dbPTM

EIF3A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EIF3A_HUMAN
UniProt AC	Q14152
Protein Name	Eukaryotic translation initiation factor 3 subunit A {ECO:0000255\|HAMAP-Rule:MF_03000}
Gene Name	EIF3A {ECO:0000255\|HAMAP-Rule:MF_03000}
Organism	Homo sapiens (Human).
Sequence Length	1382
Subcellular Localization	Cytoplasm .
Protein Description	RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. [PubMed: 17581632]
Protein Sequence	MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVMKSKKHRTWQKIHEPIMLKYLELCVDLRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKMAEEKTEAAKEESQQMVLDIEDLDNIQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQCLDLLRNNSRVERLYHDIAQQAFKFCLQYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSAISMELWQEAFKAVEDIHGLFSLSKKPPKPQLMANYYNKVSTVFWKSGNALFHASTLHRLYHLSREMRKNLTQDEMQRMSTRVLLATLSIPITPERTDIARLLDMDGIIVEKQRRLATLLGLQAPPTRIGLINDMVRFNVLQYVVPEVKDLYNWLEVEFNPLKLCERVTKVLNWVREQPEKEPELQQYVPQLQNNTILRLLQQVSQIYQSIEFSRLTSLVPFVDAFQLERAIVDAARHCDLQVRIDHTSRTLSFGSDLNYATREDAPIGPHLQSMPSEQIRNQLTAMSSVLAKALEVIKPAHILQEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSLRPDDDRVPRRGMDDDRGPRRGPEEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDDRPPRRGLDEDRGSWRTADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGLDDDRGPRRGMDDDRGPRRGMDDDRGPRRGMDDDRGPRRGLDDDRGPWRNADDDRIPRRGAEDDRGPWRNMDDDRLSRRADDDRFPRRGDDSRPGPWRPLVKPGGWREKEKAREESWGPPRESRPSEEREWDREKERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAEKDRESLRRTKNETDEDGWTTVRR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPAYFQRPENA ----CCCCCCCHHHH	15.80	28152594
11	Ubiquitination	YFQRPENALKRANEF CCCCHHHHHHHHHHH	16.88	-
13	Ubiquitination	QRPENALKRANEFLE CCHHHHHHHHHHHHH	47.24	21890473
13	Methylation	QRPENALKRANEFLE CCHHHHHHHHHHHHH	47.24	-
13	Ubiquitination	QRPENALKRANEFLE CCHHHHHHHHHHHHH	47.24	22817900
23	2-Hydroxyisobutyrylation	NEFLEVGKKQPALDV HHHHHHCCCCCHHHH	54.10	-
23	Acetylation	NEFLEVGKKQPALDV HHHHHHCCCCCHHHH	54.10	25953088
23	Malonylation	NEFLEVGKKQPALDV HHHHHHCCCCCHHHH	54.10	30639696
23	Ubiquitination	NEFLEVGKKQPALDV HHHHHHCCCCCHHHH	54.10	21906983
24	Ubiquitination	EFLEVGKKQPALDVL HHHHHCCCCCHHHHH	56.43	29967540
32	Phosphorylation	QPALDVLYDVMKSKK CCHHHHHHHHHHHCC	13.31	27259358
34	Acetylation	ALDVLYDVMKSKKHR HHHHHHHHHHHCCCC	3.08	-
34	Ubiquitination	ALDVLYDVMKSKKHR HHHHHHHHHHHCCCC	3.08	-
36	Acetylation	DVLYDVMKSKKHRTW HHHHHHHHHCCCCCH	60.00	25953088
36	Ubiquitination	DVLYDVMKSKKHRTW HHHHHHHHHCCCCCH	60.00	32015554
39	Ubiquitination	YDVMKSKKHRTWQKI HHHHHHCCCCCHHHC	45.47	23000965
41	Ubiquitination	VMKSKKHRTWQKIHE HHHHCCCCCHHHCCH	46.68	-
45	Ubiquitination	KKHRTWQKIHEPIML CCCCCHHHCCHHHHH	37.28	21890473
45	Acetylation	KKHRTWQKIHEPIML CCCCCHHHCCHHHHH	37.28	26051181
45	Ubiquitination	KKHRTWQKIHEPIML CCCCCHHHCCHHHHH	37.28	23000965
50	Ubiquitination	WQKIHEPIMLKYLEL HHHCCHHHHHHHHHH	4.62	-
51	Sulfoxidation	QKIHEPIMLKYLELC HHCCHHHHHHHHHHH	3.75	30846556
54	Acetylation	HEPIMLKYLELCVDL CHHHHHHHHHHHHHH	11.05	19413330
68	2-Hydroxyisobutyrylation	LRKSHLAKEGLYQYK HHHHHHHHHHHHHHH	59.69	-
68	Acetylation	LRKSHLAKEGLYQYK HHHHHHHHHHHHHHH	59.69	19608861
68	Malonylation	LRKSHLAKEGLYQYK HHHHHHHHHHHHHHH	59.69	26320211
68	Ubiquitination	LRKSHLAKEGLYQYK HHHHHHHHHHHHHHH	59.69	33845483
71	Ubiquitination	SHLAKEGLYQYKNIC HHHHHHHHHHHHHHH	2.24	-
72	Phosphorylation	HLAKEGLYQYKNICQ HHHHHHHHHHHHHHH	22.21	28152594
74	Phosphorylation	AKEGLYQYKNICQQV HHHHHHHHHHHHHHC	7.76	28152594
75	Acetylation	KEGLYQYKNICQQVN HHHHHHHHHHHHHCC	25.06	25953088
75	Ubiquitination	KEGLYQYKNICQQVN HHHHHHHHHHHHHCC	25.06	21906983
78	Glutathionylation	LYQYKNICQQVNIKS HHHHHHHHHHCCCCC	3.02	22555962
84	Acetylation	ICQQVNIKSLEDVVR HHHHCCCCCHHHHHH	43.73	26051181
84	Ubiquitination	ICQQVNIKSLEDVVR HHHHCCCCCHHHHHH	43.73	29967540
95	Acetylation	DVVRAYLKMAEEKTE HHHHHHHHHHHHHHH	24.32	25953088
95	Ubiquitination	DVVRAYLKMAEEKTE HHHHHHHHHHHHHHH	24.32	32015554
100	Ubiquitination	YLKMAEEKTEAAKEE HHHHHHHHHHHHHHH	43.07	23503661
101	Phosphorylation	LKMAEEKTEAAKEES HHHHHHHHHHHHHHH	33.85	24043423
105	Ubiquitination	EEKTEAAKEESQQMV HHHHHHHHHHHHHHC	69.89	33845483
108	Phosphorylation	TEAAKEESQQMVLDI HHHHHHHHHHHCCCH	27.14	24043423
123	Phosphorylation	EDLDNIQTPESVLLS HHHCCCCCCHHHHHH	25.81	24043423
126	Phosphorylation	DNIQTPESVLLSAVS CCCCCCHHHHHHHHC	21.19	24043423
130	Phosphorylation	TPESVLLSAVSGEDT CCHHHHHHHHCCCCC	23.59	24043423
133	Phosphorylation	SVLLSAVSGEDTQDR HHHHHHHCCCCCCCC	35.86	24043423
147	Phosphorylation	RTDRLLLTPWVKFLW CHHHHHHHHHHHHHH	18.31	-
162	Acetylation	ESYRQCLDLLRNNSR HHHHHHHHHHHCCHH	51.81	-
162	Ubiquitination	ESYRQCLDLLRNNSR HHHHHHHHHHHCCHH	51.81	-
174	Phosphorylation	NSRVERLYHDIAQQA CHHHHHHHHHHHHHH	12.03	28152594
196	Acetylation	TRKAEFRKLCDNLRM HHHHHHHHHHHHHHH	59.81	23749302
196	Malonylation	TRKAEFRKLCDNLRM HHHHHHHHHHHHHHH	59.81	26320211
196	Ubiquitination	TRKAEFRKLCDNLRM HHHHHHHHHHHHHHH	59.81	29967540
203	Sulfoxidation	KLCDNLRMHLSQIQR HHHHHHHHHHHHHHH	4.14	30846556
206	Phosphorylation	DNLRMHLSQIQRHHN HHHHHHHHHHHHHHC	15.57	20873877
243	Sulfoxidation	QLDSAISMELWQEAF HHHHHHHHHHHHHHH	3.92	28183972
251	Ubiquitination	ELWQEAFKAVEDIHG HHHHHHHHHHHHHHH	59.58	-
261	Phosphorylation	EDIHGLFSLSKKPPK HHHHHHHHCCCCCCC	36.45	21406692
263	Phosphorylation	IHGLFSLSKKPPKPQ HHHHHHCCCCCCCCC	37.12	21406692
265	Ubiquitination	GLFSLSKKPPKPQLM HHHHCCCCCCCCCCC	64.28	29967540
268	Ubiquitination	SLSKKPPKPQLMANY HCCCCCCCCCCCHHH	54.65	32015554
274	Ubiquitination	PKPQLMANYYNKVST CCCCCCHHHHHHCEE	26.34	-
278	Ubiquitination	LMANYYNKVSTVFWK CCHHHHHHCEEEEEE	22.80	32015554
285	Ubiquitination	KVSTVFWKSGNALFH HCEEEEEECCCHHHH	36.70	23000965
294	Phosphorylation	GNALFHASTLHRLYH CCHHHHHHHHHHHHH	23.96	20873877
295	Phosphorylation	NALFHASTLHRLYHL CHHHHHHHHHHHHHH	27.63	20873877
300	Phosphorylation	ASTLHRLYHLSREMR HHHHHHHHHHCHHHH	10.73	24719451
303	Phosphorylation	LHRLYHLSREMRKNL HHHHHHHCHHHHHCC	16.94	24719451
308	Malonylation	HLSREMRKNLTQDEM HHCHHHHHCCCHHHH	55.81	26320211
308	Ubiquitination	HLSREMRKNLTQDEM HHCHHHHHCCCHHHH	55.81	23000965
311	Phosphorylation	REMRKNLTQDEMQRM HHHHHCCCHHHHHHH	43.28	21406692
315	Sulfoxidation	KNLTQDEMQRMSTRV HCCCHHHHHHHHHHH	4.05	30846556
317	Ubiquitination	LTQDEMQRMSTRVLL CCHHHHHHHHHHHHH	21.51	-
319	Phosphorylation	QDEMQRMSTRVLLAT HHHHHHHHHHHHHHH	18.43	28176443
320	Phosphorylation	DEMQRMSTRVLLATL HHHHHHHHHHHHHHH	18.56	28176443
326	Phosphorylation	STRVLLATLSIPITP HHHHHHHHHCCCCCC	22.47	28176443
328	Phosphorylation	RVLLATLSIPITPER HHHHHHHCCCCCCCC	23.20	28176443
332	Phosphorylation	ATLSIPITPERTDIA HHHCCCCCCCCCCHH	17.47	28176443
336	Phosphorylation	IPITPERTDIARLLD CCCCCCCCCHHHHHC	30.05	26270265
344	Sulfoxidation	DIARLLDMDGIIVEK CHHHHHCCCCCHHHH	5.26	21406390
351	2-Hydroxyisobutyrylation	MDGIIVEKQRRLATL CCCCHHHHHHHHHHH	37.91	-
351	Acetylation	MDGIIVEKQRRLATL CCCCHHHHHHHHHHH	37.91	26051181
351	Ubiquitination	MDGIIVEKQRRLATL CCCCHHHHHHHHHHH	37.91	21906983
368	Ubiquitination	LQAPPTRIGLINDMV CCCCCCHHHHHHHHH	6.07	-
374	Sulfoxidation	RIGLINDMVRFNVLQ HHHHHHHHHHHCHHH	1.69	30846556
375	Ubiquitination	IGLINDMVRFNVLQY HHHHHHHHHHCHHHH	7.63	-
382	Phosphorylation	VRFNVLQYVVPEVKD HHHCHHHHHCHHHHH	10.15	27259358
386	Ubiquitination	VLQYVVPEVKDLYNW HHHHHCHHHHHHHCH	51.06	-
402	Ubiquitination	EVEFNPLKLCERVTK CCCCCHHHHHHHHHH	52.96	21906983
409	Ubiquitination	KLCERVTKVLNWVRE HHHHHHHHHHHHHHH	41.70	21890473
409	Acetylation	KLCERVTKVLNWVRE HHHHHHHHHHHHHHH	41.70	26051181
409	Ubiquitination	KLCERVTKVLNWVRE HHHHHHHHHHHHHHH	41.70	22817900
420	Ubiquitination	WVREQPEKEPELQQY HHHHCCCCCHHHHHH	82.39	21890473
420	Acetylation	WVREQPEKEPELQQY HHHHCCCCCHHHHHH	82.39	26051181
420	Ubiquitination	WVREQPEKEPELQQY HHHHCCCCCHHHHHH	82.39	23000965
435	Phosphorylation	VPQLQNNTILRLLQQ HHHHHHHHHHHHHHH	29.01	24719451
478	S-nitrosocysteine	IVDAARHCDLQVRID HHHHHHHCCEEEEEE	4.68	-
478	S-nitrosylation	IVDAARHCDLQVRID HHHHHHHCCEEEEEE	4.68	19483679
490	Phosphorylation	RIDHTSRTLSFGSDL EEECCCCCEECCCCC	26.90	30266825
492	Phosphorylation	DHTSRTLSFGSDLNY ECCCCCEECCCCCCC	27.27	30266825
495	Phosphorylation	SRTLSFGSDLNYATR CCCEECCCCCCCCCC	36.59	30266825
498	Ubiquitination	LSFGSDLNYATREDA EECCCCCCCCCCCCC	29.41	-
499	Phosphorylation	SFGSDLNYATREDAP ECCCCCCCCCCCCCC	19.35	30266825
501	Phosphorylation	GSDLNYATREDAPIG CCCCCCCCCCCCCCC	25.00	30266825
504	Acetylation	LNYATREDAPIGPHL CCCCCCCCCCCCHHH	55.12	-
514	Sulfoxidation	IGPHLQSMPSEQIRN CCHHHHCCCHHHHHH	2.46	30846556
524	Phosphorylation	EQIRNQLTAMSSVLA HHHHHHHHHHHHHHH	15.56	20068231
525	Ubiquitination	QIRNQLTAMSSVLAK HHHHHHHHHHHHHHH	12.40	-
528	Phosphorylation	NQLTAMSSVLAKALE HHHHHHHHHHHHHHH	14.20	21712546
532	Ubiquitination	AMSSVLAKALEVIKP HHHHHHHHHHHHHCH	49.71	33845483
538	2-Hydroxyisobutyrylation	AKALEVIKPAHILQE HHHHHHHCHHHHHHH	41.13	-
538	Acetylation	AKALEVIKPAHILQE HHHHHHHCHHHHHHH	41.13	23236377
538	Ubiquitination	AKALEVIKPAHILQE HHHHHHHCHHHHHHH	41.13	33845483
546	Acetylation	PAHILQEKEEQHQLA HHHHHHHHHHHHHHH	54.30	25953088
546	Ubiquitination	PAHILQEKEEQHQLA HHHHHHHHHHHHHHH	54.30	33845483
557	Ubiquitination	HQLAVTAYLKNSRKE HHHHHHHHHHHCHHH	14.62	-
559	Acetylation	LAVTAYLKNSRKEHQ HHHHHHHHHCHHHHH	39.95	25953088
559	Malonylation	LAVTAYLKNSRKEHQ HHHHHHHHHCHHHHH	39.95	26320211
559	Methylation	LAVTAYLKNSRKEHQ HHHHHHHHHCHHHHH	39.95	-
559	Ubiquitination	LAVTAYLKNSRKEHQ HHHHHHHHHCHHHHH	39.95	33845483
563	Ubiquitination	AYLKNSRKEHQRILA HHHHHCHHHHHHHHH	60.41	23503661
569	Ubiquitination	RKEHQRILARRQTIE HHHHHHHHHHHHHHH	3.10	-
574	Phosphorylation	RILARRQTIEERKER HHHHHHHHHHHHHHH	28.66	27273156
584	Phosphorylation	ERKERLESLNIQREK HHHHHHHHCCHHHHH	31.16	19664994
591	Ubiquitination	SLNIQREKEELEQRE HCCHHHHHHHHHHHH	59.69	33845483
598	Methylation	KEELEQREAELQKVR HHHHHHHHHHHHHHH	46.30	-
598	Ubiquitination	KEELEQREAELQKVR HHHHHHHHHHHHHHH	46.30	-
599	Methylation	EELEQREAELQKVRK HHHHHHHHHHHHHHH	25.62	-
599	Ubiquitination	EELEQREAELQKVRK HHHHHHHHHHHHHHH	25.62	-
600	Methylation	ELEQREAELQKVRKA HHHHHHHHHHHHHHH	47.16	-
600	Ubiquitination	ELEQREAELQKVRKA HHHHHHHHHHHHHHH	47.16	-
603	Acetylation	QREAELQKVRKAEEE HHHHHHHHHHHHHHH	57.54	25953088
603	Ubiquitination	QREAELQKVRKAEEE HHHHHHHHHHHHHHH	57.54	27667366
617	Ubiquitination	ERLRQEAKEREKERI HHHHHHHHHHHHHHH	57.46	-
617	Ubiquitination	ERLRQEAKEREKERI HHHHHHHHHHHHHHH	57.46	29967540
620	Ubiquitination	RQEAKEREKERILQE HHHHHHHHHHHHHHH	61.43	-
621	Ubiquitination	QEAKEREKERILQEH HHHHHHHHHHHHHHH	59.52	29967540
632	2-Hydroxyisobutyrylation	LQEHEQIKKKTVRER HHHHHHHHHHHHHHH	48.16	-
632	Acetylation	LQEHEQIKKKTVRER HHHHHHHHHHHHHHH	48.16	25953088
632	Methylation	LQEHEQIKKKTVRER HHHHHHHHHHHHHHH	48.16	23644510
632	Ubiquitination	LQEHEQIKKKTVRER HHHHHHHHHHHHHHH	48.16	21906983
633	Methylation	QEHEQIKKKTVRERL HHHHHHHHHHHHHHH	56.13	23644510
633	Ubiquitination	QEHEQIKKKTVRERL HHHHHHHHHHHHHHH	56.13	22817900
634	Methylation	EHEQIKKKTVRERLE HHHHHHHHHHHHHHH	47.45	23644510
634	Ubiquitination	EHEQIKKKTVRERLE HHHHHHHHHHHHHHH	47.45	22817900
635	Phosphorylation	HEQIKKKTVRERLEQ HHHHHHHHHHHHHHH	33.40	-
638	Ubiquitination	IKKKTVRERLEQIKK HHHHHHHHHHHHHHH	58.23	-
644	Ubiquitination	RERLEQIKKTELGAK HHHHHHHHHCHHHHH	54.02	27667366
645	Ubiquitination	ERLEQIKKTELGAKA HHHHHHHHCHHHHHH	49.19	32015554
646	Phosphorylation	RLEQIKKTELGAKAF HHHHHHHCHHHHHHC	31.29	30576142
651	2-Hydroxyisobutyrylation	KKTELGAKAFKDIDI HHCHHHHHHCCCCCH	53.19	-
651	Ubiquitination	KKTELGAKAFKDIDI HHCHHHHHHCCCCCH	53.19	21906983
654	Ubiquitination	ELGAKAFKDIDIEDL HHHHHHCCCCCHHHH	59.64	21906983
660	Ubiquitination	FKDIDIEDLEELDPD CCCCCHHHHHHHCHH	60.77	-
670	Sulfoxidation	ELDPDFIMAKQVEQL HHCHHHHHHHHHHHH	3.73	30846556
672	Ubiquitination	DPDFIMAKQVEQLEK CHHHHHHHHHHHHHH	37.18	21906983
677	Ubiquitination	MAKQVEQLEKEKKEL HHHHHHHHHHHHHHH	6.85	-
679	Ubiquitination	KQVEQLEKEKKELQE HHHHHHHHHHHHHHH	81.22	33845483
681	Ubiquitination	VEQLEKEKKELQERL HHHHHHHHHHHHHHH	63.72	29967540
682	Ubiquitination	EQLEKEKKELQERLK HHHHHHHHHHHHHHH	65.82	29967540
686	Ubiquitination	KEKKELQERLKNQEK HHHHHHHHHHHHHHH	73.02	-
689	Ubiquitination	KELQERLKNQEKKID HHHHHHHHHHHHHHH	63.91	22817900
693	Acetylation	ERLKNQEKKIDYFER HHHHHHHHHHHHHHH	45.31	7978581
693	Ubiquitination	ERLKNQEKKIDYFER HHHHHHHHHHHHHHH	45.31	22817900
694	Acetylation	RLKNQEKKIDYFERA HHHHHHHHHHHHHHH	39.80	26051181
694	Malonylation	RLKNQEKKIDYFERA HHHHHHHHHHHHHHH	39.80	26320211
694	Ubiquitination	RLKNQEKKIDYFERA HHHHHHHHHHHHHHH	39.80	22817900
697	Phosphorylation	NQEKKIDYFERAKRL HHHHHHHHHHHHHHH	15.71	28152594
700	Methylation	KKIDYFERAKRLEEI HHHHHHHHHHHHHHC	35.19	-
711	Ubiquitination	LEEIPLIKSAYEEQR HHHCCCCHHHHHHHC	36.39	21890473
711	2-Hydroxyisobutyrylation	LEEIPLIKSAYEEQR HHHCCCCHHHHHHHC	36.39	-
711	Acetylation	LEEIPLIKSAYEEQR HHHCCCCHHHHHHHC	36.39	25953088
711	Ubiquitination	LEEIPLIKSAYEEQR HHHCCCCHHHHHHHC	36.39	23000965
720	2-Hydroxyisobutyrylation	AYEEQRIKDMDLWEQ HHHHHCCCCCCHHHH	49.54	-
720	Ubiquitination	AYEEQRIKDMDLWEQ HHHHHCCCCCCHHHH	49.54	21906983
722	Sulfoxidation	EEQRIKDMDLWEQQE HHHCCCCCCHHHHHH	3.76	30846556
736	Sulfoxidation	EEERITTMQLEREKA HHHHHHHHHHHHHHH	2.99	21406390
741	Ubiquitination	TTMQLEREKALEHKN HHHHHHHHHHHHHHH	33.05	-
742	2-Hydroxyisobutyrylation	TMQLEREKALEHKNR HHHHHHHHHHHHHHH	65.57	-
742	Ubiquitination	TMQLEREKALEHKNR HHHHHHHHHHHHHHH	65.57	24816145
743	Ubiquitination	MQLEREKALEHKNRM HHHHHHHHHHHHHHH	17.27	-
747	2-Hydroxyisobutyrylation	REKALEHKNRMSRML HHHHHHHHHHHHHHH	36.55	-
757	Methylation	MSRMLEDRDLFVMRL HHHHHCHHCHHHHHH	32.91	-
770	Phosphorylation	RLKAARQSVYEEKLK HHHHHHHHHHHHHHH	22.55	23401153
772	Phosphorylation	KAARQSVYEEKLKQF HHHHHHHHHHHHHHH	24.50	28152594
775	Ubiquitination	RQSVYEEKLKQFEER HHHHHHHHHHHHHHH	49.39	21890473
775	2-Hydroxyisobutyrylation	RQSVYEEKLKQFEER HHHHHHHHHHHHHHH	49.39	-
775	Acetylation	RQSVYEEKLKQFEER HHHHHHHHHHHHHHH	49.39	27452117
775	Neddylation	RQSVYEEKLKQFEER HHHHHHHHHHHHHHH	49.39	32015554
775	Ubiquitination	RQSVYEEKLKQFEER HHHHHHHHHHHHHHH	49.39	21906983
777	Ubiquitination	SVYEEKLKQFEERLA HHHHHHHHHHHHHHH	65.10	21890473
777	Ubiquitination	SVYEEKLKQFEERLA HHHHHHHHHHHHHHH	65.10	23000965
782	Methylation	KLKQFEERLAEERHN HHHHHHHHHHHHHHH	31.81	-
790	Ubiquitination	LAEERHNRLEERKRQ HHHHHHHHHHHHHHH	37.03	-
822	Sulfoxidation	QRRAEEQMLKEREER HHHHHHHHHHHHHHH	6.98	30846556
824	Ubiquitination	RAEEQMLKEREERER HHHHHHHHHHHHHHH	49.75	21906983
842	Methylation	AKREEELREYQERVK HHHHHHHHHHHHHHH	43.80	-
844	Phosphorylation	REEELREYQERVKKL HHHHHHHHHHHHHHH	14.83	-
850	Ubiquitination	EYQERVKKLEEVERK HHHHHHHHHHHHHHH	59.27	24816145
881	Phosphorylation	EERRLGDSSLSRKDS HHHHHCCCCCCCCCC	31.23	29255136
882	Phosphorylation	ERRLGDSSLSRKDSR HHHHCCCCCCCCCCC	34.79	29255136
884	Phosphorylation	RLGDSSLSRKDSRWG HHCCCCCCCCCCCCC	38.95	30266825
888	Phosphorylation	SSLSRKDSRWGDRDS CCCCCCCCCCCCCCC	32.73	26074081
895	Phosphorylation	SRWGDRDSEGTWRKG CCCCCCCCCCCCCCC	38.53	25159151
898	Phosphorylation	GDRDSEGTWRKGPEA CCCCCCCCCCCCCCC	20.32	22115753
916	Acetylation	WRRGPPEKEWRRGEG CCCCCCHHHCCCCCC	69.24	26051181
949	Phosphorylation	DDEDREPSLRPDDDR CCCCCCCCCCCCCCC	32.05	26657352
956	Methylation	SLRPDDDRVPRRGMD CCCCCCCCCCCCCCC	47.54	-
960	Methylation	DDDRVPRRGMDDDRG CCCCCCCCCCCCCCC	38.42	-
966	Methylation	RRGMDDDRGPRRGPE CCCCCCCCCCCCCCH	65.10	-
976	Methylation	RRGPEEDRFSRRGAD CCCCHHHCCCCCCCC	34.42	-
978	Phosphorylation	GPEEDRFSRRGADDD CCHHHCCCCCCCCCC	23.20	29255136
986	Methylation	RRGADDDRPSWRNTD CCCCCCCCCCCCCCC	33.86	-
988	Phosphorylation	GADDDRPSWRNTDDD CCCCCCCCCCCCCCC	39.29	26091039
992	Phosphorylation	DRPSWRNTDDDRPPR CCCCCCCCCCCCCCC	32.03	28555341
1006	Methylation	RRIADEDRGNWRHAD CCCCCCCCCCCCCCC	37.99	-
1026	Methylation	RRGLDEDRGSWRTAD CCCCCCCCCCCCCCC	38.71	-
1028	Phosphorylation	GLDEDRGSWRTADED CCCCCCCCCCCCCCC	17.80	23401153
1031	Phosphorylation	EDRGSWRTADEDRGP CCCCCCCCCCCCCCC	32.00	30576142
1040	Methylation	DEDRGPRRGMDDDRG CCCCCCCCCCCCCCC	48.17	-
1046	Methylation	RRGMDDDRGPRRGGA CCCCCCCCCCCCCCC	65.10	-
1057	Methylation	RGGADDERSSWRNAD CCCCCCCCHHCCCCC	42.88	-
1058	Phosphorylation	GGADDERSSWRNADD CCCCCCCHHCCCCCC	32.00	27251275
1059	Phosphorylation	GADDERSSWRNADDD CCCCCCHHCCCCCCC	35.95	20068231
1071	Methylation	DDDRGPRRGLDDDRG CCCCCCCCCCCCCCC	53.83	-
1081	Methylation	DDDRGPRRGMDDDRG CCCCCCCCCCCCCCC	48.17	-
1087	Methylation	RRGMDDDRGPRRGMD CCCCCCCCCCCCCCC	65.10	-
1091	Methylation	DDDRGPRRGMDDDRG CCCCCCCCCCCCCCC	48.17	-
1097	Methylation	RRGMDDDRGPRRGMD CCCCCCCCCCCCCCC	65.10	-
1101	Methylation	DDDRGPRRGMDDDRG CCCCCCCCCCCCCCC	48.17	-
1107	Methylation	RRGMDDDRGPRRGLD CCCCCCCCCCCCCCC	65.10	-
1111	Methylation	DDDRGPRRGLDDDRG CCCCCCCCCCCCCCC	53.83	-
1117	Methylation	RRGLDDDRGPWRNAD CCCCCCCCCCCCCCC	61.13	-
1127	Methylation	WRNADDDRIPRRGAE CCCCCCCCCCCCCCC	48.05	-
1137	Methylation	RRGAEDDRGPWRNMD CCCCCCCCCCCCCCC	66.45	-
1149	Phosphorylation	NMDDDRLSRRADDDR CCCCHHHHHHCCCCC	22.18	25850435
1156	Methylation	SRRADDDRFPRRGDD HHHCCCCCCCCCCCC	50.92	-
1174	Acetylation	GPWRPLVKPGGWREK CCCCCCCCCCCHHHH	45.70	12433583
1188	Phosphorylation	KEKAREESWGPPRES HHHHHHHHCCCCCCC	32.36	23401153
1195	Phosphorylation	SWGPPRESRPSEERE HCCCCCCCCCCHHHH	51.26	23403867
1198	Phosphorylation	PPRESRPSEEREWDR CCCCCCCCHHHHHHH	51.48	25159151
1238	Methylation	RDVDREDRFRRPRDE CCCCHHHHCCCCCCC	23.40	-
1256	Phosphorylation	RRGPAEESSSWRDSS CCCCCCCCCCCCCCC	22.60	28857561
1257	Phosphorylation	RGPAEESSSWRDSSR CCCCCCCCCCCCCCC	36.88	26434776
1258	Phosphorylation	GPAEESSSWRDSSRR CCCCCCCCCCCCCCC	35.10	28985074
1262	Phosphorylation	ESSSWRDSSRRDDRD CCCCCCCCCCCCCCC	19.71	26434776
1263	Phosphorylation	SSSWRDSSRRDDRDR CCCCCCCCCCCCCCH	35.31	22617229
1302	Phosphorylation	RRGPPLRSEREEVSS CCCCCCHHHHHHHHH	49.00	28555341
1309	Phosphorylation	SEREEVSSWRRADDR HHHHHHHHHCCCCCC	29.76	-
1336	Phosphorylation	RVPPPALSRDRERDR CCCCCCCCCHHHHHH	33.95	23401153
1351	Acetylation	DREREGEKEKASWRA HHHHHHHHHHHHHHH	75.31	20167786
1355	Phosphorylation	EGEKEKASWRAEKDR HHHHHHHHHHHHHHH	28.32	-
1364	Phosphorylation	RAEKDRESLRRTKNE HHHHHHHHHHHHCCC	28.24	28355574
1368	Phosphorylation	DRESLRRTKNETDED HHHHHHHHCCCCCCC	31.61	26074081
1372	Phosphorylation	LRRTKNETDEDGWTT HHHHCCCCCCCCCCC	54.83	21815630
1378	Phosphorylation	ETDEDGWTTVRR--- CCCCCCCCCCCC---	22.42	26074081
1379	Phosphorylation	TDEDGWTTVRR---- CCCCCCCCCCC----	12.90	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1364	S	Phosphorylation	Kinase	PKCB ISO2	P05771-2	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EIF3A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EIF3A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EIF3L_HUMAN	EIF3L	physical	17353931
EIF3E_HUMAN	EIF3E	physical	17353931
EIF3H_HUMAN	EIF3H	physical	17353931
EIF3I_HUMAN	EIF3I	physical	17353931
EIF3F_HUMAN	EIF3F	physical	17353931
EIF3K_HUMAN	EIF3K	physical	17353931
EIF3M_HUMAN	EIF3M	physical	17353931
EIF3D_HUMAN	EIF3D	physical	17353931
EIF3K_HUMAN	EIF3K	physical	14519125
EIF3B_HUMAN	EIF3B	physical	14519125
EIF3E_HUMAN	EIF3E	physical	14519125
EIF3G_HUMAN	EIF3G	physical	14519125
EIF3I_HUMAN	EIF3I	physical	14519125
EIF3J_HUMAN	EIF3J	physical	14519125
EIF3C_HUMAN	EIF3C	physical	14519125
EIF3D_HUMAN	EIF3D	physical	14519125
EIF3F_HUMAN	EIF3F	physical	14519125
EIF3H_HUMAN	EIF3H	physical	14519125
EIF3I_HUMAN	EIF3I	physical	8995409
EIF3L_HUMAN	EIF3L	physical	11590142
EIF3B_HUMAN	EIF3B	physical	9822659
EIF3C_HUMAN	EIF3C	physical	9822659
EIF3D_HUMAN	EIF3D	physical	9822659
EIF3F_HUMAN	EIF3F	physical	9822659
EIF3G_HUMAN	EIF3G	physical	9822659
EIF3H_HUMAN	EIF3H	physical	9822659
EIF3J_HUMAN	EIF3J	physical	9822659
EIF3B_HUMAN	EIF3B	physical	8995410
EIF3D_HUMAN	EIF3D	physical	9341143
EIF3F_HUMAN	EIF3F	physical	9341143
EIF3G_HUMAN	EIF3G	physical	9341143
EIF3F_HUMAN	EIF3F	physical	19245811
EIF3B_HUMAN	EIF3B	physical	19245811
EIF3B_HUMAN	EIF3B	physical	22939629
EIF3I_HUMAN	EIF3I	physical	22939629
EIF3E_HUMAN	EIF3E	physical	22939629
EIF3F_HUMAN	EIF3F	physical	22939629
EIF3D_HUMAN	EIF3D	physical	22939629
EIF3K_HUMAN	EIF3K	physical	22939629
EIF3C_HUMAN	EIF3C	physical	22939629
EIF3G_HUMAN	EIF3G	physical	22939629
EIF3H_HUMAN	EIF3H	physical	22939629
EIF3L_HUMAN	EIF3L	physical	22939629
EIF3M_HUMAN	EIF3M	physical	22939629
IF4H_HUMAN	EIF4H	physical	22939629
RLA1_HUMAN	RPLP1	physical	22939629
NUCL_HUMAN	NCL	physical	22939629
NP1L4_HUMAN	NAP1L4	physical	22939629
HNRPF_HUMAN	HNRNPF	physical	22939629
MSMO1_HUMAN	MSMO1	physical	22939629
MYH9_HUMAN	MYH9	physical	22939629
RM46_HUMAN	MRPL46	physical	22939629
MYH11_HUMAN	MYH11	physical	22939629
TOM40_HUMAN	TOMM40	physical	22939629
TBB6_HUMAN	TUBB6	physical	22939629
RENT1_HUMAN	UPF1	physical	18423202
EIF3E_HUMAN	EIF3E	physical	22863883
EIF3K_HUMAN	EIF3K	physical	22863883
LARP1_HUMAN	LARP1	physical	22863883
CPSF5_HUMAN	NUDT21	physical	22863883
RS25_HUMAN	RPS25	physical	22863883
RS9_HUMAN	RPS9	physical	22863883
YTHD2_HUMAN	YTHDF2	physical	22863883
TFP11_HUMAN	TFIP11	physical	25416956
ABCF2_HUMAN	ABCF2	physical	26344197
EIF3B_HUMAN	EIF3B	physical	26344197
EIF3C_HUMAN	EIF3C	physical	26344197
EIFCL_HUMAN	EIF3CL	physical	26344197
EIF3D_HUMAN	EIF3D	physical	26344197
EIF3F_HUMAN	EIF3F	physical	26344197
EIF3G_HUMAN	EIF3G	physical	26344197
EIF3H_HUMAN	EIF3H	physical	26344197
EIF3I_HUMAN	EIF3I	physical	26344197
EIF3K_HUMAN	EIF3K	physical	26344197
UBIM_HUMAN	FAU	physical	27082860

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EIF3A_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-68, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-492, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-584 AND SER-1336, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Structural characterization of the human eukaryotic initiation factor3 protein complex by mass spectrometry."; Damoc E., Fraser C.S., Zhou M., Videler H., Mayeur G.L.,Hershey J.W.B., Doudna J.A., Robinson C.V., Leary J.A.; Mol. Cell. Proteomics 6:1135-1146(2007). Cited for: IDENTIFICATION IN THE EIF-3 COMPLEX, CHARACTERIZATION OF THE EIF-3COMPLEX, CLEAVAGE OF INITIATOR METHIONINE, PHOSPHORYLATION AT SER-881;SER-1198; SER-1336 AND SER-1364, AND MASS SPECTROMETRY.	17322308 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-382, AND MASSSPECTROMETRY.	18083107 [Abstract]