ESTD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ESTD_MOUSE
• UniProt AC: Q9R0P3
• Protein Name: S-formylglutathione hydrolase
• Gene Name: Esd
• Organism: Mus musculus (Mouse).
• Sequence Length: 282
• Subcellular Localization: Cytoplasm. Cytoplasmic vesicle.
• Protein Description: Serine hydrolase involved in the detoxification of formaldehyde..
• Protein Sequence: MALKQISSNRCFGGLQKVFEHSSVELKCKMRFAVYLPPQAESGKCPALYWLSGLTCTEQNFISKSGYQQAASEHGLVVIAPDTSPRGCNIKGEDDSWDFGTGAGFYVNATEDPWKANYRMYSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKYRSVSAFAPICNPVLCSWGKKAFSGYLGPDESKWKAYDATCLVKAYSGSQIDILIDQGKDDEFLSNGQLLPDNFIAACTEKKIPVVFRLQEGYDHSYYFIATFIADHIRHHAKYLNA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MALKQISSN ------CCCHHHCCC	24.38	23806337
4	Acetylation	----MALKQISSNRC ----CCCHHHCCCCC	35.73	22826441
4	Succinylation	----MALKQISSNRC ----CCCHHHCCCCC	35.73	-
4	Ubiquitination	----MALKQISSNRC ----CCCHHHCCCCC	35.73	-
4	Malonylation	----MALKQISSNRC ----CCCHHHCCCCC	35.73	26320211
4	Succinylation	----MALKQISSNRC ----CCCHHHCCCCC	35.73	23806337
11	S-palmitoylation	KQISSNRCFGGLQKV HHHCCCCCCCHHHHH	4.32	26165157
11	Glutathionylation	KQISSNRCFGGLQKV HHHCCCCCCCHHHHH	4.32	24333276
17	Ubiquitination	RCFGGLQKVFEHSSV CCCCHHHHHHHCCCE	54.67	22790023
22	Phosphorylation	LQKVFEHSSVELKCK HHHHHHCCCEEEEEE	28.96	29472430
23	Phosphorylation	QKVFEHSSVELKCKM HHHHHCCCEEEEEEE	22.86	19060867
27	Malonylation	EHSSVELKCKMRFAV HCCCEEEEEEEEEEE	20.50	26320211
27	Acetylation	EHSSVELKCKMRFAV HCCCEEEEEEEEEEE	20.50	22826441
27	Ubiquitination	EHSSVELKCKMRFAV HCCCEEEEEEEEEEE	20.50	-
28	Glutathionylation	HSSVELKCKMRFAVY CCCEEEEEEEEEEEE	7.00	24333276
49	Phosphorylation	SGKCPALYWLSGLTC CCCCCCEEEECCCCC	13.35	25367039
52	Phosphorylation	CPALYWLSGLTCTEQ CCCEEEECCCCCCCC	20.01	25367039
55	Phosphorylation	LYWLSGLTCTEQNFI EEEECCCCCCCCCEE	22.40	25367039
56	S-palmitoylation	YWLSGLTCTEQNFIS EEECCCCCCCCCEEC	4.79	28526873
57	Phosphorylation	WLSGLTCTEQNFISK EECCCCCCCCCEECC	35.06	25367039
63	Phosphorylation	CTEQNFISKSGYQQA CCCCCEECCCCHHHH	19.34	25367039
65	Phosphorylation	EQNFISKSGYQQAAS CCCEECCCCHHHHHH	35.62	25367039
67	Phosphorylation	NFISKSGYQQAASEH CEECCCCHHHHHHHC	12.44	25367039
72	Phosphorylation	SGYQQAASEHGLVVI CCHHHHHHHCCEEEE	32.89	25367039
83	Phosphorylation	LVVIAPDTSPRGCNI EEEECCCCCCCCCCC	39.30	25367039
84	Phosphorylation	VVIAPDTSPRGCNIK EEECCCCCCCCCCCC	21.71	25367039
88	Glutathionylation	PDTSPRGCNIKGEDD CCCCCCCCCCCCCCC	5.13	24333276
115	Acetylation	NATEDPWKANYRMYS ECCCCCCHHHEEHHH	31.94	23954790
158	Glutathionylation	GGHGALICALKNPGK CCCCEEEEEECCCCC	3.64	24333276
158	S-nitrosylation	GGHGALICALKNPGK CCCCEEEEEECCCCC	3.64	21278135
158	S-nitrosocysteine	GGHGALICALKNPGK CCCCEEEEEECCCCC	3.64	-
165	Acetylation	CALKNPGKYRSVSAF EEECCCCCCCEEEEC	38.45	22826441
176	S-palmitoylation	VSAFAPICNPVLCSW EEECCCCCCEEEEHH	4.60	28526873
176	Glutathionylation	VSAFAPICNPVLCSW EEECCCCCCEEEEHH	4.60	24333276
181	S-palmitoylation	PICNPVLCSWGKKAF CCCCEEEEHHCHHHC	3.06	28526873
181	Glutathionylation	PICNPVLCSWGKKAF CCCCEEEEHHCHHHC	3.06	24333276
185	Ubiquitination	PVLCSWGKKAFSGYL EEEEHHCHHHCCCCC	34.37	22790023
186	Ubiquitination	VLCSWGKKAFSGYLG EEEHHCHHHCCCCCC	51.21	-
186	Malonylation	VLCSWGKKAFSGYLG EEEHHCHHHCCCCCC	51.21	26320211
189	Phosphorylation	SWGKKAFSGYLGPDE HHCHHHCCCCCCCCH	31.24	29514104
197	Phosphorylation	GYLGPDESKWKAYDA CCCCCCHHHHEEEEE	51.72	30352176
198	Acetylation	YLGPDESKWKAYDAT CCCCCHHHHEEEEEE	51.14	23236377
198	Ubiquitination	YLGPDESKWKAYDAT CCCCCHHHHEEEEEE	51.14	-
198	Malonylation	YLGPDESKWKAYDAT CCCCCHHHHEEEEEE	51.14	26320211
200	Ubiquitination	GPDESKWKAYDATCL CCCHHHHEEEEEEEE	40.58	-
200	Acetylation	GPDESKWKAYDATCL CCCHHHHEEEEEEEE	40.58	23806337
200	Glutarylation	GPDESKWKAYDATCL CCCHHHHEEEEEEEE	40.58	24703693
202	Phosphorylation	DESKWKAYDATCLVK CHHHHEEEEEEEEEE	11.46	25367039
206	S-nitrosocysteine	WKAYDATCLVKAYSG HEEEEEEEEEEECCC	4.39	-
206	S-palmitoylation	WKAYDATCLVKAYSG HEEEEEEEEEEECCC	4.39	28526873
206	S-nitrosylation	WKAYDATCLVKAYSG HEEEEEEEEEEECCC	4.39	21278135
206	Glutathionylation	WKAYDATCLVKAYSG HEEEEEEEEEEECCC	4.39	24333276
211	Phosphorylation	ATCLVKAYSGSQIDI EEEEEEECCCCEEEE	14.09	23984901
212	Phosphorylation	TCLVKAYSGSQIDIL EEEEEECCCCEEEEE	36.51	30352176
214	Phosphorylation	LVKAYSGSQIDILID EEEECCCCEEEEEEE	20.30	25521595
230	Phosphorylation	GKDDEFLSNGQLLPD CCCHHHHCCCCCCCC	44.21	23984901
243	Glutathionylation	PDNFIAACTEKKIPV CCCEEHHHCCCCCCE	3.59	24333276
243	S-palmitoylation	PDNFIAACTEKKIPV CCCEEHHHCCCCCCE	3.59	28526873
247	Acetylation	IAACTEKKIPVVFRL EHHHCCCCCCEEEEE	46.11	22826441
247	Malonylation	IAACTEKKIPVVFRL EHHHCCCCCCEEEEE	46.11	26320211
247	Ubiquitination	IAACTEKKIPVVFRL EHHHCCCCCCEEEEE	46.11	-
278	Acetylation	DHIRHHAKYLNA--- HHHHHHHHHHCC---	46.01	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ESTD_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ESTD_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ESTD_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ESTD_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.