LAR4B_MOUSE - dbPTM
LAR4B_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAR4B_MOUSE
UniProt AC Q6A0A2
Protein Name La-related protein 4B
Gene Name Larp4b
Organism Mus musculus (Mouse).
Sequence Length 741
Subcellular Localization Cytoplasm, cytosol . Localized in cytoplasmic mRNP granules containing untranslated mRNAs in response to arsenite treatment.
Protein Description Stimulates mRNA translation..
Protein Sequence MTSDQDAKVVAEPQAQRVQEGKDSSHLMNGPISQTTSQTRSLPALTQVPTTKVSELNPNAKVWGTHMLHLEASSAAVGVNAAWEEAPGHPTDCDQQVLGLDANGDGDKSRENAALPDAQEAEQTDMSTLALDHSEYEPLPENNDTGGNESQPESQEDPREVLKKTLEFCLSRENLASDMYLISQMDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDEKGEKVRPNQNRCIVILREISESTPVEEVEALFKGDNLPKFINCEFAYNDNWFITFETEADAQQAYKYLREEVRTFQGKPIKARIKAKAIAINTFLPKNGFRPLDMNLYTQQRYATSFYLPPVYSPQQQFPLYSLITPQTWSTTHSYLDPPLVTPFPSTGFINGFTSPTFKPATSPLTSLRQYPPRSRNPSKSHLRHAIPSTERGPGLLESPSIFNFTADRLINGVRSPQTRQAGQTRTRIQNPSAYAKREIGTGRVEPSSLESSPGLGRGRKNSFGYRKKREEKFTSSQTQSPTPPKPPSPSFELGLSNFPPLPGAAGNLKTEDLFENRLSSLIIGSSKERNLSTDASTNTVPVVGPREPSVPAPCAVSAAFERSPSPVHLPEDPKVAEKQRETQSVDRLPSTPTTTACKSVQVNGAATELRKPSYAEICQRTSKDPSSSSPLQPPKEQKPSTVACGKEEKQLSEPVERHREPPALKSTPGVPKDQRRQPGRRASPPAAGKRLSKEQNTPPKSPQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MTSDQDAK
-------CCCHHHHH		7.95-
2Phosphorylation------MTSDQDAKV
------CCCHHHHHE		40.8024759943
41PhosphorylationQTTSQTRSLPALTQV
CCCCCCCCCCCCCCC		41.9325521595
51O-linked_GlycosylationALTQVPTTKVSELNP
CCCCCCCCCHHHCCC		24.3130059200
246PhosphorylationIVILREISESTPVEE
EEEEEEHHCCCCHHH		22.2719144319
248PhosphorylationILREISESTPVEEVE
EEEEHHCCCCHHHHH		31.0828066266
313UbiquitinationIKARIKAKAIAINTF
CCHHHHHEEEEEECC		35.0122790023
319PhosphorylationAKAIAINTFLPKNGF
HEEEEEECCCCCCCC		22.0422802335
334PhosphorylationRPLDMNLYTQQRYAT
CCCCCCHHHCCCCEE		9.4825367039
335PhosphorylationPLDMNLYTQQRYATS
CCCCCHHHCCCCEEE		22.7625367039
399PhosphorylationSPTFKPATSPLTSLR
CCCCCCCCCCCCCHH		39.1326643407
400PhosphorylationPTFKPATSPLTSLRQ
CCCCCCCCCCCCHHH		21.7326824392
403PhosphorylationKPATSPLTSLRQYPP
CCCCCCCCCHHHCCC		29.1528066266
406MethylationTSPLTSLRQYPPRSR
CCCCCCHHHCCCCCC		33.48-
416 (in isoform 2)Phosphorylation-50.7929895711
416PhosphorylationPPRSRNPSKSHLRHA
CCCCCCCCHHHHHHC		50.7925266776
418PhosphorylationRSRNPSKSHLRHAIP
CCCCCCHHHHHHCCC		31.9028066266
421MethylationNPSKSHLRHAIPSTE
CCCHHHHHHCCCCCC		16.27-
426PhosphorylationHLRHAIPSTERGPGL
HHHHCCCCCCCCCCC		36.47-
436PhosphorylationRGPGLLESPSIFNFT
CCCCCCCCCCCEEEC		24.7426643407
438PhosphorylationPGLLESPSIFNFTAD
CCCCCCCCCEEECHH		49.4428066266
443PhosphorylationSPSIFNFTADRLING
CCCCEEECHHHHHCC		28.8422817900
453PhosphorylationRLINGVRSPQTRQAG
HHHCCCCCCCCCCCC		20.9626824392
456PhosphorylationNGVRSPQTRQAGQTR
CCCCCCCCCCCCCCC		28.2926643407
470PhosphorylationRTRIQNPSAYAKREI
CCCCCCHHHHHHEEE		41.2725367039
472PhosphorylationRIQNPSAYAKREIGT
CCCCHHHHHHEEECC		19.5925367039
485PhosphorylationGTGRVEPSSLESSPG
CCCCCCHHHHCCCCC		33.7730635358
486PhosphorylationTGRVEPSSLESSPGL
CCCCCHHHHCCCCCC		47.0430635358
489PhosphorylationVEPSSLESSPGLGRG
CCHHHHCCCCCCCCC		47.3130635358
490PhosphorylationEPSSLESSPGLGRGR
CHHHHCCCCCCCCCC		17.3830635358
495MethylationESSPGLGRGRKNSFG
CCCCCCCCCCCCCCC		46.9524129315
497MethylationSPGLGRGRKNSFGYR
CCCCCCCCCCCCCCC		33.3530987765
500PhosphorylationLGRGRKNSFGYRKKR
CCCCCCCCCCCCHHC		24.0826824392
503PhosphorylationGRKNSFGYRKKREEK
CCCCCCCCCHHCHHH		19.7628285833
512PhosphorylationKKREEKFTSSQTQSP
HHCHHHCCCCCCCCC		38.2422942356
513PhosphorylationKREEKFTSSQTQSPT
HCHHHCCCCCCCCCC		24.4723684622
514PhosphorylationREEKFTSSQTQSPTP
CHHHCCCCCCCCCCC		33.9025168779
516PhosphorylationEKFTSSQTQSPTPPK
HHCCCCCCCCCCCCC		32.7222942356
518PhosphorylationFTSSQTQSPTPPKPP
CCCCCCCCCCCCCCC		33.8422942356
520PhosphorylationSSQTQSPTPPKPPSP
CCCCCCCCCCCCCCC		58.4323684622
526PhosphorylationPTPPKPPSPSFELGL
CCCCCCCCCCCEECC		41.5226824392
528PhosphorylationPPKPPSPSFELGLSN
CCCCCCCCCEECCCC		35.3726824392
534PhosphorylationPSFELGLSNFPPLPG
CCCEECCCCCCCCCC		34.3322942356
557PhosphorylationDLFENRLSSLIIGSS
HHHHHHHHHHHHCCC		21.6223984901
558PhosphorylationLFENRLSSLIIGSSK
HHHHHHHHHHHCCCC		28.3425521595
563PhosphorylationLSSLIIGSSKERNLS
HHHHHHCCCCCCCCC		28.0329472430
564PhosphorylationSSLIIGSSKERNLST
HHHHHCCCCCCCCCC		33.0729472430
565UbiquitinationSLIIGSSKERNLSTD
HHHHCCCCCCCCCCC		63.4922790023
570PhosphorylationSSKERNLSTDASTNT
CCCCCCCCCCCCCCC		27.9926824392
571PhosphorylationSKERNLSTDASTNTV
CCCCCCCCCCCCCCC		38.4622942356
574PhosphorylationRNLSTDASTNTVPVV
CCCCCCCCCCCCCCC		25.6221743459
575PhosphorylationNLSTDASTNTVPVVG
CCCCCCCCCCCCCCC		36.3125777480
577PhosphorylationSTDASTNTVPVVGPR
CCCCCCCCCCCCCCC		26.6924453211
587PhosphorylationVVGPREPSVPAPCAV
CCCCCCCCCCCCCEE		35.6625159016
595PhosphorylationVPAPCAVSAAFERSP
CCCCCEEEHHCCCCC		8.7122324799
601PhosphorylationVSAAFERSPSPVHLP
EEHHCCCCCCCCCCC		23.6425521595
603PhosphorylationAAFERSPSPVHLPED
HHCCCCCCCCCCCCC		40.5827087446
620PhosphorylationVAEKQRETQSVDRLP
HHHHHHHCCCCCCCC		28.4725619855
622PhosphorylationEKQRETQSVDRLPST
HHHHHCCCCCCCCCC		33.1425619855
628PhosphorylationQSVDRLPSTPTTTAC
CCCCCCCCCCCCCCC		52.1628725479
629PhosphorylationSVDRLPSTPTTTACK
CCCCCCCCCCCCCCC		23.7926824392
631PhosphorylationDRLPSTPTTTACKSV
CCCCCCCCCCCCCEE		36.5525619855
632PhosphorylationRLPSTPTTTACKSVQ
CCCCCCCCCCCCEEE		17.3825619855
633PhosphorylationLPSTPTTTACKSVQV
CCCCCCCCCCCEEEE		32.3225619855
635GlutathionylationSTPTTTACKSVQVNG
CCCCCCCCCEEEECC		2.9524333276
651PhosphorylationATELRKPSYAEICQR
HHCCCCCCHHHHHHH		39.7622817900
656GlutathionylationKPSYAEICQRTSKDP
CCCHHHHHHHCCCCC		1.3624333276
664PhosphorylationQRTSKDPSSSSPLQP
HHCCCCCCCCCCCCC		53.6526745281
665PhosphorylationRTSKDPSSSSPLQPP
HCCCCCCCCCCCCCC		39.9826745281
666PhosphorylationTSKDPSSSSPLQPPK
CCCCCCCCCCCCCCC		40.0727841257
667PhosphorylationSKDPSSSSPLQPPKE
CCCCCCCCCCCCCCC		31.4226745281
690PhosphorylationGKEEKQLSEPVERHR
CCCHHHCCCCHHHHC		37.0427149854
721PhosphorylationRQPGRRASPPAAGKR
CCCCCCCCCCHHHHC		29.6025521595
727AcetylationASPPAAGKRLSKEQN
CCCCHHHHCCCHHCC		45.50-
730PhosphorylationPAAGKRLSKEQNTPP
CHHHHCCCHHCCCCC		37.8725159016
735PhosphorylationRLSKEQNTPPKSPQ-
CCCHHCCCCCCCCC-		40.4327087446
739PhosphorylationEQNTPPKSPQ-----
HCCCCCCCCC-----		34.0225521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAR4B_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAR4B_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAR4B_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LAR4B_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAR4B_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-500 AND SER-721, ANDMASS SPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-721, AND MASSSPECTROMETRY.

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