EIF3I_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EIF3I_MOUSE
• UniProt AC: Q9QZD9
• Protein Name: Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008}
• Gene Name: Eif3i
• Organism: Mus musculus (Mouse).
• Sequence Length: 325
• Subcellular Localization: Cytoplasm .
• Protein Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression..
• Protein Sequence: MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDSNEPYMKIPCNDSKITSAVWGPLGECVIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKPILLQGH ------CCCEEECCC	40.54	-
2	Acetylation	------MKPILLQGH ------CCCEEECCC	40.54	22826441
76	S-nitrosocysteine	TGSADNSCRLWDCET ECCCCCCCEEEECCC	5.34	-
76	S-nitrosylation	TGSADNSCRLWDCET ECCCCCCCEEEECCC	5.34	21278135
85	Ubiquitination	LWDCETGKQLALLKT EEECCCCCEEEEEEC	49.94	-
85	Acetylation	LWDCETGKQLALLKT EEECCCCCEEEEEEC	49.94	22826441
91	Acetylation	GKQLALLKTNSAVRT CCEEEEEECCCCCHH	46.65	23954790
144	Glutathionylation	EPYMKIPCNDSKITS CCCEECCCCCCHHEE	11.42	24333276
176	Ubiquitination	ELNQYSAKSGEVLVN CCCEEECCCCCEEEE	53.72	-
218	Phosphorylation	TAKLFDSTTLEHQKT CCCCCCCCCCEEECE	36.93	18779572
219	Phosphorylation	AKLFDSTTLEHQKTF CCCCCCCCCEEECEE	33.82	-
224	Ubiquitination	STTLEHQKTFRTERP CCCCEEECEECCCCC	52.09	-
264	Acetylation	TTSTRIGKFEARFFH ECCCCEEEEEEEHHH	37.35	-
264	Ubiquitination	TTSTRIGKFEARFFH ECCCCEEEEEEEHHH	37.35	27667366
282	Ubiquitination	EEEFGRVKGHFGPIN HHHHCCCCCCCCCCC	45.36	-
298	Ubiquitination	VAFHPDGKSYSSGGE EEECCCCCCCCCCCC	54.31	-
301	Phosphorylation	HPDGKSYSSGGEDGY CCCCCCCCCCCCCCE	29.60	26525534
302	Phosphorylation	PDGKSYSSGGEDGYV CCCCCCCCCCCCCEE	42.45	26525534
308	Phosphorylation	SSGGEDGYVRIHYFD CCCCCCCEEEEEEEC	10.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EIF3I_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EIF3I_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EIF3I_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LN28A_MOUSE	Lin28a	physical	17473174
NUCL_MOUSE	Ncl	physical	17473174
PARP1_HUMAN	PARP1	physical	26496610
IF4G2_HUMAN	EIF4G2	physical	26496610
MSH6_HUMAN	MSH6	physical	26496610
HNRPL_HUMAN	HNRNPL	physical	26496610
EIF3E_HUMAN	EIF3E	physical	26496610
ITAV_HUMAN	ITGAV	physical	26496610
RFC1_HUMAN	RFC1	physical	26496610
RFC5_HUMAN	RFC5	physical	26496610
RL23A_HUMAN	RPL23A	physical	26496610
RS3_HUMAN	RPS3	physical	26496610
RS6_HUMAN	RPS6	physical	26496610
RS15A_HUMAN	RPS15A	physical	26496610
RS16_HUMAN	RPS16	physical	26496610
RUXE_HUMAN	SNRPE	physical	26496610
TOP2A_HUMAN	TOP2A	physical	26496610
CBX4_HUMAN	CBX4	physical	26496610
EIF3A_HUMAN	EIF3A	physical	26496610
EIF3B_HUMAN	EIF3B	physical	26496610
EIF3C_HUMAN	EIF3C	physical	26496610
EIF3D_HUMAN	EIF3D	physical	26496610
EIF3F_HUMAN	EIF3F	physical	26496610
EIF3G_HUMAN	EIF3G	physical	26496610
EIF3H_HUMAN	EIF3H	physical	26496610
EIF3J_HUMAN	EIF3J	physical	26496610
H1X_HUMAN	H1FX	physical	26496610
PUM3_HUMAN	KIAA0020	physical	26496610
RCL1_HUMAN	RCL1	physical	26496610
EIF3M_HUMAN	EIF3M	physical	26496610
TCPQ_HUMAN	CCT8	physical	26496610
STRAP_HUMAN	STRAP	physical	26496610
SP16H_HUMAN	SUPT16H	physical	26496610
DHX30_HUMAN	DHX30	physical	26496610
PRC2C_HUMAN	PRRC2C	physical	26496610
RRP12_HUMAN	RRP12	physical	26496610
GNL3_HUMAN	GNL3	physical	26496610
PELP1_HUMAN	PELP1	physical	26496610
EIF3K_HUMAN	EIF3K	physical	26496610
ABC3C_HUMAN	APOBEC3C	physical	26496610
UTP18_HUMAN	UTP18	physical	26496610
DDX47_HUMAN	DDX47	physical	26496610
EIF3L_HUMAN	EIF3L	physical	26496610
TEX10_HUMAN	TEX10	physical	26496610
WDR18_HUMAN	WDR18	physical	26496610
DDX55_HUMAN	DDX55	physical	26496610
RM38_HUMAN	MRPL38	physical	26496610
SPAS2_HUMAN	SPATS2	physical	26496610
WDR76_HUMAN	WDR76	physical	26496610
PRC2B_HUMAN	PRRC2B	physical	26496610
HNRL2_HUMAN	HNRNPUL2	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.