ANXA3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANXA3_MOUSE
• UniProt AC: O35639
• Protein Name: Annexin A3
• Gene Name: Anxa3
• Organism: Mus musculus (Mouse).
• Sequence Length: 323
• Protein Description: Inhibitor of phospholipase A2, also possesses anti-coagulant properties..
• Protein Sequence: MASIWVGPRGTIKDYPGFSPSVDAEAIRKAIRGLGTDEKTLINILTERSNAQRQLIVKQYQAAYEQELKDDLKGDLSGHFEHVMVALVTAPALFDAKQLKKSMKGTGTDEDALIEILTTRSSRQMKEISQAYYTVYKKSLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKKDAQILYNAGENKWGTDEDKFTEVLCLRSFPQLKLTFDEYRNISQKDIEDSIKGELSGHFEDLLLAIVHCARNTPAFLAERLHQALKGAGTDEFTLNRIMVSRSEIDLLDIRHEFKKHYGYSLYSAIQSDTSGDYRTVLLKICGEDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASIWVGPR ------CCCEEECCC	15.10	-
3	Phosphorylation	-----MASIWVGPRG -----CCCEEECCCC	18.71	25338131
15	Phosphorylation	PRGTIKDYPGFSPSV CCCCCCCCCCCCCCC	10.56	11905027
19	Phosphorylation	IKDYPGFSPSVDAEA CCCCCCCCCCCCHHH	23.37	28507225
21	Phosphorylation	DYPGFSPSVDAEAIR CCCCCCCCCCHHHHH	31.28	29550500
69	Ubiquitination	AAYEQELKDDLKGDL HHHHHHHHHHHCCCC	48.74	22790023
69	Acetylation	AAYEQELKDDLKGDL HHHHHHHHHHHCCCC	48.74	23236377
102	Phosphorylation	DAKQLKKSMKGTGTD CHHHHHHHCCCCCCC	24.92	21183079
104	Ubiquitination	KQLKKSMKGTGTDED HHHHHHCCCCCCCHH	61.48	22790023
106	Phosphorylation	LKKSMKGTGTDEDAL HHHHCCCCCCCHHHH	31.24	28973931
108	Phosphorylation	KSMKGTGTDEDALIE HHCCCCCCCHHHHHH	35.73	21183079
119	Phosphorylation	ALIEILTTRSSRQMK HHHHHHHCCCHHHHH	25.71	25338131
126	Acetylation	TRSSRQMKEISQAYY CCCHHHHHHHHHHHH	43.49	22826441
133	Phosphorylation	KEISQAYYTVYKKSL HHHHHHHHHHHHHHH	7.86	6975625
137	Acetylation	QAYYTVYKKSLGDDI HHHHHHHHHHHCCCC	31.39	23236377
139	Phosphorylation	YYTVYKKSLGDDISS HHHHHHHHHCCCCCC	33.17	30635358
146	Phosphorylation	SLGDDISSETSGDFR HHCCCCCCCCCHHHH	45.27	25338131
154	Acetylation	ETSGDFRKALLTLAD CCCHHHHHHHHHHHC	43.30	22826441
167	Phosphorylation	ADGRRDESLKVDEHL HCCCCCCCCCCCHHH	37.47	26824392
176	Acetylation	KVDEHLAKKDAQILY CCCHHHHHHHHHHHH	58.51	7609109
177	Acetylation	VDEHLAKKDAQILYN CCHHHHHHHHHHHHH	53.33	23806337
196	Acetylation	KWGTDEDKFTEVLCL CCCCCHHHHHHHHHH	52.73	22826441
210	Ubiquitination	LRSFPQLKLTFDEYR HHCCCCCEEEHHHHC	39.99	22790023
263	Acetylation	ERLHQALKGAGTDEF HHHHHHHCCCCCCCH	50.13	23236377
263	Ubiquitination	ERLHQALKGAGTDEF HHHHHHHCCCCCCCH	50.13	22790023
267	Phosphorylation	QALKGAGTDEFTLNR HHHCCCCCCCHHHCE	31.64	29176673
293	Acetylation	DIRHEFKKHYGYSLY HHHHHHHHHHCCCHH	47.59	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANXA3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANXA3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANXA3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ANXA3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.