PLPL6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLPL6_HUMAN
• UniProt AC: Q8IY17
• Protein Name: Neuropathy target esterase
• Gene Name: PNPLA6
• Organism: Homo sapiens (Human).
• Sequence Length: 1366
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type I membrane protein ; Cytoplasmic side . Anchored to the cytoplasmic face of the endoplasmic reticulum by its N-terminal transmembrane segment.
• Protein Description: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy..
• Protein Sequence: MGTSSHGLATNSSGAKVAERDGFQDVLAPGEGSAGRICGAQPVPFVPQVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPAVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISGLQGGPRSDFDMAYERGRISVSLQEEASGGSLAAPARTPTQEPREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAKQELAKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPAGSGLGVPPHSELTNPASNLATVAILPVCAEVPMVAFTLELQHALQAIGPTLLLNSDIIRARLGASALDSIQEFRLSGWLAQQEDAHRIVLYQTDASLTPWTVRCLRQADCILIVGLGDQEPTLGQLEQMLENTAVRALKQLVLLHREEGAGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSPAKLHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKFDQIYDVGYQYGKAVFGGWSRGNVIEKMLTDRRSTDLNESRRADVLAFPSSGFTDLAEIVSRIEPPTSYVSDGCADGEESDCLTEYEEDAGPDCSRDEGGSPEGASPSTASEMEEEKSILRQRRCLPQEPPGSATDA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGTSSHGLAT -----CCCCCCCCCC	38.63	23322592
4	Phosphorylation	----MGTSSHGLATN ----CCCCCCCCCCC	31.07	23322592
5	Phosphorylation	---MGTSSHGLATNS ---CCCCCCCCCCCC	22.78	22210691
7 (in isoform 2)	Phosphorylation	-	20.96	26552605
7 (in isoform 5)	Phosphorylation	-	20.96	26552605
10	Phosphorylation	TSSHGLATNSSGAKV CCCCCCCCCCCCCCH	40.45	23322592
11	N-linked_Glycosylation	SSHGLATNSSGAKVA CCCCCCCCCCCCCHH	28.68	UniProtKB CARBOHYD
13	Phosphorylation	HGLATNSSGAKVAER CCCCCCCCCCCHHHC	44.85	22210691
20	N-linked_Glycosylation	SGAKVAERDGFQDVL CCCCHHHCCCCCCEE	39.35	-
24 (in isoform 2)	Phosphorylation	-	45.49	26552605
24 (in isoform 5)	Phosphorylation	-	45.49	26552605
33	Phosphorylation	VLAPGEGSAGRICGA EECCCCCCCCCCCCC	24.21	20068231
63	Phosphorylation	AGVAVVVTAVLILLV HHHHHHHHHHHHHHH	10.23	-
79	Phosphorylation	RRLRVPKTPAPDGPR HHCCCCCCCCCCCCC	20.72	28555341
107	Phosphorylation	RKIMRKVSQSTSSLV HHHHHHHHHCCCCHH	22.81	30631047
109	Phosphorylation	IMRKVSQSTSSLVDT HHHHHHHCCCCHHCC	23.81	28555341
110	Phosphorylation	MRKVSQSTSSLVDTS HHHHHHCCCCHHCCC	18.07	28985074
111	Phosphorylation	RKVSQSTSSLVDTSV HHHHHCCCCHHCCCC	27.24	28985074
112	Phosphorylation	KVSQSTSSLVDTSVS HHHHCCCCHHCCCCC	32.28	28985074
116	Phosphorylation	STSSLVDTSVSATSR CCCCHHCCCCCCCCC	24.45	28985074
116 (in isoform 4)	Phosphorylation	-	24.45	24719451
117	Phosphorylation	TSSLVDTSVSATSRP CCCHHCCCCCCCCCH	15.04	28555341
118	Phosphorylation	SSLVDTSVSATSRPR CCHHCCCCCCCCCHH	4.98	-
118 (in isoform 4)	Phosphorylation	-	4.98	27251275
119	Phosphorylation	SLVDTSVSATSRPRM CHHCCCCCCCCCHHH	26.12	28555341
121	Phosphorylation	VDTSVSATSRPRMRK HCCCCCCCCCHHHHH	20.12	30177828
122	Phosphorylation	DTSVSATSRPRMRKK CCCCCCCCCHHHHHH	39.75	27080861
131	Malonylation	PRMRKKLKMLNIAKK HHHHHHHHHHHHHHH	50.66	26320211
137	Malonylation	LKMLNIAKKILRIQK HHHHHHHHHHHHHHH	36.23	26320211
140	Ubiquitination	LNIAKKILRIQKETP HHHHHHHHHHHHCCC	5.61	-
144	Malonylation	KKILRIQKETPTLQR HHHHHHHHCCCCCCC	62.27	26320211
146	Phosphorylation	ILRIQKETPTLQRKE HHHHHHCCCCCCCCC	28.71	21815630
146	Ubiquitination	ILRIQKETPTLQRKE HHHHHHCCCCCCCCC	28.71	-
148	Phosphorylation	RIQKETPTLQRKEPP HHHHCCCCCCCCCCC	42.83	25627689
153	Ubiquitination	TPTLQRKEPPPAVLE CCCCCCCCCCCCEEE	66.29	-
155	Phosphorylation	TLQRKEPPPAVLEAD CCCCCCCCCCEEEEE	30.49	-
171	Phosphorylation	TEGDLANSHLPSEVL CCCCCCCCCCCHHHH	22.31	23663014
175	Phosphorylation	LANSHLPSEVLYMLK CCCCCCCHHHHHHHH	46.85	23663014
179	Phosphorylation	HLPSEVLYMLKNVRV CCCHHHHHHHHCCEE	12.94	23663014
192	Ubiquitination	RVLGHFEKPLFLELC EECCCCCHHHHHHHH	46.18	-
201	Ubiquitination	LFLELCRHMVFQRLG HHHHHHHHHHHHHHC	18.76	-
259	Ubiquitination	DSVNSLLSILDVITG CHHHHHHHHHHHHHC	26.80	21890473
259 (in isoform 2)	Ubiquitination	-	26.80	21890473
275	Phosphorylation	QHPQRTVSARAARDS CCCCCCCCHHHHCCC	16.07	-
283	Phosphorylation	ARAARDSTVLRLPVE HHHHCCCCEEECCHH	28.05	24719451
293	Phosphorylation	RLPVEAFSAVFTKYP ECCHHHHHHHHHHCH	30.48	-
298	Ubiquitination	AFSAVFTKYPESLVR HHHHHHHHCHHHHHH	47.55	21890473
298 (in isoform 3)	Ubiquitination	-	47.55	21890473
299	Phosphorylation	FSAVFTKYPESLVRV HHHHHHHCHHHHHHH	14.80	24043423
302	Phosphorylation	VFTKYPESLVRVVQI HHHHCHHHHHHHHHH	27.88	24043423
307	Ubiquitination	PESLVRVVQIIMVRL HHHHHHHHHHHHHHH	2.07	21890473
307	Ubiquitination	PESLVRVVQIIMVRL HHHHHHHHHHHHHHH	2.07	-
345	Phosphorylation	QPLRLFPSPGLPTRT CCCCCCCCCCCCCCC	25.02	29255136
350	Phosphorylation	FPSPGLPTRTSPVRG CCCCCCCCCCCCCCC	52.18	30266825
352	Phosphorylation	SPGLPTRTSPVRGSK CCCCCCCCCCCCCCC	39.60	23927012
353	Phosphorylation	PGLPTRTSPVRGSKR CCCCCCCCCCCCCCC	20.36	23927012
354	Phosphorylation	GLPTRTSPVRGSKRM CCCCCCCCCCCCCCE	21.15	18691976
355 (in isoform 2)	Ubiquitination	-	12.40	21890473
358	Phosphorylation	RTSPVRGSKRMVSTS CCCCCCCCCCEEECC	13.41	22617229
359	Phosphorylation	TSPVRGSKRMVSTSA CCCCCCCCCEEECCC	47.54	20068231
361	Phosphorylation	PVRGSKRMVSTSATD CCCCCCCEEECCCCC	2.99	20068231
362	Phosphorylation	VRGSKRMVSTSATDE CCCCCCEEECCCCCC	7.01	23186163
362 (in isoform 4)	Phosphorylation	-	7.01	24719451
363	Phosphorylation	RGSKRMVSTSATDEP CCCCCEEECCCCCCC	13.80	29255136
364	Phosphorylation	GSKRMVSTSATDEPR CCCCEEECCCCCCCC	15.80	29255136
365	Phosphorylation	SKRMVSTSATDEPRE CCCEEECCCCCCCCC	22.97	19691289
367	Phosphorylation	RMVSTSATDEPRETP CEEECCCCCCCCCCC	40.43	19691289
372	Phosphorylation	SATDEPRETPGRPPD CCCCCCCCCCCCCCC	70.80	19691289
372 (in isoform 4)	Phosphorylation	-	70.80	24719451
394	Ubiquitination	GPTGDPVKPTSLETP CCCCCCCCCCCCCCC	48.22	21906983
394 (in isoform 1)	Ubiquitination	-	48.22	21890473
397	Phosphorylation	GDPVKPTSLETPSAP CCCCCCCCCCCCCCC	32.51	28555341
400	Phosphorylation	VKPTSLETPSAPLLS CCCCCCCCCCCCHHH	28.03	26074081
402	Phosphorylation	PTSLETPSAPLLSRC CCCCCCCCCCHHHHH	50.35	26074081
403	Ubiquitination	TSLETPSAPLLSRCV CCCCCCCCCHHHHHC	10.44	-
407	Phosphorylation	TPSAPLLSRCVSMPG CCCCCHHHHHCCCCC	31.17	26074081
411	Phosphorylation	PLLSRCVSMPGDISG CHHHHHCCCCCCCCC	23.92	23927012
417	Phosphorylation	VSMPGDISGLQGGPR CCCCCCCCCCCCCCC	37.88	23403867
420	Phosphorylation	PGDISGLQGGPRSDF CCCCCCCCCCCCCHH	59.32	23186163
420 (in isoform 4)	Phosphorylation	-	59.32	24719451
431	Phosphorylation	RSDFDMAYERGRISV CCHHHHHHHCCCEEE	10.26	28796482
437	Phosphorylation	AYERGRISVSLQEEA HHHCCCEEEEEECHH	12.32	26699800
439	Phosphorylation	ERGRISVSLQEEASG HCCCEEEEEECHHHC	19.97	26699800
440 (in isoform 4)	Phosphorylation	-	7.52	27642862
445	Phosphorylation	VSLQEEASGGSLAAP EEEECHHHCCCCCCC	47.14	30266825
448	Phosphorylation	QEEASGGSLAAPART ECHHHCCCCCCCCCC	20.54	30266825
448 (in isoform 4)	Phosphorylation	-	20.54	27251275
455	Phosphorylation	SLAAPARTPTQEPRE CCCCCCCCCCCCCCC	32.56	30266825
457	Phosphorylation	AAPARTPTQEPREQP CCCCCCCCCCCCCCC	44.97	30266825
464	Phosphorylation	TQEPREQPAGACEYS CCCCCCCCCCCCCCE	28.10	24275569
464 (in isoform 4)	Phosphorylation	-	28.10	24719451
470	Phosphorylation	QPAGACEYSYCEDES CCCCCCCCEECCCCC	12.57	21712546
471	Phosphorylation	PAGACEYSYCEDESA CCCCCCCEECCCCCC	10.87	29214152
487	Phosphorylation	GGCPFGPYQGRQTSS CCCCCCCCCCCCHHH	24.79	-
500	Ubiquitination	SSIFEAAKQELAKLM HHHHHHHHHHHHHHC	51.89	-
509	Ubiquitination	ELAKLMRIEDPSLLN HHHHHCCCCCHHHHC	4.36	-
586	Phosphorylation	TGEPLIFTLRAQRDC HCCCEEEEEEECCCC	14.35	24719451
600	Ubiquitination	CTFLRISKSDFYEIM CCEEEEEHHHHHHHH	52.23	-
609	Ubiquitination	DFYEIMRAQPSVVLS HHHHHHHHCCCHHHH	14.30	-
667	Phosphorylation	VLNGRLRSVIQRGSG EECCCHHHHHHCCCC	28.32	-
675	Acetylation	VIQRGSGKKELVGEY HHHCCCCCHHHCCCC	44.78	19809977
676	Acetylation	IQRGSGKKELVGEYG HHCCCCCHHHCCCCC	60.86	19815121
701	Phosphorylation	LTRQPRATTVHAVRD HHCCCCCEEEEEECC	30.54	22210691
702	Phosphorylation	TRQPRATTVHAVRDT HCCCCCEEEEEECCC	14.87	22210691
718	Phosphorylation	LAKLPEGTLGHIKRR HHCCCCCCHHHHHHH	28.09	-
722	Ubiquitination	PEGTLGHIKRRYPQV CCCCHHHHHHHHHHH	3.35	-
809	Phosphorylation	GPTLLLNSDIIRARL CHHEEECHHHHHHHH	30.10	19664995
818	Phosphorylation	IIRARLGASALDSIQ HHHHHHCCHHHHHHH	9.02	-
845	Phosphorylation	DAHRIVLYQTDASLT CCCEEEEEECCCCCC	9.85	20068231
847	Phosphorylation	HRIVLYQTDASLTPW CEEEEEECCCCCCHH	21.70	20068231
850	Phosphorylation	VLYQTDASLTPWTVR EEEECCCCCCHHHHH	35.27	22617229
852	Phosphorylation	YQTDASLTPWTVRCL EECCCCCCHHHHHHH	17.81	22617229
854	Phosphorylation	TDASLTPWTVRCLRQ CCCCCCHHHHHHHHH	11.42	20068231
855	Phosphorylation	DASLTPWTVRCLRQA CCCCCHHHHHHHHHC	10.16	20068231
859	Phosphorylation	TPWTVRCLRQADCIL CHHHHHHHHHCCEEE	2.97	-
861	Phosphorylation	WTVRCLRQADCILIV HHHHHHHHCCEEEEE	28.71	-
864	Phosphorylation	RCLRQADCILIVGLG HHHHHCCEEEEEECC	2.82	20068231
880	Ubiquitination	QEPTLGQLEQMLENT CCCCHHHHHHHHHHH	4.72	21890473
893	Ubiquitination	NTAVRALKQLVLLHR HHHHHHHHHHHHHHH	40.37	-
902	Ubiquitination	LVLLHREEGAGPTRT HHHHHHCCCCCCCCE	55.06	-
907 (in isoform 2)	Ubiquitination	-	37.75	21890473
936	Phosphorylation	RRLFSRRSPAKLHEL HHHHHCCCHHHHHHH	28.26	24719451
944	Phosphorylation	PAKLHELYEKVFSRR HHHHHHHHHHHHHHH	15.66	24719451
945	Phosphorylation	AKLHELYEKVFSRRA HHHHHHHHHHHHHHH	56.20	-
945 (in isoform 3)	Ubiquitination	-	56.20	21890473
945 (in isoform 4)	Phosphorylation	-	56.20	24719451
946	Ubiquitination	KLHELYEKVFSRRAD HHHHHHHHHHHHHHH	34.72	21890473
953	Phosphorylation	KVFSRRADRHSDFSR HHHHHHHHCCCCHHH	47.19	-
953 (in isoform 4)	Phosphorylation	-	47.19	24719451
955	Ubiquitination	FSRRADRHSDFSRLA HHHHHHCCCCHHHHH	32.06	21890473
955	Ubiquitination	FSRRADRHSDFSRLA HHHHHHCCCCHHHHH	32.06	-
956	Phosphorylation	SRRADRHSDFSRLAR HHHHHCCCCHHHHHH	41.04	20860994
959	Phosphorylation	ADRHSDFSRLARVLT HHCCCCHHHHHHHHC	31.23	20860994
966	Phosphorylation	SRLARVLTGNTIALV HHHHHHHCCCEEEEE	26.06	23879269
969	Phosphorylation	ARVLTGNTIALVLGG HHHHCCCEEEEEECC	14.69	-
1019	Phosphorylation	ALYAEERSASRTKQR HHHHHHHHCHHHHHH	33.60	25137130
1021	Phosphorylation	YAEERSASRTKQRAR HHHHHHCHHHHHHHH	41.55	25137130
1093	Ubiquitination	ASAMRVHKDGSLWRY HHHEEECCCCCHHHH	62.01	-
1096	Phosphorylation	MRVHKDGSLWRYVRA EEECCCCCHHHHHHH	34.59	24719451
1102	Ubiquitination	GSLWRYVRASMTLSG CCHHHHHHHCEECCC	16.41	-
1128	Phosphorylation	HLLMDGGYINNLPAD CEEECCCCCCCCCHH	13.15	-
1190	Ubiquitination	KVPDMAEIQSRLAYV CCCCHHHHHHHHHHH	3.06	-
1232	Ubiquitination	MDFGKFDQIYDVGYQ CCCCCCHHHEECCHH	38.99	-
1265	Ubiquitination	LTDRRSTDLNESRRA HHCCCCCCCCHHHHH	49.06	-
1269	Phosphorylation	RSTDLNESRRADVLA CCCCCCHHHHHCEEE	26.45	21815630
1279	Phosphorylation	ADVLAFPSSGFTDLA HCEEECCCCCCCCHH	36.32	-
1280	Phosphorylation	DVLAFPSSGFTDLAE CEEECCCCCCCCHHH	37.86	-
1283	Phosphorylation	AFPSSGFTDLAEIVS ECCCCCCCCHHHHHH	33.36	-
1290	Phosphorylation	TDLAEIVSRIEPPTS CCHHHHHHCCCCCCC	32.95	-
1296	Phosphorylation	VSRIEPPTSYVSDGC HHCCCCCCCCCCCCC	43.32	-
1298	Phosphorylation	RIEPPTSYVSDGCAD CCCCCCCCCCCCCCC	13.37	26074081
1300	Phosphorylation	EPPTSYVSDGCADGE CCCCCCCCCCCCCCC	21.76	26074081
1309	Phosphorylation	GCADGEESDCLTEYE CCCCCCCCCCCCCCH	29.35	22798277
1313	Phosphorylation	GEESDCLTEYEEDAG CCCCCCCCCCHHHCC	42.74	-
1315	Phosphorylation	ESDCLTEYEEDAGPD CCCCCCCCHHHCCCC	21.27	22798277
1330	Phosphorylation	CSRDEGGSPEGASPS CCCCCCCCCCCCCCC	30.54	23401153
1335	Phosphorylation	GGSPEGASPSTASEM CCCCCCCCCCCHHHH	30.18	25850435
1337	Phosphorylation	SPEGASPSTASEMEE CCCCCCCCCHHHHHH	33.82	-
1339	Phosphorylation	EGASPSTASEMEEEK CCCCCCCHHHHHHHH	14.08	18452278
1344	Phosphorylation	STASEMEEEKSILRQ CCHHHHHHHHHHHHH	70.21	-
1347	Phosphorylation	SEMEEEKSILRQRRC HHHHHHHHHHHHHCC	30.09	24719451
1355	Ubiquitination	ILRQRRCLPQEPPGS HHHHHCCCCCCCCCC	4.68	-
1356	Phosphorylation	LRQRRCLPQEPPGSA HHHHCCCCCCCCCCC	39.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLPL6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLPL6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLPL6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PLPL6_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00266: Hereditary spastic paraplegia (SPG)
• OMIM Disease
• 612020: Spastic paraplegia 39, autosomal recessive (SPG39)
• 215470: Boucher-Neuhauser syndrome (BNHS)
• 245800: Laurence-Moon syndrome (LNMS)
• 275400: Oliver-McFarlane syndrome (OMCS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-345; THR-352 ANDSER-353, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-345 AND SER-411, ANDMASS SPECTROMETRY.
PubMed: 18691976

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, AND MASSSPECTROMETRY.
PubMed: 19007248