CNN3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNN3_MOUSE
• UniProt AC: Q9DAW9
• Protein Name: Calponin-3
• Gene Name: Cnn3
• Organism: Mus musculus (Mouse).
• Sequence Length: 330
• Protein Description: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)..
• Protein Sequence: MTHFNKGPSYGLSAEVKNKIASKYDQQAEEDLRNWIEEVTGLGIGTNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYPDDYPREYQYGDDQGIDY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MTHFNKGPSYGLS --CCCCCCCCCCCCC	71.85	23806337
6	Ubiquitination	--MTHFNKGPSYGLS --CCCCCCCCCCCCC	71.85	-
6	Malonylation	--MTHFNKGPSYGLS --CCCCCCCCCCCCC	71.85	26320211
9	Phosphorylation	THFNKGPSYGLSAEV CCCCCCCCCCCCHHH	40.27	28833060
10	Phosphorylation	HFNKGPSYGLSAEVK CCCCCCCCCCCHHHH	25.81	29514104
13	Phosphorylation	KGPSYGLSAEVKNKI CCCCCCCCHHHHHHH	20.30	28833060
17	Ubiquitination	YGLSAEVKNKIASKY CCCCHHHHHHHHHHH	43.99	22790023
23	Acetylation	VKNKIASKYDQQAEE HHHHHHHHHHHHHHH	43.77	23806337
64	Ubiquitination	ILCELINKLQPGSVK HHHHHHHHHCCCCEE	41.32	-
156	Acetylation	TRRFDEGKLKAGQSV CCCCCCCCCCCCCEE	44.78	23236377
158	Ubiquitination	RFDEGKLKAGQSVIG CCCCCCCCCCCEEEE	54.69	22790023
158	Methylation	RFDEGKLKAGQSVIG CCCCCCCCCCCEEEE	54.69	-
162	Phosphorylation	GKLKAGQSVIGLQMG CCCCCCCEEEEEECC	18.13	22324799
175	Phosphorylation	MGTNKCASQAGMTAY CCCCHHHHHHCCCCC	29.99	29514104
182	Phosphorylation	SQAGMTAYGTRRHLY HHHCCCCCCCCCCCC	15.18	22817900
184	Phosphorylation	AGMTAYGTRRHLYDP HCCCCCCCCCCCCCC	16.32	-
215	Phosphorylation	MGTNKGASQAGMLAP ECCCCCCHHCCCCCC	29.27	29514104
232	Ubiquitination	RRDIYDQKLTLQPVD CCCCCCCCCEEEECC	40.31	-
241	Phosphorylation	TLQPVDNSTISLQMG EEEECCCCEEEEEEC	23.74	29514104
244	Phosphorylation	PVDNSTISLQMGTNK ECCCCEEEEEECCCH	16.79	29514104
251	Ubiquitination	SLQMGTNKVASQKGM EEEECCCHHHCCCCC	38.73	22790023
254	Phosphorylation	MGTNKVASQKGMSVY ECCCHHHCCCCCCEE	35.10	-
256	Ubiquitination	TNKVASQKGMSVYGL CCHHHCCCCCCEECC	54.83	22790023
256	Acetylation	TNKVASQKGMSVYGL CCHHHCCCCCCEECC	54.83	23806337
259	Phosphorylation	VASQKGMSVYGLGRQ HHCCCCCCEECCCCC	22.36	24899341
261	Phosphorylation	SQKGMSVYGLGRQVY CCCCCCEECCCCCCC	10.18	26643407
271	Ubiquitination	GRQVYDPKYCAAPTE CCCCCCCCCCCCCCC	50.49	-
277	Phosphorylation	PKYCAAPTEPVIHNG CCCCCCCCCCEEECC	48.47	25338131
285	Phosphorylation	EPVIHNGSQGTGTNG CCEEECCCCCCCCCC	30.65	25338131
288	Phosphorylation	IHNGSQGTGTNGSEI EECCCCCCCCCCCCC	32.94	22802335
290	Phosphorylation	NGSQGTGTNGSEISD CCCCCCCCCCCCCCC	35.92	22802335
293	Phosphorylation	QGTGTNGSEISDSDY CCCCCCCCCCCCCCC	33.55	19060867
296	Phosphorylation	GTNGSEISDSDYQAE CCCCCCCCCCCCCCC	27.32	19060867
298	Phosphorylation	NGSEISDSDYQAEYP CCCCCCCCCCCCCCC	31.28	17242355
300	Phosphorylation	SEISDSDYQAEYPDE CCCCCCCCCCCCCCC	17.36	-
316	Phosphorylation	HGEYPDDYPREYQYG CCCCCCCCCCHHCCC	16.15	22817900
320	Phosphorylation	PDDYPREYQYGDDQG CCCCCCHHCCCCCCC	14.33	22817900
322	Phosphorylation	DYPREYQYGDDQGID CCCCHHCCCCCCCCC	22.94	-
330	Phosphorylation	GDDQGIDY------- CCCCCCCC-------	20.66	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
293	S	Phosphorylation	Kinase	ERK2	P63085	PSP
293	S	Phosphorylation	Kinase	ERK1	Q63844	PSP
293	S	Phosphorylation	Kinase	ROCK1	Q13464	PSP
293	S	Phosphorylation	Kinase	ROCK1	P70335	PSP
293	S	Phosphorylation	Kinase	ROCK2	O75116	PSP
293	S	Phosphorylation	Kinase	ROCK2	P70336	PSP
296	S	Phosphorylation	Kinase	ROCK1	Q13464	PSP
296	S	Phosphorylation	Kinase	ROCK1	P70335	PSP
296	S	Phosphorylation	Kinase	ROCK2	O75116	PSP
296	S	Phosphorylation	Kinase	ROCK2	P70336	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNN3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNN3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CNN3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.