HNRL1_MOUSE - dbPTM
HNRL1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HNRL1_MOUSE
UniProt AC Q8VDM6
Protein Name Heterogeneous nuclear ribonucleoprotein U-like protein 1
Gene Name Hnrnpul1
Organism Mus musculus (Mouse).
Sequence Length 859
Subcellular Localization Nucleus.
Protein Description Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro (By similarity)..
Protein Sequence MDVRRLKVNELREELQRRGLDTRGLKAELAERLLAALEAEEPEDERELEADDDPGLPGHNNEEVETEGGSELEGTAQPPPPGLQPHPEPGGYSGPDGHYVMDNITRQNQFYETPVIKQENESSYDRRPLDMEPQQQVYHPELKTEMKQEAPPSFLPPEASQLKTDRPQFQNRKRPFEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTIGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQTNVYGSAQRRKMRPFEGFQRKAIVICPTDEDLKDRTVKRTDEEGKDVPDHAVLEMKANFTLPDVGDFLDEVLFIELQREEADKLVRQYNEEGRKAGPPPEKRFDSRGGGFRGRGGGGGFQRYDNRGPPGGNRGGFQNRGGGGGSGGGGGNYRGGFNRSGGGGYNQNRWGNNNRDNNNSNNRGNYNRAPQQQPPPQQPPPPQPPPQQPPPPPSYSPARNPPGASSYNKNSNIPGSSANTSTPTVSSYTPPQPSYSQPPYNQGGYTQGYTAPPPPPPPPPAYNYGSYGPYNPAPYTPPPPPTAQTYPQPSYNQYQQYAQQWSQYYQNQSQWPPYYGNYDYGGYSGSTQGGTSTQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
117SumoylationFYETPVIKQENESSY
CCCCCCCCCCCCCCC		52.3628289178
123PhosphorylationIKQENESSYDRRPLD
CCCCCCCCCCCCCCC		25.5228285833
180MethylationKRPFEENRGRGYFEH
CCCCHHCCCCCCCCC		39.19-
195PhosphorylationREDRRGRSPQPPAEE
CCCCCCCCCCCCCCC		30.6127087446
210PhosphorylationDEDDFDDTLVAIDTY
CCCCCCCCEEEEECC		25.6122802335
216PhosphorylationDTLVAIDTYNCDLHF
CCEEEEECCCCCEEE		15.5525619855
217PhosphorylationTLVAIDTYNCDLHFK
CEEEEECCCCCEEEE		15.2825619855
418PhosphorylationRGTIGPKSKAECEIL
CCCCCCCCHHHHEEE		39.99-
441UbiquitinationGKTTWAIKHAASNPS
CCHHHHHHHHHCCCC		21.3122790023
445PhosphorylationWAIKHAASNPSKKYN
HHHHHHHCCCCCCEE		50.4818779572
508PhosphorylationRNYILDQTNVYGSAQ
CCCCCCCCCCCCCHH		26.7330635358
511PhosphorylationILDQTNVYGSAQRRK
CCCCCCCCCCHHHHC		13.8723984901
513PhosphorylationDQTNVYGSAQRRKMR
CCCCCCCCHHHHCCC		11.9827566939
518MalonylationYGSAQRRKMRPFEGF
CCCHHHHCCCCCCCC		41.2626320211
552AcetylationKRTDEEGKDVPDHAV
CCCCCCCCCCCCCEE		59.8523954790
618DimethylationDSRGGGFRGRGGGGG
CCCCCCCCCCCCCCC		36.85-
620MethylationRGGGFRGRGGGGGFQ
CCCCCCCCCCCCCCC		36.01-
620DimethylationRGGGFRGRGGGGGFQ
CCCCCCCCCCCCCCC		36.01-
639Asymmetric dimethylarginineRGPPGGNRGGFQNRG
CCCCCCCCCCCCCCC		50.30-
639MethylationRGPPGGNRGGFQNRG
CCCCCCCCCCCCCCC		50.3024129315
645MethylationNRGGFQNRGGGGGSG
CCCCCCCCCCCCCCC		34.0624129315
645Asymmetric dimethylarginineNRGGFQNRGGGGGSG
CCCCCCCCCCCCCCC		34.06-
659Asymmetric dimethylarginineGGGGGNYRGGFNRSG
CCCCCCCCCCCCCCC		42.64-
659MethylationGGGGGNYRGGFNRSG
CCCCCCCCCCCCCCC		42.6424129315
664DimethylationNYRGGFNRSGGGGYN
CCCCCCCCCCCCCCC		34.12-
664MethylationNYRGGFNRSGGGGYN
CCCCCCCCCCCCCCC		34.1224129315
674MethylationGGGYNQNRWGNNNRD
CCCCCCCCCCCCCCC		32.68-
688MethylationDNNNSNNRGNYNRAP
CCCCCCCCCCCCCCC		38.70-
719PhosphorylationQQPPPPPSYSPARNP
CCCCCCCCCCCCCCC		43.9723684622
720PhosphorylationQPPPPPSYSPARNPP
CCCCCCCCCCCCCCC		25.1726160508
721PhosphorylationPPPPPSYSPARNPPG
CCCCCCCCCCCCCCC		19.2027087446
730PhosphorylationARNPPGASSYNKNSN
CCCCCCCCCCCCCCC		38.9926643407
731PhosphorylationRNPPGASSYNKNSNI
CCCCCCCCCCCCCCC		31.9926643407
732PhosphorylationNPPGASSYNKNSNIP
CCCCCCCCCCCCCCC		27.8826643407
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HNRL1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HNRL1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HNRL1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HNRL1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HNRL1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-195, AND MASSSPECTROMETRY.

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