PP4P1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PP4P1_HUMAN
• UniProt AC: Q86T03
• Protein Name: Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
• Gene Name: PIP4P1 {ECO:0000312|HGNC:HGNC:19299}
• Organism: Homo sapiens (Human).
• Sequence Length: 277
• Subcellular Localization: Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein .
• Protein Description: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate..
• Protein Sequence: MAADGERSPLLSEPIDGGAGGNGLVGPGGSGAGPGGGLTPSAPPYGAAFPPFPEGHPAVLPGEDPPPYSPLTSPDSGSAPMITCRVCQSLINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPVHPGPLSPEPQPMGVRVICGHCKNTFLWTEFTDRTLARCPHCRKVSSIGRRYPRKRCICCFLLGLLLAVTATGLAFGTWKHARRYGGIYAAWAFVILLAVLCLGRALYWACMKVSHPVQNFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8 (in isoform 3)	Phosphorylation	-		29514088
8	Phosphorylation	MAADGERSPLLSEPI CCCCCCCCCCCCCCC		25159151
8 (in isoform 2)	Phosphorylation	-		29514088
12 (in isoform 3)	Phosphorylation	-		29514088
12 (in isoform 2)	Phosphorylation	-		29514088
39	Phosphorylation	AGPGGGLTPSAPPYG CCCCCCCCCCCCCCC		-
41 (in isoform 3)	Phosphorylation	-		-
41	Phosphorylation	PGGGLTPSAPPYGAA CCCCCCCCCCCCCCC		-
45 (in isoform 3)	Phosphorylation	-		-
45	Phosphorylation	LTPSAPPYGAAFPPF CCCCCCCCCCCCCCC		-
79 (in isoform 2)	Phosphorylation	-		28348404
80 (in isoform 2)	Phosphorylation	-		28348404
96	Ubiquitination	SLINVEGKMHQHVVK HHHCCCCEECEEEEE		33845483
103 (in isoform 2)	Ubiquitination	-		-
103	Ubiquitination	KMHQHVVKCGVCNEA EECEEEEECCCCCCC		32015554
110	Ubiquitination	KCGVCNEATPIKNAP ECCCCCCCCCCCCCC		32015554
111	Phosphorylation	CGVCNEATPIKNAPP CCCCCCCCCCCCCCC		21815630
146	Phosphorylation	RIACPRPYCKRIINL CCCCCCHHCCEEEEC		28064214
148	Ubiquitination	ACPRPYCKRIINLGP CCCCHHCCEEEECCC		-
155 (in isoform 2)	Ubiquitination	-		-
162	Phosphorylation	PVHPGPLSPEPQPMG CCCCCCCCCCCCCCC		29255136
169	Phosphorylation	SPEPQPMGVRVICGH CCCCCCCCEEEEECC		32142685
178	Ubiquitination	RVICGHCKNTFLWTE EEEECCCCCCEEECC		-
185 (in isoform 2)	Ubiquitination	-		-
277	Phosphorylation	SHPVQNFS------- CCCCCCCC-------		25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PP4P1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PP4P1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PP4P1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBC9B_HUMAN	TBC1D9B	physical	26186194
GLMN_HUMAN	GLMN	physical	26186194
TBC9B_HUMAN	TBC1D9B	physical	28514442
GLMN_HUMAN	GLMN	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.