dbPTM

RHG39_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RHG39_HUMAN
UniProt AC	Q9C0H5
Protein Name	Rho GTPase-activating protein 39
Gene Name	ARHGAP39
Organism	Homo sapiens (Human).
Sequence Length	1083
Subcellular Localization	Nucleus .
Protein Description
Protein Sequence	MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVRIKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASAESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLEKDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGVRSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQPSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPNKQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAPNPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQDTLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAEGEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVVRAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAACAQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANMLAWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGLRDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTKGVAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAKNAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAHYDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSQTQDYEC ------CCCCCCCHH	53.92	22814378
7	Phosphorylation	-MSQTQDYECRSHNV -CCCCCCCHHHHCCC	13.70	25159151
64	Phosphorylation	AGVRIKRTSENQWWE CCCEEEECCCCCCEE	35.08	25627689
83	Phosphorylation	NTSRFYYYNASTQRT CCCEEEEEECCCCCE	7.90	-
115	Phosphorylation	TLKQNTESPRASAES HHHHCCCCCCCCCCC	20.04	25159151
119	Phosphorylation	NTESPRASAESSPGR CCCCCCCCCCCCCCC	33.57	23312004
122	Phosphorylation	SPRASAESSPGRGSS CCCCCCCCCCCCCCC	41.36	25159151
123	Phosphorylation	PRASAESSPGRGSSV CCCCCCCCCCCCCCC	23.91	25849741
128	Phosphorylation	ESSPGRGSSVSREGS CCCCCCCCCCCCCCC	26.63	23312004
129	Phosphorylation	SSPGRGSSVSREGST CCCCCCCCCCCCCCC	27.25	23312004
131	Phosphorylation	PGRGSSVSREGSTSS CCCCCCCCCCCCCCC	26.94	23312004
135	Phosphorylation	SSVSREGSTSSSLEP CCCCCCCCCCCCCCC	21.99	25159151
136	Phosphorylation	SVSREGSTSSSLEPE CCCCCCCCCCCCCCC	43.41	25159151
137	Phosphorylation	VSREGSTSSSLEPEP CCCCCCCCCCCCCCC	21.45	25159151
138	Phosphorylation	SREGSTSSSLEPEPD CCCCCCCCCCCCCCC	38.74	24719451
139	Phosphorylation	REGSTSSSLEPEPDT CCCCCCCCCCCCCCH	36.20	28985074
169	Phosphorylation	FGTVKEDSGSSSPPG CCEEECCCCCCCCCC	41.48	25159151
171	Phosphorylation	TVKEDSGSSSPPGVF EEECCCCCCCCCCEE	31.43	20873877
172	Phosphorylation	VKEDSGSSSPPGVFL EECCCCCCCCCCEEE	50.84	25159151
173	Phosphorylation	KEDSGSSSPPGVFLE ECCCCCCCCCCEEEE	36.49	28355574
183	Phosphorylation	GVFLEKDYEIYRDYS CEEEECCCEEEECCC	18.46	21945579
186	Phosphorylation	LEKDYEIYRDYSADG EECCCEEEECCCCCC	5.86	21945579
189	Phosphorylation	DYEIYRDYSADGQLL CCEEEECCCCCCCEE	9.21	21945579
190	Phosphorylation	YEIYRDYSADGQLLH CEEEECCCCCCCEEE	24.95	21945579
198	Phosphorylation	ADGQLLHYRTSSLRW CCCCEEEEEECCCCC	18.63	23917254
200	Phosphorylation	GQLLHYRTSSLRWNS CCEEEEEECCCCCCC	18.59	25627689
201	Phosphorylation	QLLHYRTSSLRWNSG CEEEEEECCCCCCCC	20.55	25159151
202	Phosphorylation	LLHYRTSSLRWNSGA EEEEEECCCCCCCCC	22.72	25159151
223	Phosphorylation	KVADREPSFLAAQGN EEECCCCCCCCCCCC	28.30	20736484
242	Phosphorylation	DGPPGVRSRRPSGSQ CCCCCCCCCCCCCCC	30.18	30576142
246	Phosphorylation	GVRSRRPSGSQHSPS CCCCCCCCCCCCCCC	49.63	27273156
248	Phosphorylation	RSRRPSGSQHSPSLQ CCCCCCCCCCCCCHH	29.11	17525332
251	Phosphorylation	RPSGSQHSPSLQTFA CCCCCCCCCCHHCCC	14.46	27273156
253	Phosphorylation	SGSQHSPSLQTFAPE CCCCCCCCHHCCCCC	35.80	30576142
256	Phosphorylation	QHSPSLQTFAPEADG CCCCCHHCCCCCCCC	27.36	30576142
264	Phosphorylation	FAPEADGTIFFPERR CCCCCCCCEECCCCC	18.37	23312004
273	Phosphorylation	FFPERRPSPFLKRAE ECCCCCCCCCCHHCC	26.86	28985074
284	Phosphorylation	KRAELPGSSSPLLAQ HHCCCCCCCCCCCCC	26.21	29255136
285	Phosphorylation	RAELPGSSSPLLAQP HCCCCCCCCCCCCCC	41.72	29255136
286	Phosphorylation	AELPGSSSPLLAQPR CCCCCCCCCCCCCCC	22.67	29255136
296	Phosphorylation	LAQPRKPSGDSQPSS CCCCCCCCCCCCCCC	59.26	28102081
299	Phosphorylation	PRKPSGDSQPSSPRY CCCCCCCCCCCCCCC	47.73	25849741
302	Phosphorylation	PSGDSQPSSPRYGYE CCCCCCCCCCCCCCC	45.39	28102081
303	Phosphorylation	SGDSQPSSPRYGYEP CCCCCCCCCCCCCCC	21.78	25849741
340	Phosphorylation	QFEAGGGYQAGSPQR EEECCCCCCCCCCCC	9.85	28348404
344	Phosphorylation	GGGYQAGSPQRSPGR CCCCCCCCCCCCCCC	22.37	22468782
348	Phosphorylation	QAGSPQRSPGRKPRP CCCCCCCCCCCCCCC	26.85	28348404
366	Phosphorylation	PNKQGPPSPCQQLVL CCCCCCCCHHHHHEE	41.25	30278072
374	Phosphorylation	PCQQLVLTKQKCPER HHHHHEECCCCCCHH	24.77	25159151
375	Ubiquitination	CQQLVLTKQKCPERF HHHHEECCCCCCHHH	43.53	-
384	Phosphorylation	KCPERFLSLEYSPAG CCCHHHHCCCCCCCC	19.22	21945579
387	Phosphorylation	ERFLSLEYSPAGKEY HHHHCCCCCCCCHHH	25.83	21945579
388	Phosphorylation	RFLSLEYSPAGKEYV HHHCCCCCCCCHHHH	10.01	21945579
394	Phosphorylation	YSPAGKEYVRQLVYV CCCCCHHHHHHHEHH	12.38	28442448
400	Phosphorylation	EYVRQLVYVEQAGSS HHHHHHEHHEECCCC	13.58	21945579
406	Phosphorylation	VYVEQAGSSPKLRAG EHHEECCCCCCCCCC	46.62	21945579
407	Phosphorylation	YVEQAGSSPKLRAGP HHEECCCCCCCCCCC	25.74	19664994
418	Phosphorylation	RAGPRHKYAPNPGGG CCCCCCCCCCCCCCC	22.59	21945579
426	Phosphorylation	APNPGGGSYSLQPSP CCCCCCCCCCCCCCC	18.15	21945579
427	Phosphorylation	PNPGGGSYSLQPSPC CCCCCCCCCCCCCCC	19.37	21945579
428	Phosphorylation	NPGGGSYSLQPSPCL CCCCCCCCCCCCCCC	23.40	21945579
432	Phosphorylation	GSYSLQPSPCLLRDQ CCCCCCCCCCCCCCC	18.45	21945579
445	Phosphorylation	DQRLGVKSGDYSTME CCCCCCCCCCCCCCC	34.19	28152594
448	Phosphorylation	LGVKSGDYSTMEGPE CCCCCCCCCCCCCCC	15.01	25884760
449	Phosphorylation	GVKSGDYSTMEGPEL CCCCCCCCCCCCCCC	26.47	28152594
450	Phosphorylation	VKSGDYSTMEGPELR CCCCCCCCCCCCCCC	17.02	28152594
474	Phosphorylation	QAQEDAMSWSSQQDT HHHHHHHCCHHCCCH	26.06	27251275
476	Phosphorylation	QEDAMSWSSQQDTLS HHHHHCCHHCCCHHH	15.80	30576142
477	Phosphorylation	EDAMSWSSQQDTLSS HHHHCCHHCCCHHHC	26.13	27251275
481	Phosphorylation	SWSSQQDTLSSTGYS CCHHCCCHHHCCCCC	24.97	25159151
483	Phosphorylation	SSQQDTLSSTGYSPG HHCCCHHHCCCCCCC	28.13	30576142
484	Phosphorylation	SQQDTLSSTGYSPGT HCCCHHHCCCCCCCC	29.03	30576142
485	Phosphorylation	QQDTLSSTGYSPGTR CCCHHHCCCCCCCCC	36.44	27251275
487	Phosphorylation	DTLSSTGYSPGTRKR CHHHCCCCCCCCCCC	16.27	27251275
488	Phosphorylation	TLSSTGYSPGTRKRK HHHCCCCCCCCCCCC	20.42	25159151
491	Phosphorylation	STGYSPGTRKRKSRK CCCCCCCCCCCCCCC	36.08	27251275
496	Phosphorylation	PGTRKRKSRKPSLCQ CCCCCCCCCCCCCCC	49.96	23312004
500	Phosphorylation	KRKSRKPSLCQATSA CCCCCCCCCCCCCCC	44.83	28348404
505	Phosphorylation	KPSLCQATSATPTEG CCCCCCCCCCCCCCC	7.94	23312004
506	Phosphorylation	PSLCQATSATPTEGP CCCCCCCCCCCCCCC	32.91	23312004
508	Phosphorylation	LCQATSATPTEGPGD CCCCCCCCCCCCCCC	30.43	23312004
510	Phosphorylation	QATSATPTEGPGDLL CCCCCCCCCCCCCEE	49.58	23312004
531	Phosphorylation	EEQPPCGTSLAPVKR CCCCCCCCCCCCCHH	27.55	23312004
532	Phosphorylation	EQPPCGTSLAPVKRA CCCCCCCCCCCCHHH	14.07	23312004
574	Phosphorylation	HFHMKQRSSWDSQQD HCHHCHHCCCCCCCC	33.03	27251275
575	Phosphorylation	FHMKQRSSWDSQQDG CHHCHHCCCCCCCCC	36.77	27251275
587	Phosphorylation	QDGSGYESDGALPLP CCCCCCCCCCCCCCC	32.62	24719451
604	Phosphorylation	GPVVRAFSEDEALAQ CCEEEEECHHHHHHH	43.06	23927012
621	Phosphorylation	NRHWRRGTFEKLGFP HHHHHCHHHHHHCCC	27.15	27422710
644	Phosphorylation	SVQTNLASPEPYLHP CCCCCCCCCCCCCCC	32.72	25159151
652	Phosphorylation	PEPYLHPSQSEDLAA CCCCCCCCCCHHHHH	35.27	28348404
654	Phosphorylation	PYLHPSQSEDLAACA CCCCCCCCHHHHHHH	37.10	28348404
675	Phosphorylation	QSRSGVPSSSCVFPT HHCCCCCCHHCCCCE	32.26	24719451
676	Phosphorylation	SRSGVPSSSCVFPTF HCCCCCCHHCCCCEE	22.99	28348404
677	Phosphorylation	RSGVPSSSCVFPTFT CCCCCCHHCCCCEEE	20.73	28348404
684	Phosphorylation	SCVFPTFTLRKPSSE HCCCCEEEECCCCCC	28.29	24719451
687	Ubiquitination	FPTFTLRKPSSETDI CCEEEECCCCCCCHH	52.98	-
689	Phosphorylation	TFTLRKPSSETDIEN EEEECCCCCCCHHHH	43.79	23927012
690	Phosphorylation	FTLRKPSSETDIENW EEECCCCCCCHHHHH	53.71	23927012
692	Phosphorylation	LRKPSSETDIENWAS ECCCCCCCHHHHHHH	44.20	23927012
699	Phosphorylation	TDIENWASKHFNKHT CHHHHHHHHHHHHHC	20.48	23927012
700	Ubiquitination	DIENWASKHFNKHTQ HHHHHHHHHHHHHCH	44.46	-
715	Phosphorylation	GLFRRKVSIANMLAW HHHHHHHHHHHHHHH	21.01	27251275
726	Phosphorylation	MLAWSSESIKKPMIV HHHHCCCCCCCCEEE	41.47	24076635
741	Ubiquitination	TSDRHVKKEACELFK CCCHHHHHHHHHHHH	49.83	-
852	Phosphorylation	STYAKYCYHKLQKAA HHHHHHHHHHHHHHH	10.01	-
866 (in isoform 2)	Phosphorylation	-	41.86	30631047
876 (in isoform 2)	Phosphorylation	-	27.30	30631047
877 (in isoform 2)	Phosphorylation	-	46.87	30631047
883	Phosphorylation	RHAKNAVFSPSMFGS HHHHHCCCCHHHHHH	9.15	-
884	Phosphorylation	HAKNAVFSPSMFGSA HHHHCCCCHHHHHHH	14.96	-
886	Phosphorylation	KNAVFSPSMFGSALQ HHCCCCHHHHHHHHH	26.08	-
951	Ubiquitination	KLQVDQWKVPTGLED EEEEEECCCCCCCCC	32.48	-
964	Phosphorylation	EDPHVPASLLKLWYR CCCCCCHHHHHHHHH	28.32	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RHG39_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RHG39_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RHG39_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RHG39_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RHG39_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366 AND SER-690, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406; SER-407 ANDSER-604, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-388 AND SER-604, ANDMASS SPECTROMETRY.	18691976 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173, AND MASSSPECTROMETRY.	15302935 [Abstract]