dbPTM

RAB5C_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RAB5C_MOUSE
UniProt AC	P35278
Protein Name	Ras-related protein Rab-5C
Gene Name	Rab5c
Organism	Mus musculus (Mouse).
Sequence Length	216
Subcellular Localization	Cell membrane Lipid-anchor Cytoplasmic side. Early endosome membrane Lipid-anchor. Melanosome.
Protein Description	Protein transport. Probably involved in vesicular traffic (By similarity)..
Protein Sequence	MAGRGGAARPNGPAAGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNTDTFARAKNWVKELQRQASPNIVIALAGNKADLASKRAVEFQEAQAYADDNSLLFMETSAKTAMNVNEIFMAIAKKLPKNEPQNAAGAPGRTRGVDLQESNPASRSQCCSN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	KLVLLGESAVGKSSL EEEEECCCCCCCCHH	26.84	22817900
34	Ubiquitination	LGESAVGKSSLVLRF ECCCCCCCCHHHHHH	30.21	-
35	Phosphorylation	GESAVGKSSLVLRFV CCCCCCCCHHHHHHH	23.99	23737553
36	Phosphorylation	ESAVGKSSLVLRFVK CCCCCCCHHHHHHHC	26.44	23737553
64	Glutathionylation	AFLTQTVCLDDTTVK HEEEEEEECCCCEEE	3.81	24333276
83	Phosphorylation	DTAGQERYHSLAPMY CCCCCCCCHHCCCCH	8.60	25367039
85	Phosphorylation	AGQERYHSLAPMYYR CCCCCCHHCCCCHHC	19.79	25367039
90	Phosphorylation	YHSLAPMYYRGAQAA CHHCCCCHHCCCCEE	6.75	29514104
117	Ubiquitination	ARAKNWVKELQRQAS HHHHHHHHHHHHHCC	44.30	-
117	Acetylation	ARAKNWVKELQRQAS HHHHHHHHHHHHHCC	44.30	23864654
117	Malonylation	ARAKNWVKELQRQAS HHHHHHHHHHHHHCC	44.30	26320211
124	Phosphorylation	KELQRQASPNIVIAL HHHHHHCCCCEEEEE	15.33	26643407
135	Ubiquitination	VIALAGNKADLASKR EEEECCCHHHHHHHH	42.22	-
141	Ubiquitination	NKADLASKRAVEFQE CHHHHHHHHHHHHHH	38.48	-
184	Acetylation	AIAKKLPKNEPQNAA HHHHHCCCCCCCCCC	81.84	23201123
205	Phosphorylation	RGVDLQESNPASRSQ CCCCCCCCCCCCHHH	34.84	25159016
209	Phosphorylation	LQESNPASRSQCCSN CCCCCCCCHHHHCCC	33.45	25159016
213	Geranylgeranylation	NPASRSQCCSN---- CCCCHHHHCCC----	2.64	-
214	Geranylgeranylation	PASRSQCCSN----- CCCHHHHCCC-----	3.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RAB5C_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
85	S	Phosphorylation		-
Phosphorylation of Ser-85 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RAB5C_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPR1B_HUMAN	SPRR1B	physical	20360068
PIP_HUMAN	PIP	physical	20360068
GDIB_HUMAN	GDI2	physical	20360068
RAB5C_HUMAN	RAB5C	physical	20360068
ABCD1_HUMAN	ABCD1	physical	26496610
VATA_HUMAN	ATP6V1A	physical	26496610
VATB2_HUMAN	ATP6V1B2	physical	26496610
VPP1_HUMAN	ATP6V0A1	physical	26496610
HCN2_HUMAN	HCN2	physical	26496610
CAV1_HUMAN	CAV1	physical	26496610
RAE1_HUMAN	CHM	physical	26496610
CLCN7_HUMAN	CLCN7	physical	26496610
COX5B_HUMAN	COX5B	physical	26496610
CX6B1_HUMAN	COX6B1	physical	26496610
STOM_HUMAN	STOM	physical	26496610
FLOT2_HUMAN	FLOT2	physical	26496610
GALT2_HUMAN	GALNT2	physical	26496610
GDIB_HUMAN	GDI2	physical	26496610
GMDS_HUMAN	GMDS	physical	26496610
PDIA3_HUMAN	PDIA3	physical	26496610
TF3B_HUMAN	BRF1	physical	26496610
PLAK_HUMAN	JUP	physical	26496610
KTN1_HUMAN	KTN1	physical	26496610
NDUA2_HUMAN	NDUFA2	physical	26496610
NDUA7_HUMAN	NDUFA7	physical	26496610
NDUAA_HUMAN	NDUFA10	physical	26496610
NDUB1_HUMAN	NDUFB1	physical	26496610
NDUB4_HUMAN	NDUFB4	physical	26496610
NDUS1_HUMAN	NDUFS1	physical	26496610
NDUV1_HUMAN	NDUFV1	physical	26496610
NDUS5_HUMAN	NDUFS5	physical	26496610
NDUS6_HUMAN	NDUFS6	physical	26496610
NDUV2_HUMAN	NDUFV2	physical	26496610
PCDH7_HUMAN	PCDH7	physical	26496610
PHB_HUMAN	PHB	physical	26496610
RAB5B_HUMAN	RAB5B	physical	26496610
RNF5_HUMAN	RNF5	physical	26496610
RS10_HUMAN	RPS10	physical	26496610
SL9A1_HUMAN	SLC9A1	physical	26496610
SOAT1_HUMAN	SOAT1	physical	26496610
STX5_HUMAN	STX5	physical	26496610
TAP1_HUMAN	TAP1	physical	26496610
TFR1_HUMAN	TFRC	physical	26496610
TPM4_HUMAN	TPM4	physical	26496610
QCR1_HUMAN	UQCRC1	physical	26496610
UCRI_HUMAN	UQCRFS1	physical	26496610
VDAC1_HUMAN	VDAC1	physical	26496610
VDAC2_HUMAN	VDAC2	physical	26496610
STX10_HUMAN	STX10	physical	26496610
RAI3_HUMAN	GPRC5A	physical	26496610
VA0D1_HUMAN	ATP6V0D1	physical	26496610
XPR1_HUMAN	XPR1	physical	26496610
VAPB_HUMAN	VAPB	physical	26496610
COG1_HUMAN	COG1	physical	26496610
ABCG2_HUMAN	ABCG2	physical	26496610
GOSR1_HUMAN	GOSR1	physical	26496610
SC22B_HUMAN	SEC22B	physical	26496610
PIEZ1_HUMAN	PIEZO1	physical	26496610
FLOT1_HUMAN	FLOT1	physical	26496610
RT31_HUMAN	MRPS31	physical	26496610
ERLN1_HUMAN	ERLIN1	physical	26496610
PLPL6_HUMAN	PNPLA6	physical	26496610
CKAP4_HUMAN	CKAP4	physical	26496610
MIC60_HUMAN	IMMT	physical	26496610
ERLN2_HUMAN	ERLIN2	physical	26496610
PHB2_HUMAN	PHB2	physical	26496610
ACINU_HUMAN	ACIN1	physical	26496610
FKBP8_HUMAN	FKBP8	physical	26496610
SUN2_HUMAN	SUN2	physical	26496610
CHM2B_HUMAN	CHMP2B	physical	26496610
MYOF_HUMAN	MYOF	physical	26496610
TBL2_HUMAN	TBL2	physical	26496610
CHM2A_HUMAN	CHMP2A	physical	26496610
GOLI4_HUMAN	GOLIM4	physical	26496610
METL5_HUMAN	METTL5	physical	26496610
STML2_HUMAN	STOML2	physical	26496610
RM27_HUMAN	MRPL27	physical	26496610
S38A2_HUMAN	SLC38A2	physical	26496610
NDUBB_HUMAN	NDUFB11	physical	26496610
INO80_HUMAN	INO80	physical	26496610
DAAF5_HUMAN	DNAAF5	physical	26496610
MIC19_HUMAN	CHCHD3	physical	26496610
OCAD1_HUMAN	OCIAD1	physical	26496610
S35F6_HUMAN	SLC35F6	physical	26496610
PTCD3_HUMAN	PTCD3	physical	26496610
RMD3_HUMAN	RMDN3	physical	26496610
MACOI_HUMAN	TMEM57	physical	26496610
TM165_HUMAN	TMEM165	physical	26496610
NDUAC_HUMAN	NDUFA12	physical	26496610
KDIS_HUMAN	KIDINS220	physical	26496610
EP15R_HUMAN	EPS15L1	physical	26496610
TM109_HUMAN	TMEM109	physical	26496610
TMM43_HUMAN	TMEM43	physical	26496610
CYBR1_HUMAN	CYBRD1	physical	26496610
S35E1_HUMAN	SLC35E1	physical	26496610
ERMP1_HUMAN	ERMP1	physical	26496610
RHG39_HUMAN	ARHGAP39	physical	26496610
TMUB1_HUMAN	TMUB1	physical	26496610
SPNS1_HUMAN	SPNS1	physical	26496610
HOOK3_HUMAN	HOOK3	physical	26496610
ATAD1_HUMAN	ATAD1	physical	26496610
PP4P1_HUMAN	TMEM55B	physical	26496610
MMGT1_HUMAN	MMGT1	physical	26496610
RM55_HUMAN	MRPL55	physical	26496610
CC127_HUMAN	CCDC127	physical	26496610
TM199_HUMAN	TMEM199	physical	26496610
CAVN1_HUMAN	PTRF	physical	26496610
RAB37_HUMAN	RAB37	physical	26496610
UBAC2_HUMAN	UBAC2	physical	26496610
1C07_HUMAN	HLA-C	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RAB5C_MOUSE

Related Literatures of Post-Translational Modification

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