYSGIPLNLTLDNRV EECCCCCEEEECCCH	26.14	-
127	Ubiquitination	DTYFLNDKKSFVHGV CEEECCCCCCEEEEE	49.60	-
156	Phosphorylation	VLYGLRITTTAACMM EEEEEEEEHHHHHHH	16.20	-
157	Phosphorylation	LYGLRITTTAACMMD EEEEEEEHHHHHHHH	16.44	-
158	Phosphorylation	YGLRITTTAACMMDL EEEEEEHHHHHHHHH	12.01	-
174	N-linked_Glycosylation	RYPLDEQNCTLEIES CCCCCCCCCEEEEEE	20.77	-
227	Phosphorylation	SKKVEFTTGAYPRLS EEEEEECCCCCCCEE	25.74	21538884
230	Phosphorylation	VEFTTGAYPRLSLSF EEECCCCCCCEEEEE	7.10	21538884
234	Phosphorylation	TGAYPRLSLSFRLKR CCCCCCEEEEEEEHH	24.21	26370283
236	Phosphorylation	AYPRLSLSFRLKRNI CCCCEEEEEEEHHHE	12.63	26370283
282	Phosphorylation	RVALGITTVLTMTTI HHHHCCCCHHHHHHH	16.17	-
287	Phosphorylation	ITTVLTMTTISTHLR CCCHHHHHHHHHHHH	18.75	21538884
288	Phosphorylation	TTVLTMTTISTHLRE CCHHHHHHHHHHHHH	11.34	21538884
290	Phosphorylation	VLTMTTISTHLRETL HHHHHHHHHHHHHHC	14.00	21538884
291	Phosphorylation	LTMTTISTHLRETLP HHHHHHHHHHHHHCC	22.53	21538884
396	Phosphorylation	DPKATMYSYDSASIQ CCCCEEEEECCCEEE	16.19	21538884
399	Phosphorylation	ATMYSYDSASIQYRK CEEEEECCCEEEECC	18.71	21538884
401	Phosphorylation	MYSYDSASIQYRKPL EEEECCCEEEECCCC	17.74	21538884
404	Phosphorylation	YDSASIQYRKPLSSR ECCCEEEECCCCCCC	20.95	21538884
409	Phosphorylation	IQYRKPLSSREGFGR EEECCCCCCCCCCCC	35.56	10195104
410	Phosphorylation	QYRKPLSSREGFGRG EECCCCCCCCCCCCC	41.87	10195104
434	Phosphorylation	GRIRRRASQLKVKIP HHHHHHHHHCCCCCC	33.95	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
409	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
409	S	Phosphorylation	Kinase	KCC2A	P11798	PhosphoELM
409	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
409	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
410	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
434	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
434	S	Phosphorylation	Kinase	KCC2A	P11798	PhosphoELM
434	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
434	S	Phosphorylation	Kinase	PRKG1	P0C605	GPS
434	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
434	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
434	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBRB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBRB1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GBRB1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.