TIRR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIRR_HUMAN
• UniProt AC: Q9BRJ7
• Protein Name: Tudor-interacting repair regulator protein {ECO:0000303|PubMed:28241136}
• Gene Name: NUDT16L1 {ECO:0000312|HGNC:HGNC:28154}
• Organism: Homo sapiens (Human).
• Sequence Length: 211
• Subcellular Localization: Nucleus .
• Protein Description: Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. [PubMed: 28241136 In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus]
• Protein Sequence: MSTAAVPELKQISRVEAMRLGPGWSHSCHAMLYAANPGQLFGRIPMRFSVLMQMRFDGLLGFPGGFVDRRFWSLEDGLNRVLGLGLGCLRLTEADYLSSHLTEGPHRVVAHLYARQLTLEQLHAVEISAVHSRDHGLEVLGLVRVPLYTQKDRVGGFPNFLSNAFVSTAKCQLLFALKVLNMMPEEKLVEALAAATEKQKKALEKLLPASS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTAAVPEL ------CCCCCCHHH		21406692
3	Phosphorylation	-----MSTAAVPELK -----CCCCCCHHHH		21406692
10 (in isoform 2)	Ubiquitination	-		-
10	Ubiquitination	TAAVPELKQISRVEA CCCCHHHHHHCCHHC		28241136
13	Phosphorylation	VPELKQISRVEAMRL CHHHHHHCCHHCCCC		24719451
49	Phosphorylation	GRIPMRFSVLMQMRF CCCCCCHHHHHHCCC		20068231
96	Phosphorylation	LRLTEADYLSSHLTE HHHHHHHHHHHHCCC		-
148	Phosphorylation	GLVRVPLYTQKDRVG EEEEEEECCCCCCCC		29496907
151	Succinylation	RVPLYTQKDRVGGFP EEEECCCCCCCCCCC		23954790
151	Ubiquitination	RVPLYTQKDRVGGFP EEEECCCCCCCCCCC		21890473
151 (in isoform 1)	Ubiquitination	-		21890473
164 (in isoform 2)	Phosphorylation	-		22210691
165 (in isoform 2)	Phosphorylation	-		22210691
177 (in isoform 2)	Phosphorylation	-		22210691
187	Ubiquitination	LNMMPEEKLVEALAA HHCCCHHHHHHHHHH		-
198	Ubiquitination	ALAAATEKQKKALEK HHHHCHHHHHHHHHH		2190698
198 (in isoform 1)	Ubiquitination	-		21890473
201	Ubiquitination	AATEKQKKALEKLLP HCHHHHHHHHHHHCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RNF185	Q96GF1	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIRR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIRR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
NUD16_HUMAN	NUDT16	physical	28514442
TP53B_HUMAN	TP53BP1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.