MTAP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTAP_MOUSE
• UniProt AC: Q9CQ65
• Protein Name: S-methyl-5'-thioadenosine phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}
• Gene Name: Mtap
• Organism: Mus musculus (Mouse).
• Sequence Length: 283
• Subcellular Localization: Cytoplasm. Nucleus .
• Protein Description: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates..
• Protein Sequence: MASGSACTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDMVIIDQFIDRTSLRPQTFYDGSHCSARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTIVTIEGPRFSSRAESLIFRTWGADVVNMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDGVLKTMKENANKAKSLLLTTIPQIGSMEWSETLRNLKNMAQFSVLPPRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASGSACTAV -----CCCCCCCCEE	31.79	29514104
18	Phosphorylation	KIGIIGGTGLDDPEI EEEEECCCCCCCHHH	29.38	30352176
32	Acetylation	ILEGRTEKYVDTPFG HHCCCCEEECCCCCC	50.38	22826441
40	Acetylation	YVDTPFGKPSDALIL ECCCCCCCCCCEEEE	41.55	23236377
40	Ubiquitination	YVDTPFGKPSDALIL ECCCCCCCCCCEEEE	41.55	27667366
49	Acetylation	SDALILGKIKNVDCV CCEEEEEEECCCCEE	47.24	23806337
49	Succinylation	SDALILGKIKNVDCV CCEEEEEEECCCCEE	47.24	23806337
51	Succinylation	ALILGKIKNVDCVLL EEEEEEECCCCEEEE	55.17	23806337
51	Acetylation	ALILGKIKNVDCVLL EEEEEEECCCCEEEE	55.17	23806337
51	Malonylation	ALILGKIKNVDCVLL EEEEEEECCCCEEEE	55.17	26320211
55	S-nitrosocysteine	GKIKNVDCVLLARHG EEECCCCEEEEECCC	1.70	-
55	Glutathionylation	GKIKNVDCVLLARHG EEECCCCEEEEECCC	1.70	24333276
55	S-nitrosylation	GKIKNVDCVLLARHG EEECCCCEEEEECCC	1.70	21278135
71	Ubiquitination	QHTIMPSKVNYQANI CCEECCCCCCCCCEE	28.73	-
130	S-nitrosocysteine	TFYDGSHCSARGVCH CCCCCCCCCCCCEEE	3.49	-
130	Glutathionylation	TFYDGSHCSARGVCH CCCCCCCCCCCCEEE	3.49	24333276
130	S-nitrosylation	TFYDGSHCSARGVCH CCCCCCCCCCCCEEE	3.49	20925432
136	Glutathionylation	HCSARGVCHIPMAEP CCCCCCEEECCCCCC	2.41	24333276
145	Glutathionylation	IPMAEPFCPKTREVL CCCCCCCCCCCHHHH	5.03	24333276
157	Acetylation	EVLIETAKKLGLRCH HHHHHHHHHHCCEEE	56.82	7613471

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTAP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTAP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTAP_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MTAP_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.