RCL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RCL1_HUMAN
• UniProt AC: Q9Y2P8
• Protein Name: RNA 3'-terminal phosphate cyclase-like protein
• Gene Name: RCL1
• Organism: Homo sapiens (Human).
• Sequence Length: 373
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity)..
• Protein Sequence: MATQAHSLSYAGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKITNGSRIEINQTGTTLYYQPGLLYGGSVEHDCSVLRGIGYYLESLLCLAPFMKHPLKIVLRGVTNDQVDPSVDVLKATALPLLKQFGIDGESFELKIVRRGMPPGGGGEVVFSCPVRKVLKPIQLTDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGVNSGKSPGFGLSLVAETTSGTFLSAELASNPQGQGAAVLPEDLGRNCARLLLEEIYRGGCVDSTNQSLALLLMTLGQQDVSKVLLGPLSPYTIEFLRHLKSFFQIMFKIETKPCGEELKGGDKVLMTCVGIGFSNLSKTLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 2)	Phosphorylation	-	14.39	22210691
5 (in isoform 2)	Phosphorylation	-	7.00	22210691
15 (in isoform 2)	Phosphorylation	-	7.47	22210691
26	Phosphorylation	RLVLSTLSGRPVKIR HHHHHHHCCCCEEEE	32.61	19664994
31	Acetylation	TLSGRPVKIRKIRAR HHCCCCEEEEEEEEC	39.20	25953088
57	Acetylation	SFIRLLDKITNGSRI HHHHHHHHHHCCCCE	51.94	26051181
59	Phosphorylation	IRLLDKITNGSRIEI HHHHHHHHCCCCEEE	38.99	-
62	Phosphorylation	LDKITNGSRIEINQT HHHHHCCCCEEECCC	31.96	-
71	Phosphorylation	IEINQTGTTLYYQPG EEECCCCCEEEECCC	19.60	-
74	Phosphorylation	NQTGTTLYYQPGLLY CCCCCEEEECCCEEC	9.65	22817900
75	Phosphorylation	QTGTTLYYQPGLLYG CCCCEEEECCCEECC	16.02	22817900
81	Phosphorylation	YYQPGLLYGGSVEHD EECCCEECCCCCHHC	25.20	22817900
114	Acetylation	PFMKHPLKIVLRGVT HHHCCCEEEEEECCC	34.91	26051181
114	Ubiquitination	PFMKHPLKIVLRGVT HHHCCCEEEEEECCC	34.91	-
118	Methylation	HPLKIVLRGVTNDQV CCEEEEEECCCCCCC	27.00	115490957
133	Ubiquitination	DPSVDVLKATALPLL CCCHHHHHHHHHHHH	43.47	21906983
141	Ubiquitination	ATALPLLKQFGIDGE HHHHHHHHHHCCCCC	51.79	2190698
170	Phosphorylation	GGGEVVFSCPVRKVL CCCCEEEECCCCCCC	13.10	25278378
175	Ubiquitination	VFSCPVRKVLKPIQL EEECCCCCCCCCEEC	52.75	-
178	Ubiquitination	CPVRKVLKPIQLTDP CCCCCCCCCEECCCC	42.96	-
183	Phosphorylation	VLKPIQLTDPGKIKR CCCCEECCCCCCEEE	24.63	-
187	Ubiquitination	IQLTDPGKIKRIRGM EECCCCCCEEEEECC	50.90	-
207	Methylation	VSPQMANRIVDSARS ECHHHHHHHHHHHHH	22.29	115490963
214	Phosphorylation	RIVDSARSILNKFIP HHHHHHHHHHHHHCC	31.01	24719451
224	Phosphorylation	NKFIPDIYIYTDHMK HHHCCCEEEEECCCC	8.68	-
321	Phosphorylation	KVLLGPLSPYTIEFL HHHHCCCCHHHHHHH	20.99	-
333	Phosphorylation	EFLRHLKSFFQIMFK HHHHHHHHHHHHHCE	37.34	20860994
343	Phosphorylation	QIMFKIETKPCGEEL HHHCEEECCCCCCCC	43.70	22210691
351	Ubiquitination	KPCGEELKGGDKVLM CCCCCCCCCCCEEEE	65.22	-
359	Phosphorylation	GGDKVLMTCVGIGFS CCCEEEEEEEEECCC	10.40	-
366	Phosphorylation	TCVGIGFSNLSKTLK EEEEECCCCHHHHCC	31.48	-
369	Phosphorylation	GIGFSNLSKTLK--- EECCCCHHHHCC---	28.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RCL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RCL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RCL1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RCL1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.