| UniProt ID | TM109_HUMAN | |
|---|---|---|
| UniProt AC | Q9BVC6 | |
| Protein Name | Transmembrane protein 109 | |
| Gene Name | TMEM109 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 243 | |
| Subcellular Localization |
Nucleus outer membrane Multi-pass membrane protein . Endoplasmic reticulum membrane Multi-pass membrane protein . Sarcoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. [PubMed: 23542032 Can form voltage-gated calcium and potassium channels in vitro (By similarity] | |
| Protein Sequence | MAASSISSPWGKHVFKAILMVLVALILLHSALAQSRRDFAPPGQQKREAPVDVLTQIGRSVRGTLDAWIGPETMHLVSESSSQVLWAISSAISVAFFALSGIAAQLLNALGLAGDYLAQGLKLSPGQVQTFLLWGAGALVVYWLLSLLLGLVLALLGRILWGLKLVIFLAGFVALMRSVPDPSTRALLLLALLILYALLSRLTGSRASGAQLEAKVRGLERQVEELRWRQRRAAKGARSVEEE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MAASSISSPWG ----CCCCCCCCHHH | 20.75 | 23401153 | |
| 5 | Phosphorylation | ---MAASSISSPWGK ---CCCCCCCCHHHH | 23.05 | 23401153 | |
| 8 | Phosphorylation | MAASSISSPWGKHVF CCCCCCCCHHHHHHH | 24.01 | 20068231 | |
| 46 | Ubiquitination | FAPPGQQKREAPVDV CCCCCCCCCCCCHHH | 44.30 | 24816145 | |
| 178 | Phosphorylation | GFVALMRSVPDPSTR HHHHHHHCCCCHHHH | 24.84 | - | |
| 203 | Phosphorylation | YALLSRLTGSRASGA HHHHHHHHCCCCCCH | 31.81 | 30576142 | |
| 215 | Ubiquitination | SGAQLEAKVRGLERQ CCHHHHHHHHCHHHH | 24.08 | 21906983 | |
| 239 | Phosphorylation | RAAKGARSVEEE--- HHHHCCCCCCCC--- | 33.09 | 28355574 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TM109_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TM109_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TM109_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CRYAB_HUMAN | CRYAB | physical | 23542032 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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