LMNB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LMNB2_MOUSE
• UniProt AC: P21619
• Protein Name: Lamin-B2
• Gene Name: Lmnb2
• Organism: Mus musculus (Mouse).
• Sequence Length: 596
• Subcellular Localization: Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.
• Protein Description: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin..
• Protein Sequence: MASLPPHAGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLRISEKEEVTTREVSGIKTLYESELADARRVLDETARERARLQIEIGKVQAELEEARKSAKKREGELTVAQGRVKDLESLFHRSEAELATALSDKQGLETEVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELAFSKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEDLRSQHDEQVRLYRVELEQTYQAKLDNAKLLSDQNDKAAHAAREELKEARMRVESLSYQLLGLQKQASAAENHIHELEEALAGERDKFRKMLDAKEQEMTEVRDAMQQQLAEYQELLDIKLALDMEISAYRKLLEGEEERLKLSPSPSSRITISRATSSSSSSSGVGMSVGQGRGKRRRLETEDTSGSPSRASRVSSGSRLAQQTVATGVVNIDEVDPEGRFVRLKNSSDKDQSLGNWRIKRQVLEGEDIAYKFTPKYVLRAGQTVTVWAAGAGATHSPPSTLVWKSQTNWGPGESFRTALVSADGEEVAVKAAKHSSVQGRENGEEEEEEEAEFGEEDLFHQQGDPRTTSRGCRLM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASLPPHAGP -----CCCCCCCCCC	39.86	25619855
12	Phosphorylation	PPHAGPATPLSPTRL CCCCCCCCCCCHHHH	28.09	26824392
15	Phosphorylation	AGPATPLSPTRLSRL CCCCCCCCHHHHHHH	25.98	27566939
17	Phosphorylation	PATPLSPTRLSRLQE CCCCCCHHHHHHHHH	40.65	25619855
20	Phosphorylation	PLSPTRLSRLQEKEE CCCHHHHHHHHHHHH	27.88	26745281
25	Acetylation	RLSRLQEKEELRELN HHHHHHHHHHHHHHH	43.45	22631261
59	Acetylation	LLLRISEKEEVTTRE EEEEEECCCCCCCHH	53.00	23954790
59	Ubiquitination	LLLRISEKEEVTTRE EEEEEECCCCCCCHH	53.00	-
59	Malonylation	LLLRISEKEEVTTRE EEEEEECCCCCCCHH	53.00	26320211
68	Phosphorylation	EVTTREVSGIKTLYE CCCCHHCCCCCHHHH	30.01	22871156
74	Phosphorylation	VSGIKTLYESELADA CCCCCHHHHHHHHHH	23.73	22871156
101	Ubiquitination	RLQIEIGKVQAELEE HHHHHHHHHHHHHHH	36.51	22790023
115	Ubiquitination	EARKSAKKREGELTV HHHHHHHHHHCCEEE	56.23	22790023
128	Ubiquitination	TVAQGRVKDLESLFH EEEECCCCCHHHHHH	56.06	22790023
132	Phosphorylation	GRVKDLESLFHRSEA CCCCCHHHHHHHHHH	43.57	22802335
143	Phosphorylation	RSEAELATALSDKQG HHHHHHHHHHHHCCC	40.53	22802335
146	Phosphorylation	AELATALSDKQGLET HHHHHHHHHCCCHHH	40.05	22802335
148	Ubiquitination	LATALSDKQGLETEV HHHHHHHCCCHHHHH	42.78	22790023
164	Ubiquitination	ELRAQLAKAEDGHAV HHHHHHHHCCCCCHH	61.98	22790023
173	Acetylation	EDGHAVAKKQLEKET CCCCHHHHHHHHHHH	34.16	23864654
178	Acetylation	VAKKQLEKETLMRVD HHHHHHHHHHHHHCC	65.67	23954790
233	Ubiquitination	RQQEYDFKMAQALED HHHHHHHHHHHHHHH	30.35	22790023
263	Ubiquitination	LEQTYQAKLDNAKLL HHHHHHHHHHCCHHC	40.63	22790023
263	Acetylation	LEQTYQAKLDNAKLL HHHHHHHHHHCCHHC	40.63	23954790
268	Ubiquitination	QAKLDNAKLLSDQND HHHHHCCHHCCCCCH	57.10	22790023
268	Acetylation	QAKLDNAKLLSDQND HHHHHCCHHCCCCCH	57.10	23954790
276	Malonylation	LLSDQNDKAAHAARE HCCCCCHHHHHHHHH	55.83	26320211
276	Ubiquitination	LLSDQNDKAAHAARE HCCCCCHHHHHHHHH	55.83	-
294	Phosphorylation	EARMRVESLSYQLLG HHHHHHHHHHHHHHH	21.54	29472430
296	Phosphorylation	RMRVESLSYQLLGLQ HHHHHHHHHHHHHHH	21.80	23984901
304	Acetylation	YQLLGLQKQASAAEN HHHHHHHHHHHHHHH	53.53	23954790
329	Ubiquitination	GERDKFRKMLDAKEQ CCHHHHHHHHHHHHH	47.12	22790023
334	Acetylation	FRKMLDAKEQEMTEV HHHHHHHHHHHHHHH	60.64	23954790
367	Phosphorylation	LALDMEISAYRKLLE HHHHHHHHHHHHHHC	13.12	26824392
369	Phosphorylation	LDMEISAYRKLLEGE HHHHHHHHHHHHCCH	11.07	29895711
371	Acetylation	MEISAYRKLLEGEEE HHHHHHHHHHCCHHH	44.76	22631253
371	Ubiquitination	MEISAYRKLLEGEEE HHHHHHHHHHCCHHH	44.76	-
381	Ubiquitination	EGEEERLKLSPSPSS CCHHHHHCCCCCCCC	53.81	-
383	Phosphorylation	EEERLKLSPSPSSRI HHHHHCCCCCCCCCE	23.03	26824392
385	Phosphorylation	ERLKLSPSPSSRITI HHHCCCCCCCCCEEE	33.76	26824392
387	Phosphorylation	LKLSPSPSSRITISR HCCCCCCCCCEEEEE	36.26	27149854
388	Phosphorylation	KLSPSPSSRITISRA CCCCCCCCCEEEEEE	30.96	27149854
393	Phosphorylation	PSSRITISRATSSSS CCCCEEEEEEECCCC	13.76	24719451
396	Phosphorylation	RITISRATSSSSSSS CEEEEEEECCCCCCC	28.21	25521595
397	Phosphorylation	ITISRATSSSSSSSG EEEEEEECCCCCCCC	27.51	25521595
398	Phosphorylation	TISRATSSSSSSSGV EEEEEECCCCCCCCC	29.86	22802335
399	Phosphorylation	ISRATSSSSSSSGVG EEEEECCCCCCCCCC	33.72	30635358
400	Phosphorylation	SRATSSSSSSSGVGM EEEECCCCCCCCCCC	35.87	25521595
401	Phosphorylation	RATSSSSSSSGVGMS EEECCCCCCCCCCCC	30.39	27087446
402	Phosphorylation	ATSSSSSSSGVGMSV EECCCCCCCCCCCCC	32.81	27087446
403	Phosphorylation	TSSSSSSSGVGMSVG ECCCCCCCCCCCCCC	39.17	25521595
408	Phosphorylation	SSSGVGMSVGQGRGK CCCCCCCCCCCCCCC	19.71	28833060
413	Methylation	GMSVGQGRGKRRRLE CCCCCCCCCCCCCCC	39.30	24129315
421	Phosphorylation	GKRRRLETEDTSGSP CCCCCCCCCCCCCCC	43.69	25521595
424	Phosphorylation	RRLETEDTSGSPSRA CCCCCCCCCCCCCHH	28.84	27742792
425	Phosphorylation	RLETEDTSGSPSRAS CCCCCCCCCCCCHHH	49.98	23527152
427	Phosphorylation	ETEDTSGSPSRASRV CCCCCCCCCCHHHCC	21.33	27087446
429	Phosphorylation	EDTSGSPSRASRVSS CCCCCCCCHHHCCCC	42.02	25521595
432	Phosphorylation	SGSPSRASRVSSGSR CCCCCHHHCCCCCCH	31.91	25159016
435	Phosphorylation	PSRASRVSSGSRLAQ CCHHHCCCCCCHHHH	28.07	25338131
436	Phosphorylation	SRASRVSSGSRLAQQ CHHHCCCCCCHHHHC	37.62	-
467	Phosphorylation	RFVRLKNSSDKDQSL CEEEEECCCCCCCCC	38.02	25338131
470	Ubiquitination	RLKNSSDKDQSLGNW EEECCCCCCCCCCCC	60.66	22790023
473	Phosphorylation	NSSDKDQSLGNWRIK CCCCCCCCCCCCEEE	48.67	-
491	Phosphorylation	LEGEDIAYKFTPKYV EECCCCEEEECHHHH	13.63	25521595
492	Malonylation	EGEDIAYKFTPKYVL ECCCCEEEECHHHHC	33.47	26320211
494	Phosphorylation	EDIAYKFTPKYVLRA CCCEEEECHHHHCCC	18.08	25521595
496	Malonylation	IAYKFTPKYVLRAGQ CEEEECHHHHCCCCC	44.95	26320211
496	Ubiquitination	IAYKFTPKYVLRAGQ CEEEECHHHHCCCCC	44.95	-
504	Phosphorylation	YVLRAGQTVTVWAAG HHCCCCCEEEEEECC	19.75	25159016
506	Phosphorylation	LRAGQTVTVWAAGAG CCCCCEEEEEECCCC	17.45	27600695
515	Phosphorylation	WAAGAGATHSPPSTL EECCCCCCCCCCCEE	23.20	23984901
517	Phosphorylation	AGAGATHSPPSTLVW CCCCCCCCCCCEEEE	33.86	25159016
520	Phosphorylation	GATHSPPSTLVWKSQ CCCCCCCCEEEEECC	37.44	23984901
521	Phosphorylation	ATHSPPSTLVWKSQT CCCCCCCEEEEECCC	30.98	23984901
526	Phosphorylation	PSTLVWKSQTNWGPG CCEEEEECCCCCCCC	26.90	22817900
528	Phosphorylation	TLVWKSQTNWGPGES EEEEECCCCCCCCHH	39.78	28066266
551	Ubiquitination	DGEEVAVKAAKHSSV CCHHHHHHHHHHCCC	32.65	22790023
593	Methylation	PRTTSRGCRLM---- CCCCCCCCCCC----	2.68	-
593	Farnesylation	PRTTSRGCRLM---- CCCCCCCCCCC----	2.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LMNB2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LMNB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LMNB2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LMNB2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-427, AND MASSSPECTROMETRY.
PubMed: 16452087

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-494, AND MASSSPECTROMETRY.
PubMed: 19367708